Faculty

Steven Szabo

Assistant Professor of Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Translational Neuroscience
School of Medicine

Dept of Psychiatry, Box 3837, Durham, NC 27710

(919) 684-8111 steven.szabo@duke.edu

Dr. Szabo received his undergraduate degree from the University of New Hampshire at Plymouth and earned his PhD in Neurosciences at McGill University.  He completed postdoctoral training in Psychopharmacology at the University of Florida and in Mood and Anxiety Disorders at NIMH before earning his medical degree from the Medical University of the Americas.  He completed his psychiatry residency training at Duke before joining the faculty in 2013.  As a substance abuse counselor, Dr. Szabo first observed the high prevalence of anxiety disorders among the chemically dependent and later investigated the neurobiological relationships between anxiety and withdrawal states to drugs of abuse. His training as both a neuroscientist and psychiatrist and his longstanding interest in psychopharmacology and experimental therapeutics have solidified his bench to bedside approach to research. Dr. Szabo conducts government and industry-funded clinical trials and is currently an investigator for the NIMH sponsored Fast-Fail Trials (FAST-MAS), which is a flagship NIMH contract study employing an experimental therapeutic and biomarker approach to early phase treatment studies in patients with mood and anxiety disorders.  He has published more than 40 scientific papers in peer-reviewed journals and continues to gain support from the NIMH and NIEHS. He is also passionate about psychiatry resident education and is the course master for biological psychiatry.


 


 


Education & Training

Ph.D. 2002

McGill University (Canada)

M.D. 2009

Medical University of the Americas (West Indies)

Grants

A Pilot Dose-Response Biomarker Study of Brexpiprazole Treatment in PTSD

TRANSFORM-1

SUSTAIN-1, 3003

Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear

University of California, San Francisco

FAST-MAS Phase 2A - Duke Site

National Institutes of Health

2/3 Reducing Suicide Ideation Through Insomnia Treatment (REST-IT)

National Institutes of Health

Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear

National Institutes of Health
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Publications

Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial.

PMID 32119096
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Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease.

PMID 32109936
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Reducing Suicidal Ideation Through Insomnia Treatment (REST-IT): A Randomized Clinical Trial.

PMID 31537089
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Resilience as a translational endpoint in the treatment of PTSD.

PMID 30867558
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Efficacy and safety of ketamine in the management of anxiety and anxiety spectrum disorders: a review of the literature.

PMID 31339086
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Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans.

PMID 31253239
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Relationship between traumatic brain injury history and recent suicidal ideation in Iraq/Afghanistan-era veterans.

PMID 30382745
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Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.

PMID 30503715
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The association of resilience on psychiatric, substance use, and physical health outcomes in combat trauma-exposed military service members and veterans.

PMID 31263518
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Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels.

PMID 31798395
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The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.

PMID 30591715
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Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans.

PMID 29859179
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Effect of γ-hydroxybutyrate (Xyrem) on locus coeruleus activity as measured by pupillometry in a patient with narcolepsy.

PMID 30178743
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Informing Federal Policy on Firearm Restrictions for Veterans with Fiduciaries: Risk Indicators in the Post-Deployment Mental Health Study.

PMID 29797151
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The Association Between Alcohol Consumption, Lifetime Alcohol Use Disorder, and Psychiatric Distress Among Male and Female Veterans.

PMID 30079875
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Maintenance ECT in schizophrenia: A systematic review.

PMID 29631245
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Risk factors for concurrent suicidal ideation and violent impulses in military veterans.

PMID 28627921
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Intravenous Ketamine Relieves Pain and Depression After Traumatic Suicide Attempts: A Case Series.

PMID 29424806
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Exploring resilience models in a sample of combat-exposed military service members and veterans: a comparison and commentary

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Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder.

PMID 29651256
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Sleep quality in returning veterans: The influence of mild traumatic brain injury.

PMID 28703617
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Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning.

PMID 28122941
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Strategies for dementia prevention: latest evidence and implications

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Development of a Diverse Learning Experience for Diverse Psychiatry Resident Needs: A Four-Year Biological Psychiatry Curriculum Incorporating Principles of Neurobiology, Psychopharmacology, and Evidence-Based Practice.

PMID 28539947
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Tardive dyskinesia: 21st century may bring new treatments to a forgotten disorder.

PMID 28207919
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Sexual revictimization among Iraq and Afghanistan war era veterans.

PMID 27149409
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Neurosteroids and traumatic brain injury translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veterans

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Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls.

PMID 26721301
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Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.

PMID 26176345
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An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.

PMID 27533747
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Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.

PMID 26670285
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Functional correlates of military sexual assault in male veterans.

PMID 26524280
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Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.

PMID 26184988
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Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.

PMID 25957156
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A pilot randomized placebo-controlled trial of adjunctive aripiprazole for chronic PTSD in US military Veterans resistant to antidepressant treatment.

PMID 25647451
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Lessons learned and potentials for improvement in cns drug development: Isctm section on designing the right series of experiments

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Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.

PMID 25410258
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Depression

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Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.

PMID 24806493
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Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine.

PMID 24412684
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A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

PMID 23276723
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Cortical control of affective networks.

PMID 23325249
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A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans.

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Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy.

PMID 22356892
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Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine.

PMID 21571009
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Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania.

PMID 18789340
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Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder.

PMID 17641532
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Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety.

PMID 16336034
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Focus on CaMKII: a molecular switch in the pathophysiology and treatment of mood and anxiety disorders.

PMID 15154976
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Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression.

PMID 15269270
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Regulation of cellular plasticity and resilience by mood stabilizers: the role of AMPA receptor trafficking.

PMID 22034247
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Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neurons.

PMID 15110737
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Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression.

PMID 14684466
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Problematic internet use: proposed classification and diagnostic criteria.

PMID 12820176
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Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons.

PMID 12183655
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Serotonin (1A) receptor ligands act on norepinephrine neuron firing through excitatory amino acid and GABA(A) receptors: a microiontophoretic study in the rat locus coeruleus.

PMID 11746719
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Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons.

PMID 11730697
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Response of the norepinephrine system to antidepressant drugs

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Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus.

PMID 11750178
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Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity.

PMID 11690604
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Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons.

PMID 11422448
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Enhancement of serotoninergic function - A sometimes insufficient cause of antidepressant action

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Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments.

PMID 10700654
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Progressive attenuation of the firing activity of locus coeruleus noradrenergic neurons by sustained administration of selective serotonin reuptake inhibitors

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Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers.

PMID 10188964
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Updates on Preclinical and Translational Neuroscience of Mood Disorders: A Brief Historical Focus on Ketamine for the Clinician.

PMID 31688400
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