2608 Erwin Road, Suite 300, Durham, NC 27705
3527, Durham, NC 27710
Joe McClernon, Ph.D. is Professor and Director of the Addiction Division in the Department of Psychiatry and Behavioral Sciences and is Founder/Director of the Center for Addiction Science and Technology (CfAST) at the Duke University Medical Center. He earned a Ph.D. in clinical psychology in 2001 from Southern Illinois University-Carbondale and completed a postdoctoral fellowship at Duke in 2002. Joe’s research is focused on increasing our understanding of tobacco and other addictions, developing new and more effective interventions to treat substance abuse, and informing the FDA’s regulation of tobacco products. He makes use of behavioral pharmacology, neuroimaging, epidemiology and clinical trial approaches in his work. He has led groundbreaking research on: the influence of drug-associated environments on drug use, relapse, and treatment; tobacco use disparities among individuals with comorbid psychiatric (e.g. ADHD) and health (e.g. HIV) problems; the role of nicotine in smoking behavior; and the evaluation of potential FDA tobacco regulatory actions. He has been continuously NIH- and FDA-funded since 2002. He has authored over 130 peer-reviewed publications, has one patent, has served as Chair of NIH grant review panels, and is recipient of numerous awards including the SRNT Jarvik-Russell New Investigator Award.
Increased subjective and reinforcing effects of initial nicotine exposure in young adults with attention deficit hyperactivity disorder (ADHD) compared to matched peers: results from an experimental model of first-time tobacco use.
Relationships between the Nicotine Metabolite Ratio and a Panel of Exposure and Effect Biomarkers: Findings from Two Studies of U.S. Commercial Cigarette Smokers.
Risk perceptions regarding cigarette smoking in the United States continue to decline.
Digital envirotyping: quantifying environmental determinants of health and behavior.
The Impact of Gradual and Immediate Nicotine Reduction on Subjective Cigarette Ratings.
Anticipated Effects of Nicotine Reduction on Youth Smoking Initiation and Maintenance.
Not quite the rule, but no longer the exception: multiple tobacco product use and implications for treatment, research, and regulation.
Smoking abstinence effects on emotion dysregulation in adult cigarette smokers with and without attention-deficit/hyperactivity disorder.
Neural Mechanisms Underlying Effects of Propranolol on Drug Cue ReactivityRead Full Text
Formative, multimethod case studies of learn to quit, an acceptance and commitment therapy smoking cessation app designed for people with serious mental illness.
Very low nicotine content cigarettes disrupt the feedback loop of affective states and smoking behavior.
Pilot Randomized Controlled Trial of a Novel Smoking Cessation App Designed for Individuals with Co-Occurring Tobacco Dependence and Serious Mental Illness.
Development and Piloting Testing of An Experimental Tobacco and Nicotine Product Marketplace.
Graphic Warning Labels Affect Hypothetical Cigarette Purchasing Behavior among Smokers Living with HIV.
Identifying Smoking Environments From Images of Daily Life With Deep Learning.
Age Moderates Smokers' Subjective Response to Very-Low Nicotine Content Cigarettes: Evidence from a Randomized Controlled Trial.
Mobile Applications for the Treatment of Tobacco Use and Dependence.
The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.
Using Neuroscience to Inform Tobacco Control Policy.
Correlates of support for a nicotine-reduction policy in smokers with 6-week exposure to very low nicotine cigarettes.
A Conceptual Framework for Understanding Multiple Tobacco Product Use and the Impact of Regulatory Action.
Combined Smoking Cues Enhance Reactivity and Predict Immediate Subsequent Smoking.
Young adult dual combusted cigarette and e-cigarette users' anticipated responses to a nicotine reduction policy and menthol ban in combusted cigarettes.
Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein.
Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation.
Young adult dual combusted cigarette and e-cigarette users' anticipated responses to hypothetical e-cigarette market restrictions.
Whether to push or pull? Nicotine reduction and non-combusted alternatives - Two strategies for reducing smoking and improving public health.
What Do Smokers Want in A Smartphone-Based Cessation Application?
Perceived risk of developing smoking-related disease among persons living with HIV.
Smartphone-Based Contingency Management Intervention to Improve Pre-Exposure Prophylaxis Adherence: Pilot Trial.
Adherence to Pharmacological Smoking Cessation Interventions: A Literature Review and Synthesis of Correlates and Barriers.
Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial.
Predicting Smoking Events with a Time-Varying Semi-Parametric Hawkes Process Model.
Perceived nicotine content of reduced nicotine content cigarettes is a correlate of perceived health risks.
Effects of reduced nicotine content cigarettes on individual withdrawal symptoms over time and during abstinence.
Decline in the perceived risk of cigarette smoking between 2006 and 2015: Findings from a U.S. nationally representative sample.
FEASIBILITY AND PRELIMINARY EFFECTS OF INCORPORATING SMOKING-RELATED CONTEXTS INTO AN EXTINCTION-BASED CESSATION THERAPYRead Full Text
Childhood ADHD Symptoms and Future Illicit Drug Use: The Role of Adolescent Cigarette Use.
ADHD, Smoking Withdrawal, and Inhibitory Control: Results of a Neuroimaging Study with Methylphenidate Challenge.
Perceptual Characterization of the Macronutrient Picture System (MaPS) for Food Image fMRI.
Cannabinoid exposure and altered DNA methylation in rat and human sperm.
Predicting Smoking Events with a Time-Varying Semi-Parametric Hawkes Process Model.Read Full Text
Implicit Attitudes and Smoking Behavior in a Smoking Cessation Induction Trial.
Precision medicine in addiction research: where has the time gone?
Increased Activation in Precuneus and Parahippocampus When Smokers View Tobacco Retail Outlets: Results of a GPS plus fMRI 'Community Neuroscience' StudyRead Full Text
A Pilot Trial Examining African American and White Responses to Algorithm-Guided Smoking Cessation Medication Selection in Persons Living with HIV.
Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability.
Smoking environment cues reduce ability to resist smoking as measured by a delay to smoking task.
Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers.
Reducing nicotine exposure results in weight gain in smokers randomised to very low nicotine content cigarettes.
Use and Perceived Risk of Electronic Cigarettes Among North Carolina Middle and High School Students.
Evaluation of a reduced nicotine product standard: Moderating effects of and impact on cannabis use.
Smoking Abstinence-Induced Changes in Resting State Functional Connectivity with Ventral Striatum Predict Lapse During a Quit Attempt.
The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function.
Non-cigarette tobacco and poly-tobacco use among persons living with HIV drawn from a nationally representative sample.
Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt.
Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence.
"I Use Weed for My ADHD": A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD.
The fMRI BOLD response to unisensory and multisensory smoking cues in nicotine-dependent adults.
Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes.
Suboptimal foraging behavior: a new perspective on gambling.
Randomized Trial of Reduced-Nicotine Standards for Cigarettes.
Racial differences in parenting style typologies and heavy episodic drinking trajectories.
Prediction of smoking cessation with treatment: the emerging contribution of brain imaging research.
Attention Deficit Hyperactivity Disorder symptoms and smoking trajectories: race and gender differences.
Olfactory cue reactivity in nicotine-dependent adult smokers.
ADHD and smokingRead Full Text
Smoking abstinence and neurocognition: implications for cessation and relapse.
Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior.
Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling.
Effects of varenicline and cognitive bias modification on neural response to smoking-related cues: study protocol for a randomized controlled study.
Examining the effects of initial smoking abstinence on response to smoking-related stimuli and response inhibition in a human laboratory model.
ASSOCIATION BETWEEN ATTENTION DEFICIT HYPERACTIVITY DISORDER SYMPTOMS AND ILLICIT DRUG USE IN ADD HEALTH SAMPLERead Full Text
A pilot study of lis-dexamfetamine dimesylate (LDX/SPD489) to facilitate smoking cessation in nicotine-dependent adults with ADHD.
Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards.
Smoking motivation in adults with attention-deficit/hyperactivity disorder using the Wisconsin inventory of smoking dependence motives.
Combined ecological momentary assessment and global positioning system tracking to assess smoking behavior: a proof of concept study.
Associations between smoking and psychiatric comorbidity in U.S. Iraq- and Afghanistan-era veterans.
Effects of smoking on the acoustic startle response and prepulse inhibition in smokers with and without posttraumatic stress disorder.
Childhood economic strains in predicting substance use in emerging adulthood: mediation effects of youth self-control and parenting practices.
Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood.
If you see something, swipe towards it: Crowdsourced event localization using smartphonesRead Full Text
I am your smartphone, and I know you are about to smoke: the application of mobile sensing and computing approaches to smoking research and treatment.
Methylphenidate does not influence smoking-reinforced responding or attentional performance in adult smokers with and without attention deficit hyperactivity disorder (ADHD).
Individual- and community-level correlates of cigarette-smoking trajectories from age 13 to 32 in a U.S. population-based sample.
THE EFFECT OF SMOKING ON THE ACOUSTIC STARTLE RESPONSE AND PREPULSE INHIBITION PREDICTS A SUCCESSFUL QUIT ATTEMPT IN SMOKERS WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDERRead Full Text
The association of dehydroepiandrosterone and dehydroepiandrosterone sulfate with anxiety sensitivity and electronic diary negative affect among smokers with and without posttraumatic stress disorder.
Biomarkers for smoking cessation.
Effects of smoking abstinence on smoking-reinforced responding, withdrawal, and cognition in adults with and without attention deficit hyperactivity disorder.
COMBINED EMA AND GPS FOR ASSESSING THE SPATIAL DISTRIBUTION OF SMOKING BEHAVIOR: A PROOF OF CONCEPT STUDYRead Full Text
RELATIONSHIP BETWEEN CHANGES IN IMPLICIT ATTITUDES TOWARD SMOKING AND SMOKING CESSATIONRead Full Text
Smoking and the bandit: a preliminary study of smoker and nonsmoker differences in exploratory behavior measured with a multiarmed bandit task.
Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition.
Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study.
Assessing the role of attention-deficit/hyperactivity disorder symptoms in smokers with and without posttraumatic stress disorder.
Sex, ADHD symptoms, and smoking outcomes: an integrative model.
Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing.
COMMUNITY AND INDIVIDUAL LEVEL SOCIAL CORRELATES OF SMOKING TRAJECTORIES FROM ADOLESCENCE TO ADULTHOODRead Full Text
Nicotine withdrawal modulates frontal brain function during an affective Stroop task.
Smoking withdrawal in smokers with and without posttraumatic stress disorder.
An examination of differences in variables maintaining smoking behavior in adult smokers with and without attention-deficit/hyperactivity disorderRead Full Text
A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults.
Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes.
Erratum: Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: A preliminary studyRead Full Text
Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study.
Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition.
Meditation-State Functional Connectivity (msFC): Strengthening of the Dorsal Attention Network and Beyond.
Understanding the phenotypic structure of adult retrospective ADHD symptoms during childhood in the United States.
Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: a pilot study.
Effects of Nicotine on Emotional Reactivity in PTSD and Non-PTSD Smokers: Results of a Pilot fMRI Study.
Yoga meditation practitioners exhibit greater gray matter volume and fewer reported cognitive failures: results of a preliminary voxel-based morphometric analysis.
Genotype and ADHD symptoms interact to predict adolescents' early smoking experiences in an epidemiological sampleRead Full Text
Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes.
Smoking withdrawal symptoms are more severe among smokers with ADHD and independent of ADHD symptom change: results from a 12-day contingency-managed abstinence trial.
Cognitive enhancers for the treatment of ADHD.
Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study.
Repetitive Transcranial Magnetic Stimulation (rTMS) of the Superior Frontal Gyrus Modulates Craving for CigarettesRead Full Text
The effect of nicotine and trauma context on acoustic startle in smokers with and without posttraumatic stress disorder.
Nicotine withdrawal modulates frontal brain function during an affective Stroop taskRead Full Text
Smoking withdrawal modulates right inferior frontal cortex but not presupplementary motor area activation during inhibitory control.
Silver acetate interactions with nicotine and non-nicotine smoke components.
Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition.
Bringing the real world into the laboratory: personal smoking and nonsmoking environments.
Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis.
Monetary incentives promote smoking abstinence in adults with attention deficit hyperactivity disorder (ADHD).
Translational Development of Novel Pharmacotherapeutic Strategies for Psychostimulant DependenceRead Full Text
Reversal of Consolidated Behavioral Sensitization and Associated Neurochemical Changes by Local Infusion of PKC Zeta (zeta) Inhibitory Pseudosubstrate (ZIP) Peptide in Nucleus Accumbens CoreRead Full Text
Does Macronutrient Content Matter? Results of a Preliminary fMRI Study of Visual Food Cue ReactivityRead Full Text
Effects of nicotine on novelty detection and memory recognition performance: double-blind, placebo-controlled studies of smokers and nonsmokers.
Adverse childhood events are associated with obesity and disordered eating: results from a U.S. population-based survey of young adults.
Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms.
24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum.
Interactions between genotype and depressive symptoms on obesity.
Neuroimaging of Nicotine Dependence: Key Findings and Application to the Study of Smoking-Mental Illness Comorbidity.
Association between smoking and retrospectively reported attention-deficit/hyperactivity disorder symptoms in a large sample of new mothers.
Effects of smoking abstinence on reaction time variability in smokers with and without ADHD: an ex-Gaussian analysis.
ADHD and smoking: from genes to brain to behavior.
Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues.
Ad lib smoking in post-traumatic stress disorder: an electronic diary study.
Proximal versus distal cues to smoke: the effects of environments on smokers' cue-reactivity.
Association between trauma exposure and smoking in a population-based sample of young adults.
Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary study.
Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.
Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults.
The effects of cigarette smoking on script-driven imagery in smokers with and without posttraumatic stress disorder.
Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood.
DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues.
Increases in impulsivity following smoking abstinence are related to baseline nicotine intake and boredom susceptibility.
Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study.
Automatic affective responses to smoking cues.
The effects of foods, beverages, and other factors on cigarette palatability.
Brain indices of nicotine's effects on attentional bias to smoking and emotional pictures and to task-relevant targets.
Smoking and StressRead Full Text
The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms.
Effects of 24 hour smoking abstinence on sustained and event-related brain activity during continuous working memory: Preliminary results of an fMRI studyRead Full Text
Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial.
Enhanced cue-elicited brain activation in African American compared with Caucasian smokers: an fMRI studyRead Full Text
Enhanced cue-elicited brain activation in African American compared with Caucasian smokers: an fMRI study.
Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization.
Effects of 24 hour smoking abstinence on sustained attention: Preliminary results of an fMRI studyRead Full Text
Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues.
Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults.
Abstinence-induced changes in self-reported craving are correlated with changes in brain responses to smoking cues: An event-related fMRI studyRead Full Text
Mecamylamine moderates cue-induced emotional responses in smokers.
Erratum: "Human functional neuroimaging in nicotine and tobacco research" (Nicotine & Tobacco Research vol. 6 (6) (941-959))Read Full Text
The effects of trauma recall on smoking topography in posttraumatic stress disorder and non-posttraumatic stress disorder trauma survivors.
Human functional neuroimaging in nicotine and tobacco research: basics, background, and beyond.
Effects of nicotine on brain responses to emotional pictures.
Cigarette smoking, ambulatory cardiovascular monitoring, and mood in Vietnam veterans with and without chronic posttraumatic stress disorder.
Mood-related symptoms in participants following a low-carbohydrate dietRead Full Text
The effects of controlled deep breathing on smoking withdrawal symptoms in dependent smokers.
Effects of quitting smoking on EEG activation and attention last for more than 31 days and are more severe with stress, dependence, DRD2 A1 allele, and depressive traits.
Effects of transdermal nicotine on lateralized identification and memory interference.
Mood disturbance fails to resolve across 31 days of cigarette abstinence in women.
Content and context: Additional sources of variability in affective picture processing ERPs?Read Full Text
Prepulse inhibition as a marker for genetically-mediated smoking riskRead Full Text
A smoke cloud of confusion.
Relationships between EEG power spectrum and the five-factor model of personalityRead Full Text
P300 attenuation fails to recover after 31 days of tobacco abstinenceRead Full Text
EEG, physiology, and task-related mood fail to resolve across 31 days of smoking abstinence: relations to depressive traits, nicotine exposure, and dependence.
Effects of monetary contingencies on smoking relapse: influences of trait depression, personality, and habitual nicotine intake.
Effects of smoking abstinence on mood and craving in men: Influences of negative-affect-related personality traits, habitual nicotine intake and repeated measurementsRead Full Text
The psychology of the smokerRead Full Text
Effects of smoking and telic/paratelic dominance on the contingent negative variation (CNV).
EFFECTS OF RESPIRATORY MANEUVERS ON END-TIDAL CO2 AND THE EGG OF SMOKERSRead Full Text
THE INTERACTION OF SMOKING EFFECTS AND INDIVIDUAL-DIFFERENCES ON CARDIAC AND EMG ACTIVITYRead Full Text
Smoking and EEG power spectra: effects of differences in arousal seeking.