Faculty

Paolo Mannelli

Associate Professor of Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Addiction
School of Medicine

2213 Elba Street, Suite 156, Durham, NC 27705

Box 3074 Med Ctr, Durham, NC 27710

(919) 668-3757 paolo.mannelli@duke.edu


Education & Training

M.D. 1986

Catholic University (Italy)

Grants

Impact of new standards for tobacco products among dual e-cigarette/combusted cigarette users

National Institutes of Health

Early-phase Studies of a Tailored Evidence-Based Smoking Cessation mHealth App for Persons Living with HIV

National Institutes of Health

Alkermes ALK6428-A302

Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

National Institutes of Health

Mid Southern Primary Care Networks Node

National Institutes of Health

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

University of Minnesota

Substance Abuse & Treatment Gaps in Asians, Pacific Islanders & Multiple-race Individuals

National Institutes of Health

ALK648-A301 - NXT-VIV

Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

National Institutes of Health

A feasibility study for testing the effects of extended-release naltrexone (Vivitrol) on recidivism and other participant outcomes in drug court settings

RCT of an Integrated Treatment of Persons with Co-Occurring HCV and Alcohol Abuse

National Institutes of Health

Retrospective Evaluation of Zubsolv Outcomes - A Longitudinal View (REZOLV)

Carolinas Comprehensive Substance Abuse Services Project

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

University of Minnesota

Project 2: Evaluating New Nicotine Standards for Cigarettes - Supplement

University of Minnesota

Southern Consortium Node of the Clinical Trials Network

Medical University of South Carolina

Carolina Alcohol and Drug Expansion Team (CADET)

Epidemiology of Non-Medical Prescription Analgesic Use

National Institutes of Health

Integrated Treatment of Persons with Co-Occurring HCV and Alcohol Use/Abuse

National Institutes of Health

Place of Low-Dose Naltrexone in Opiate Detoxification

National Institutes of Health

Serotonin and Cocaine Dependence

National Institutes of Health
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Publications

Commentary on Winhusen et al. (2019): Substance use disorders, chronic diseases, and electronic health records-a paradigm for screening and intervention.

PMID 31243837
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Clinical epidemiology of substance use disorders: Understanding patterns, sharing knowledge, planning interventions.

PMID 31411168
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Prevalence and patterns of opioid misuse and opioid use disorder among primary care patients who use tobacco.

PMID 30513477
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Opioid use disorder deaths and the effects of medication therapy.

PMID 30849238
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The Hepatitis C-Alcohol Reduction Treatment (Hep ART) intervention: Study protocol of a multi-center randomized controlled trial.

PMID 30006024
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Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone.

PMID 30028058
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Prevalence, patterns, and correlates of multiple substance use disorders among adult primary care patients.

PMID 29635217
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Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial.

PMID 29674251
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Transition to Extended-release Naltrexone: Heroin Versus Prescription Opioid Users

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Outpatient Transition to Extended-release Naltrexone in Patients With Opioid-use Disorder

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Substance use disorders and medical comorbidities among high-need, high-risk patients with diabetes.

PMID 29554592
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Antagonists in the medical management of opioid use disorders: Historical and existing treatment strategies.

PMID 29596725
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Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States.

PMID 28599214
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The opioid overdose epidemic: opportunities for pharmacists.

PMID 28814912
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Family substance use screening: less to hide, more to gain.

PMID 27748291
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Primary care for opioid use disorder.

PMID 27574479
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Pharmacological and Integrated Treatments in Older Adults with Substance Use Disorders

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Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: a very low dose naltrexone and buprenorphine open label trial.

PMID 24602363
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Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study.

PMID 24342767
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Substance Use Outcomes of an Integrated HIV-Substance Use Treatment Model Implemented by Social Workers and HIV Medical Providers

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Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people.

PMID 24060266
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Smoking and opioid detoxification: behavioral changes and response to treatment.

PMID 23572466
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The burden of caring: drug users & their families.

PMID 23703330
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Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults.

PMID 22819723
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Alcohol and drug use disorders among adults in emergency department settings in the United States.

PMID 22424657
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Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy.

PMID 22356892
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The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal.

PMID 22233189
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An integrated alcohol abuse and medical treatment model for patients with hepatitis C.

PMID 22134784
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Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives.

PMID 22280332
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Once-monthly extended-release naltrexone injections improve opioid abstinence over 24 weeks compared with placebo.

PMID 22009238
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Pharmacological enhancement of naltrexone treatment for opioid dependence: a review.

PMID 21731898
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Problem drinking and low-dose naltrexone-assisted opioid detoxification.

PMID 21513688
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Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions.

PMID 21686045
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Reduced cannabis use after low-dose naltrexone addition to opioid detoxification.

PMID 20631574
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Agonist-antagonist combinations in opioid dependence: a translational approach.

PMID 22448305
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Opioid use affects antioxidant activity and purine metabolism: preliminary results.

PMID 19760630
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Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study.

PMID 19649617
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History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia.

PMID 19433129
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The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention.

PMID 19361931
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Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial.

PMID 18715283
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Early outcomes following low dose naltrexone enhancement of opioid detoxification.

PMID 19283561
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Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial.

PMID 19512961
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Childhood abuse and treatment response in patients with irritable bowel syndrome: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release.

PMID 19125906
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A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome.

PMID 19213976
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History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release.

PMID 19382010
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Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.

PMID 18321529
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Hallucinogen use disorders among adult users of MDMA and other hallucinogens.

PMID 18770077
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Prescription pain reliever abuse and dependence among adolescents: a nationally representative study.

PMID 18664996
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Reply to Dr Ng's comments on "A Randomized, Double-Blind, Placebo-Controlled Trial of Augmentation with An Extended Release Formulation of Methylphenidate in Outpatients with Treatment-Resistant Depression" [11]

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An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical features.

PMID 18615172
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Polypharmacy in pregnant women with major psychiatric illness: a pilot study.

PMID 18032983
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Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence.

PMID 17873678
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Long-acting injectable naltrexone for the treatment of alcohol dependence.

PMID 17939765
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Trends in nonheroin opioid abuse admissions: 1992-2004.

PMID 17957981
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Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal.

PMID 17408614
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Recent advances in poststroke depression.

PMID 17521519
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Medical comorbidity and alcohol dependence.

PMID 17521518
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A randomized, controlled, trial of controlled release paroxetine in fibromyalgia

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A randomized, controlled, trial of controlled release paroxetine in fibromyalgia.

PMID 17466657
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Sodium oxybate for the treatment of fibromyalgia: A double-blind, placebo-controlled trial

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Bupropion reinstates cocaine seeking behavior in rats

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A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression.

PMID 17110825
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Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.

PMID 17000009
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Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence.

PMID 16915581
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A randomized, double-blind, placebo-controlled, flexible-dose, trial of augmentation with OROS methylphenidate in Treatment Resistant Depression

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Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients.

PMID 16418827
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Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats.

PMID 16385558
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Changes in tobacco smoking following treatment for cocaine dependence.

PMID 16595320
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Antagonist treatment of opioid withdrawal translational low dose approach.

PMID 16785213
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An open-label, rater-blinded, augmentation study of aripiprazole in treatment-resistant depression.

PMID 16862232
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A functional prodynorphin promoter polymorphism and opioid dependence.

PMID 16314761
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Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals.

PMID 16109588
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Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence.

PMID 15558714
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Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients.

PMID 15804876
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The distribution of cocaine in mice differs by age and strain.

PMID 15451047
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Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence.

PMID 15064918
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Chronic very low dose naltrexone administration attenuates opioid withdrawal expression.

PMID 15312814
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Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers.

PMID 15091312
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Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patients.

PMID 15077843
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Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients.

PMID 15132346
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Relationship of Aggression, Sensation Seeking, and Impulsivity, with Severity of Cocaine Use

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High- and low-structure treatments for substance dependence: role of learned helplessness.

PMID 14510041
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Continuing care versus revolving door following opiate detoxification

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Use of very low-dose naltrexone during opiate detoxification.

PMID 12703669
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Very low antagonist dosing in opiate detoxification

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Psychological discomfort and mental illness in patients with AIDS: implications for home care.

PMID 10813035
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Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone.

PMID 10461561
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Serendipitous rapid detoxification from opiates: the importance of time-dependent processes.

PMID 10605854
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Adjuvant trazodone in the treatment of alcoholism: an open study.

PMID 9719394
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Effects of fluoxetine at antidepressant doses on short-term outcome of detoxified alcoholics.

PMID 8803648
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Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine.

PMID 7851281
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Low-dose buprenorphine detoxification in long term methadone addicts

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Sources of differentiation of cocaine withdrawal symptomatology

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Prediction in drug abuse: cocaine interactions with alcohol and buprenorphine.

PMID 8217067
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Prediction in drug abuse: Cocaine interactions with alcohol and buprenorphine

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Psychological status, life and social conditions: A study in a population of institutionalized elderly people

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Serotoninergic hypothesis on the drug mechanism of cocaine

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Benzodiazepine use and dependency risk in geriatric inpatients

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[Benzodiazepines consumption and risk of dependence in institutionalized geriatric patients].

PMID 1684219
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Zipeprol is a newly abused antitussive with an opioid spectrum and hallucinogenic effects.

PMID 2055160
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Patterns of cocaine abuse and indications for treatment

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Serotoninergic hypothesis on the drug mechanism of cocaine

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Benzodiazepine use and dependency risk in geriatric inpatients

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Clinical reports on recent abuse of an antitussive.

PMID 2378997
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Lefetamine: new abuse of an old drug--clinical evaluation of opioid activity.

PMID 2571492
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Lephetamine abuse and dependence: clinical effects and withdrawal syndrome.

PMID 2917208
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