Undergraduate School
Haverford College
Graduate School
Duke University School of Medicine
Medical School
Duke University School of Medicine
Interests and Career Goals
Clinically, I am interested in child/adolescent and consultation/liaison psychiatry. Scientifically, I am interested in translational neuroscience, particularly related to neurodevelopment. I am passionate about increasing communication between the basic science and clinical worlds and hope to incorporate teaching into my career.
Favorite Pastimes
I love anything that involves being outside, particularly running and hiking. I also enjoy tending to my vegetable garden (lots of tomatoes!), drawing, trying new restaurants, and being a dog-mom.
Strengths of the Program
The people!! But also: a supportive culture where being honest and vulnerable is valued and modeled by leadership, multiple clinical settings with diverse patient populations, tons of elective and research opportunities, a responsive leadership team that welcomes feedback, and a new inpatient facility with outdoor courtyards and lots of natural light for patients (and residents!)
Areas of Prior Research
- Immunology/Stem Cell Biology – Ex vivo maintenance of long-term hematopoietic stem cells
- Cancer Biology – Preclinical trials for novel treatments of neuroblastoma
- Molecular Neurobiology – Mouse models of genetic mutations and molecular mechanisms underlying neurodevelopmental/neurodegenerative disease processes
Publications
- Courtland JL*, Bradshaw TWA*, Waitt G, Soderblom EJ, Ho T, Rajab A, Vancini R, Kim IH, Soderling SH. Genetic Disruption of WASHC4 Drives Endo-lysosomal Dysfunction and Cognitive-Movement Impairments in Mice and Humans. eLife, 2021 Mar 22; 10: e61590. doi: 10.7554/eLife.61590. PMID: 33749590
- Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH. Chemico-genetic discovery of astrocytic control of inhibition in vivo. Nature, December 2020. doi: 10.1038/s41586-020-2926-0. PMID: 33177716
- Kim IH, Kim N, Kim S, Toda K, Catavero C, Courtland J, Yin H, Soderling SH. Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology Leading to Social Dysfunction. Cell Reports, 2020 Jul 28;32(4):107965. doi: 10.1016/j.celrep.2020.107965. PMID: 32726629
- Gao Y, Hisey E, Bradshaw TWA, Erata E, Brown WE, Courtland JL, Uezu A, Xiang Y, Diao Y, Soderling SH. Plug and Play Proteome Modification using Homology-independent Universal Genome Engineering. Neuron, 2019. PMID: 31272828
- Croucher JL*, Iyer R, Li N, Molteni V, Loren J, Gordon WP, Tuntland T, Liu B, Brodeur GM. TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. Cancer Chemother Pharmacol. 2015 Jan;75(1):131-41. Epub 2014 Nov 14. PMID: 25394774
- Iyer R*, Croucher JL*, Chorny M, Mangino JL, Alferiev IS, Levy RJ, Kolla V, Brodeur GM. Nanoparticle delivery of SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer Lett. 2015 May 1;360(2):205-12. Epub 2015 Feb 12. PMID: 25684664
- Alferiev IS*, Iyer R*, Croucher JL*, Adamo RF, Zhang K, Mangino JL, Kolla V, Fishbein I, Brodeur GM, Levy RJ, Chorny M. Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials. 2015 May;51:22-9. Epub 2015 Feb 16. PMID: 25770994
- Iyer R*, Wehrmann L*, Golden RL, Naraparaju K, Croucher JL, MacFarland SP, Guan P, Kolla V, Wei G, Cam N, Li G, Hornby Z, Brodeur GM. Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model. Cancer Lett. 2016 Mar 28;372(2):179-86. Epub 2016 Jan 18. PMID: 26797418
- Brodeur GM*, Iyer R, Croucher JL, Zhuang T, Higashi M, Kolla V. Therapeutic targets for neuroblastomas. Expert Opin Ther Targets. 2014 Mar;18(3):277-92. Epub 2014 Jan 6. Review. PMID: 24387342
*denotes first-authorship, previous surname: Croucher
Selected Presentations
- American Society for Cell Biology, Virtual Minisymposium: “Cell Biology of the Nervous System,” 2020. Oral Presentation: Genetic Disruption of the WASH Complex Drives Endo-lysosomal Dysfunction and Cognitive-Movement Impairments in Mice and Humans.
- 35th Annual National MD-PhD Conference. Virtual due to COVID-19, 2020. Oral Presentation: Unraveling the Role of the WASH Complex in Neurologic Dysfunction.
- Duke Neurobiology Seminar Series. Durham, NC, 2020. Oral Presentation: Unraveling the Role of the WASH Complex in Neurologic Disorders.
- In House Cell Biology Seminar Series. Durham, NC, 2020. Oral Presentation: Unravelling the Role of the WASH Complex in Neurologic Dysfunction.
- American Academy of Child and Adolescent Psychiatry. Chicago, IL, 2019. Poster Presentation: From Patients to Organelles: Uncovering the Molecular Basis of an Inherited Cognitive and Movement Disorder.
- 34th National Annual MD-PhD Conference, Copper Mountain, CO, 2019. Poster Presentation: Unraveling the Role of the WASH Complex in Neurologic Dysfunction.
- Society for Neuroscience. San Diego, CA, 2018. Poster Presentation: Unraveling the Role of the WASH Complex in Neurologic Dysfunction.