Undergraduate School
Tufts University
Graduate School
Tufts University School of Biomedical Sciences
Medical School
Tufts University School of Medicine
Interests & Career Goals
Neuropsych, psychotherapy, perinatal psychiatry, mood disorders; I aim to study the genetics and underlying molecular biology of psychiatric/neuropsychiatric disease
Favorite Pastimes
Swimming, cross country skiing, hiking, spending time with my husband and daughter
Strengths of the Program
Supportive community, strong research and PSTP program, psychotherapy and family studies, leadership
Areas of Prior Research
Genome instability - mechanisms of repeat expansion and instability in repeat expansion disorders
Publications/Abstracts
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Hisey, J. A., Masnovo, C., Mirkin, S. M. (2024) Triplex H-DNA structure: the long and winding road from the discovery to its role in human disease. Nucleic Acids Research Molecular Medicine, 1, ugae024.
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Hisey, J. A., Radchenko, E. A., Mandel, N. H., McGinty, R. J., Matos-Rodrigues, G., Rastokina, A., Masnovo, C., Ceschi, S., Hernandez, A., Nussenzweig, A., Mirkin, S. M. (2024) Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Research, 52, 4361-4374.
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Matos-Rodrigues, G.#, Hisey, J. A.#, Nussenzweig, A., Mirkin, S. M. (2023) Detection of alternative DNA structures and its implications for human disease. Molecular Cell, 83, 3622-3641. #Co-first authors
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Neil, A. J.#, Hisey, J. A.#, Quasem, I., McGinty, R. J., Hitczenko, M., Khristich, A. N., Mirkin, S. M. (2021) Replication-Independent Instability of Friedreich’s Ataxia GAA Repeats during Chronological Aging. Proceedings of the National Academy of Sciences of the United States of America, 118. #Co-first authors
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McGinty, R. J., Puleo, F., Aksenova, A. Y., Hisey, J. A., Shishkin, A.A., Pearson, E. L., Wang, E. T., Housman, D. E., Moore, C., Mirkin, S. M. (2017) A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich’s Ataxia. Cell Reports, 20, 2490-2500.
Poster Presentations
- Structure-Function Analysis of AAGGG Repeats Implicated in the Repeat Expansion Disease, CANVAS. 7th US-EU Conference on Endogenous DNA Damage and Repair, Stony Brook, NY, 11/2022.
- Structure-Function Analysis of AAGGG Repeats Implicated in the Repeat Expansion Disease, CANVAS. MD/PhD Annual Retreat, Tufts University, Medford, MA, 7/2022.
- Replication-Independent Instability in Friedreich’s Ataxia GAA Repeats during Chronological Aging. Genomic Stability and DNA Repair (Keystone eSymposia), virtual symposium, 9/2020.
- Mechanisms of GAA repeat-mediated instability in quiescent Saccharomyces cerevisiae. APSA Northeast Regional MD/PhD Student Symposium, Boston University, MA, 12/2019.
Oral Presentations
- Structure-Function Analysis of AAGGG Repeats Implicated in the Repeat Expansion Disease, CANVAS. The Dynamic DNA Structures in Biology Conference (FASEB), Nova Scotia, CA, 6/2022.
- DNA Repair Pathways Promote GAA Repeat-Mediated Mutation in Nondividing Yeast. Genomic Repeats Link Cancer and Neurodegeneration, The New York Academy of Sciences, 4/2021.
- Replication-independent instability of Friedreich’s Ataxia GAA repeats during chronological aging. DNA Repair and Mutagenesis (DRAM), MIT, 1/2021.
- Exploring the Biological Role of Triplex DNA Structures. Graduate Student Speaker Series, Tufts University, virtual speaker series, 8/2020.
- 3-minute thesis talk - Investigating the mechanisms of somatic instability of Friedreich’s Ataxia’s GAA Repeats. 24th Graduate Student Research Symposium, Tufts University, Medford, MA, 3/2020.
- Mechanisms of Friedreich’s ataxia’s GAA repeat-mediated instability in quiescent yeast. P01 Retreat on Replication, Recombination, and Repair, Tufts University, Medford, MA, 1/2020.