Faculty

Brenda Plassman

Professor in Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
School of Medicine

Professor of Neurology

Neurology, Behavioral Neurology
School of Medicine

Faculty Network Member of the Duke Institute for Brain Sciences

Duke Institute for Brain Sciences
Institutes and Provost's Academic Units
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2200 W. Main Street, Suite A200, Durham, NC 27705

Box 3925 Med Ctr, Durham, NC 27710

(919) 668-1586 brenda.plassman@duke.edu

My research interests include the following areas:
1) Epidemiological studies to examine the prevalence and incidence of dementia and cognitive impairment, not dementia (CIND)
2) Studies examining risk and protective factors for dementia and CIND
3) Behavioral genetics of aging and dementia with an emphasis on twin studies
4) Long term outcomes of traumatic brain injury
5) Oral health and cognition in later life


Education & Training

Ph.D. 1986

University of Arizona

Grants

Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type Dementias

National Institutes of Health

Behavioral and Physiology in Aging

National Institutes of Health

NC Registry for Brain Health

State of North Carolina

Caregivers' Reactions and Experience: Imaging Dementia-Evidence for Amyloid Scanning-CARE IDEAS

Brown University

Life Course Process of Alzheimer's Disease: Sex Difference and Biosocial Mechanisms

University of North Carolina - Chapel Hill

Decision Making for Cardiovascular Therapy in Adults with Mild Cognitive Impairment

University of Michigan

Alzheimer's Disease, Genes, and Pesticide Use in the Agricultural Health Study

National Institutes of Health

Validation of a Performance Based Measure of Functioning in MCI and Early AD (VRFCAT)

NeuroCog Trials

Innovating Tablet-Based Cognitive Assessment for CNS Disorders of Aging

NeuroCog Trials

Genes, environments, interactions, and cognitive decline in the HRS

Wake Forest University

Assessing feasibility of computer virtual reality instrument

NeuroCog Trials

The Greatest Generation: The NAS-NRC WWII Twins Registry as a Scientific Resource - Data Archiving

University of Southern California

Caregivers' Reactions and Experience: Imaging Dementia - Evidence for Amyloid Scanning - CARE IDEAS

Brown University

Epidemiology of mTBI and Neurosensory Outcomes

Virginia Commonwealth University

Developing an Oral Health Intervention for Individuals with Mild Dementia

National Institutes of Health

Behavior And Physiology In Aging

National Institutes of Health

Genes, environments, interactions, and cognitive decline in the HRS

National Institutes of Health

Trend and Trajectories of Oral Health among Older Americans

National Institutes of Health

Cognitive Endophenotypes for Genetic Studies of Alzheimer's Disease

National Institutes of Health

Epidemiology of dementia in Cache County, Utah

National Institutes of Health

IPA - Plassman

Veterans Administration Medical Center

NIH State-of-the-Science Conference on Preventing Alzheimer's Disease and Cognitive Decline

Agency for Healthcare Research and Quality

IPA - Brenda Plassman

Veterans Administration Medical Center

Genetic Epidemiology of Alzheimer's Disease in Twins

National Institutes of Health

IPA - Brenda Plassman

Veterans Administration Medical Center

Job Complexity and Cognition in Older Twin Pairs

National Institutes of Health
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Publications

Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?

PMID 29396109
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Short-Term Changes in the Prevalence of Probable Dementia: An Analysis of the 2011-2015 National Health and Aging Trends Study.

PMID 29669099
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TOMMORROW neuropsychological battery: German language validation and normative study.

PMID 30094331
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Assessment of Instrumental Activities of Daily Living in Older Adults with Subjective Cognitive Decline Using the Virtual Reality Functional Capacity Assessment Tool (VRFCAT).

PMID 30298179
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Trends in decayed teeth among middle-aged and older adults in the United States: socioeconomic disparities persist over time.

PMID 27061828
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Association Between Oral Health and Cognitive Status: A Systematic Review.

PMID 27530100
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Visit-to-Visit Variability in Blood Pressure Is Related to Late-Life Cognitive Decline.

PMID 27217401
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Mediation Effect of Oral Hygiene on the Relationship Between Cognitive Function and Oral Health in Older Adults

PMID 26716459
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Epigenetic assimilation in the aging human brain.

PMID 27122015
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Association Between Oral Health and Cognitive Status: A Systematic Review.

PMID 27037761
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Authors' Response to Kaufman and Muntaner.

PMID 27018017
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The association between intelligence and lifespan is mostly genetic.

PMID 26213105
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Trajectories of depressive symptoms and oral health outcomes in a community sample of older adults.

PMID 25962827
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Dietary Patterns and Cognitive Decline Among Chinese Older Adults.

PMID 26133024
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Heritability of Health and Aging Limitations on Personally Desired Activities.

PMID 26973959
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Stability of Diagnoses of Cognitive Impairment, Not Dementia in a Veterans Affairs Primary Care Population.

PMID 26032518
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Dental care utilization among older adults with cognitive impairment in the USA

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Dental care utilization among older adults with cognitive impairment in the USA.

PMID 24612371
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Factors associated with cognitive evaluations in the United States.

PMID 25428689
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Traumatic brain injury and late-life dementia.

PMID 25701916
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Effect of APOE and CD33 on Cognitive Decline.

PMID 26102276
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Correction: Effect of APOE and CD33 on Cognitive Decline.

PMID 26230933
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Social stratification and tooth loss among middle-aged and older Americans from 1988 to 2004.

PMID 24975550
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A comparison of neuropsychological performance between US and Russia: Preparing for a global clinical trial

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A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial.

PMID 25066497
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Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study.

PMID 24910391
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Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.

PMID 24080384
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Fish intake is associated with slower cognitive decline in Chinese older adults.

PMID 25080536
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2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.

PMID 25341459
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Social stratification, oral hygiene, and trajectories of dental caries among old Americans.

PMID 24891565
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Community engagement in diverse populations for Alzheimer disease prevention trials.

PMID 24614272
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Community engagement in diverse populations for alzheimer disease prevention trials

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Social stratification and tooth loss among middle-aged and older Americans from 1988 to 2004

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Pre-clinical cognitive phenotypes for alzheimer disease: A latent profile approach

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Racial disparities in trajectories of dental caries experience

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AN ADAPTIVE LEADERSHIP ORAL HEALTH INTERVENTION FOR CAREGIVERS AND INDIVIDUALS WITH MILD DEMENTIA

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ASSOCIATION BETWEEN ORAL HEALTH AND COGNITIVE STATUS: REVIEW OF LONGITUDINAL STUDIES

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TRAJECTORIES OF COGNITIVE FUNCTIONING AND EDENTUALISM AMONG OLDER AMERICANS

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COGNITIVE FUNCTION AND DENTAL CARE UTILIZATION AMONG OLDER ADULTS

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DRILLING DOWN ON THE ASSOCIATION BETWEEN ORAL HEALTH AND COGNITIVE IMPAIRMENT

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Trends of edentulism among middle-aged and older Asian Americans.

PMID 23865668
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Cognitive function and oral health-related quality of life in older adults.

PMID 24028360
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Functional limitations in older adults who have cognitive impairment without dementia.

PMID 23559664
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Neuropsychological predictors of dementia in late-life major depressive disorder.

PMID 23395197
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The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer's dementia: findings from a nationally representative study.

PMID 23356599
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Racial disparities in trajectories of dental caries experience

PMID 23465078
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Cognitive function and oral health-related quality of life in older adults

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TREND OF DENTAL CARIES EXPERIENCES: ANALYSIS OF NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES) (1988-1994) AND NHANES (1999-2004)

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PHYSICAL ACTIVITY AND COGNITIVE IMPAIRMENT NOT DEMENTIA (CIND) IN LATE LIFE

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TRAJECTORIES OF PERIODONTAL DISEASE AMONG OLDER AMERICANS. DOES SOCIAL STRATIFICATION MATTER?

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ORAL HYGIENE AND THE DYNAMICS OF DENTAL CARIES AMONG OLD ADULTS

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High throughput DNA sequencing to detect differences in the subgingival plaque microbiome in elderly subjects with and without dementia.

PMID 22998923
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Screening for cognitive impairment: comparing the performance of four instruments in primary care.

PMID 22646750
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Edentulism trends among middle-aged and older adults in the United States: comparison of five racial/ethnic groups.

PMID 21974715
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Neuropsychological Predictors of Dementia in Late-Life Major Depressive Disorder.

PMID 22415312
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Hygiene self-care of older adults in West Virginia: effects of gender.

PMID 22947846
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Erratum: Edentulism trends among middle-aged and older adults in the United States: Comparison of five racial/ethnic groups (Community Dentistry and Oral Epidemiology (2012) 40 (145-153))

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The Mini-Cog had sensitivity similar to the longer 3MS for detecting cognitive impairment or dementia

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RACIAL AND ETHNIC VARIATIONS IN NUMBER OF TEETH MISSING AMONG ADULTS AGED 50 AND ABOVE IN THE U.S

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Incidence of dementia and cognitive impairment, not dementia in the United States.

PMID 21425187
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Risk factors and preventive interventions for Alzheimer disease: state of the science.

PMID 21555601
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Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis.

PMID 21172323
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Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time.

PMID 21606904
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Differences in self-reported oral health among community-dwelling black, Hispanic, and white elders.

PMID 20858912
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Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study.

PMID 21391937
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Caring for individuals with dementia and cognitive impairment, not dementia: findings from the aging, demographics, and memory study.

PMID 21391939
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Oral health among white, black, and Mexican-American elders: an examination of edentulism and dental caries.

PMID 22320289
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Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2.

PMID 21255742
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National estimates of the prevalence of Alzheimer's disease in the United States.

PMID 21255744
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Sources of variability in estimates of the prevalence of Alzheimer's disease in the United States.

PMID 21255745
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Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 1.

PMID 21255747
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Social network and health: A comparison of Chinese older adults in Shanghai and elderly immigrants in Boston

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Recruitment of rural and cognitively impaired older adults for dental research.

PMID 20831737
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Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.

PMID 20547887
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Depressive symptoms and health problems among Chinese immigrant elders in the US and Chinese elders in China.

PMID 20686981
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Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study.

PMID 20576093
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Differences in functional impairment across subtypes of dementia.

PMID 20018827
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Preventing Alzheimer's disease and cognitive decline.

PMID 21500874
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Hyposalivation and xerostomia in dentate older adults.

PMID 20194383
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Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.

PMID 20374406
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Genetic and environmental contributions to cognitive decline in aging and Alzheimer's disease

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Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites.

PMID 19896583
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Prevalence of depression among older Americans: the Aging, Demographics and Memory Study.

PMID 19519984
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THE QUANTITY OF ACTIVE HELP AND SUPERVISION PROVIDED TO OLDER ADULTS WITH NEUROPSYCHIATRIC SYMPTOMS: THE AGING, DEMOGRAPHICS, AND MEMORY STUDY (ADAMS)

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A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.

PMID 19404731
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Prevalence of Cognitive Impairment Without Dementia (vol 148, pg 427, 2008)

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Lifespan influences on mid- to late-life cognitive function in a Chinese birth cohort.

PMID 19620606
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Twin pairs discordant for neuropathologically confirmed Lewy body dementia.

PMID 19372291
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Parental education and late-life dementia in the United States.

PMID 19073840
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Longitudinal Outcomes of Subtypes of Cognitive Impairment Not Dementia (CIND)

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The accuracy of Medicare claims as an epidemiological tool: the case of dementia revisited.

PMID 19542620
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Prevalence of cognitive impairment without dementia in the United States (Annals of Internal Medicine (2008) 148, (427-434))

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Midlife activity predicts risk of dementia in older male twin pairs.

PMID 18790459
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Associations of job demands and intelligence with cognitive performance among men in late life

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Cognitive function and oral health among community-dwelling older adults.

PMID 18511753
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Associations of job demands and intelligence with cognitive performance among men in late life.

PMID 18077796
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Prevalence of cognitive impairment without dementia in the United States.

PMID 18347351
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Identification of dementia: agreement among national survey data, medicare claims, and death certificates.

PMID 18211532
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Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study.

PMID 17607801
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The effect of spousal caregiving and bereavement on depressive symptoms.

PMID 18297484
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Children of persons with Alzheimer disease: what does the future hold?

PMID 18317242
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Cognitive function and dental care utilization among community-dwelling older adults.

PMID 17971546
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Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the neurocognitive outcomes of depression in the elderly study.

PMID 17623814
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Autopsy-confirmed Alzheimer's disease versus clinically diagnosed Alzheimer's disease in the Cache County Study on Memory and Aging: a comparison of quantitative MRI and neuropsychological findings.

PMID 17564920
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Job demands and dementia risk among male twin pairs.

PMID 18591984
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Vascular risk factors and cognitive decline among elderly male twins - Reply

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Prevalence of dementia in the United States: the aging, demographics, and memory study.

PMID 17975326
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Intelligence in early adulthood and life span up to 65 years later in male elderly twins

PMID 17374599
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Reply from the authors [5]

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Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry.

PMID 17254435
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Vascular risk factors and cognitive decline among elderly male twins.

PMID 17101888
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Occupational characteristics and cognitive performance among elderly male twins.

PMID 17060563
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Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples.

PMID 19595851
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A population-based study of the association between coronary artery bypass graft surgery (CABG) and cognitive decline: The Cache County Study

PMID 16645936
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Prevalence and clinical correlates of neuropsychiatric symptoms in dementia.

PMID 16396442
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Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later.

PMID 16176721
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The Aging, Demographics, and Memory Study: study design and methods.

PMID 16103729
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A population study of Alzheimer's disease: findings from the Cache County Study on Memory, Health, and Aging.

PMID 16544872
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Age effects of coronary artery bypass graft on cognitive status change among elderly male twins.

PMID 15623681
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Methodology and preliminary results from the neurocognitive outcomes of depression in the elderly study.

PMID 15533991
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A twin study of the genetic contribution to age-related functional impairment.

PMID 15345739
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Alzheimer's disease in the NAS-NRC twin registry of WWII veterans

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Prevalence of restless legs symptoms in an elderly American veteran cohort

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Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study.

PMID 12701674
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Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: The Cache County, Utah, study of memory and aging

PMID 12959500
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Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.

PMID 12413371
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Dementia, asymmetry of temporal lobe structures, and apolipoprotein E genotype: relationships to cerebral atrophy and neuropsychological impairment.

PMID 12405544
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An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study.

PMID 11877549
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Head injury in early adulthood and the lifetime risk of depression.

PMID 11779276
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Hormone replacement therapy and reduced cognitive decline in older women: the Cache County Study.

PMID 11756599
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Documented head injury in early adulthood and risk of stroke in late life.

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Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias.

PMID 11071494
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Prevalence of depression and its treatment in an elderly population: the Cache County study.

PMID 10839339
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APOE and AD concordance in twin pairs as predictors of AD in first-degree relatives.

PMID 10680788
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Telephone adaptation of the Modified Mini-Mental State Exam (3MS). The Cache County Study.

PMID 10527112
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Enhanced cognitive performance with estrogen use in nondemented community-dwelling older women.

PMID 10522948
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APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.

PMID 10430421
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APOE-ε4 count predicts age when prevalence of AD increases, then declines: The cache county study

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Cognitive decline in aging: What is the role of education?

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A new method for quantifying cerebral atrophy in Alzheimer's disease

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Onset of Alzheimer's disease in susceptible subjects: Influence of APOE

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Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years.

PMID 9539409
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Apolipoprotein E epsilon 4 allele and hippocampal volume in twins with normal cognition.

PMID 9109888
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A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease.

PMID 9099411
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The genetics of dementia in late life.

PMID 9139296
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Recent advances in the genetics of Alzheimer's disease and vascular dementia with an emphasis on gene-environment interactions.

PMID 8856006
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Apolipoprotein E and cognitive decline in Alzheimer's disease.

PMID 8756999
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A twin study of late-onset depression and APOE e4 as risk factors for dementia

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Intelligence and education as predictors of cognitive state in late life: a 50-year follow-up.

PMID 7644038
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Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance.

PMID 7639628
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Smoking, Alzheimer's disease, and confounding with genes.

PMID 7772122
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Smoking, Alzheimer's disease, and confounding with genes [18]

PMID 7723525
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PROPERTIES OF THE TELEPHONE INTERVIEW FOR COGNITIVE STATUS - APPLICATION IN EPIDEMIOLOGIC AND LONGITUDINAL-STUDIES

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INTELLIGENCE AND EDUCATION AS PREDICTORS OF COGNITIVE STATE IN LATE-LIFE - A 50-YEAR FOLLOW-UP

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Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

PMID 8309563
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Prospects of the telephone interview for cognitive status. Application in epidemiological and longitudinal studies

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CONFOUNDING WITH GENES MAY EXPLAIN THE INVERSE ASSOCIATION OF SMOKING AND ALZHEIMERS-DISEASE

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CONFOUNDING WITH GENES MAY EXPLAIN THE INVERSE ASSOCIATION OF SMOKING AND ALZHEIMERS-DISEASE

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Inspiratory muscle strength and endurance during hyperinflation and histamine induced bronchoconstriction.

PMID 1465749
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Activation of human respiratory muscles during different voluntary manoeuvres.

PMID 2231418
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Perceptual cues used to reproduce an inspired lung volume.

PMID 2246161
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High-voltage stimulation over the human spinal cord: sources of latency variation.

PMID 2539436
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Comparison of human motor cortical projections to abdominal muscles and intrinsic muscles of the hand.

PMID 2532150
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Abdominal muscle activity during speech production.

PMID 3215865
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Responses in human intercostal and truncal muscles to motor cortical and spinal stimulation.

PMID 3175362
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EFFECTS OF MOTOR CORTICAL STIMULATION ON HUMAN RESPIRATORY MUSCLES DURING DIFFERENT TASKS

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Maximal activation of the human diaphragm but not inspiratory intercostal muscles during static inspiratory efforts.

PMID 3041320
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Inspiratory muscle responses to airway occlusion during learned breathing movements.

PMID 3559676
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