Veterans Study of Memory in Aging

Veterans Study of Memory in Aging is a population-based historical prospective cohort design among WW II male veterans aimed at examining the association between head injury in early adulthood and risk of dementia in late life. Head injury exposure was based on documentation in military medical records. In 1996 and 1997, a total of 548 veterans with head injury and 1228 without head injury were assessed for dementia using a multi-stage procedure. Individuals suspected of having dementia based on a telephone screening instrument were then assessed for cognitive impairment using a comprehensive in-person examination. Information on job history and medical history was collected on all participants. The study was funded by NIH (NO1-AG-4-2142).

The data is available through the Institute of Medicine.

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Primary references:

Plassman, B.L., Havlik, R.J., Steffens, D.C., Helms, M.J., Newman, T.N., Drosdick, D., Phillips, C., Gau, B.A., Welsh-Bohmer, K.A., Burke, J.R., Guralnik, J., Breitner, J.C.S. (2000). Documented head injury in early adulthood increases risk of Alzheimer’s disease and other dementias 50 years later. Neurology. 55:1158-1166.

Holsinger, T., Steffens, D.C., Phillips, C., Helms, M.J., Havlik, R.J., Breitner, J.C.S., Guralnik, J.M., Plassman, B.L. (2002). Documented head injury in early adulthood and lifetime risk of depression. Archives of General Psychiatry, 59:17-22.