242 Civitan Bldg, Durham, NC 27710
Box 3930 Med Ctr, Durham, NC 27710
During the past year my research efforts continued in brain blood flow and metabolism. Areas of focus have been on the effects of marijuana and other substances of abuse on cerebral blood flow and metabolism and brain morphology. Several new grants to continue this research have been submitted. An ongoing project involves the effects of marijuana on cerebral blood flow measured with Positron Emission Tomography. This project will look at
neurocognative effects of marijuana. In this project subjects who have used marijuana in the past are studied while THC (marijuana) is infused. A third project has been funded on the effects of marijuana on postural syncope. The plans for the coming year include the continuation of these two with new grant submissions, and further expansion of this research using PET and other imaging technology. This includes an new grant submission to examine the
effects of merijuana on learning and memory. In addition to these basic research efforts I continue my interest in clinical psychopharmacology. In that effort I have been the PI on one clinical trial this past year on outpatient schizophrenia.
Finally, because of my research and statistical background, I continue to collaborate with a number of investigators in the Departments of Psychiatry and Radiology.
Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback.
Pathophysiology of hypercortisolism in depression.
Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study.
Brain activation during affective visual cues in schizophrenia: A pilot study using fMRI Read Full Text
A visual guide to expected blood levels of long-acting injectable risperidone in clinical practiceRead Full Text
Postural syncope after marijuana: a transcranial Doppler study of the hemodynamics.
Reliabilities and intercorrelations of reported and objective measures of smoking in patients with schizophrenia.
Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography.
Nicotine decreases bradykinesia-rigidity in haloperidol-treated patients with schizophrenia.
Source-monitoring deficits for self-generated stimuli in schizophrenia: multinomial modeling of data from three sources.
Leukocytosis and hypoalbuminemia in mixed bipolar states: evidence for immune activation.
Smoking and psychosis in patients with bipolar I disorder.
Insight is greater in mixed than in pure manic episodes of bipolar I disorder.
Mecamylamine increases cigarette smoking in psychiatric patients.
Brain morphological changes and early marijuana use: a magnetic resonance and positron emission tomography study.
Smoking and therapeutic response to clozapine in patients with schizophrenia.
Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration.
A family study of chronic post-traumatic stress disorder following rape trauma.
Cerebellar activity and disturbed time sense after THC.
Marijuana smoking and brain morphologyRead Full Text
Intracranial and extracranial blood flow during acute anxiety.
Effect of nitrous oxide on cerebral blood velocity while reclining and standing.
Psychomotor effects of the anxiolytic abecarnil: a comparison with lorazepam.
Cerebral vasodilation and vasoconstriction associated with acute anxiety.
Marijuana intoxication and brain activation in marijuana smokers.
A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia.
Nicotine-haloperidol interactions and cognitive performance in schizophrenics.
Acute changes in cranial blood flow after cocaine hydrochloride.
A retrospective study of the concept of spirituality as understood by recovering individuals.
Response of patients with treatment-refractory schizophrenia to clozapine within three serum level rangesRead Full Text
Common sense, insight, and neuropsychological test performance in schizophrenia patients.
Time required for initial improvement during clozapine treatment of refractory schizophreniaRead Full Text
Endogenous opioids and HIV infection.
Insight in schizophrenia and mania.
beta-Endorphin enhances the replication of neurotropic human immunodeficiency virus in fetal perivascular microglia.
Substance abuse consultation in a teaching hospital.
Measurement of materialism and spiritualism in substance abuse research.
18-Month outcome of clozapine treatment for 100 patients in a state psychiatric hospitalRead Full Text
Clozapine treatment in Russia: A review of clinical researchRead Full Text
Do anticonvulsants hinder clozapine treatment?Read Full Text
Effects of marijuana on performance of a computerized cognitive-neuromotor test battery.
Clinical usefulness of clozapine Read Full Text
Open clozapine treatment following a controlled clinical trial of lithium augmentation of haloperidol for refractory schizophreniaRead Full Text
Seizures associated with clozapine treatment in a state hospitalRead Full Text
The fifth psychoactive drug usage guide Read Full Text
Treatment of social phobia with clonazepam and placebo.
Asymmetry of rCBF in schizophrenia: relationship to AP-gradient and duration of illness.
Psychiatric disorders in adult children of alcoholics: data from the Epidemiologic Catchment Area project.
Depersonalization after marijuana smoking.
Biology of social phobiaRead Full Text
Acute changes in cerebral blood flow after smoking marijuana.
Impact of clozapine on medication use in a state hospitalRead Full Text
Disseminating the partnership: The Pew Memorial Trust State-University Collaboration ProjectRead Full Text
State hospital curriculum: Public academic liaison for psychiatric educationRead Full Text
Collaboration for trainingRead Full Text
Response to Fred W. Becker's 'The politics of closing state mental hospitals'Read Full Text
Addition of lithium to haloperidol in non-affective, antipsychotic non-responsive schizophrenia: A double blind, placebo controlled, parallel design clinical trialRead Full Text
Regional cerebral blood flow after marijuana smoking.
Middle cerebral artery velocity during upright posture after marijuana smoking.
Changes in middle cerebral artery velocity after marijuana.
Changes in cerebral blood velocity after intravenous diazepam.
Temporal disintegration and its psychological and physiological correlates: Changes in the experience of time after marijuana smokingRead Full Text
Response to Kahn and Kahn, "group treatment assignment for outpatients with schizophrenia"Read Full Text
The spectrum of clozapine response in refractory schizophrenia: Four case reportsRead Full Text
RU486 in depression.
Clinical review of clozapine treatment in a state hospitalRead Full Text
Psychiatric education in the State Hospital: A current approachRead Full Text
The Brief Social Phobia Scale.
Evaluation of the effects of diazepam and an experimental anti-anxiety drug on regional cerebral blood flow.
Substance abuse and cerebral blood flow.
P100 latency as a function of head sizeRead Full Text
Changes in cerebral blood flow after diazepam evaluated with 3 measurement techniquesRead Full Text
Predictors of therapeutic response to haloperidol in acute schizophrenia.
Role of serotonin in hypothalamo pituitary adrenal axis escape from dexamethasone suppression.
Nocturnal and early morning secretion of ACTH and cortisol in humans.
Anxiety and cerebral blood flow.
Behavioral and cerebrovascular effects of caffeine in patients with anxiety disorders.
Cerebral blood flow responses to inhaled carbon dioxide in schizophrenia.
Chronicity and a low anteroposterior gradient of cerebral blood flow in schizophrenia.
Clinical Care Update: The chronically mentally ill group treatment for individuals with schizophreniaRead Full Text
Responses to hypercarbia induced by acetazolamide in panic disorder patients.
Cerebral blood flow responses to CO2 and acetazolamide: the effect of anxiety.
Regional cerebral blood flow changes associated with amyl nitrite inhalation.
Acute changes in cerebral blood flow associated with marijuana smoking.
Sex roles and regional cerebral blood flow.
Diagnostic consultation to a state hospitalRead Full Text
Changes in cerebral blood flow and mental state after amphetamine challenge in schizophrenic patients.
Regional cerebral blood flow correlates of a dichotic listening task.
Circadian rhythm of adrenergic regulation of adrenocorticotropin and cortisol secretion in man.
Abnormal resting regional cerebral blood flow patterns and their correlates in schizophrenia.
Cerebral blood flow changes induced by CO2 in anxiety.
Social stimulation and the regulation of premature infants' state prior to term ageRead Full Text
Double‐blind placebo‐controlled study of the autonomic effects of clovoxamine, imipramine, and amitriptyline in normal volunteersRead Full Text
Elevated hematocrit in patients with schizophrenia.
Augmentation of ECT seizures with caffeine.
PIP syndrome.Read Full Text
Cerebral ischemic symptoms in anxiety disorders.Read Full Text
Intra-interrater reliability of SAFTEE using videotape interviews and clinical trial dataRead Full Text
Lithium in schizophrenia.Read Full Text
The prevalence of abnormal involuntary movements among chronic schizophrenics.Read Full Text
The effects of clovoxamine on sleep of normal volunteers: A double-blind placebo-controlled studyRead Full Text
Double-blind dose determination study of a new antidepressant-sertralineRead Full Text
Caffeine-induced cerebral blood flow changes in schizophreniaRead Full Text
Regional cerebral blood flow changes associated with ethanol intoxicationRead Full Text
Determinants of resting regional cerebral blood flow in normal subjectsRead Full Text
Research methodology and the pharmacotherapy of the chronic schizophreniasRead Full Text
Reliability and validity of SAFTEE: Preliminary analysesRead Full Text
Hematocrit and anxietyRead Full Text
Flexible system criteria in chronic schizophreniaRead Full Text
An international survey of tardive dyskinesiaRead Full Text
A psychotherapeutic approach to task-oriented groups of severely ill patientsRead Full Text
Dextroamphetamine-induced changes in regional cerebral blood flowRead Full Text
The effect of nonsedating doses of diazepam on regional cerebral blood flowRead Full Text
Pharmacotherapy of chronic hospitalized schizophrenics: Prescription practicesRead Full Text
Neuroleptic-induced skin pigmentation in chronic hospitalized schizophrenic patientsRead Full Text
Caffeine induced changes in cerebral circulationRead Full Text
Caffeine consumption, withdrawal and cerebral blood flowRead Full Text
Regional cerebral blood flow in dialysis encephalopathy and primary degenerative dementiaRead Full Text
The AMDP-system in chronic hospitalized schizophrenicsRead Full Text
Description and distribution of the subtypes of chronic schizophrenia based on Leonhard's classification.Read Full Text
The psychopharmacological treatment of depression in the medically ill patientRead Full Text
Pharmacotherapy of chronic hospitalized schizophrenics: Diagnosis and treatmentRead Full Text
Leonhard's classification of the chronic schizophreniasRead Full Text
Rapid tranquilization: A comparative study of thiothixene and haloperidolRead Full Text
Approaches to the management of the acutely psychotic patientRead Full Text
A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depressionRead Full Text
Catatonia and encephalopathy following a disulfiram overdoseRead Full Text
Disulfiram and encephalopathyRead Full Text
Case report of phenothiazine-induced torsade de pointesRead Full Text
A double-blind clinical trial of fluvoxamine and imipramine in patients with primary depressionRead Full Text
Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range studyRead Full Text
Organizing and conducting clinical trialsRead Full Text
Carbon dioxide levels and cerebral blood flow.Read Full Text
Specific responses to drug therapy and Leonhard classification of chronic schizophreniaRead Full Text
A double-blind placebo-controlled study to compare the autonomic effects of fluvoxamine with those of amitriptyline and doxepin in healthy volunteersRead Full Text
Distribution of Leonhard's subtypes of chronic schizophrenia in two culturesRead Full Text
Autonomic effects of fluvoxamine versus amitriptyline, doxepin, and placeboRead Full Text
Minimal maintenance medication: Effects of three dose schedules on relapse rates and symptoms in chronic schizophrenic outpatientsRead Full Text
Bromperidol maintenance in schizophrenia.Read Full Text
A collaborative study of a new antidepressant, viloxazine, in neurotic and endogenous depressivesRead Full Text
Viloxazine HCl in the treatment of endogenous depression: A standard (imipramine) controlled clinical studyRead Full Text
A double-blind dose-determination study with flutroline: A new neurolepticRead Full Text
Repeated-measures Latin square designs in clinical pharmacologyRead Full Text
Viloxazine in the treatment of endogenous depression. A standard (amitriptyline) controlled clinical studyRead Full Text
Viloxazine and amitriptyline in endogenous depressionRead Full Text
Psychopharmacology and Leonhard's classification of chronic schizophreniasRead Full Text
Loxapine in psychogeriatrics: A placebo- and standard-controlled clinical investigationRead Full Text
Systematic studies with amoxapine, a new antidepressantRead Full Text
Measuring chronic schizophrenic patients' attitudes toward their illness and treatmentRead Full Text
A double-blind comparison of bromperidol and haloperidol in newly admitted schizophrenic patientsRead Full Text
Multicenter clinical trials: methodological aspects.Read Full Text
Effects of viloxazine with and without alcohol on performance tests related to driving in normal volunteersRead Full Text
The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled studyRead Full Text
Amoxapine: Once versus divided daily doses in neurotic and endogenous depressionRead Full Text
Amoxapine: A review of literatureRead Full Text
Viloxazine in the treatment of depressive neurosis: A placebo and standard (imipramine) controlled clinical studyRead Full Text
A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophreniaRead Full Text
Viloxazine: A review of the literatureRead Full Text
Utility of videotape in establishing interrater reliability.Read Full Text
Acute effects of viloxazine HCl and flurazepam when given alone and in combination on sleep EEG: A double-blind interaction study with normalsRead Full Text
Possible lack of anticholinergic effects with mianserin: A pilot studyRead Full Text
Mianserin: Determination of therapeutic dose rangeRead Full Text