Tobacco & Cannabis

Woman breaking a cigarette

Researchers in the Department of Psychiatry and & Behavioral Sciences at Duke have a long history of conducting cutting-edge research on the causes and consequences of tobacco and cannabis use. 

Duke Center for Addiction Science and Technology (CfAST) 

Led by Joseph McClernon, PhD, CfAST is dedicated to increasing our understanding of tobacco use, developing novel interventions to help those most in need, and informing regulators and policy makers. CfAST researchers are evaluating the effects of flavors in e-cigarettes on the use of combusted cigarettes and how environmental contexts influence smoking behavior and relapse.

CfAST is also part of the national Center for the Evaluation of Nicotine in Cigarettes, which is evaluating the effects of reducing nicotine in cigarettes on smokers’ use of less harmful, non-combusted tobacco products. 

Maggie Sweitzer, PhD, leads a program of research on the interactive effects of smoking and pain among smokers with and without chronic pain conditions.

Access to Behavioral Health for All Lab

The Access to Behavioral Health for All (ABHA) Lab in the Center for Addiction Science and Technology, led by Roger Vilardaga, PhD, ideates, develops and tests digital behavioral health interventions for underserved populations, such as individuals who experience persistent mental health symptoms, addiction or HIV.

Learn More about ABHA Lab 

Duke Center for Smoking Cessation

The Duke Center for Smoking Cessation is committed to researching novel treatments to help smokers break the addiction of nicotine. The Center’s director, Jed E. Rose, PhD, is a co-inventor of the nicotine patch and has been a pioneer in the field of nicotine and cessation research. Current research in the center is focused on developing personalized smoking cessation pharmacotherapy interventions and the testing and evaluation of novel pharmacotherapies. Research led by Alexey Mukhin, MD, is evaluating the effects of e-cigarette vapor on the accumulation of nicotine in the brain.

Neurobehavioral Research Lab

Researchers at the Neurobehavioral Research Lab, led by Ed Levin, PhD, aim to increase understanding basic neural interactions underlying cognitive function and addiction and to apply this knowledge to better understand cognitive dysfunction and addiction disorders and to develop novel therapeutic treatments. 

The lab has documented the basic effects of nicotine on learning, memory, and attention as well as nicotine self-administration. Mechanistic studies in rat models use selective lesions, local infusions and neurotransmitter interaction studies.

VA Healthcare System Smoking Cessation and Cannabis Research Program 

This program is dedicated to evaluating personalized smoking cessation interventions for vulnerable VA populations, including those with co-morbid psychiatric and physical disorders. Drs. Jean Beckham, Daniel Blalock, Patrick Calhoun, Eric Dedert, Nathan Kimbrel, Sarah Wilson and Jonathan Young collaborate on multiple projects within the program, including: 

  • Evaluating a national smoking cessation texting program for veterans
  • Investigating whether individuals with PTSD who smoke cannabis heavily reduce their cannabis use whether their functional and psychiatric symptoms will improve

Other Cannabis Studies

Researchers are studying the effects of cannabis use on epigenetic changes in male sperm and the effects of paternal cannabis use on birth outcomes and infant health outcomes.

Another team of researchers is using fetal MRI scans to study the effects of prenatal cannabis exposure on the developing brain. This research will shed light on the safety of cannabis use during pregnancy, testing whether this prenatal exposure negatively affects children’s mental health.


Click on a faculty member’s name to view their profile, including their grants and publications.