Alexander Moghadam, MD, PhD

Alexander Moghadam

Undergraduate School
Johns Hopkins University 

Medical School
New York Medical College
 

 
 

Interests and Career Goals

Neuroscience research in realm of psychiatric disorders, psychotic disorders (clinical practice and research).

Favorite Pastimes

Running (marathoner), video games, gardening, hiking, camping, playing guitar, painting and drawing.

Strengths of the Program

Duke Psychiatry is tremendously supportive in both professional and personal settings. If you have specific interests, faculty and colleagues are resourceful and encouraging. Additionally, there are numerous research opportunities and a strong collaborative environment, which makes Duke a fantastic place to pursue scientific interests.

Areas of Prior Research

Animal models of schizophrenia, ingestive behavior

Publications

  • Moghadam AA, Vose LR, Miry O, Zhang XL, Stanton PK. Pairing of neonatal phencyclidine exposure and acute adolescent stress in male rats as a novel developmental model of schizophrenia. Behav Brain Res. 2021 Jul 9;409:113308. doi: 10.1016/j.bbr.2021.113308. Epub 2021 Apr 16. PMID: 33872663.
  • Moghadam AA, Moran TH, Dailey MJ. Alterations in circadian and meal-induced gut peptide levels in lean and obese rats. Exp Biol Med (Maywood). 2017;242(18):1786–1794. doi:10.1177/1535370217732041
  • Moghadam AA, Moran TH, Dailey MJ. Jejunal infusions of glucose decreases energy intake to a greater extent than fructose in adult male rats. Journal of Nutrition. 2016 Oct;146(10):2124-2128.
  • Gopaul KR, Irfan M, Miry O,Vose LR, Moghadam A, Subah G, H kfelt T, Bark C, Stanton PK. Developmental Time Course of SNAP-25 Isoforms Regulate Hippocampal Long-Term Synaptic Plasticity and Hippocampus-Dependent Learning. Int. J. Mol. Sci. 2020, 21, 1448.
  • Ni P, Noh H, Shao Z…Moghadam AA…et al. Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells. Mol Ther Methods Clin Dev. 2019;13:414-430. Published 2019 Apr 8. doi:10.1016/j.omtm.2019.04.002
  • Sullivan JA, Zhang XL, Sullivan AP, Vose LR, Moghadam AA, Fried VA. Stanton PK. Zinc enhances hippocampal long-term potentiation at CA1 synapses through NR2B containing NMDA receptors. PLoS One. 2018;13(11):e0205907. Published 2018 Nov 28. doi:10.1371/journal.pone.0205907
  • Shao Z, Noh H, Bin Kim W…Moghadam AA…et al. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci. 2019;22(2):229–242. doi:10.1038/s41593- 018-0313-z
  • Smith WW, Smith M, Yang D, Choi PP, Moghadam AA, Li T, Moran TH. CCK response deficiency in synphilin-1 transgenic mice. PLoS One. 2015 Nov 16;10(11):e0142314.
  • Yang Y, Moghadam AA, Cordner ZA. Liang NC, Moran TH. Long term exendin-4 treatment reduces food intake and body weight and alters expression of brain homeostatic and reward makers. Endocrinology. 2014 Sep;155(9):3473-83.
  • Li X, Treesukosol Y, Moghadam AA, Smith M, Ofeldt E, Yang D, Li T, Tamashiro K, Choi P, Moran TH, Smith WW. Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice. PLoS One. 2014 May 14;9(5):e91449.
  • Treesukosol Y, Sun B, Moghadam AA, Liang NC, Tamashiro KL, Moran TH. Maternal high-fat diet during pregnancy and lactation reduces the appetitive behavioral component in female offspring testing in a brief-access taste procedure. Am J Physiol Regul Integr Comp. 2014 Apr 1;306(7):R499-509.
  • Boersma GJ, Moghadam AA, Cordner ZA, Tamashiro KL. Prenatal stress and stress coping style interact to predict metabolic risk in male rats. Endocrinology. 2014 Apr;155(4):1302- 12.
  • Dailey MJ, Moghadam AA, Moran TH. Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. Am J Physiol Regul Integr Comp. 2014 Mar 15;306(6):R420-8.
  • Boersma GJ, Lee RS, Cordner ZA, Ewald ER, Purcell RH, Moghadam AA, Tamashiro KL. Prenatal stress decreases Bdnf expression and increases methylation of Bdnf exon IV in rats. Epigenetics. 2014 Mar;9(3):437-47.
  • Dailey MJ, Moghadam AA, Moran TH. Jejunal lineoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1184-90

Poster Presentations

  • Moghadam AA, Vose LR, Miry O, Zhang XL, Stanton PK. Pairing of neonatal phencyclidine exposure and acute adolescent stress as a developmental model of schizophrenia. Society for neuroscience, Nov 2017
  • Moghadam AA, Moran TH. Feeding and endocrine effects of jejunal fructose infusions. Society for the Study of Ingestive Behavior, Seattle, USA, July 2014.