Dr. Szabo received his undergraduate degree from the University of New Hampshire at Plymouth and earned his PhD in Neurosciences at McGill University. He completed postdoctoral training in Psychopharmacology at the University of Florida and in Mood and Anxiety Disorders at NIMH before earning his medical degree from the Medical University of the Americas. He completed his psychiatry residency training at Duke before joining the faculty in 2013. As a substance abuse counselor, Dr. Szabo first observed the high prevalence of anxiety disorders among the chemically dependent and later investigated the neurobiological relationships between anxiety and withdrawal states to drugs of abuse. His training as both a neuroscientist and psychiatrist and his longstanding interest in psychopharmacology and experimental therapeutics have solidified his bench to bedside approach to research. Dr. Szabo conducts government and industry-funded clinical trials and is currently an investigator for the NIMH sponsored Fast-Fail Trials (FAST-MAS), which is a flagship NIMH contract study employing an experimental therapeutic and biomarker approach to early phase treatment studies in patients with mood and anxiety disorders. He has published more than 40 scientific papers in peer-reviewed journals and continues to gain support from the NIMH and NIEHS. He is also passionate about psychiatry resident education and is the course master for biological psychiatry.
Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial.
Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease.
Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.
Resilience as a translational endpoint in the treatment of PTSD.
Efficacy and safety of ketamine in the management of anxiety and anxiety spectrum disorders: a review of the literature.
Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans.
Relationship between traumatic brain injury history and recent suicidal ideation in Iraq/Afghanistan-era veterans.
Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.
The association of resilience on psychiatric, substance use, and physical health outcomes in combat trauma-exposed military service members and veterans.
Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels.
The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.
Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans.
Effect of γ-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy.
Informing Federal Policy on Firearm Restrictions for Veterans with Fiduciaries: Risk Indicators in the Post-Deployment Mental Health Study.
The Association Between Alcohol Consumption, Lifetime Alcohol Use Disorder, and Psychiatric Distress Among Male and Female Veterans.
Maintenance ECT in schizophrenia: A systematic review.
Risk factors for concurrent suicidal ideation and violent impulses in military veterans.
Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series.
Exploring resilience models in a sample of combat-exposed military service members and veterans: a comparison and commentaryRead Full Text
Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder.
Sleep quality in returning veterans: The influence of mild traumatic brain injury.
Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning.
Strategies for dementia prevention: latest evidence and implicationsRead Full Text
Development of a Diverse Learning Experience for Diverse Psychiatry Resident Needs: A Four-Year Biological Psychiatry Curriculum Incorporating Principles of Neurobiology, Psychopharmacology, and Evidence-Based Practice.
Tardive dyskinesia: 21st century may bring new treatments to a forgotten disorder.
Sexual revictimization among Iraq and Afghanistan war era veterans.
Neurosteroids and traumatic brain injury translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veteransRead Full Text
Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls.
Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.
An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.
Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.
Functional correlates of military sexual assault in male veterans.
Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.
Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.
A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment.
Lessons learned and potentials for improvement in cns drug development: Isctm section on designing the right series of experimentsRead Full Text
Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.
DepressionRead Full Text
Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.
Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine.
A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.
Cortical control of affective networks.
A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.Read Full Text
Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy.
Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine.
Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania.
Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder.
Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety.
Focus on CaMKII: a molecular switch in the pathophysiology and treatment of mood and anxiety disorders.
Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression.
Regulation of cellular plasticity and resilience by mood stabilizers: the role of AMPA receptor trafficking.
Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neurons.
Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression.
Problematic internet use: proposed classification and diagnostic criteria.
Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons.
Serotonin (1A) receptor ligands act on norepinephrine neuron firing through excitatory amino acid and GABA(A) receptors: a microiontophoretic study in the rat locus coeruleus.
Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons.
Response of the norepinephrine system to antidepressant drugsRead Full Text
Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus.
Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity.
Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons.
Enhancement of serotoninergic function - A sometimes insufficient cause of antidepressant actionRead Full Text
Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments.
Progressive attenuation of the firing activity of locus coeruleus noradrenergic neurons by sustained administration of selective serotonin reuptake inhibitorsRead Full Text
Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers.
Updates on Preclinical and Translational Neuroscience of Mood Disorders: A Brief Historical Focus on Ketamine for the Clinician.