Box 2969 Med Ctr, Durham, NC 27710
Suite 22B Brightleaf Square, 905 West Main Streer, Durham, NC 27701
My research efforts are in the area of developmental health psychology and organized around understanding the role of personality in health and disease in middle and later life.
My primary research activity is as Principal Investigator of the UNC Alumni Heart Study (UNCAHS) a prospective epidemiologic study of 5000 middle aged men and women and 1200 of their spouses that evaluates the role of personality on coronary heart disease and coronary heart disease risk, cancer, and normal aging.
As head of Cancer Prevention Research Unit , I study the role of psychological factors related to mammography behavior and estrogen replacement therapy is being studied in UNCAHS women.
Siegler, I.C., Zonderman, A.B., Barefoot, J.C., Williams, R.B., Jr., Costa, P.T., Jr., & McCrae, R. R. (1990). Predicting personality from college MMPI scores: Implications for follow-up studies in psychosomatic medicine. Psychosomatic Medicine, 52, 644-652.
Siegler, I.C., Peterson, B.L., Barefoot, J.C., & Williams, R.B. (1992). Hostility during late adolescence predicts coronary risk factors at midlife. American Journal of Epidemiology, 138(2), 146-154.
Siegler, I.C., Peterson, B.L., Barefoot, J.C., Harvin, S.H. Dahlstrom, W.G., Kaplan, B.H., Costa, P.T. Jr., & Williams, R.B. (1992). Using college alumni populations in epidemiologic research: The UNC Alumni Heart Study. Journal of Clinical Epidemiology, 45(11), 1243-1250.
Siegler, I.C., Dawson, D.V., & Welsh, K.A. (1994). Caregiver ratings of personality change in Alzheimer's disease patients: A replication. Psychology and Aging, 9, 464-466.
Siegler, I.C., Feaganes, J.R., & Rimer, B.K. (1995). Predictors of adoption of mammography in women under age 50. Health Psychology, 14, 274-278.
Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.
Corrigendum to "Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c" [J. Psychiatr Res. (2010) 44:373-377].
Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).
The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.
The role of genetic and environmental influences on the association between childhood ADHD symptoms and BMI.
Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.
Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention.
Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.
The effect of Brain- Derived Neurotrophic Factor (BDNF) Val66Met Variants on the Path from Psychosocial Stress to Depression, Body Mass Index and Pre-Clinical AtherosclerosisRead Full Text
Neuroticism Increases PTSD Symptom Severity by Amplifying the Emotionality, Rehearsal, and Centrality of Trauma Memories.
Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort.
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.
Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence.
Commentary-Pre- and Posttrauma Predictors of Posttraumatic Stress Disorder Symptom Severity: Reply to van der Velden and van der Knaap (2017).
Personality Traits and Successful Aging: Findings From the Georgia Centenarian Study.
Maladaptive trauma appraisals mediate the relation between attachment anxiety and PTSD symptom severity.
Accounting for Posttraumatic Stress Disorder Symptom Severity With Pre- and Posttrauma Measures: A Longitudinal Study of Older Adults.
Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health).
Capability for suicide interacts with states of heightened arousal to predict death by suicide beyond the effects of depression and hopelessness.
Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.
The relation between insecure attachment and posttraumatic stress: Early life versus adulthood traumas.
Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.
Population frequencies of the Triallelic 5HTTLPR in six Ethnicially diverse samples from North America, Southeast Asia, and Africa.
Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.
Successful aging and subjective well-being among oldest-old adults.
Personality Structure Among Centenarians: The Georgia Centenarian Study.
Octogenarian and centenarian performance on the Fuld Object Memory Evaluation.
A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.
Personality facets and all-cause mortality among Medicare patients aged 66 to 102 years: a follow-on study of Weiss and Costa (2005).
Changes in neuroticism following trauma exposure.
APOE ϵ4, rated life experiences, and affect among centenarians.
MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors.
A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.
Cumulative exposure to traumatic events in older adults.
The impact of the developmental timing of trauma exposure on PTSD symptoms and psychosocial functioning among older adults.
Socioeconomic indices as independent correlates of C-reactive protein in the National Longitudinal Study of Adolescent Health.
The Frequency and Impact of Exposure to Potentially Traumatic Events Over the Life Course.
Social, behavioral, and genetic linkages from adolescence into adulthood.
Consistency and timing of marital transitions and survival during midlife: the role of personality and health risk behaviors.
Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples.
Correlates of functional capacity among centenarians.
Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.
A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.
The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach.
Behavioral Stability and Change in Health Across the Adult Life CycleRead Full Text
Parenting styles and body mass index trajectories from adolescence to adulthood.
Associations of Social Support and 8-Year Follow-Up Depressive Symptoms: Differences in African American and White Caregivers.
Understanding dementia prevalence among centenarians.
Diabetes mellitus in centenarians.
Systolic blood pressure and adiposity: examination by race and gender in a nationally representative sample of young adults.
Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.
Life events and personality predicting loneliness among centenarians: findings from the Georgia Centenarian Study.
Two versions of life: emotionally negative and positive life events have different roles in the organization of life story and identity.
Systolic blood pressure, socioeconomic status, and biobehavioral risk factors in a nationally representative US young adult sample.
Recovery expectations and long-term prognosis of patients with coronary heart disease.
Effects of 5HTTLPR on cardiovascular response to an emotional stressor.
Affect and loneliness among centenarians and the oldest old: the role of individual and social resources.
Low life course socioeconomic status (SES) is associated with negative NEO PI-R personality patterns.
Associations between APOE variants and metabolic traits and the impact of psychological stress.
Cognitive function, physical performance, health, and disease: norms from the georgia centenarian study.
Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.
Caregiving, residence, race, and depressive symptoms.
Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.
Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall.
Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c.
Personality: Life span compass for healthRead Full Text
Personality and inflammation: the protective effect of openness to experience.
Predicting successful aging in a population-based sample of georgia centenarians.
Depression among centenarians and the oldest old: contributions of cognition and personality.
Engaged Lifestyle, Personality, and Mental Status Among Centenarians.
Positive affect is associated with cardiovascular reactivity, norepinephrine level, and morning rise in salivary cortisol.
Hostility and fasting glucose in African American women.
HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR).
5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.
Associations among central nervous system serotonergic function and neuroticism are moderated by gender.
Lipid levels are associated with a regulatory polymorphism of the monoamine oxidase-A gene promoter (MAOA-uVNTR).
Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress.
Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR).
Personality as a predictor of dietary quality in spouses during midlife.
Discrimination, dispositions, and cardiovascular responses to stress.
Sleep quality varies as a function of 5-HTTLPR genotype and stress.
Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.
Facets of openness predict mortality in patients with cardiac disease.
Dietary differences between centenarians residing in communities and in skilled nursing facilities: The Georgia centenarian studyRead Full Text
Prediction of all-cause mortality by the Minnesota Multiphasic Personality Inventory Optimism-Pessimism Scale scores: study of a college sample during a 40-year follow-up period.
Personality and longevity: findings from the Georgia Centenarian Study.
Prospective associations between sedentary lifestyle and BMI in midlife.
NEO personality domains and gender predict levels and trends in body mass index over 14 years during midlifeRead Full Text
Associations among perceptions of social support, negative affect, and quality of sleep in caregivers and noncaregivers.
Neighborhood characteristics moderate effects of caregiving on glucose functioning.
Effect of race on cultural justifications for caregiving.
Psychophysiological mediators of caregiver stress and differential cognitive decline.
Hostility, age, and mortality in a sample of cardiac patients.
Ratings of positive and depressive emotion as predictors of mortality in coronary patients.
Does personality at college entry predict number of reported pain conditions at mid-life? A longitudinal study.
Initiation and discontinuation of hormone therapy for menopausal symptoms: results from a community sample.
Perceived social support as a predictor of mortality in coronary patients: effects of smoking, sedentary behavior, and depressive symptoms.
Facets of personality and the phenomenology of autobiographical memoryRead Full Text
Hostility as a predictor of survival in patients with coronary artery disease.
Prospective study of perceived stress in cardiac patients.
OverviewRead Full Text
Community recruitment process by race, gender, and SES gradient: lessons learned from the Community Health and Stress Evaluation (CHASE) Study experience.
Effect of smoking and sedentary behavior on the association between depressive symptoms and mortality from coronary heart disease.
Patterns of change in hostility from college to midlife in the UNC Alumni Heart Study predict high-risk status.
Self-blame, social introversion, and male suicides: Prospective data from a longitudinal studyRead Full Text
Another round in the mammography controversy.
Associations among the NEO personality inventory, revised and the serotonin transporter gene-linked polymorphic region in elders: Effects of depression and genderRead Full Text
Serotonin-related gene polymorphisms and central nervous system serotonin function.
Coping styles and personality domains related to menopausal stress.
Associations among social support, income, and symptoms of depression in an educated sample: the UNC Alumni Heart Study.
Evaluating participants' use of a hormone replacement therapy decision-making intervention.
Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study.
Terminal change in cognitive function: an updated review of longitudinal studies.
A tailored intervention to aid decision-making about hormone replacement therapy.
Behavioral medicine and aging.
Predictors of smoking cessation in patients with a diagnosis of coronary artery disease.
Hostility, race, and glucose metabolism in nondiabetic individuals.
A path model of chronic stress, the metabolic syndrome, and coronary heart disease.
Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression.
The relationship between hostility and behavioral risk factors for poor health in women veterans.
Racial differences in physician recommendation of hormone replacement therapy.
Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.
Enhancing recovery in coronary heart disease (ENRICHD): baseline characteristics.
Depressive symptoms, menopausal status, and climacteric symptoms in women at midlife.
Are the salutogenic effects of social supports modified by income? A test of an "added value hypothesis".
Erratum: Association among NEO personality assessment and well-being at midlife: Facet-level analyses (Psychology and Aging (2000) 15:4 (710-714))Read Full Text
Central nervous system serotonin function and cardiovascular responses to stress.
Characteristics of socially isolated patients with coronary artery disease who are at elevated risk for mortality.
Cigarette smoking in veteran women: the impact of job strain.
Personality and coping with a common stressor: cardiac catheterization.
Psycho-social predictors of survival among centenariansRead Full Text
Associations among NEO personality assessments and well-being at midlife: facet-level analyses.
Relation of subjective and received social support to clinical and self-report assessments of depressive symptoms in an elderly population.
Personality at midlife: stability, intrinsic maturation, and response to life events.
Self-perceptions of stability and change in personality at midlife: the UNC Alumni Heart Study.
Depressive symptoms and survival of patients with coronary artery disease.
Reliability of interview-assessed hostility ratings across mode of assessment and time.
Relationships among breast cancer perceived absolute risk, comparative risk, and worries.
Moderators of the effect of social support on depressive symptoms in cardiac patients.
Measurement of dietary intake in the UNC Alumni Heart Study. University of North Carolina.
Hostility predicts magnitude and duration of blood pressure response to anger.
Anger proneness predicts coronary heart disease risk: prospective analysis from the atherosclerosis risk in communities (ARIC) study.
Hostility in marital dyads: associations with depressive symptoms.
Relation between informant-rated personality and clinician-rated depression in patients with memory disorders.
Premorbid personality predicts level of rated personality change in patients with Alzheimer disease.
Coronary catherization patient and wife's perceptions of social support: effects due to characteristics of recipient, provider, and their interaction.
Social support and quality of life in patients with coronary artery disease.
Stress, sleep problems, and immune function in persons with cancer historiesRead Full Text
The association between self-rated health and mortality in a well-characterized sample of coronary artery disease patients.
Age and distance to death in the Seattle Longitudinal StudyRead Full Text
Osteoporosis risk factors: Association with use of hormone replacement therapy and with worry about osteoporosisRead Full Text
The relationship between self-rated health and health status among coronary artery patients.
Trust, health, and longevity.
Social support and hostility as predictors of depressive symptoms in cardiac patients one month after hospitalization: a prospective study.
Introduction to the special section: in search of a double paradigm.
Coronary heart disease moderates the relationship of chronic stress with the metabolic syndrome.
Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer's disease.
Differences in providers' beliefs about benefits and risks of hormone replacement therapy in managed care.
Symptoms of depression and changes in body weight from adolescence to mid-life.
Benefits and drawbacks to hormone replacement therapy among nursing home patients.
Measures of hostility as predictors of facial affect during social interaction: evidence for construct validity.
Psychosocial stress moderates the relationship of cancer history with natural killer cell activity.
Promoting informed decision making: hormone replacement therapy.
Perceptions of menopausal stage and patterns of hormone replacement therapy use.
Stress in employed women: impact of marital status and children at home on neurohormone output and home strain.
Psychosocial correlates of job strain in a sample of working women.
Surrogate assessment of coronary artery disease patients' functional capacity.
Stability in extraversion and aspects of social support at midlife.
Relation of mood ratings and neurohormonal responses during daily life in employed women.
Depression and long-term mortality risk in patients with coronary artery disease.
Impact of National Cancer Institute revised mammography screening guidelines on women 40-49.
Psychometric characteristics of the Mini-Mental State Examination in a community population - A grade of membership analysis: Part IRead Full Text
The importance of distinguishing the belief in a just world for self versus for others: Implications for psychological well-beingRead Full Text
Awareness of and responses to changes in the National Cancer Institute's guidelines for mammography in women aged 35-49Read Full Text
Approaches to the nonparametric analysis of limited longitudinal data sets.
Correlates of perceived social support and equality of interpersonal relationships at mid-life.
Do comparative self-appraisals during young adulthood predict adult personality?
Predictors of adoption of mammography in women under age 50.
Personality and breast cancer screening behaviorsRead Full Text
Caregiver ratings of personality change in Alzheimer's disease patients: a replication.
Caffeine and cholesterol: interactions with hostility.
A short MMPI scale to identify people likely to begin smoking.
Personality measures as predictors of smoking initiation and cessation in the UNC Alumni Heart Study.
The belief in a just world and perceptions of discrimination.
Age and gender differences in the content scales of the Minnesota Multiphasic Personality Inventory.
Age differences in hostility among middle-aged and older adults.
Longitudinal studies of aging in social and psychological gerontologyRead Full Text
Life goals, satisfaction, and self-rated health: preliminary findings.
Using college alumni populations in epidemiologic research: the UNC Alumni Heart Study.
Hostility during late adolescence predicts coronary risk factors at mid-life.
Prognostic importance of social and economic resources among medically treated patients with angiographically documented coronary artery disease.
Hostility during late adolescence predicts coronary risk factors at midlifeRead Full Text
The Georgia Centenarian Study: comments from friends.
Ratings of personality change in patients being evaluated for memory disorders.
Hostility patterns and health implications: correlates of Cook-Medley Hostility Scale scores in a national survey.
Predicting personality in adulthood from college MMPI scores: implications for follow-up studies in psychosomatic medicine.
Paradigms in developmental health psychology--from theory to application: introduction to a special issue.
Religious coping and personality in later lifeRead Full Text
Type A behavior and survival: a follow-up study of 1,467 patients with coronary artery disease.
Religious And Non-Religious Coping: Impact On Adaptation In Later LifeRead Full Text
A caution on the use of the MMPI K-correction in research on psychosomatic medicine.
The use of religion and other emotion-regulating coping strategies among older adults.
Suspiciousness, health, and mortality: a follow-up study of 500 older adults.
Relationships between motivation and hostility among type A and type B middle-aged menRead Full Text
Relationships between motivation and hostility among type A and type B middle-aged menRead Full Text
Patterns of intellectual development in later life.
The normal psychology of the aging male: Sex differences in coping and perceptions of life eventsRead Full Text
FUZZY AND CRISP SET-THEORETIC BASED CLASSIFICATION OF HEALTH AND DISEASE: A QUALITATIVE AND QUANTITATIVE COMPARISON.Read Full Text
Fuzzy and crisp set-theoretic-based classification of health and disease. A qualitative and quantitative comparison.
Sex differences in coping and perceptions of life events.
Cross-sectional and longitudinal patterns of three Wechsler Memory Scale Subtests.
Wechsler Memory Scale Scores, selective attrition, and distance from death.
Locus of Control and Long-term CareRead Full Text
Methodological comments: From a symposium methodological considerations for aging research: Introduction to a symposium and methodological commentaryRead Full Text
Separating age, cohort, and time of measurement: analysis of variance or multiple regression.
Intellectual ability among the elderly: Simultaneous cross-sectional and longitudinal comparisonsRead Full Text
Stress and adaptation in later life.
A long-term longitudinal study of intellectual ability of older adults: the matter of selective subject attrition.
Individual and community: normative conflicts in the development of a new therapeutic community for older persons.
Cautiousness and verbal learning in adulthood.
Sex differences in serial learning for aged persons with high verbal ability.
The perception of outcome-effort covariation in younger and older menRead Full Text
Relation between preference for intermediate risk and adult age in men: A cross-cultural validationRead Full Text
Learning to live in a therapeutic community: a study of elderly inpatients.
The terminal drop hypothesis: fact or artifact?
Contemporary views on behavioral development: A review of the 1973 meetings of the international society for the study of behavioral developmentRead Full Text
Markov Network Analysis: suggestions for innovations in covariance structure analysis.