Alexandra Bey, MD, PhD

Alex Bey

Medical School & Graduate School
Duke University

Psychiatry Residency
Duke University


Interests and Career Goals

Autism and developmental disorders, translational research, biomarkers for pre-clinical and clinical autism research.

Favorite Pastimes

Gardening and hiking with my family.

Why I Chose Duke

Duke is a great place to train in terms of breadth and depth of training experiences and elective opportunities. Durham is the best place to live.


  • Bey AL, Gorman MP, Gallentine W, Kohlenberg TM, Frankovich J, Jiang YH, van Haren K. (2020) Subacute neuropsychiatric syndrome in girls with SHANK3 mutations responds to immunomodulation. Pediatrics. 145(2):e20191490
  • Towers AJ, Tremblay MW, Chung L, Li XL, Bey AL, Zhang W, Cao X, Wang X, Wang P, Duffney LJ, Siecinski SK, Xu S, Kim Y, Kong X, Gregory S, Xie W, Jiang YH. (2018) Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders. JCI Insights 3(23):e120592 
  • Hulbert SW, Bey AL, Jiang YH. (2018) Environmental enrichment has minimal effects on behavior in the Shank3 complete knockout model of autism. Brain and Behavior. 8(11):e01107
  • Bey AL*, Wang X*, Yan H, Kim N, Passman RL, Yang Y, Cao X, Towers AJ, Hulbert SW, Duffney LJ, Gaidis E, Rodriguiz RM, Wetsel WC, Yin HH, Jiang YH. (2018) Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.Translational Psychiatry 8(1):9. *Co-first authors.
  • Chung L, Bey AL, Towers AJ, Cao X, Kim IH, Jiang YH. (2018) Lovastatin suppresses hyperexcitability and seizure in Angelman syndrome model. Neurobiology of Disease 110:12-19.
  • Pappas AL, Bey AL, Wang X, Rossi M, Kim YH, Yan H, Porkka F, Duffney LJ, Phillips SM, Cao X, Ding J, Rodriguiz RM, Yin HH, Weinberg RJ, Ji RR, Wetsel WC, Jiang YH. (2017) Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. JCI Insights 2(20):e92052.
  • Han Q, Kim YH, Wang X, Liu D, Zhang ZJ, Bey AL, Lay M, Chang W, Berta T, Zhang Y, Jiang YH, Ji RR. (2016) SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. Neuron 92(6):1279-1293
  • Wang X*, Bey AL*, Katz BM, Badea A, Kim N, David L, Duffney LJ, Kumar S, Mague SD, Hulbert SW, Dutta N, Harapetyan V, Yu C, Gaidis E, Ding J, Xu Q, Chung L, Rodriguiz RM, Weinberg RJ, Wetsel WC, Dzirasa K, Yin H , Jiang Y-H (2016) Altered mGluR5-Homer Scaffolds and Neural Connectivity in a Shank3 Complete Knockout Model of Autism. Nature Communications. 7:11459 *Co-first authors.
  • Wang X, Xu Q, Bey AL, Lee Y, and Jiang YH (2014) Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice. Molecular Autism 5(30): eCollection 2014.
  • Sales KU, Hobson JP, Wagenaar-Miller R, Szabo R, Rasmussen AL, Bey A, Shah MF, Molinolo AA, and Bugge TH (2011) Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT. Public Library of Science One 6(8):e23261.
  • Sales KU, Masedunskas A, Bey AL, Rasmussen AL, Weigert R, List K, Szabo R, Overbeek PA, and Bugge TH (2010) Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nature Genetics 42(8): 676-83.
  • Connolly BM, Choi EY, Gardsvoll H, Bey AL, Currie BM, Chavakis T, Liu S, Molinolo A, Ploug M, Leppla SH, and Bugge TH (2010) Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood 116(9): 1593-63.
  • List K, Kosa P, Szabo R, Bey AL, Wang CB, Molinolo A, and Bugge TH (2009) Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. American Journal of Pathology 175(4): 1453-63.
  • Berchowitz LE, Francis KE, Bey AL and Copenhaver GP (2007) The Role of AtMUS81 in Interference-Insensitive Crossovers in A. thaliana. Public Library of Sciences Genetics 3(8): e132.
  • Francis KE, Lam SY, Harrison BD, Bey AL, Berchowitz LE and Copenhaver GP (2007) Pollen Tetrad-based Visual Assay for Meiotic Recombination in Arabidopsis. Proceedings of the National Academy of Sciences 104: 3913-3918.

Scientific Reviews

  • Bey AL and Jiang YH (2014) Overview of mouse models of autism spectrum disorders. Current Protocols in Pharmacology 66(5):1-26.
  • Wang X, Bey AL, Chung L, Krystal AD, and Jiang YH. (2014), Therapeutic approaches for shankopathies. Developmental Neurobiology 74: 123–135.
  • Chung L, Bey AL, and Jiang YH. (2012), Synaptic plasticity in mouse models of autism spectrum disorders. Korean Journal of Physiology and Pharmacology 16(6): 369–378.


  • Hulbert SW, Yan H, Wang X, Bey AL, Lin MS, and Jiang YH (2020) Incompletely disrupting Shank3 expression postnatally is insufficient to produce phenotypes associated with germline deficiency. Under review.

Poster Presentations

  • Bey A, Sabatos-DeVito M, Howell T, Yuan A, Rohloff A, Belvin K, Simmons R, Troy J, Herold B, Carpenter K, Lorzenzi J, Murias M, Dawson G. (2019). Automated Video Tracking Biomarkers of Parent-Child Interaction Correlate with Autism Symptom Severity: Implications for Translational Research. 1st prize poster at NC Council of Child and Adolescent Psychiatry at annual meeting.
  • Bey A, Sabatos-DeVito M, Howell T, Yuan A, Rohloff A, Belvin K, Simmons R, Troy J, Herold B, Murias M, Dawson G. (2019). Poster presentation at 2019 DIBS Distinguished Lecture & Symposium, “From Brain Circuits to Behavior: How Technology is Transforming the Science of Mental Health.
  • Bey AL, Brimble E, Gorman M, Gallentine W, Kohlenberg TM, Frankovich J, Van Mater H, Jiang YH, Van Haren K. (2018) Acute neuropsychiatric decline in adolescents with SHANK3-related disorders responds to immunomodulatory therapy: a case series. 1st prize poster at NC Council of Child and Adolescent Psychiatry at annual meeting.