Dr. Levin is Chief of the Neurobehavioral Research Lab in the Psychiatry Department of Duke University Medical Center. His primary academic appointment is as Professor in the Department of Psychiatry and Behavioral Sciences. He also has secondary appointments in the Department Pharmacology and Cancer Biology, the Department of Psychological and Brain Sciences and the Nicholas School of the Environment at Duke. His primary research effort is to understand basic neural interactions underlying cognitive function and addiction and to apply this knowledge to better understand cognitive dysfunction and addiction disorders and to develop novel therapeutic treatments.
The three main research components of his laboratory are focused on the themes of the basic neurobiology of cognition and addiction, neurobehavioral toxicology and the development of novel therapeutic treatments for cognitive dysfunction and substance abuse. Currently, our principal research focus concerns nicotine. We have documented the basic effects of nicotine on learningm memory and attention as well as nicotine self-administration. We are continuing with more mechanistic studies in rat models using selective lesions, local infusions and neurotransmitter interaction studies. We have found that nicotine improves memory performance not only in normal rats, but also in rats with lesions of hippocampal and basal forebrain connections. We are concentrating on alpha7 and alpha4beta2 nicotinic receptor subtypes in the hippocampus, amygdala , thalamus and frontal cortex and how they interact with dopamine D1 and D2 and glutamate NMDA systems with regard to memory and addiction. I am also conducting studies on human cognitive behavior. We have current studies to assess nicotine effects on attention, memory and mental processing speed in schizophrenics, Alzheimer's Disease patients and people with Attention Deficit Hyperactivity Disorder. In the area of neurobehavioral toxicology, I have continuing projects to characterize the adverse effects of prenatal and adolescent nicotine exposure. Our primary project in neurobehavioral toxicology focuses on the cognitive deficits caused by the marine toxins including domoic acid, ciguatera toxin and pfiesteria. We have documented a persistent neurobehavioral effects caused by Pfiesteria and domoic acid exposure. We are determining the neurobehavioral nature and mechanisms of this deficit. The basic and applied aims of our research complement each other nicely. The findings concerning neural mechanisms underlying cognitive function help direct the behavioral toxicology and therapeutic development studies, while the applied studies provide important functional information concerning the importance of the basic mechanisms under investigation.
Zebrafish show long-term behavioral impairments resulting from developmental vitamin D deficiency.
Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats.
Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats.
Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function.
Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.
Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the rat.
Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats.
Chronic memantine decreases nicotine self-administration in rats.
Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.
Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.
Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.
Corrigendum to "The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems".
Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD).
α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.
Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish.
Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin.
Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene.
Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance.
Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish.
Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae.
Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.
Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio).
Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats.
Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio).
Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.
Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats.
Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity.
The ventral hippocampal muscarinic cholinergic system plays a key role in sexual dimorphisms of spatial working memory in rats.
Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society.
Developmental neurotoxicity of succeeding generations of insecticides.
Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development.
Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?
Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats.
Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes.
Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice.
Acute oral 18-methoxycoronaridine (18-MC) decreases both alcohol intake and IV nicotine self-administration in rats.
Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.
Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone.
Crumbling Infrastructure and Learning Impairment: A Call for Responsibility.
Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.
Dextromethorphan interactions with histaminergic and serotonergic treatments to reduce nicotine self-administration in rats.
Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administrationRead Full Text
Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish.
Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish.
Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.
Pharmacological analyses of learning and memory in zebrafish (Danio rerio).
Perspectives on zebrafish neurobehavioral pharmacology.
Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior.
Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery.
Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures.
Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish.
Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats.
Nicotinic treatments not only for tobacco, but also other addictionsRead Full Text
Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine.
Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine.
Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats.
Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.
Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish.
Low dose tobacco smoke extract exposure during development causes long-term behavioral dysfunction in ratsRead Full Text
The neurobehavioral toxicity of FireMaster 550® in zebrafish ( Danio rerio ): Chronic developmental and acute adolescent exposuresRead Full Text
Early-life exposure to organophosphate flame retardants alters behavior in adult zebrafish: A comparison with organophosphate pesticidesRead Full Text
Age and sex differences in starting nicotine self-administration in early, mid or late adolescence vs. adulthood: Cause and effect relationships determined in a rat modelRead Full Text
Bupropion-varenicline interactions and nicotine self-administration behavior in rats.
Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish.
Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition.
Inhibition of aldehyde dehydrogenase-2 (ALDH-2) suppresses nicotine self-administration in ratsRead Full Text
Heterogeneity across brain regions and neurotransmitter interactions with nicotinic effects on memory function.
Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats.
Assessment of pregnenolone effects on alcohol intake and preference in male alcohol preferring (P) rats.
IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs.
Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats.
Lorcaserin, a selective 5-HT(2C) receptor agonist, decreases alcohol intake in female alcohol preferring rats.
LONG-TERM BEHAVIORAL EFFECTS OF EMBRYONIC ETHANOL EXPOSURE IN ZEBRAFISHRead Full Text
Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats.
Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene.
Sex-selective interaction of prenatal nicotine with neonatal chlorpyrifos on novel object recognition in ratsRead Full Text
Nicotinic attention-deficit/hyperactivity disorder treatment.
Meclizine enhancement of sensorimotor gating in healthy male subjects with high startle responses and low prepulse inhibition.
Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor.
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.
Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats.
Complex relationships of nicotinic receptor actions and cognitive functions.
Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice.
Nicotinic α4β2 antagonist treatment attenuates impairments in radial-arm maze repeated acquisition caused by dizocilpine in ratsRead Full Text
Effects of caffeine on alcohol consumption and nicotine self-administration in rats.
DESENSITIZATION OF A4 beta 2 NICOTINIC RECEPTORS ATTENUATES ALCOHOL INTAKE AND PREFERENCE IN ALCOHOL PREFERRING P RATSRead Full Text
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.
Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats.
Zebrafish model systems for developmental neurobehavioral toxicology.
Improvement of attentional function with antagonism of nicotinic receptors in female rats.
Branched-chain amino acids alter neurobehavioral function in rats.
Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review.
Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding.
Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes.
Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.
Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats.
Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.
Design, synthesis, and characterization of picomolar selective a4b2 nicotinic acetylcholine receptor inhibitorsRead Full Text
Novel medication targets for the treatment of alcoholism: preclinical studies.
Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats.
Differential effects of the antidepressant mirtazapine on amphetamine- and dizocilpine-induced PPI deficits.
Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.
α7-Nicotinic receptors and cognition.
Mouse models for studying genetic influences on factors determining smoking cessation success in humans.
Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial.
The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats.
Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition.
Threshold of adulthood for the onset of nicotine self-administration in male and female rats.
Glutamate and nicotinic receptor interactions in working memory: importance for the cognitive impairment of schizophrenia.
Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.
Introduction to zebrafish: current discoveries and emerging technologies for neurobehavioral toxicology and teratology.
Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity.
Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish.
Using zebrafish to fill the gap between in vitro and rodent models for nicotinic drug developmentRead Full Text
Attentional improvement in rats with the nicotinic agonist AZ12564698 (AZD3480)Read Full Text
Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats.
The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.
Attention-modulating effects of cognitive enhancers.
Differing Effects of 3 Organophosphates (Chlorpyrifos, Diazinon and Parathion) on Developing Zebrafish Nervous SystemRead Full Text
EFFECTS OF A NOVEL, SELECTIVE BRAIN NPY Y2 RECPTOR ANATONIST JNJ-31020028, ON ALCOHOL CONSUMPTION, RELAPSE AND ANXIETY IN RATSRead Full Text
Role of individual and developmental differences in voluntary cocaine intake in rats.
Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.
JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.
D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response.
Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes.
Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.
Nicotinic receptor systems and neurobehavioral function in zebrafishRead Full Text
Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development.
IV nicotine self-administration in rats using the consummatory operant licking response.
Lasting Behavioral Consequences of Organophosphate Pesticide Exposure During DevelopmentRead Full Text
PPI deficit induced by amphetamine is attenuated by the histamine H1 antagonist pyrilamine, but is exacerbated by the serotonin 5-HT2 antagonist ketanserin.
Gene-environment interactions: neurodegeneration in non-mammals and mammals.
Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.
NICOTINE SELF-ADMINISTRATION IN SELECTIVELY-BRED ALCOHOL PREFERRING (P) RATS: NICOTINIC INVOLVEMENTRead Full Text
Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol.
Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum.
Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging.
Nicotinic receptors in the habenula: importance for memory.
Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats.
Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits.
Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze.
Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology.
Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits.
Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood.
Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety.
Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function.
Genetic aspects of behavioral neurotoxicology.
Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models.
The toxicology of climate change: environmental contaminants in a warming world.
Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.
Hippocampal infusions of apolipoprotein E peptides induce long-lasting cognitive impairment.
Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats.
Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats.
Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats.
Attenuation of auditory startle and prepulse inhibition by unexpected changes in ambient illumination through dopaminergic mechanisms.
Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice.
Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood.
Nicotine effects on learning in zebrafish: the role of dopaminergic systems.
Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.
Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.
Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood.
The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish.
Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood.
Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine.
Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints.
Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration.
Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.
Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition.
Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.
Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood.
Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems.
Mercury-induced cognitive impairment in metallothionein-1/2 null mice.
Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats.
Developmental diazinon neurotoxicity in rats: later effects on emotional response.
Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon.
Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1.
Sazetidine-A, a nicotinic desensitizing agent, decreases nicotine self-administration in ratsRead Full Text
Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function.
Interaction of nicotinic and histamine H(3) systems in the radial-arm maze repeated acquisition task.
Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.
Complementary zebrafish and rat models of developmental neurobehavioral toxicity: The case of organophosphate pesticide exposureRead Full Text
Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine.
Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response.
Guidelines on nicotine dose selection for in vivo research.
Anxiolytic effects of nicotine in zebrafish.
Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats.
Nicotinic treatment for both symptomatic relief and attenuation of cognitive decline with aging and Alzheimer's dementia.Read Full Text
Low dose early postnatal diazinon exposure causes impaired working memory on the radial-arm maze in rats during adulthood.Read Full Text
Assessing stress in zebrafish: Anxiolytic effects of nicotineRead Full Text
Increased nicotine self-administration following prenatal exposure in female rats.
Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial.
Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats.
Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats.
Persisting effects of early postnatal diazinon exposure on emotional reactivity in ratsRead Full Text
Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.
Cholinergic involvement in neurocognitive function: From zebrafish to humans.Read Full Text
Developing nicotinic therapy for cognitive impairment of schizophrenia and aging-related dementiaRead Full Text
Nicotine-antipsychotic drugs interaction and sustained attention in ratsRead Full Text
Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure.
Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis.
Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity.
Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.
Metallothionein expression and neurocognitive function in mice.
Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization.
Timing of nicotine effects on learning in zebrafish.
Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia.
Chronic nicotine interactions with clozapine and risperidone and attentional function in rats.
Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus).
The rationale for studying transmitter interactions to understand the neural bases of cognitive function.
Nicotinic-antipsychotic drug interactions and cognitive function.
Clozapine effects on memory function are reversed by hippocampal damageRead Full Text
Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine.
Ketanserin attenuates nicotine-induced working memory improvement in rats.
Marine and freshwater toxin impacts on neurobehavioral functionRead Full Text
Persisting behavioral consequences of prenatal domoic acid exposure in rats.
Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats.
Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models.
Memory decline of aging reduced by extracellular superoxide dismutase overexpression.
Fetal nicotinic overload, blunted sympathetic responsivity, and obesity.
Developmental origins and environmental influences--Introduction. NIEHS symposium.
Reversal of clozapine effects on working memory in rats with fimbria-fornix lesions.
Nicotinic-serotonergic drug interactions and attentional performance in rats.
Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade.
Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function.
Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression.
Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.
Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging.
Nicotinic involvement in memory function in zebrafish.
The use of zebrafish (Danio rerio) as a model system in neurobehavioral toxicology.
Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior.
Baclofen interactions with nicotine in rats: effects on memory.
Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature.
Adolescent rats show differential effects of nicotine and alcohol relative to adults.Read Full Text
Nicotinic receptor modulation of attention: An endophenotype for therapeutic drug developmentRead Full Text
Erratum: Nicotine-antipsychotic drug interactions and attentional performance in female rats (European Journal of Pharmacology (2004) 486 (175-182) DOI: 10.1016/j.ejphar.2003.12.021.)Read Full Text
Nicotine-antipsychotic drug interactions and attentional performance in female rats.
Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment.
Neurobehavioral assessment of mice after developmental AZT exposure.
Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.
Heterogeneity of toxicant response: sources of human variability.
Ventral hippocampal NMDA blockade and nicotinic effects on memory function.
Adolescent-onset nicotine self-administration modeled in female rats.
Lobeline-induced learning improvement of rats in the radial-arm maze.
Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats.
NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function.
Learning impairment caused by a toxin produced by Pfiesteria piscicida infused into the hippocampus of rats.
Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats.
A zebrafish model for studying the neurobehavioral impacts of developmental chlorpyrifos exposure.Read Full Text
Learning impairment caused by infusion of a toxin produced by Pfiesteria piscicida into the hippocampus of rats.Read Full Text
Reliabilities and intercorrelations of reported and objective measures of smoking in patients with schizophrenia.
Nicotinic mechanisms of memory: effects of acute local DHbetaE and MLA infusions in the basolateral amygdala.
Erratum: Chlorpyrifos exposure of developing zebrafish: Effects on survival and long-term effects on response latency and spatial discrimination (Neurotoxicology and Teratology (2003) 25 (51-57))Read Full Text
Behavioral Toxicology Society 2002 annual meeting reportRead Full Text
Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination.
Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats.
Nicotinic receptor subtypes and cognitive function.
Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.
Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats.
Nicotinic treatment for cognitive dysfunction.
Nicotine-alcohol interactions and cognitive function in rats.
Developmental neurotoxicity of chlorpyrifos: Defining the vulnerable periodRead Full Text
A naturalistic study of the effects of smoking on the cognitive side effects of ECT.Read Full Text
Chronic inhibition of alpha4beta2 nicotinic receptors in the ventral hippocampus of rats: impacts on memory and nicotine response.
Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice.
Persistence of nicotinic agonist RJR 2403-induced working memory improvement in ratsRead Full Text
Effect of long-term stabilization of cationic liposomes as defibrotide delivery system for antithrombotic activityRead Full Text
Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory.
Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze.
Specificity of cognitive impairment from Pfiesteria piscicida exposure in rats: attention and visual function versus behavioral plasticity.
A rat model of the cognitive impairment from Pfiesteria piscicida exposure.
Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats.
Cognitive effects of nicotine.
Effects of chronic nicotine and methylphenidate in adults with attention deficit/hyperactivity disorder.
Spatial and non-spatial visual discrimination learning in zebrafish (danio rerio)Read Full Text
The nicotinic antagonist mecamylamine preferentially inhibits cocaine vs. food self-administration in rats.
Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior.
Ventral hippocampal alpha4beta2 nicotinic receptors and chronic nicotine effects on memory.
Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol.
Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease.
Rapid neurobehavioral analysis of Pfiesteria piscicida effects in juvenile and adult rats.
Attention as a target of intoxication: insights and methods from studies of drug abuse.
Nicotine enhances stimulus detection performance of middle- and old-aged rats: a longitudinal study.
Development of nicotinic drug therapy for cognitive disorders.
Molecular overexpression of extracellular superoxide dismutase increases the dependency of learning and memory performance on motivational state.
Assessment of immunotoxicology in wild populations: Review and recommendationsRead Full Text
AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.
Mutually potentiating effects of mecamylamine and haloperidol in producing catalepsy in ratsRead Full Text
Bridged nicotine, isonicotine, and norisonicotine effects on working memory performance of rats in the radial-arm mazeRead Full Text
Pfiesteria toxin and learning performance.
Nicotine and/or cocaine alters postnatal ventilatory control in the rat pup gestationally exposedRead Full Text
Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease.
Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats.
Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.
Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.
Transdermal nicotine effects on attention.
Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze.
Molecular manipulations of extracellular superoxide dismutase: functional importance for learning.
Nicotinic acetylcholine involvement in cognitive function in animals.
Oxidative stress in toxicology: established mammalian and emerging piscine model systems.
Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected].
Differential effects of ethanol on memory in adolescent and adult rats.
Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats.
Chronic haloperidol administration does not block acute nicotine-induced improvements in radial-arm maze performance in the rat.
Persisting learning deficits in rats after exposure to Pfiesteria piscicida.
Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics.
Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat.
Chronic nicotinic agonist and antagonist effects on T-maze alternation.
Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze.
Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats?
Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges.
Nicotinic agonist and antagonist effects on memoryRead Full Text
Chronic nicotine-induced improvement of spatial working memory and D
Epibatidine, a potent nicotinic agonist: Effects on learning and memory in the radial-arm mazeRead Full Text
Nicotine and neurobehavioral functionRead Full Text
Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia.
Prenatal cocaine and/or nicotine exposure in rats: preliminary findings on long-term cognitive outcome and genital development at birth.
Nicotine-haloperidol interactions and cognitive performance in schizophrenics.
Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs.
Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade.
Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats.
Acute and chronic nicotine effects on working memory in aged rats.
Nicotine effects on adults with attention-deficit/hyperactivity disorder.
Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD).
Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze.
Smoking in Vietnam combat veterans with post-traumatic stress disorder.
Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze.
Acute and chronic nicotinic interactions with dopamine systems and working memory performance.
Combined administration of agonist-antagonist as a method of regulating receptor activation.
Haloperidol increases smoking in patients with schizophrenia.
Clozapine decreases smoking in patients with chronic schizophrenia.
PRENATAL COCAINE AND NICOTINE EXPOSURE IN RATS - EFFECTS ON LONG-TERM COGNITIVE OUTCOME AND SEXUAL-DIFFERENTIATIONRead Full Text
ReplyRead Full Text
Triphenyl phosphite-induced impairment of spatial alternation learning.
Nicotine skin patch treatment and adverse reactions: skin irritation, skin sensitization, and nicotine as a hapten.
Spatial working and reference memory in rats bred for autonomic sensitivity to cholinergic stimulation: acquisition, accuracy, speed, and effects of cholinergic drugs.
NICOTINE EFFECTS ON MEMORY PERFORMANCERead Full Text
Nicotine as a therapeutic drug.
Behavioral and neurochemical consequences of ibotenic acid lesion in the subthalamic nucleus of the common marmoset.
[A transformylation reaction--transfer of an N-formyl residue to amino acids and peptides in nucleophilic groups--as a side reaction of peptide synthesis].
Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra.
Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone.
Nicotine skin patch treatment increases abstinence, decreases withdrawal symptoms, and attenuates rewarding effects of smoking.
Promise of nicotinic‐based therapeutic treatmentsRead Full Text
Nicotine interactions with dopamine agonists: Effects on working memory functionRead Full Text
Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking SatisfactionRead Full Text
Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in ratsRead Full Text
CLOZAPINE DECREASES DRIVE TO SMOKERead Full Text
Saliva nicotine as an index of plasma levels in nicotine skin patch users.
Clinical trials using ascorbic acid aerosol to aid smoking cessation.
Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection.
The nicotine patch in smoking cessation. A randomized trial with telephone counseling.
Effects of dopaminergic drugs on working and reference memory in rats.
Prenatal nicotine exposure and cognitive performance in rats.
Development of treatments for toxicant-induced cognitive deficits.
SMOKING WHILE WEARING THE NICOTINE PATCH - IS SMOKING STILL SATISFYINGRead Full Text
PREDICTING SUCCESS OF THE NICOTINE PATCH IN SMOKING CESSATION USING BASE-LINE CLINICAL INFORMATIONRead Full Text
Chronic nicotinic stimulation and blockade effects on working memory.
Role of nicotine dose and sensory cues in the regulation of smoke intake.
Clinical evaluation of a citric acid inhaler for smoking cessation.
Sertraline attenuates hyperphagia in rats following nicotine withdrawal.
Sex-related spatial learning differences after prenatal cocaine exposure in the young adult rat.
SMOKING WHILE WEARING THE NICOTINE PATCH - IS SMOKING SATISFYING OR HARMFULRead Full Text
DERIVATION OF A LOGISTIC MODEL USING BASE-LINE CLINICAL INFORMATION TO PREDICT SUCCESS WITH THE NICOTINE PATCH IN SMOKING CESSATIONRead Full Text
Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions.
The effect of halothane on cultured fibroblasts and neuroblastoma cells.
Dopaminergic drugs reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway.
Persistence of chronic nicotine-induced cognitive facilitation.
Use of the lesion model for examining toxicant effects on cognitive behavior.
ANIMAL-MODELS OF NICOTINE EFFECTS ON WEIGHT REGULATIONRead Full Text
Erratum: Use of the lesion model for examining toxicant effects on cognitive behavior (Neurotoxicol. Teratol. 14 (131-142) 1992)Read Full Text
Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence.
Nicotinic systems and cognitive function.
National working conference on smoking and body weight. Task Force 2: Methods of assessment, strategies for research.
Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze.
Neurobehavioral toxicology of halothane in rats.
The effects of smoking-related sensory cues on psychological stress.
Inter-relationships between conditioned and primary reinforcement in the maintenance of cigarette smoking.
Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance.
Long‐term neurobehavioral effects of perinatal polychlorinated biphenyl (PCB) exposure in monkeysRead Full Text
Impairment of radial-arm maze performance in rats following lesions involving the cholinergic medial pathway: reversal by arecoline and differential effects of muscarinic and nicotinic antagonists.
Cholinergic-dopaminergic interactions in cognitive performance.
The use of flavor in cigarette substitutes.
Contrasting effects of centromedial and basolateral amygdaloid lesions on stress-related responses in the rat.
Development of a citric acid aerosol as a smoking cessation aid.
Transdermal nicotine facilitates smoking cessation.
Chronic nicotine and withdrawal effects on radial-arm maze performance in rats.
Long-term effects of developmental halothane exposure on radial arm maze performance in rats.
Characterization of the cognitive effects of combined muscarinic and nicotinic blockade.
Low-nicotine regenerated smoke aerosol reduces desire for cigarettes.
d-Amphetamine-induced "floating limb" syndrome in young rhesus monkeys.
Anticholinergic sensitivity following chronic nicotine administration as measured by radial-arm maze performance in rats.
Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats.
Effects of dopamine D1 and D2 receptor antagonists on oral activity in rats.
Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555.
Nicotinic-dopaminergic relationships and radial-arm maze performance in rats.
D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.
Controlling puff volume without disrupting smoking topographyRead Full Text
Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys.
Mecamylamine increases nicotine preference and attenuates nicotine discrimination.
Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze.
Morphological and behavioral effects of perinatal exposure to aspartame (Nutrasweet®) on rat pupsRead Full Text
Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.
Chronic neuroleptic effects on spatial reversal learning in monkeys.
Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs.
Long-term effects of chronic postnatal lead exposure on delayed spatial alternation in monkeys.
Neurobiochemical changes in tardive dyskinesia.
Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats.
Behavioral effects of developmental lead exposure in rhesus monkeys.
Cholinergic-dopaminergic interactions in radial-arm maze performance.
Characteristics of oral movements in rats during and after chronic haloperidol and fluphenazine administration.
Delayed spatial alternation deficits resulting from perinatal PCB exposure in monkeys.
Psychopharmacological effects in the radial-arm maze.
Behavioral effects of acute hexamethonium in rats chronically intoxicated with nicotine.
Chronic neuroleptics alter the effects of the D1 agonist SK&F 38393 and the D2 agonist LY171555 on oral movements in rats.
Neurobehavioral effects of chronic halothane exposure during developmental and juvenile periods in the rat.
Neuroleptic-induced oral movements in rats: methodological issues.
Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats.
Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788.
Opposite effects of a D1 and a D2 agonist on oral movements in rats.
Chronic haloperidol effects on oral movements and radial-arm maze performance in rats.
Psychopharmacological investigations of a lead-induced long-term cognitive deficit in monkeys.
The effects of D1 and D2 receptor antagonists on pain sensitivity and morphine analgesia in the rat.
Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats.
Tremorous mouth movements in rats administered chronic neuroleptics.
Effects of the dopamine D-2 receptor agonist, LY 171555, on radial arm maze performance in rats.
Behavioral effects of chronic exposure to low concentrations of halothane during development in rats.
Long-term lead effects on the Hamilton Search Task and delayed alternation in monkeys.
Scopolamine effects on Hamilton search task performance in monkeys.
Behavioral evaluation of perinatal PCB exposure in rhesus monkeys: fixed-interval performance and reinforcement-omission.
A visual exploration apparatus for infant monkeysRead Full Text
A model for tardive dyskinesia: The effects of chronic fluphenazine decanoate on guinea pigsRead Full Text
Analgesia produced by the benzodiazepine antagonist R015-1788Read Full Text
Effects of halothane on the development of rat brain: a golgi study of dendritic growth.
Effects of halothane on synaptogenesis and learning behavior in rats.
The effect of pre- or postnatal lead exposure on Hamilton Search Task in monkeys.
Effects of zinc deficiency on lead toxicity in rats.
Isoelectric focusing of proteins in gelsRead Full Text