Duke South Hospital, Rm 3521, Box 3903, Durham, NC 27710
Duke University Medical Center, Psychiatry Box 3903, Durham, NC 27710
Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.
Director: Duke Community Based Substance Use Disorder Research Program.
Node Principal Investigator/Director: Mid-Southern Node of the National Drug Abuse Treatment Clinical Trials Network (NIDA CTN)
Research interests: Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior.
FUNDED Research projects (Principal Investigator, PI or Site PI):
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA CTN-0057, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA CTN-0059, PI).
UG1: CAMP, Computer-facilitated intervention for adolescent marijuana use prevention (NIDA CTN-0060, PI).
UG1: NIDA CTN Mid-Southern Node (NIDA Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA CTN-0071, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA CTN-0075, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Duke Site PI).
R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Duke Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward to Wu, Investigator).
UG1: Medication Treatment for Opioid-dependent Expecting Mothers: A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (supplement award to Wu for study site, NIDA CTN-0080)
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (supplement award to Wu, CTN-0101, Investigator)
Pilot: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI)
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, CTN-0105, PI)
Committee member of the NIDA Asian American and Pacific Islander Researchers and Scholars Workgroup (NIDA AAPI Workgroup).
Using a health information technology survey to explore the availability of addiction treatment data in the electronic health records: A National Drug Abuse Treatment Clinical Trials Network study.
Comparison of timeline follow-back self-report and oral fluid testing to detect substance use in adult primary care patients.
Chronic non-cancer pain among adults with substance use disorders: Prevalence, characteristics, and association with opioid overdose and healthcare utilization.
Sources of Misused Prescription Opioids and Their Association with Prescription Opioid Use Disorder in the United States: Sex and Age Differences.
Prevalence and Health Characteristics of Prescription Opioid Use, Misuse, and Use Disorders Among U.S. Adolescents.
E-Cigarette Use Among Adult Primary Care Patients: Results from a Multisite Study.
Electronic self-administered screening for substance use in adult primary care patients: feasibility and acceptability of the tobacco, alcohol, prescription medication, and other substance use (myTAPS) screening tool.
Clinical Workflow and Substance Use Screening, Brief Intervention, and Referral to Treatment Data in the Electronic Health Records: A National Drug Abuse Treatment Clinical Trials Network Study.
Commentary on Winhusen et al. (2019): Substance use disorders, chronic diseases, and electronic health records-a paradigm for screening and intervention.
Relationship between Smoking and Abdominal Aorta Calcification on Computed Tomography.
Trends and correlates of driving under the influence of alcohol among different types of adult substance users in the United States: a national survey study.
Discharge against medical advice from hospitalizations for substance use disorders: The potential impact of the Affordable Care Act.
Clinical epidemiology of substance use disorders: Understanding patterns, sharing knowledge, planning interventions.
Interpretation and integration of the federal substance use privacy protection rule in integrated health systems: A qualitative analysis.
Trends in Drug Use-Associated Infective Endocarditis and Heart Valve Surgery, 2007 to 2017: A Study of Statewide Discharge Data.
Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco.
Sex differences in the prevalence and correlates of emergency department utilization among adults with prescription opioid use disorder.
Opioid use disorder deaths and the effects of medication therapy.
Pharmacists' attitudes toward dispensing naloxone and medications for opioid use disorder: A scoping review of the literature.
Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data.
Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone.
National trends and characteristics of inpatient detoxification for drug use disorders in the United States.
Prevalence, patterns, and correlates of multiple substance use disorders among adult primary care patients.
Substance Use and Suicide in Pacific Islander, American Indian, and Multiracial Youth.
Substance use disorders and medical comorbidities among high-need, high-risk patients with diabetes.
Trends and correlates of cocaine use and cocaine use disorder in the United States from 2011 to 2015.
Differences in behavioral health disorders and unmet treatment needs between medical marijuana users and recreational marijuana users: Results from a national adult sample.
DSM-5 substance use disorders among adult primary care patients: Results from a multisite study.
Problem alcohol use and healthcare utilization among persons with cannabis use disorder in the United States.
Validation of the TAPS-1: A Four-Item Screening Tool to Identify Unhealthy Substance Use in Primary Care.
Prevalence, reasons, perceived effects, and correlates of medical marijuana use: A review.
Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States.
Age of first drunkenness and risks for all-cause mortality: A 27-year follow-up from the epidemiologic catchment area study.
Identifying substance misuse in primary care: TAPS Tool compared to the WHO ASSIST.
VALIDATION OF THE 4-ITEM SCREENING COMPONENT OF THE TAPS TOOL TO IDENTIFY UNHEALTHY SUBSTANCE USE AMONG PRIMARY CARE PATIENTSRead Full Text
Marijuana use and sex with multiple partners among lesbian, gay and bisexual youth: results from a national sample.
The opioid overdose epidemic: opportunities for pharmacists.
Treatment utilization among persons with opioid use disorder in the United States.
Performance of the Tobacco, Alcohol, Prescription Medication, and Other Substance Use (TAPS) Tool for Substance Use Screening in Primary Care Patients.
Corrigendum to "Design of the NIDA clinical trials network validation study of tobacco, alcohol, prescription medications, and substance use/misuse (TAPS) tool" [Contemporary Clinical Trials. 2016 Jul. 19; 50: 90-97].
The Association of Gasoline Prices With Hospital Utilization and Costs for Motorcycle and Nonmotorcycle Motor Vehicle Injuries in the United States.
Design of the NIDA clinical trials network validation study of tobacco, alcohol, prescription medications, and substance use/misuse (TAPS) tool.
Trends in cannabis use disorders among racial/ethnic population groups in the United States.
Family substance use screening: less to hide, more to gain.
Substance use after bariatric surgery: A review.
Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South AfricaRead Full Text
Nonmedical Opioid Pain Relievers and All-Cause Mortality: A 27-Year Follow-Up From the Epidemiologic Catchment Area Study.
Using electronic health record data for substance use Screening, Brief Intervention, and Referral to Treatment among adults with type 2 diabetes: Design of a National Drug Abuse Treatment Clinical Trials Network study.
Association Between Substance Use and Gun-Related Behaviors.
Primary care for opioid use disorder.
Reference periods in retrospective behavioral self-report: A qualitative investigation.
Substance use and mental diagnoses among adults with and without type 2 diabetes: Results from electronic health records data.
Mortality among heroin users and users of other internationally regulated drugs: A 27-year follow-up of users in the Epidemiologic Catchment Area Program household samples.
Smoking cessation interventions for adults aged 50 or older: A systematic review and meta-analysis.
Psychotic experiences and risk of death in the general population: 24-27 year follow-up of the Epidemiologic Catchment Area study.
Perceived cannabis use norms and cannabis use among adolescents in the United States.
Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific Islanders.
Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific IslandersRead Full Text
Associations between cigarette smoking and pain among veterans.
Sexual risk behaviors and HIV risk among Americans aged 50 years or older: a review.
IntroductionRead Full Text
RecommendationsRead Full Text
Pharmacological and Integrated Treatments in Older Adults with Substance Use DisordersRead Full Text
Epidemiology and Demography of Illicit Drug Use and Drug Use Disorders Among Adults Aged 50 and OlderRead Full Text
Cigarette Smoking Among Adults Aged 45 and Older in the United States, 2002-2011Read Full Text
Substance Use and Older PeopleRead Full Text
Epidemiology of Use of Treatment Services for Substance Use ProblemsRead Full Text
Tobacco Use CessationRead Full Text
Nonmedical stimulant use among young Asian-Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals aged 12-34 years in the United States.
Suicidal ideation and substance use among adolescents and young adults: a bidirectional relation?
E-cigarette prevalence and correlates of use among adolescents versus adults: a review and comparison.
Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: a very low dose naltrexone and buprenorphine open label trial.
Substance use disorders and psychiatric comorbidity in mid and later life: a review.
Suicide and substance use among female veterans: a need for research.
Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study.
IntroductionRead Full Text
Psychiatric correlates of snuff and chewing tobacco use.
Illicit and nonmedical drug use among Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals.
Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people.
The relationship of mental and behavioral disorders to all-cause mortality in a 27-year follow-up of 4 epidemiologic catchment area samples.
Smoking and opioid detoxification: behavioral changes and response to treatment.
Tobacco use among Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals: 2002-2010.
Referring heroin users from compulsory detoxification centers to community methadone maintenance treatment: a comparison of three models.
Substance Use among Adolescent Mothers: A Review.
Screening instruments for substance use and brief interventions targeting adolescents in primary care: a literature review.
Using electronic health records data to assess comorbidities of substance use and psychiatric diagnoses and treatment settings among adults.
Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults.
The national drug abuse treatment clinical trials network data share project: website design, usage, challenges, and future directions.
The Treatment Effectiveness Assessment (TEA).
Prescription drug overdose: between patients and their doctors.
Food, class, and health: the role of the perceived body in the social reproduction of health.
Postpartum substance use and depressive symptoms: a review.
InhalantsRead Full Text
Datapoints: Use of medications and counseling for depression by Asian and multiple-race adolescents aged 12-17 years.
Alcohol limits in older people.
Risk profiles among adolescent nonmedical opioid users in the United States.
Alcohol and drug use disorders among adults in emergency department settings in the United States.
Correlates of handgun carrying among adolescents in the United States.
Substance abuse among individuals with intellectual disabilities.
A dimensional approach to understanding severity estimates and risk correlates of marijuana abuse and dependence in adults.
Advances in opioid antagonist treatment for opioid addiction.
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal.
Screening for alcohol and drug use disorders among adults in primary care: a review.
Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.
Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives.
Alcohol and drug dependence symptom items as brief screeners for substance use disorders: results from the Clinical Trials Network.
Use of Salvia divinorum in a nationally representative sample.
Electronic health records: essential tools in integrating substance abuse treatment with primary care.
Patterns of tobacco use and tobacco-related psychiatric morbidity and substance use among middle-aged and older adults in the United States.
Treatment use and barriers among adolescents with prescription opioid use disorders.
Use of item response theory and latent class analysis to link poly-substance use disorders with addiction severity, HIV risk, and quality of life among opioid-dependent patients in the Clinical Trials Network.
Substance use disorders and comorbid Axis I and II psychiatric disorders among young psychiatric patients: findings from a large electronic health records database.
Racial/ethnic variations in substance-related disorders among adolescents in the United States.
Conducting research with racial/ethnic minorities: methodological lessons from the NIDA Clinical Trials Network.
The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sample.
Buprenorphine for prescription opioid addiction in a patient with depression and alcohol dependence.
Pharmacological enhancement of naltrexone treatment for opioid dependence: a review.
Problem drinking and low-dose naltrexone-assisted opioid detoxification.
Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
The prevalence and clinical significance of inhalant withdrawal symptoms among a national sample.
Illicit and nonmedical drug use among older adults: a review.
Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers.
Abuse and dependence on prescription opioids in adults: a mixture categorical and dimensional approach to diagnostic classification.
How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
Co-occurring amphetamine use and associated medical and psychiatric comorbidity among opioid-dependent adults: results from the Clinical Trials Network.
Depressive symptoms, substance use, and HIV-related high-risk behaviors among opioid-dependent individuals: results from the Clinical Trials Network.
Gender and racial/ethnic differences in addiction severity, HIV risk, and quality of life among adults in opioid detoxification: results from the National Drug Abuse Treatment Clinical Trials Network.
Subtypes of nonmedical opioid users: results from the national epidemiologic survey on alcohol and related conditions.
Substance abuse and rehabilitation: responding to the global burden of diseases attributable to substance abuse.
Reduced cannabis use after low-dose naltrexone addition to opioid detoxification.
Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study.
An item response theory analysis of DSM-IV criteria for hallucinogen abuse and dependence in adolescents.
Drs. Blazer and Wu Reply.
The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sampleRead Full Text
The variety of ecstasy/MDMA users: results from the National Epidemiologic Survey on alcohol and related conditions.
The epidemiology of at-risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health.
Hallucinogen-related disorders in a national sample of adolescents: the influence of ecstasy/MDMA use.
The construct and measurement equivalence of cocaine and opioid dependences: a National Drug Abuse Treatment Clinical Trials Network (CTN) study.
The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention.
Association of MDMA/ecstasy and other substance use with self-reported sexually transmitted diseases among college-aged adults: a national study.
Nonprescription use of pain relievers by middle-aged and elderly community-living adults: National Survey on Drug Use and Health.
Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South Africa.
Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents.
An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network study.
Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.
Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial.
Early outcomes following low dose naltrexone enhancement of opioid detoxification.
The impact of the CONSORT statement on reporting of randomized clinical trials in psychiatry.
The epidemiology of substance use and disorders among middle aged and elderly community adults: national survey on drug use and health.
RecommendationsRead Full Text
Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.
Hallucinogen use disorders among adult users of MDMA and other hallucinogens.
Prescription pain reliever abuse and dependence among adolescents: a nationally representative study.
Substance use disorders among inhalant users: results from the National Epidemiologic Survey on alcohol and related conditions.
Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network study.
Non-prescribed use of pain relievers among adolescents in the United States.
Inhalant use among incarcerated adolescents in the United States: prevalence, characteristics, and correlates of use.
Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence.
Misuse of methamphetamine and prescription stimulants among youths and young adults in the community.
Trends in nonheroin opioid abuse admissions: 1992-2004.
Psychiatric disorders in inhalant users: results from The National Epidemiologic Survey on Alcohol and Related Conditions.
Alcohol Use Disorders and the Use of Treatment Services Among College-Age Young AdultsRead Full Text
Alcohol use disorders and the use of treatment services among college-age young adults.
Is inhalant use a risk factor for heroin and injection drug use among adolescents in the United States?
Corrigendum to "Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths" [Drug and Alcohol Dependence 84 (1) (2006) 102-113] (DOI:10.1016/j.drugalcdep.2006.01.002)Read Full Text
Inhalant use and disorders among adults in the United States.
Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths.
Psychiatric symptoms and substance use disorders in a nationally representative sample of American adolescents involved with foster care.
Use of alcohol treatment and mental health services among adolescents with alcohol use disorders.
Use of substance abuse services by young uninsured american adults.
Use of nitrite inhalants ("poppers") among American youth.
High prevalence of substance use disorders among adolescents who use marijuana and inhalants.
Cocaine use and the occurrence of panic attacks in the community: a case-crossover approach.
Alcohol Dependence and Use of Treatment Services Among Women in the CommunityRead Full Text
Inhalant abuse and dependence among adolescents in the United States.
Alcohol dependence and use of treatment services among women in the community.
Private health insurance coverage for substance abuse and mental health services, 1995 to 1998.
Injection drug use among stimulant users in a national sample.
Substance use, dependence, and service utilization among the US uninsured nonelderly population.
Use of substance abuse treatment services by persons with mental health and substance use problems.
The relationship between employment and substance use among students aged 12 to 17.
Psychostimulant dependence in a community sample.
The estimated rate of depressed mood in US adults: recent evidence for a peak in later life.
The use of the case-crossover design in studying illicit drug use.
Tobacco smoking and depressed mood in late childhood and early adolescence.
Panic attacks and suicide attempts in mid-adolescence.
Influence of comorbid alcohol and psychiatric disorders on utilization of mental health services in the National Comorbidity Survey.
Tobacco smoking and other suspected antecedents of nonmedical psychostimulant use in the United States, 1995.
Trends and Correlates of Cannabis-involved Emergency Department Visits: 2004 to 2011.
Sex Differences in Cannabis Use Disorder Diagnosis Involved Hospitalizations in the United States.
Inhalant-Related DisordersRead Full Text
Psychopharmacology and the Consequences of Alcohol and Drug InteractionsRead Full Text