Faculty

William Wilson

Professor Emeritus in Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Translational Neuroscience
School of Medicine

242 Civitan Bldg, Durham, NC 27710

Box 3930 Med Ctr, Durham, NC 27710

(919) 684-6386 wilso066@mc.duke.edu

During the past year my research efforts continued in brain blood flow and metabolism. Areas of focus have been on the effects of marijuana and other substances of abuse on cerebral blood flow and metabolism and brain morphology. Several new grants to continue this research have been submitted. An ongoing project involves the effects of marijuana on cerebral blood flow measured with Positron Emission Tomography. This project will look at
neurocognative effects of marijuana. In this project subjects who have used marijuana in the past are studied while THC (marijuana) is infused. A third project has been funded on the effects of marijuana on postural syncope. The plans for the coming year include the continuation of these two with new grant submissions, and further expansion of this research using PET and other imaging technology. This includes an new grant submission to examine the
effects of merijuana on learning and memory. In addition to these basic research efforts I continue my interest in clinical psychopharmacology. In that effort I have been the PI on one clinical trial this past year on outpatient schizophrenia.
Finally, because of my research and statistical background, I continue to collaborate with a number of investigators in the Departments of Psychiatry and Radiology.


Education & Training

Ph.D. 1973

Vanderbilt University

Grants

Schizophenia Liability Genes among African-Americans

National Institutes of Health

Same

National Institutes of Health

Same

National Institutes of Health

Fluoxetine And Behavior Therapy In Social Phobia

National Institutes of Health

Kava Kava in Generalized Anxiety: A Double-Blind Trial

National Institute of Mental Health (NIMH)

Same

National Institutes of Health

Same

National Institutes of Health

Depression In Late Life

National Institutes of Health

Marijuana Intoxication And Brain Activation

National Institutes of Health

Neuroendocrine Regulation In Depression

National Institutes of Health

Fluoxetine And Behavior Therapy In Social Phobia

National Institutes of Health

Fluoxetine And Behavior Therapy In Social Phobia

National Institutes of Health

Neuroendocrine Regulation In Depression

National Institutes of Health

Marijuana Smoking And Postural Syncope

National Institutes of Health

Cortisol Cognition Brain Atrophy And Depression

National Institutes of Health

Fluoxetine Treatment Of Postraumatic Stress Disorder

National Institutes of Health

Tetrahydrocannabinol And Cerebral Blood Flow

National Institutes of Health
Show More

Publications

Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback.

PMID 22211368
Read Full Text

Pathophysiology of hypercortisolism in depression.

PMID 17280575
Read Full Text

Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study.

PMID 15738748
Read Full Text

Brain activation during affective visual cues in schizophrenia: A pilot study using fMRI [3]

Read Full Text

A visual guide to expected blood levels of long-acting injectable risperidone in clinical practice

Read Full Text

Postural syncope after marijuana: a transcranial Doppler study of the hemodynamics.

PMID 12873621
Read Full Text

Reliabilities and intercorrelations of reported and objective measures of smoking in patients with schizophrenia.

PMID 12505133
Read Full Text

Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography.

PMID 12477601
Read Full Text

Nicotine decreases bradykinesia-rigidity in haloperidol-treated patients with schizophrenia.

PMID 12377405
Read Full Text

Source-monitoring deficits for self-generated stimuli in schizophrenia: multinomial modeling of data from three sources.

PMID 12165376
Read Full Text

Leukocytosis and hypoalbuminemia in mixed bipolar states: evidence for immune activation.

PMID 12086227
Read Full Text

Smoking and psychosis in patients with bipolar I disorder.

PMID 11788921
Read Full Text

Insight is greater in mixed than in pure manic episodes of bipolar I disorder.

PMID 11434641
Read Full Text

Mecamylamine increases cigarette smoking in psychiatric patients.

PMID 11106149
Read Full Text

Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study.

PMID 10772599
Read Full Text

Smoking and therapeutic response to clozapine in patients with schizophrenia.

PMID 10394482
Read Full Text

Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration.

PMID 10442442
Read Full Text

A family study of chronic post-traumatic stress disorder following rape trauma.

PMID 9789209
Read Full Text

Cerebellar activity and disturbed time sense after THC.

PMID 9666122
Read Full Text

Marijuana smoking and brain morphology

Read Full Text

Intracranial and extracranial blood flow during acute anxiety.

PMID 9204512
Read Full Text

Effect of nitrous oxide on cerebral blood velocity while reclining and standing.

PMID 9110104
Read Full Text

Psychomotor effects of the anxiolytic abecarnil: a comparison with lorazepam.

PMID 9201796
Read Full Text

Cerebral vasodilation and vasoconstriction associated with acute anxiety.

PMID 9084897
Read Full Text

Marijuana intoxication and brain activation in marijuana smokers.

PMID 9180362
Read Full Text

A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia.

PMID 8959286
Read Full Text

Nicotine-haloperidol interactions and cognitive performance in schizophrenics.

PMID 8914115
Read Full Text

Acute changes in cranial blood flow after cocaine hydrochloride.

PMID 8886294
Read Full Text

A retrospective study of the concept of spirituality as understood by recovering individuals.

PMID 8699545
Read Full Text

Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges

Read Full Text

Common sense, insight, and neuropsychological test performance in schizophrenia patients.

PMID 8938917
Read Full Text

Time required for initial improvement during clozapine treatment of refractory schizophrenia

Read Full Text

Endogenous opioids and HIV infection.

PMID 8787643
Read Full Text

Insight in schizophrenia and mania.

PMID 8522936
Read Full Text

beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.

PMID 7560019
Read Full Text

Substance abuse consultation in a teaching hospital.

PMID 7643930
Read Full Text

Measurement of materialism and spiritualism in substance abuse research.

PMID 7674683
Read Full Text

18-Month outcome of clozapine treatment for 100 patients in a state psychiatric hospital

Read Full Text

Clozapine treatment in Russia: A review of clinical research

Read Full Text

Do anticonvulsants hinder clozapine treatment?

Read Full Text

Effects of marijuana on performance of a computerized cognitive-neuromotor test battery.

PMID 8022946
Read Full Text

Clinical usefulness of clozapine [6]

Read Full Text

Open clozapine treatment following a controlled clinical trial of lithium augmentation of haloperidol for refractory schizophrenia

Read Full Text

Seizures associated with clozapine treatment in a state hospital

Read Full Text

The fifth psychoactive drug usage guide [1]

Read Full Text

Treatment of social phobia with clonazepam and placebo.

PMID 8120156
Read Full Text

Asymmetry of rCBF in schizophrenia: relationship to AP-gradient and duration of illness.

PMID 8373919
Read Full Text

Psychiatric disorders in adult children of alcoholics: data from the Epidemiologic Catchment Area project.

PMID 8480827
Read Full Text

Depersonalization after marijuana smoking.

PMID 8490070
Read Full Text

Biology of social phobia

Read Full Text

Acute changes in cerebral blood flow after smoking marijuana.

PMID 8383270
Read Full Text

Impact of clozapine on medication use in a state hospital

Read Full Text

Disseminating the partnership: The Pew Memorial Trust State-University Collaboration Project

Read Full Text

State hospital curriculum: Public academic liaison for psychiatric education

Read Full Text

Collaboration for training

Read Full Text

Response to Fred W. Becker's 'The politics of closing state mental hospitals'

Read Full Text

Addition of lithium to haloperidol in non-affective, antipsychotic non-responsive schizophrenia: A double blind, placebo controlled, parallel design clinical trial

Read Full Text

Regional cerebral blood flow after marijuana smoking.

PMID 1324250
Read Full Text

Middle cerebral artery velocity during upright posture after marijuana smoking.

PMID 1529742
Read Full Text

Changes in middle cerebral artery velocity after marijuana.

PMID 1420630
Read Full Text

Changes in cerebral blood velocity after intravenous diazepam.

PMID 1599986
Read Full Text

Temporal disintegration and its psychological and physiological correlates: Changes in the experience of time after marijuana smoking

Read Full Text

Response to Kahn and Kahn, "group treatment assignment for outpatients with schizophrenia"

Read Full Text

The spectrum of clozapine response in refractory schizophrenia: Four case reports

Read Full Text

RU486 in depression.

PMID 1325068
Read Full Text

Clinical review of clozapine treatment in a state hospital

Read Full Text

Psychiatric education in the State Hospital: A current approach

Read Full Text

The Brief Social Phobia Scale.

PMID 1757457
Read Full Text

Evaluation of the effects of diazepam and an experimental anti-anxiety drug on regional cerebral blood flow.

PMID 1684872
Read Full Text

Substance abuse and cerebral blood flow.

PMID 1992832
Read Full Text

P100 latency as a function of head size

Read Full Text

Changes in cerebral blood flow after diazepam evaluated with 3 measurement techniques

Read Full Text

Predictors of therapeutic response to haloperidol in acute schizophrenia.

PMID 1924667
Read Full Text

Role of serotonin in hypothalamo pituitary adrenal axis escape from dexamethasone suppression.

PMID 1659724
Read Full Text

Nocturnal and early morning secretion of ACTH and cortisol in humans.

PMID 2165424
Read Full Text

Anxiety and cerebral blood flow.

PMID 2113357
Read Full Text

Behavioral and cerebrovascular effects of caffeine in patients with anxiety disorders.

PMID 2399815
Read Full Text

Cerebral blood flow responses to inhaled carbon dioxide in schizophrenia.

PMID 2116076
Read Full Text

Chronicity and a low anteroposterior gradient of cerebral blood flow in schizophrenia.

PMID 2301662
Read Full Text

Clinical Care Update: The chronically mentally ill group treatment for individuals with schizophrenia

Read Full Text

Responses to hypercarbia induced by acetazolamide in panic disorder patients.

PMID 2750998
Read Full Text

Cerebral blood flow responses to CO2 and acetazolamide: the effect of anxiety.

PMID 2501807
Read Full Text

Regional cerebral blood flow changes associated with amyl nitrite inhalation.

PMID 2706385
Read Full Text

Acute changes in cerebral blood flow associated with marijuana smoking.

PMID 2923005
Read Full Text

Sex roles and regional cerebral blood flow.

PMID 2922445
Read Full Text

Diagnostic consultation to a state hospital

Read Full Text

Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients.

PMID 2615928
Read Full Text

Regional cerebral blood flow correlates of a dichotic listening task.

PMID 2535429
Read Full Text

Circadian rhythm of adrenergic regulation of adrenocorticotropin and cortisol secretion in man.

PMID 2839538
Read Full Text

Abnormal resting regional cerebral blood flow patterns and their correlates in schizophrenia.

PMID 3132127
Read Full Text

Cerebral blood flow changes induced by CO2 in anxiety.

PMID 3133683
Read Full Text

Social stimulation and the regulation of premature infants' state prior to term age

Read Full Text

Double‐blind placebo‐controlled study of the autonomic effects of clovoxamine, imipramine, and amitriptyline in normal volunteers

Read Full Text

Elevated hematocrit in patients with schizophrenia.

PMID 3607118
Read Full Text

Augmentation of ECT seizures with caffeine.

PMID 3580438
Read Full Text

PIP syndrome.

Read Full Text

Cerebral ischemic symptoms in anxiety disorders.

Read Full Text

Intra-interrater reliability of SAFTEE using videotape interviews and clinical trial data

Read Full Text

Lithium in schizophrenia.

Read Full Text

The prevalence of abnormal involuntary movements among chronic schizophrenics.

Read Full Text

The effects of clovoxamine on sleep of normal volunteers: A double-blind placebo-controlled study

Read Full Text

Double-blind dose determination study of a new antidepressant-sertraline

Read Full Text

Caffeine-induced cerebral blood flow changes in schizophrenia

Read Full Text

Regional cerebral blood flow changes associated with ethanol intoxication

Read Full Text

Determinants of resting regional cerebral blood flow in normal subjects

Read Full Text

Research methodology and the pharmacotherapy of the chronic schizophrenias

Read Full Text

Reliability and validity of SAFTEE: Preliminary analyses

Read Full Text

Hematocrit and anxiety

Read Full Text

Flexible system criteria in chronic schizophrenia

Read Full Text

An international survey of tardive dyskinesia

Read Full Text

A psychotherapeutic approach to task-oriented groups of severely ill patients

Read Full Text

Dextroamphetamine-induced changes in regional cerebral blood flow

Read Full Text

The effect of nonsedating doses of diazepam on regional cerebral blood flow

Read Full Text

Pharmacotherapy of chronic hospitalized schizophrenics: Prescription practices

Read Full Text

Neuroleptic-induced skin pigmentation in chronic hospitalized schizophrenic patients

Read Full Text

Caffeine induced changes in cerebral circulation

Read Full Text

Caffeine consumption, withdrawal and cerebral blood flow

Read Full Text

Regional cerebral blood flow in dialysis encephalopathy and primary degenerative dementia

Read Full Text

The AMDP-system in chronic hospitalized schizophrenics

Read Full Text

Description and distribution of the subtypes of chronic schizophrenia based on Leonhard's classification.

Read Full Text

The psychopharmacological treatment of depression in the medically ill patient

Read Full Text

Pharmacotherapy of chronic hospitalized schizophrenics: Diagnosis and treatment

Read Full Text

Leonhard's classification of the chronic schizophrenias

Read Full Text

Rapid tranquilization: A comparative study of thiothixene and haloperidol

Read Full Text

Approaches to the management of the acutely psychotic patient

Read Full Text

A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression

Read Full Text

Catatonia and encephalopathy following a disulfiram overdose

Read Full Text

Disulfiram and encephalopathy

Read Full Text

Case report of phenothiazine-induced torsade de pointes

Read Full Text

A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depression

Read Full Text

Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study

Read Full Text

Organizing and conducting clinical trials

Read Full Text

Carbon dioxide levels and cerebral blood flow.

Read Full Text

Specific responses to drug therapy and Leonhard classification of chronic schizophrenia

Read Full Text

A double-blind placebo-controlled study to compare the autonomic effects of fluvoxamine with those of amitriptyline and doxepin in healthy volunteers

Read Full Text

Distribution of Leonhard's subtypes of chronic schizophrenia in two cultures

Read Full Text

Autonomic effects of fluvoxamine versus amitriptyline, doxepin, and placebo

Read Full Text

Minimal maintenance medication: Effects of three dose schedules on relapse rates and symptoms in chronic schizophrenic outpatients

Read Full Text

Bromperidol maintenance in schizophrenia.

Read Full Text

A collaborative study of a new antidepressant, viloxazine, in neurotic and endogenous depressives

Read Full Text

Viloxazine HCl in the treatment of endogenous depression: A standard (imipramine) controlled clinical study

Read Full Text

A double-blind dose-determination study with flutroline: A new neuroleptic

Read Full Text

Repeated-measures Latin square designs in clinical pharmacology

Read Full Text

Viloxazine in the treatment of endogenous depression. A standard (amitriptyline) controlled clinical study

Read Full Text

Viloxazine and amitriptyline in endogenous depression

Read Full Text

Psychopharmacology and Leonhard's classification of chronic schizophrenias

Read Full Text

Loxapine in psychogeriatrics: A placebo- and standard-controlled clinical investigation

Read Full Text

Systematic studies with amoxapine, a new antidepressant

Read Full Text

Measuring chronic schizophrenic patients' attitudes toward their illness and treatment

Read Full Text

A double-blind comparison of bromperidol and haloperidol in newly admitted schizophrenic patients

Read Full Text

Multicenter clinical trials: methodological aspects.

Read Full Text

Effects of viloxazine with and without alcohol on performance tests related to driving in normal volunteers

Read Full Text

The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study

Read Full Text

Amoxapine: Once versus divided daily doses in neurotic and endogenous depression

Read Full Text

Amoxapine: A review of literature

Read Full Text

Viloxazine in the treatment of depressive neurosis: A placebo and standard (imipramine) controlled clinical study

Read Full Text

A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia

Read Full Text

Viloxazine: A review of the literature

Read Full Text

Utility of videotape in establishing interrater reliability.

Read Full Text

Acute effects of viloxazine HCl and flurazepam when given alone and in combination on sleep EEG: A double-blind interaction study with normals

Read Full Text

Possible lack of anticholinergic effects with mianserin: A pilot study

Read Full Text

Mianserin: Determination of therapeutic dose range

Read Full Text
Show More