Faculty

Henry Wagner

Associate Professor of Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Translational Neuroscience
School of Medicine

Box 3454 Med Ctr, Durham, NC 27710

Brightleaf Sq Ste 22B, 905 W Main St, Durham, NC 27701

(919) 385-0858 ryan.wagner@dm.duke.edu

My research career into neurobiology and mental health spans two distinct phases. The first includes doctoral training at the University of New Mexico in psychology and neurobiology with a major area of emphasis in behavioral neurobiology and two minor areas of emphasis in learning and memory and statistics and experimental design.  Doctoral training was subsequently supplemented with  postdoctoral study in neuropharmacology at Duke University focusing on brain monoamine systems.  For the five years subsequent, I continued exploring the mechanisms underlying receptor regulation of brain catecholamine systems within my laboratory at Columbia University.  Following a hiatus, I refocused my research interests away from the laboratory and into statistics and experimental design. This included supplementing a minor area of emphasis in statistics acquired during my doctoral training with extensive course work in biometry through the Division of Biometry within the Department of Community and Family Medicine at Duke University.  Using this background, I have continued to consult for the last two decades in the statistical design and analysis of a wide variety of research projects within the Division of Translational Neuroscience in the Department of Psychiatry and Behavioral Sciences as part of the Duke University School of Medicine; the numerous projects undertaken during this interval have included - but are not limited to - randomized clinical trials, epidemologic surveys, and a seemingly endless variety of quasi-experimental designs.  More recently, I have expanded my duties to include a position as Statistician for the Mental Illness Research, Education, and Clinical Center with the Durham VA Medical Center.


Education & Training

Ph.D. 1975

University of New Mexico

Grants

E-cigarettes: deposition, absorption and brain accumulation of nicotine

National Institutes of Health

White Matter Damage in Subconcussive Blast Exposure

National Institutes of Health

Feelings/Body Investigators:Interoceptive Exposure for Children w/Abdominal Pain

National Institutes of Health

IPA - Ryan Wagner

Durham Veterans Affairs Medical Center

Neural Markers and Rehabilitation of Executive Functioning in Veterans with TBI and PTSD

University of North Carolina - Chapel Hill

Hostility, PTSD and Physical Health Risk Factors

National Institutes of Health

IPA - Ryan Wagner

Veterans Administration Medical Center

Midcareer Investigator Award in Geriatric Depression

National Institutes of Health

Supplemental Nicotine Administration for Smoking Cessation in PTSD

National Institutes of Health

Neurodevelopmental Processes of Social Cognition in Anorexia Nervosa and Autism

National Institutes of Health

Zonisamide for Weight Reduction in Obese Adults

National Institutes of Health

Therapeutic Foster Care in a System of Care

National Institutes of Health

Improving Representative Payeeship for People with Psychiatric Disabilities and their Families

National Institute on Disability and Rehabilitation Research

Coping Skills Training for Early Rheumatoid Arthritis

National Institutes of Health

Effectively Implementing Psychiatric Advance Directives

National Institutes of Health

The Effectiveness Of Involuntary Outpatient Commitment

National Institutes of Health
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Publications

The Clinical Significance of Posterior Insular Volume in Adolescent Anorexia Nervosa.

PMID 28691997
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Paternal history of mental illness associated with posttraumatic stress disorder among veterans.

PMID 28710975
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Acceptance-based interoceptive exposure for young children with functional abdominal pain.

PMID 28826066
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Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning.

PMID 28122941
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The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans.

PMID 28656593
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Risk Factors for Concurrent Suicidal Ideation and Violent Impulses in Military Veterans.

PMID 28627921
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Cannabis use disorder and suicide attempts in Iraq/Afghanistan-era veterans.

PMID 28129565
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Does Model Matter? Examining Change Across Time for Youth in Group Homes.

PMID 28706434
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The prevalence of binge drinking and receipt of provider drinking advice among US veterans with military service in Iraq or Afghanistan.

PMID 26154366
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Subthreshold posttraumatic stress disorder: A meta-analytic review of DSM-IV prevalence and a proposed DSM-5 approach to measurement.

PMID 26390108
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Who Goes Where? Exploring Factors Related to Placement Among Group Homes.

PMID 27390510
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The Association Between Military Sexual Trauma and Use of VA and Non-VA Health Care Services Among Female Veterans With Military Service in Iraq or Afghanistan.

PMID 26802046
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Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.

PMID 26176345
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An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.

PMID 27533747
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Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.

PMID 26670285
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Functional correlates of military sexual assault in male veterans.

PMID 26524280
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Prolonged Exposure Therapy With Veterans and Active Duty Personnel Diagnosed With PTSD and Traumatic Brain Injury.

PMID 26201688
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Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.

PMID 25957156
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A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment.

PMID 25647451
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A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment

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Patterns of maltreatment and diagnosis across levels of care in group homes.

PMID 25618195
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The prevalence of posttraumatic stress disorder in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans: a meta-analysis.

PMID 25768399
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Surveying treatment preferences in U.S. Iraq-Afghanistan Veterans with PTSD symptoms: a step toward veteran-centered care.

PMID 25820339
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Self-focused attention in anorexia nervosa

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Patterns of maltreatment and diagnosis across levels of care in group homes

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Self-focused attention in anorexia nervosa.

PMID 24899215
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Subthreshold Posttraumatic Stress Disorder: A Meta-Analytic Review of DSM-IV Prevalence and a Proposed DSM-5 Approach to Measurement

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Subthreshold Posttraumatic Stress Disorder: A Meta-Analytic Review of DSM-IV Prevalence and a Proposed DSM-5 Approach to Measurement

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Subthreshold Posttraumatic Stress Disorder: A Meta-Analytic Review of DSM-IV Prevalence and a Proposed DSM-5 Approach to Measurement

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The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality.

PMID 25169889
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Screening for violence risk in military veterans: predictive validity of a brief clinical tool.

PMID 24832765
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The impact of social support on psychological distress for U.S. Afghanistan/Iraq era veterans with PTSD and other psychiatric diagnoses

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The impact of social support on psychological distress for U.S. Afghanistan/Iraq era veterans with PTSD and other psychiatric diagnoses.

PMID 24679515
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Protective mechanisms and prevention of violence and aggression in veterans.

PMID 24512537
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Use of Psychotropic Medications Among Youth in Treatment Foster Care

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Protective mechanisms and prevention of violence and aggression in veterans

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The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality

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Violent behaviour and post-traumatic stress disorder in US Iraq and Afghanistan veterans.

PMID 24578444
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Family Involvement in Treatment Foster Care.

PMID 25177104
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Homelessness and money mismanagement in Iraq and Afghanistan veterans.

PMID 24148067
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Self-report and longitudinal predictors of violence in Iraq and Afghanistan war era veterans.

PMID 24080674
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Neuropsychological predictors of dementia in late-life major depressive disorder.

PMID 23395197
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Are Iraq and Afghanistan veterans using mental health services? New data from a national random-sample survey.

PMID 23475498
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Perception of affect in biological motion cues in anorexia nervosa.

PMID 23109257
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Use of Psychotropic Medications Among Youth in Treatment Foster Care

PMID 24904200
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Emotion regulation difficulties in anorexia nervosa: Relationship to self-perceived sensory sensitivity.

PMID 22963392
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Criminal justice involvement, trauma, and negative affect in Iraq and Afghanistan war era veterans.

PMID 23025247
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Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial.

PMID 23147455
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Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.

PMID 23117638
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Zonisamide for Weight Reduction in Obese Adults: A 1-Year Randomized Controlled Trial.

PMID 23070267
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Protective factors and risk modification of violence in Iraq and Afghanistan War veterans.

PMID 22795217
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Financial well-being and postdeployment adjustment among Iraq and Afghanistan war veterans.

PMID 22730842
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Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.

PMID 22415312
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Prior Trauma Exposure for Youth in Treatment Foster Care

PMID 23730144
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The effect of nicotine and trauma context on acoustic startle in smokers with and without posttraumatic stress disorder.

PMID 21188354
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WOMEN VETERANS TRANSITIONING FROM COMBAT TO OUR HEALTH CARE SYSTEMS: WHAT ARE THEIR NEEDS AND PREFERENCES?

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Scan-rescan reliability of subcortical brain volumes derived from automated segmentation.

PMID 20162602
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Correlates of anger and hostility in Iraq and Afghanistan war veterans.

PMID 20551162
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Enhancing "usual practice" treatment foster care: findings from a randomized trial on improving youths' outcomes.

PMID 20513677
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Service use and multi-sector use for mental health problems by youth in contact with child welfare

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Sleep disturbance and baroreceptor sensitivity in women with posttraumatic stress disorder.

PMID 19960521
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Rebuttal to Hasan and Pedraza in comments and controversies: "Improving the reliability of manual and automated methods for hippocampal and amygdala volume measurements".

PMID 19616634
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A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes.

PMID 19162198
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Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia.

PMID 18700216
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The effectiveness of antipsychotic medications in patients who use or avoid illicit substances: results from the CATIE study.

PMID 18191383
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Weight gain trajectory in adolescents with anorexia nervosa: A comparison of recovered and non-recovered outpatients

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Psychiatric advance directives and reduction of coercive crisis interventions.

PMID 20221301
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Characteristics of representative payeeship involving families of beneficiaries with psychiatric disabilities.

PMID 17978253
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Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.

PMID 17854247
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Competence to complete psychiatric advance directives: effects of facilitated decision making.

PMID 17294136
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Persistent mild cognitive impairment in geriatric depression.

PMID 16834811
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Predictors of workforce turnover in a transported treatment program.

PMID 16767507
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Escitalopram treatment of trichotillomania.

PMID 17159458
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EFFECTIVELY IMPLEMENTING PSYCHIATRIC ADVANCE DIRECTIVES TO PROMOTE SELF-DETERMINATION OF TREATMENT AMONG PEOPLE WITH MENTAL ILLNESS

PMID 24198456
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Facilitated psychiatric advance directives: a randomized trial of an intervention to foster advance treatment planning among persons with severe mental illness.

PMID 17074946
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Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study.

PMID 16870961
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Atomoxetine for weight reduction in obese women: a preliminary randomised controlled trial.

PMID 16418753
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A national study of violent behavior in persons with schizophrenia.

PMID 16651506
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Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study.

PMID 16534433
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Ascending digits task as a measure of executive function in geriatric depression.

PMID 16525080
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A randomized controlled trial of paroxetine for noncardiac chest pain.

PMID 17065971
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Prefrontal neuropsychological predictors of treatment remission in late-life depression.

PMID 15340392
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Mental health need and access to mental health services by youths involved with child welfare: a national survey.

PMID 15266190
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Caregiving for persons with mental illness: the impact of outpatient commitment on caregiving strain.

PMID 15387158
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Consumers' perceptions of the fairness and effectiveness of mandated community treatment and related pressures.

PMID 15232017
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Use of psychotropic medications by youths in therapeutic foster care and group homes.

PMID 15175471
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Parental arrest and children involved with child welfare services agencies.

PMID 15113246
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Characteristics of third-party money management for persons with psychiatric disabilities.

PMID 12883142
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Assessment of four stakeholder groups' preferences concerning outpatient commitment for persons with schizophrenia.

PMID 12777273
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Zonisamide for weight loss in obese adults: a randomized controlled trial.

PMID 12684361
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Psychiatric Advance Directives: A Survey of Persons With Schizophrenia, Family Members, and Treatment Providers

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Involuntary outpatient commitment and homelessness in persons with severe mental illness.

PMID 12602644
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Does involuntary outpatient commitment lead to more intensive treatment?

PMID 16700140
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Effects of involuntary outpatient commitment on subjective quality of life in persons with severe mental illness.

PMID 12898503
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Treatment foster care in a system of care: Sequences and correlates of residential placements

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Parental incarceration among adolescents receiving mental health services

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Greater depression severity associated with less improvement in depression-associated cognitive deficits in older subjects.

PMID 12213698
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The social-environmental context of violent behavior in persons treated for severe mental illness.

PMID 12197987
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Sociodemographic and clinical predictors of mortality in geriatric depression.

PMID 12213687
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Impact of outpatient commitment on victimization of people with severe mental illness.

PMID 12153835
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Hippocampal volume and incident dementia in geriatric depression.

PMID 11790636
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The perceived coerciveness of involuntary outpatient commitment: findings from an experimental study.

PMID 12108557
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Erratum: Victimization: A link between mental illness and violence? (International Journal of Law and Psychiatry (2001) 24 (559-572) PII: S0160252701000917)

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Structural changes as measured by diffusion tensor imaging in late-life depression.

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Victimization: a link between mental illness and violence?

PMID 11795220
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Performance feedback deficit in geriatric depression.

PMID 11543739
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Effects of involuntary outpatient commitment and depot antipsychotics on treatment adherence in persons with severe mental illness.

PMID 11580001
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Bupropion for weight loss: an investigation of efficacy and tolerability in overweight and obese women.

PMID 11557835
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Evidence of white matter tract disruption in MRI hyperintensities.

PMID 11513816
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A randomized controlled trial of outpatient commitment in North Carolina.

PMID 11239099
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Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression.

PMID 11281515
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Informant-rated cognitive symptoms in normal aging, mild cognitive impairment, and dementia. Initial development of an informant-rated screen (Brief Cognitive Scale) for mild cognitive impairment and dementia.

PMID 12397880
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Can involuntary outpatient commitment reduce arrests among persons with severe mental illness?

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Effectiveness of involuntary outpatient commitment [7] (multiple letters)

PMID 11282712
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Minor depression in family practice: functional morbidity, co-morbidity, service utilization and outcomes.

PMID 11097078
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Randomized trial of sertraline in patients with unexplained chest pain of noncardiac origin.

PMID 10966532
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Involuntary out-patient commitment and reduction of violent behaviour in persons with severe mental illness.

PMID 10827879
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General medical and specialty mental health service use for major depression.

PMID 11001277
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Can involuntary outpatient commitment reduce hospital recidivism?: Findings from a randomized trial with severely mentally ill individuals.

PMID 10588412
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Consumer perceptions of involuntary outpatient commitment.

PMID 10543860
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Assertive community treatment for people with severe mental illness: the effect on hospital use and costs.

PMID 10357291
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Does a coexisting anxiety disorder predict persistence of depressive illness in primary care patients with major depression?

PMID 10378109
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Criminal victimization of persons with severe mental illness.

PMID 9890581
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Medication compliance [3] (multiple letters)

PMID 10211748
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Psychiatric impairment, social contact, and violent behavior: evidence from a study of outpatient-committed persons with severe mental disorder.

PMID 9857785
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Taking the wrong drugs: the role of substance abuse and medication noncompliance in violence among severely mentally ill individuals.

PMID 9857783
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Male-female differences in the setting and construction of violence among people with severe mental illness.

PMID 9857782
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Administrative update: utilization of services. I. Comparing use of public and private mental health services: the enduring barriers of race and age.

PMID 9620158
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Violence and severe mental illness: the effects of substance abuse and nonadherence to medication.

PMID 9464202
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I. Comparing use of public and private mental health services: The enduring barriers of race and age

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Violence and severe mental disorder in clinical and community populations: the effects of psychotic symptoms, comorbidity, and lack of treatment.

PMID 9130311
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Interpreting the effectiveness of involuntary outpatient commitment: a conceptual model.

PMID 9148879
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Patient perceptions of coercion in mental hospital admission.

PMID 9178064
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The ethical challenges of a randomized controlled trial of involuntary outpatient commitment.

PMID 9033154
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The ethical challenges of a randomized controlled trial of involuntary outpatient commitment

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New directions in research on involuntary outpatient commitment.

PMID 7788461
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The relationship between insurance coverage and psychiatric disorder in predicting use of mental health services.

PMID 7977886
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Mental health service use by the elderly in nursing homes.

PMID 8438968
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Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade.

PMID 2946007
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Plasticity of rat striatal dopamine receptors.

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Effects of chronic bromocriptine treatment on behavior and on dopamine receptor binding in the rat striatum

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Clonazepam-induced up-regulation of serotonin1 and serotonin2 binding sites in rat frontal cortex.

PMID 2418653
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The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum.

PMID 3936723
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Presynaptic inhibition of dopamine synthesis in rat striatum: effects of chronic dopamine depletion and receptor blockade.

PMID 3933764
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Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of rat.

PMID 2415867
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Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum.

PMID 6540406
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Biochemical and behavioral evaluation of pergolide as a dopamine agonist in the rat brain.

PMID 6539428
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Electroconvulsive treatment and haloperidol: effects on pre- and postsynaptic dopamine receptors in rat brain.

PMID 6431465
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Neurotensin interacts with dopaminergic neurons in rat brain.

PMID 6866808
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THE EFFECT OF NEUROTENSIN ON DOPAMINERGIC NEURONS IN RAT BRAIN

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Chlorpromazine methiodide-induced barrel rotation: an antimuscarinic effect.

PMID 7139312
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Chronic lithium administration has no effect on haloperidol-induced supersensitivity of pre- and postsynaptic dopamine receptors in rat brain.

PMID 6289974
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The effect of chronic L-dopa administration on supersensitive pre- and postsynaptic dopaminergic receptors in rat brain.

PMID 7109853
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Evaluation of two new dopamine agonists

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Dopamine receptor supersensitivity and tolerance induced by haloperidol is not inhibited by prophylactic lithium administration

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Chronic dopamine agonist treatment in an animal model of tardive dyskinesia: Differential effect on pre- and postsynaptic receptor sensitivity

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Pharmacological aspects of the subsensitivity and supersensitivity of B-adrenergic receptors

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Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels.

PMID 6251952
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Chronic estrogen treatment decreases beta-adrenergic responses in rat cerebral cortex.

PMID 223732
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beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices.

PMID 221914
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Sensitivity of noradrenergically mediated cAMP responses in the brain

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β-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices

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Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol.

PMID 687395
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Decreased spontaneous motor activity parallels reserpine-induced supersensitivity of catecholamine-responsive rat cerebral cortex adenylate cyclase.

PMID 678261
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The applicability of inescapable shock as a source of animal depression.

PMID 559062
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Dopamine-sensitive adenylate cyclase: antagonism by impiramine and its analogues.

PMID 847305
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Rapid changes in brain beta adrenergic receptors

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Histamine-stimulated adenylate cyclase: blockade by imipramine and its analogues.

PMID 203428
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The applicability of inescapable shock as a source of animal depression.

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Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections.

PMID 187979
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SUPERSENSITIVITY OF STRIATAL AND CORTICAL ADENYLATE-CYCLASE FOLLOWING RESERPINE - LACK OF EFFECT OF CHRONIC HALOPERIDOL

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Suppression of cortical epileptiform activity by generalized and localized ECoG desynchronization

PMID 52443
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Lateral inhibition and attention: comments on the neuropsychological theory of Walley and Weiden.

PMID 4445415
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Effects of tetrahydrocannabinol on hippocampal evoked afterdischarges in cats.

PMID 4746199
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