Brynna Eisele, MD, PhD

Brynna Eisele

Undergraduate School
University of Alabama at Birmingham

Medical School
Vanderbilt University



Interests and Career Goals

Research/academics, consult-liaison psychiatry

Favorite Pastimes

Grocery shopping, parenting, playing piano

Strengths of the Program

Family-friendly environment, strong academic reputation, excellent program leadership

Areas of Prior Research

Lithium-inhibited phosphatases, extracellular matrix, neuroepigenetics


  • Eisele BS, Wu AJ, Luka Z, Hale AT, and York JD. Bisphosphate nucleotidase 2 (BPNT2) regulates chondroitin sulfation patterns in the cerebral cortex. Advances in Biological Regulation. 2021. doi:0.1016/j.jbior.2021.100858 
  • Eisele BS, Luka Z, Wu AJ, Yang F, Hale AT, and York JD. Sulfation of glycosaminoglycans depends on catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. Journal of Biological Chemistry. 2021. doi:10.1016/j.jbc.2021.101293 
  • Kennedy AJ, Rahn EJ, Paulukaitis (Eisele) BS, Savell KE, Kordasiewicz HB, Wang J, Lewis JW, Posey J, Strange SK, Guzman-Karlsson MC, Philips SE, Decker K, Motley ST, Swayze EE, Ecker DJ, Michael TP, Day JJ, Sweatt JD. Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function. Cell Reports. 2016. doi:10.1016/j.celrep.2016.08.004 
  • Zovkic IB, Paulukaitis (Eisele) BS, Day JJ, Etikala DM, Sweatt JD. Histone H2A.Z subunit exchange controls consolidation of recent and remote memory. Nature. 2014. doi:10.1038/nature13707

Poster Presentations

  • Eisele BS, Wu AJ, Luka Z & York JD Bisphosphate nucleotidase 2 (BPNT2), a lithium-inhibited phosphatase, regulates chondroitin sulfation patterns in mouse brain. 36th Annual National MD-PhD Student Conference; 2021 July 9; University of Colorado. 
  • Eisele BS, Wu AJ & York JD. Investigation of a mutation in bisphosphate nucleotidase 2 (BPNT2) which underlies an autosomal recessive chondrodysplasia. Department of Pharmacology Retreat; 2020 October 16; Vanderbilt University. 
  • Eisele BS, Frederick JP &York JD. Knockout of Golgi-resident PAP phosphatase alters expression of key components of glycosaminoglycan sulfation pathways. Department of Pharmacology Retreat; 2019 October 30; Vanderbilt University. 
  • Eisele BS, Wu AJ, Hale AT & York JD. Knockdown of a lithium-sensitive phosphatase decreases chondroitin-4-sulfate and perineuronal net expression in differentiated neuroblastoma cells. Joel G. Hardman Pharmacology Forum; 2019 April 25; Vanderbilt University. 
  • Paulukaitis-Eisele BS, Zovkic IB & Sweatt JD. Histone variant H2A.Z expression is induced by KCl-mediated depolarization of cortical neurons. Vanderbilt MSTP Retreat; 2018 June 30; Vanderbilt University. 
  • Paulukaitis (Eisele) BS, Zovkic IB & Sweatt JD. H2A.Z and DNA Methylation Interact in Memory Consolidation. Ost Research Competition; 2015 April; University of Alabama At Birmingham. 
  • Paulukaitis (Eisele) BS & Pence GE. The Ethics of Care and Global Health: Prioritizing Policy based on Relationships and Reciprocity. National Undergraduate Bioethics Conference; 2013 April 5-6; Georgetown University, Washington D.C.