Faculty

Edward Levin

Professor in Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Addiction
School of Medicine

Director, Integrated Toxicology Program

School of Medicine
School of Medicine

Professor in the Environmental Sciences and Policy Division

Environmental Sciences and Policy
Nicholas School of the Environment

Associate Professor of Pharmacology & Cancer Biology

Pharmacology & Cancer Biology
School of Medicine

Professor of Psychology and Neuroscience

Psychology and Neuroscience
Trinity College of Arts & Sciences

Faculty Network Member of the Duke Institute for Brain Sciences

Duke Institute for Brain Sciences
Institutes and Provost's Academic Units

Affiliate of the Duke Initiative for Science & Society

Duke Science & Society
Institutes and Provost's Academic Units

Member of the Duke Cancer Institute

Duke Cancer Institute
School of Medicine
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323 Foster St, Durham, NC 27701

Box 104790, Durham, NC 27710

(919) 681-6273 edlevin@duke.edu

Dr. Levin is Chief of the Neurobehavioral Research Lab in the Psychiatry Department of Duke University Medical Center. His primary academic appointment is as Professor in the Department of Psychiatry and Behavioral Sciences. He also has secondary appointments in the Department Pharmacology and Cancer Biology, the Department of Psychological and Brain Sciences and the Nicholas School of the Environment at Duke. His primary research effort is to understand basic neural interactions underlying cognitive function and addiction and to apply this knowledge to better understand cognitive dysfunction and addiction disorders and to develop novel therapeutic treatments.

The three main research components of his laboratory are focused on the themes of the basic neurobiology of cognition and addiction, neurobehavioral toxicology and the development of novel therapeutic treatments for cognitive dysfunction and substance abuse. Currently, our principal research focus concerns nicotine. We have documented the basic effects of nicotine on learningm memory and attention as well as nicotine self-administration. We are continuing with more mechanistic studies in rat models using selective lesions, local infusions and neurotransmitter interaction studies. We have found that nicotine improves memory performance not only in normal rats, but also in rats with lesions of hippocampal and basal forebrain connections. We are concentrating on alpha7 and alpha4beta2 nicotinic receptor subtypes in the hippocampus, amygdala , thalamus and frontal cortex and how they interact with dopamine D1 and D2 and glutamate NMDA systems with regard to memory and addiction. I am also conducting studies on human cognitive behavior. We have current studies to assess nicotine effects on attention, memory and mental processing speed in schizophrenics, Alzheimer's Disease patients and people with Attention Deficit Hyperactivity Disorder. In the area of neurobehavioral toxicology, I have continuing projects to characterize the adverse effects of prenatal and adolescent nicotine exposure. Our primary project in neurobehavioral toxicology focuses on the cognitive deficits caused by the marine toxins including domoic acid, ciguatera toxin and pfiesteria. We have documented a persistent neurobehavioral effects caused by Pfiesteria and domoic acid exposure. We are determining the neurobehavioral nature and mechanisms of this deficit. The basic and applied aims of our research complement each other nicely. The findings concerning neural mechanisms underlying cognitive function help direct the behavioral toxicology and therapeutic development studies, while the applied studies provide important functional information concerning the importance of the basic mechanisms under investigation.


Education & Training

Ph.D. 1984

University of Wisconsin at Madison

Grants

Duke University Program in Environmental Health

National Institutes of Health

Using Zebrafish to Help Identify Which Environmental Toxicants Could Increase Autism Risk

Receptor-type protein in tyrosine phosphatase D (PTPRD) treatment with 7-BIA to reduce nicotine self-adminstration

HAB toxin exposure and Alzheimer's disease susceptibility

Paternal Transgenerational Epigenetic Legacy from Use of Cannabis

John Templeton Foundation

Pharmacological Sciences Training Program

National Institutes of Health

Reinforcing effect of nicotine alone vs. nicotine plus other chemicals in tobacco

Alzheimer's Disease, Genes, and Pesticide Use in the Agricultural Health Study

National Institutes of Health

Study of Novel Treatment to Prevent Acquisition of Opiate Self-Administration in Rats

Duke University Program in Environmental Health

National Institute of Environmental Health Sciences

Advancing Mechanistic Understanding of Neurotoxic Contributors to Autism

National Institutes of Health

Establishing an AOP for the Role of the Vitamin D Receptor in Developmental Neurotoxicity

North Carolina State University

Acute and chronic nicotine modulation of reinforcement learning

National Institutes of Health

Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats

John Templeton Foundation

Screening Potential Persisting Neurobehavioral Effects-Zebrafish Exposed to Flame Retardants

National Institute of Environmental Health Sciences

Complementary Neurotoxicological Insights from Fish, Flies, Bees and Worms Symposium

National Institutes of Health

Nicotinic Receptor Desensitization to Reduce Drug Self-Administration: Project 2

Georgetown University

Atrazine Effects in the Brain: Pilot Study

Environmental Protection Agency

Role of HPA Axis in Adolescent Vulnerability to Drug Addiction

National Institutes of Health

Neurobehavioral Teratology Society: Zebrafish Symposium

National Institutes of Health

Adolescence: A Sensitive Period for Nicotine Addiction

National Institutes of Health

MARCKS Peptides and Memory

National Institutes of Health

Neuroimaging Attentional Impairment During Abstinence

National Institutes of Health

Nicotinic-Antipsychotic Drug Interactions and Cognition

National Institutes of Health

Marine Toxin Impacts on Neurobehavioral Function

National Institutes of Health

Non-Monotonic Dose-Toxicity Functions, Multiple Mechanisms of Effect: Impacts on Health & Public Policy

Environmental Protection Agency

Collaberative Research Training In Enviromental Toxicology

Environmental Protection Agency

Behavioral Genetics and Toxic Response

National Institutes of Health

Chronic Nicotine-Infusion Induced Memory Improvement

National Institutes of Health

Smoking, Schhizophrenia, and Atypical Antipsychotics

National Institutes of Health

Neurotoxic Effects of Adult and Developmental Exposure to Pfiesteria Toxin

Environmental Protection Agency

Attention as a Target of Intoxication

National Institutes of Health

Integrated Toxicology

National Institutes of Health

Drive To Smoke And Dopamine Blockade

National Institutes of Health

The Effect Of Pfiesteriaon Learning And Memory In Rats

Environmental Protection Agency

Neurobehavioral Effects Of Dinoflagellate Toxins In Rat

Cholinergic-Dopaminergic Interactions And The Foundations

National Science Foundation

Scaling The Reinforcing Value Of Cigarette Smoke

National Institutes of Health

Cholinergic-Dopaminergic Interactions & The Foundations Of

National Science Foundation
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Publications

Gestational and perinatal exposure to diazinon causes long-lasting neurobehavioral consequences in the rat.

PMID 31704166
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Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats.

PMID 31470021
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Chronic memantine decreases nicotine self-administration in rats.

PMID 31421087
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Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.

PMID 31028824
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Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.

PMID 31103693
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Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.

PMID 30794849
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Corrigendum to "The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]pyrene: Effects on Cholinergic and Serotonergic Systems".

PMID 30615185
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Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD).

PMID 30909167
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α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.

PMID 30529197
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Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish.

PMID 30172631
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Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin.

PMID 30419272
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Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene.

PMID 29940444
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Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance.

PMID 30036564
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Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish.

PMID 28935585
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Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae.

PMID 29559250
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Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.

PMID 29339170
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Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio).

PMID 29432853
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Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats.

PMID 29407477
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Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio).

PMID 29197232
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Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.

PMID 28436446
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Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats.

PMID 28555315
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Exposure to 1,2-Propanediol Impacts Early Development of Zebrafish (Danio rerio) and Induces Hyperactivity.

PMID 28266909
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The ventral hippocampal muscarinic cholinergic system plays a key role in sexual dimorphisms of spatial working memory in rats.

PMID 28131771
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Neural mechanisms of functional impairment across the lifespan: The 15th Biennial Meeting of the International Neurotoxicology Association and 39th Annual Meeting of the Neurobehavioral Teratology Society.

PMID 28347437
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Developmental neurotoxicity of succeeding generations of insecticides.

PMID 27908457
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Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development.

PMID 27329031
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Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?

PMID 27633979
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Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats.

PMID 29416900
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Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes.

PMID 27816694
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Persisting neurobehavioral effects of developmental copper exposure in wildtype and metallothionein 1 and 2 knockout mice.

PMID 27802831
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Acute oral 18-methoxycoronaridine (18-MC) decreases both alcohol intake and IV nicotine self-administration in rats.

PMID 27984095
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Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats.

PMID 27318988
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Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone.

PMID 26919958
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Crumbling Infrastructure and Learning Impairment: A Call for Responsibility.

PMID 27136451
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Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.

PMID 26728879
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Dextromethorphan interactions with histaminergic and serotonergic treatments to reduce nicotine self-administration in rats.

PMID 26704812
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Different lines of rats selectively-bred for high alcohol-drinking demonstrate disparate preferences for nicotine self-administration

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Persistent behavioral effects following early life exposure to retinoic acid or valproic acid in zebrafish.

PMID 26439099
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Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish.

PMID 26548404
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Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.

PMID 25797492
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Pharmacological analyses of learning and memory in zebrafish (Danio rerio).

PMID 25792292
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Perspectives on zebrafish neurobehavioral pharmacology.

PMID 26675808
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Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior

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Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior.

PMID 25979796
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Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery.

PMID 26013674
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Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures.

PMID 26239867
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Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish.

PMID 26344674
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Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats.

PMID 26101069
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Nicotinic treatments not only for tobacco, but also other addictions

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Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine.

PMID 26085346
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Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine.

PMID 26391568
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Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats.

PMID 25912180
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Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.

PMID 25891525
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Neurobehavioral impairments caused by developmental imidacloprid exposure in zebrafish.

PMID 25944383
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Low dose tobacco smoke extract exposure during development causes long-term behavioral dysfunction in rats

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The neurobehavioral toxicity of FireMaster 550® in zebrafish ( Danio rerio ): Chronic developmental and acute adolescent exposures

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Early-life exposure to organophosphate flame retardants alters behavior in adult zebrafish: A comparison with organophosphate pesticides

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Age and sex differences in starting nicotine self-administration in early, mid or late adolescence vs. adulthood: Cause and effect relationships determined in a rat model

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Bupropion-varenicline interactions and nicotine self-administration behavior in rats.

PMID 25616031
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Long-term behavioral impairment following acute embryonic ethanol exposure in zebrafish.

PMID 25599606
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Prenatal nicotine changes the response to postnatal chlorpyrifos: Interactions targeting serotonergic synaptic function and cognition.

PMID 25592617
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Inhibition of aldehyde dehydrogenase-2 (ALDH-2) suppresses nicotine self-administration in rats

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Heterogeneity across brain regions and neurotransmitter interactions with nicotinic effects on memory function.

PMID 25655888
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Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats.

PMID 25064338
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Assessment of pregnenolone effects on alcohol intake and preference in male alcohol preferring (P) rats.

PMID 25016089
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IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs.

PMID 24953434
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Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats.

PMID 25122040
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Lorcaserin, a selective 5-HT(2C) receptor agonist, decreases alcohol intake in female alcohol preferring rats.

PMID 25109272
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LONG-TERM BEHAVIORAL EFFECTS OF EMBRYONIC ETHANOL EXPOSURE IN ZEBRAFISH

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Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats.

PMID 24560911
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Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene.

PMID 24642111
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Sex-selective interaction of prenatal nicotine with neonatal chlorpyrifos on novel object recognition in rats

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Nicotinic attention-deficit/hyperactivity disorder treatment.

PMID 24370349
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Meclizine enhancement of sensorimotor gating in healthy male subjects with high startle responses and low prepulse inhibition.

PMID 24045586
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Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: significance for maternal stress and preterm labor.

PMID 24177596
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Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.

PMID 24047231
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Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats.

PMID 23948214
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Complex relationships of nicotinic receptor actions and cognitive functions.

PMID 23928190
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Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice.

PMID 24036108
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Nicotinic α4β2 antagonist treatment attenuates impairments in radial-arm maze repeated acquisition caused by dizocilpine in rats

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Effects of caffeine on alcohol consumption and nicotine self-administration in rats.

PMID 23895206
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DESENSITIZATION OF A4 beta 2 NICOTINIC RECEPTORS ATTENUATES ALCOHOL INTAKE AND PREFERENCE IN ALCOHOL PREFERRING P RATS

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Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.

PMID 23540678
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Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats.

PMID 23100170
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Zebrafish model systems for developmental neurobehavioral toxicology.

PMID 23723169
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Improvement of attentional function with antagonism of nicotinic receptors in female rats.

PMID 23399762
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Branched-chain amino acids alter neurobehavioral function in rats.

PMID 23249694
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Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review.

PMID 23232494
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Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding.

PMID 23675442
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Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes.

PMID 23022260
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Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.

PMID 22899752
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Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats.

PMID 22959891
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Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.

PMID 22526540
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Design, synthesis, and characterization of picomolar selective a4b2 nicotinic acetylcholine receptor inhibitors

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Novel medication targets for the treatment of alcoholism: preclinical studies.

PMID 22574676
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Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats.

PMID 22297831
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Differential effects of the antidepressant mirtazapine on amphetamine- and dizocilpine-induced PPI deficits.

PMID 22469866
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Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.

PMID 22387853
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α7-Nicotinic receptors and cognition.

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α7-Nicotinic receptors and cognition.

PMID 22300026
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Mouse models for studying genetic influences on factors determining smoking cessation success in humans.

PMID 22304675
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Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial.

PMID 22232050
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The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats.

PMID 21710169
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Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition.

PMID 22001728
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Threshold of adulthood for the onset of nicotine self-administration in male and female rats.

PMID 21854810
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Glutamate and nicotinic receptor interactions in working memory: importance for the cognitive impairment of schizophrenia.

PMID 21884762
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Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish.

PMID 22036888
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Introduction to zebrafish: current discoveries and emerging technologies for neurobehavioral toxicology and teratology.

PMID 22117689
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Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity.

PMID 21745564
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Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish.

PMID 21741476
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Using zebrafish to fill the gap between in vitro and rodent models for nicotinic drug development

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Attentional improvement in rats with the nicotinic agonist AZ12564698 (AZD3480)

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Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats.

PMID 21636655
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The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

PMID 21145691
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Attention-modulating effects of cognitive enhancers.

PMID 21334367
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Differing Effects of 3 Organophosphates (Chlorpyrifos, Diazinon and Parathion) on Developing Zebrafish Nervous System

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EFFECTS OF A NOVEL, SELECTIVE BRAIN NPY Y2 RECPTOR ANATONIST JNJ-31020028, ON ALCOHOL CONSUMPTION, RELAPSE AND ANXIETY IN RATS

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Role of individual and developmental differences in voluntary cocaine intake in rats.

PMID 21347641
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Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.

PMID 21274704
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JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats.

PMID 21086115
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D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response.

PMID 21192967
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Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes.

PMID 21035540
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Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.

PMID 20951696
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Nicotinic receptor systems and neurobehavioral function in zebrafish

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Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development.

PMID 21615262
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IV nicotine self-administration in rats using the consummatory operant licking response.

PMID 20804779
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Lasting Behavioral Consequences of Organophosphate Pesticide Exposure During Development

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PPI deficit induced by amphetamine is attenuated by the histamine H1 antagonist pyrilamine, but is exacerbated by the serotonin 5-HT2 antagonist ketanserin.

PMID 20811878
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Gene-environment interactions: neurodegeneration in non-mammals and mammals.

PMID 20359493
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Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.

PMID 20535453
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NICOTINE SELF-ADMINISTRATION IN SELECTIVELY-BRED ALCOHOL PREFERRING (P) RATS: NICOTINIC INVOLVEMENT

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Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol.

PMID 20356869
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Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum.

PMID 20074626
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Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging.

PMID 20015457
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Nicotinic receptors in the habenula: importance for memory.

PMID 20034548
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Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats.

PMID 20007754
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Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits.

PMID 19615431
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Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze.

PMID 19854162
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Introduction to the special issue on emerging high throughput and complementary model screens for neurotoxicology.

PMID 19703556
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Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits.

PMID 19268529
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Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood.

PMID 19616088
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Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety.

PMID 19643124
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Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function.

PMID 19477167
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Genetic aspects of behavioral neurotoxicology.

PMID 19647018
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Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models.

PMID 19547960
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The toxicology of climate change: environmental contaminants in a warming world.

PMID 19375165
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Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.

PMID 19413647
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Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.

PMID 19590683
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Hippocampal infusions of apolipoprotein E peptides induce long-lasting cognitive impairment.

PMID 19185602
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Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats.

PMID 19146909
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Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats.

PMID 19110025
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Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats.

PMID 19041337
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Attenuation of auditory startle and prepulse inhibition by unexpected changes in ambient illumination through dopaminergic mechanisms.

PMID 18801390
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Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice.

PMID 18831991
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Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood.

PMID 18773955
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Nicotine effects on learning in zebrafish: the role of dopaminergic systems.

PMID 18716760
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Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion.

PMID 18817854
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Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.

PMID 18950618
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Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood.

PMID 19057696
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The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish.

PMID 18671990
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Exposure of neonatal rats to parathion elicits sex-selective impairment of acetylcholine systems in brain regions during adolescence and adulthood.

PMID 18941570
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Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine.

PMID 18456310
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Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints.

PMID 17681747
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Neonatal 6-hydroxydopamine lesions of the frontal cortex in rats: persisting effects on locomotor activity, learning and nicotine self-administration.

PMID 18511204
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Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.

PMID 18353800
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Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.

PMID 18343006
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Metallothionein in the central nervous system: Roles in protection, regeneration and cognition.

PMID 18313142
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Repeat exposure to ciguatoxin leads to enhanced and sustained thermoregulatory, pain threshold and motor activity responses in mice: relationship to blood ciguatoxin concentrations.

PMID 18280027
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Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood.

PMID 18355640
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Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems.

PMID 18335101
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Mercury-induced cognitive impairment in metallothionein-1/2 null mice.

PMID 18226494
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Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats.

PMID 17295931
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Developmental diazinon neurotoxicity in rats: later effects on emotional response.

PMID 18158111
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Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon.

PMID 18096363
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Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1.

PMID 17868886
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Sazetidine-A, a nicotinic desensitizing agent, decreases nicotine self-administration in rats

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Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function.

PMID 17714691
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Interaction of nicotinic and histamine H(3) systems in the radial-arm maze repeated acquisition task.

PMID 17544392
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Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates.

PMID 17433619
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Complementary zebrafish and rat models of developmental neurobehavioral toxicity: The case of organophosphate pesticide exposure

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Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine.

PMID 17382376
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Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response.

PMID 17355891
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Guidelines on nicotine dose selection for in vivo research.

PMID 16896961
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Anxiolytic effects of nicotine in zebrafish.

PMID 17049956
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Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats.

PMID 17207102
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Nicotinic treatment for both symptomatic relief and attenuation of cognitive decline with aging and Alzheimer's dementia.

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Low dose early postnatal diazinon exposure causes impaired working memory on the radial-arm maze in rats during adulthood.

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Assessing stress in zebrafish: Anxiolytic effects of nicotine

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Increased nicotine self-administration following prenatal exposure in female rats.

PMID 17196243
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Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial.

PMID 16977477
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Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats.

PMID 16715255
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Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats.

PMID 17046199
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Persisting effects of early postnatal diazinon exposure on emotional reactivity in rats

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Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.

PMID 17035140
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Cholinergic involvement in neurocognitive function: From zebrafish to humans.

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Developing nicotinic therapy for cognitive impairment of schizophrenia and aging-related dementia

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Nicotine-antipsychotic drugs interaction and sustained attention in rats

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Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure.

PMID 16632386
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Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis.

PMID 16569445
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Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity.

PMID 16675431
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Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.

PMID 16556437
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Metallothionein expression and neurocognitive function in mice.

PMID 16430929
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Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization.

PMID 16220335
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Timing of nicotine effects on learning in zebrafish.

PMID 16175402
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Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia.

PMID 16356617
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Chronic nicotine interactions with clozapine and risperidone and attentional function in rats.

PMID 16310917
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Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus).

PMID 16045967
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The rationale for studying transmitter interactions to understand the neural bases of cognitive function.

PMID 17019880
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Nicotinic-antipsychotic drug interactions and cognitive function.

PMID 17019889
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Clozapine effects on memory function are reversed by hippocampal damage

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Mode of action: disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction--developmental neurotoxicity of nicotine.

PMID 16417037
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Ketanserin attenuates nicotine-induced working memory improvement in rats.

PMID 16185760
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Marine and freshwater toxin impacts on neurobehavioral function

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Persisting behavioral consequences of prenatal domoic acid exposure in rats.

PMID 16054336
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Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats.

PMID 15812569
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Adolescent vulnerabilities to chronic alcohol or nicotine exposure: findings from rodent models.

PMID 16205372
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Memory decline of aging reduced by extracellular superoxide dismutase overexpression.

PMID 15971025
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Fetal nicotinic overload, blunted sympathetic responsivity, and obesity.

PMID 15959889
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Developmental origins and environmental influences--Introduction. NIEHS symposium.

PMID 15959884
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Reversal of clozapine effects on working memory in rats with fimbria-fornix lesions.

PMID 15688087
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Nicotinic-serotonergic drug interactions and attentional performance in rats.

PMID 15682310
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Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade.

PMID 15866361
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Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function.

PMID 15939205
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Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression.

PMID 15866758
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Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding.

PMID 15829222
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Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging.

PMID 15974918
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Nicotinic involvement in memory function in zebrafish.

PMID 15451037
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The use of zebrafish (Danio rerio) as a model system in neurobehavioral toxicology.

PMID 15451033
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Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior.

PMID 15451035
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Baclofen interactions with nicotine in rats: effects on memory.

PMID 15501311
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Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature.

PMID 15380834
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Adolescent rats show differential effects of nicotine and alcohol relative to adults.

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Nicotinic receptor modulation of attention: An endophenotype for therapeutic drug development

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Erratum: Nicotine-antipsychotic drug interactions and attentional performance in female rats (European Journal of Pharmacology (2004) 486 (175-182) DOI: 10.1016/j.ejphar.2003.12.021.)

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Nicotine-antipsychotic drug interactions and attentional performance in female rats (vol 486, pg 175, 2004)

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Nicotine-antipsychotic drug interactions and attentional performance in female rats.

PMID 14975706
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Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment.

PMID 14534771
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Neurobehavioral assessment of mice after developmental AZT exposure.

PMID 15001215
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Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation.

PMID 15001218
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Heterogeneity of toxicant response: sources of human variability.

PMID 12883075
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Ventral hippocampal NMDA blockade and nicotinic effects on memory function.

PMID 13679247
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Adolescent-onset nicotine self-administration modeled in female rats.

PMID 12764575
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Lobeline-induced learning improvement of rats in the radial-arm maze.

PMID 13679226
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Nicotine-alcohol interactions and attentional performance on an operant visual signal detection task in female rats.

PMID 13679219
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NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function.

PMID 12880917
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Learning impairment caused by a toxin produced by Pfiesteria piscicida infused into the hippocampus of rats.

PMID 12798959
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Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats.

PMID 12650836
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A zebrafish model for studying the neurobehavioral impacts of developmental chlorpyrifos exposure.

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Learning impairment caused by infusion of a toxin produced by Pfiesteria piscicida into the hippocampus of rats.

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Reliabilities and intercorrelations of reported and objective measures of smoking in patients with schizophrenia.

PMID 12505133
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Nicotinic mechanisms of memory: effects of acute local DHbetaE and MLA infusions in the basolateral amygdala.

PMID 12589888
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Erratum: Chlorpyrifos exposure of developing zebrafish: Effects on survival and long-term effects on response latency and spatial discrimination (Neurotoxicology and Teratology (2003) 25 (51-57))

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Behavioral Toxicology Society 2002 annual meeting report

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Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination.

PMID 12633736
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Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats.

PMID 12457266
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Nicotinic receptor subtypes and cognitive function.

PMID 12436426
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Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.

PMID 12460655
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Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats.

PMID 12377390
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Nicotinic treatment for cognitive dysfunction.

PMID 12769614
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Nicotine-alcohol interactions and cognitive function in rats.

PMID 12062576
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Developmental neurotoxicity of chlorpyrifos: Defining the vulnerable period

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A naturalistic study of the effects of smoking on the cognitive side effects of ECT.

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Chronic inhibition of alpha4beta2 nicotinic receptors in the ventral hippocampus of rats: impacts on memory and nicotine response.

PMID 11875631
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Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice.

PMID 12036109
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Persistence of nicotinic agonist RJR 2403-induced working memory improvement in rats

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Effect of long-term stabilization of cationic liposomes as defibrotide delivery system for antithrombotic activity

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Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory.

PMID 11927157
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Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze.

PMID 11796146
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Specificity of cognitive impairment from Pfiesteria piscicida exposure in rats: attention and visual function versus behavioral plasticity.

PMID 11792529
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A rat model of the cognitive impairment from Pfiesteria piscicida exposure.

PMID 11677185
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Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats.

PMID 11557096
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Cognitive effects of nicotine.

PMID 11230877
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Effects of chronic nicotine and methylphenidate in adults with attention deficit/hyperactivity disorder.

PMID 11519638
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Spatial and non-spatial visual discrimination learning in zebrafish (danio rerio)

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The nicotinic antagonist mecamylamine preferentially inhibits cocaine vs. food self-administration in rats.

PMID 11239676
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Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior.

PMID 11006350
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Ventral hippocampal alpha4beta2 nicotinic receptors and chronic nicotine effects on memory.

PMID 11044746
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Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol.

PMID 10968665
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Nicotinic treatment for degenerative neuropsychiatric disorders such as Alzheimer's disease and Parkinson's disease.

PMID 10942039
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Rapid neurobehavioral analysis of Pfiesteria piscicida effects in juvenile and adult rats.

PMID 10974591
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Attention as a target of intoxication: insights and methods from studies of drug abuse.

PMID 10974587
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Nicotine enhances stimulus detection performance of middle- and old-aged rats: a longitudinal study.

PMID 10764920
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Development of nicotinic drug therapy for cognitive disorders.

PMID 10771007
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Molecular overexpression of extracellular superoxide dismutase increases the dependency of learning and memory performance on motivational state.

PMID 10979599
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Assessment of immunotoxicology in wild populations: Review and recommendations

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AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats.

PMID 10780509
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Mutually potentiating effects of mecamylamine and haloperidol in producing catalepsy in rats

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Bridged nicotine, isonicotine, and norisonicotine effects on working memory performance of rats in the radial-arm maze

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Pfiesteria toxin and learning performance.

PMID 10386824
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Nicotine and/or cocaine alters postnatal ventilatory control in the rat pup gestationally exposed

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Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease.

PMID 10326778
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Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats.

PMID 10199609
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Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.

PMID 9888856
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Ventral hippocampal ibotenic acid lesions block chronic nicotine-induced spatial working memory improvement in rats.

PMID 9838204
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Transdermal nicotine effects on attention.

PMID 9860103
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Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze.

PMID 9768569
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Molecular manipulations of extracellular superoxide dismutase: functional importance for learning.

PMID 9926619
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Nicotinic acetylcholine involvement in cognitive function in animals.

PMID 9725745
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Oxidative stress in toxicology: established mammalian and emerging piscine model systems.

PMID 9637794
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Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected].

PMID 9591847
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Differential effects of ethanol on memory in adolescent and adult rats.

PMID 9581648
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Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats.

PMID 9330363
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Chronic haloperidol administration does not block acute nicotine-induced improvements in radial-arm maze performance in the rat.

PMID 9408193
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Persisting learning deficits in rats after exposure to Pfiesteria piscicida.

PMID 9405328
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Nicotinic system involvement in Alzheimer's and Parkinson's diseases. Implications for therapeutics.

PMID 9303280
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Apoptosis and delayed neuronal damage after carbon monoxide poisoning in the rat.

PMID 9294407
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Chronic nicotinic agonist and antagonist effects on T-maze alternation.

PMID 9177558
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Acute nicotine interactions with nicotinic and muscarinic antagonists: working and reference memory effects in the 16-arm radial maze.

PMID 9833018
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Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats?

PMID 9227840
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Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges.

PMID 8997505
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Nicotinic agonist and antagonist effects on memory

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Chronic nicotine-induced improvement of spatial working memory and D2 dopamine effects in rats

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Epibatidine, a potent nicotinic agonist: Effects on learning and memory in the radial-arm maze

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Nicotine and neurobehavioral function

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Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia.

PMID 8946433
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Prenatal cocaine and/or nicotine exposure in rats: preliminary findings on long-term cognitive outcome and genital development at birth.

PMID 8947940
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Nicotine-haloperidol interactions and cognitive performance in schizophrenics.

PMID 8914115
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Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs.

PMID 8880940
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Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade.

PMID 8865186
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Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats.

PMID 8836529
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Acute and chronic nicotine effects on working memory in aged rats.

PMID 8741959
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Nicotine effects on adults with attention-deficit/hyperactivity disorder.

PMID 8741955
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Nicotine and attention in adult attention deficit hyperactivity disorder (ADHD).

PMID 8927677
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Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze.

PMID 8587928
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Smoking in Vietnam combat veterans with post-traumatic stress disorder.

PMID 7582610
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Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze.

PMID 7667355
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Acute and chronic nicotinic interactions with dopamine systems and working memory performance.

PMID 7611680
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Combined administration of agonist-antagonist as a method of regulating receptor activation.

PMID 7611676
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Haloperidol increases smoking in patients with schizophrenia.

PMID 7675943
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Clozapine decreases smoking in patients with chronic schizophrenia.

PMID 7619979
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PRENATAL COCAINE AND NICOTINE EXPOSURE IN RATS - EFFECTS ON LONG-TERM COGNITIVE OUTCOME AND SEXUAL-DIFFERENTIATION

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Triphenyl phosphite-induced impairment of spatial alternation learning.

PMID 7723078
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Nicotine skin patch treatment and adverse reactions: skin irritation, skin sensitization, and nicotine as a hapten.

PMID 7632289
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Spatial working and reference memory in rats bred for autonomic sensitivity to cholinergic stimulation: acquisition, accuracy, speed, and effects of cholinergic drugs.

PMID 7663885
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Nicotine effects on memory performance

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Nicotine as a therapeutic drug.

PMID 7862206
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Behavioral and neurochemical consequences of ibotenic acid lesion in the subthalamic nucleus of the common marmoset.

PMID 7697384
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[A transformylation reaction--transfer of an N-formyl residue to amino acids and peptides in nucleophilic groups--as a side reaction of peptide synthesis].

PMID 7880178
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Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra.

PMID 7820615
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Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone.

PMID 8033499
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Nicotine skin patch treatment increases abstinence, decreases withdrawal symptoms, and attenuates rewarding effects of smoking.

PMID 8151002
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Promise of nicotinic‐based therapeutic treatments

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Nicotine interactions with dopamine agonists: Effects on working memory function

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Combined Effects of Nicotine and Mecamylamine in Attenuating Smoking Satisfaction

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Intracerebroventricular nicotine and mecamylamine alter radial‐arm maze performance in rats

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CLOZAPINE DECREASES DRIVE TO SMOKE

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Saliva nicotine as an index of plasma levels in nicotine skin patch users.

PMID 8249050
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Clinical trials using ascorbic acid aerosol to aid smoking cessation.

PMID 8261886
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Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection.

PMID 8257869
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The nicotine patch in smoking cessation. A randomized trial with telephone counseling.

PMID 8250653
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Effects of dopaminergic drugs on working and reference memory in rats.

PMID 8105486
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Prenatal nicotine exposure and cognitive performance in rats.

PMID 8413079
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Development of treatments for toxicant-induced cognitive deficits.

PMID 8336681
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SMOKING WHILE WEARING THE NICOTINE PATCH - IS SMOKING STILL SATISFYING

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PREDICTING SUCCESS OF THE NICOTINE PATCH IN SMOKING CESSATION USING BASE-LINE CLINICAL INFORMATION

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Chronic nicotinic stimulation and blockade effects on working memory.

PMID 11224184
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Role of nicotine dose and sensory cues in the regulation of smoke intake.

PMID 8469698
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Clinical evaluation of a citric acid inhaler for smoking cessation.

PMID 8436059
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Sertraline attenuates hyperphagia in rats following nicotine withdrawal.

PMID 8430129
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Sex-related spatial learning differences after prenatal cocaine exposure in the young adult rat.

PMID 8361675
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SMOKING WHILE WEARING THE NICOTINE PATCH - IS SMOKING SATISFYING OR HARMFUL

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DERIVATION OF A LOGISTIC MODEL USING BASE-LINE CLINICAL INFORMATION TO PREDICT SUCCESS WITH THE NICOTINE PATCH IN SMOKING CESSATION

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Fetal nicotine exposure ablates the ability of postnatal nicotine challenge to release norepinephrine from rat brain regions.

PMID 1424104
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The effect of halothane on cultured fibroblasts and neuroblastoma cells.

PMID 1461563
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Dopaminergic drugs reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway.

PMID 1357591
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Persistence of chronic nicotine-induced cognitive facilitation.

PMID 1456935
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Use of the lesion model for examining toxicant effects on cognitive behavior.

PMID 1593987
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ANIMAL-MODELS OF NICOTINE EFFECTS ON WEIGHT REGULATION

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Erratum: Use of the lesion model for examining toxicant effects on cognitive behavior (Neurotoxicol. Teratol. 14 (131-142) 1992)

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Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence.

PMID 1539072
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Nicotinic systems and cognitive function.

PMID 1357713
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National working conference on smoking and body weight. Task Force 2: Methods of assessment, strategies for research.

PMID 1396498
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Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze.

PMID 1933424
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Neurobehavioral toxicology of halothane in rats.

PMID 1921926
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The effects of smoking-related sensory cues on psychological stress.

PMID 1946567
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Inter-relationships between conditioned and primary reinforcement in the maintenance of cigarette smoking.

PMID 1859927
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Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance.

PMID 1676165
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Long‐term neurobehavioral effects of perinatal polychlorinated biphenyl (PCB) exposure in monkeys

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Impairment of radial-arm maze performance in rats following lesions involving the cholinergic medial pathway: reversal by arecoline and differential effects of muscarinic and nicotinic antagonists.

PMID 1770993
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Cholinergic-dopaminergic interactions in cognitive performance.

PMID 2078161
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The use of flavor in cigarette substitutes.

PMID 2242716
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Contrasting effects of centromedial and basolateral amygdaloid lesions on stress-related responses in the rat.

PMID 2075198
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Development of a citric acid aerosol as a smoking cessation aid.

PMID 2189719
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Transdermal nicotine facilitates smoking cessation.

PMID 2178852
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Chronic nicotine and withdrawal effects on radial-arm maze performance in rats.

PMID 2331235
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Long-term effects of developmental halothane exposure on radial arm maze performance in rats.

PMID 2302314
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Characterization of the cognitive effects of combined muscarinic and nicotinic blockade.

PMID 1967931
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Low-nicotine regenerated smoke aerosol reduces desire for cigarettes.

PMID 2136112
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d-Amphetamine-induced "floating limb" syndrome in young rhesus monkeys.

PMID 2343071
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Anticholinergic sensitivity following chronic nicotine administration as measured by radial-arm maze performance in rats.

PMID 11175437
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Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats.

PMID 2804641
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Effects of dopamine D1 and D2 receptor antagonists on oral activity in rats.

PMID 2576312
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Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555.

PMID 2575760
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Nicotinic-dopaminergic relationships and radial-arm maze performance in rats.

PMID 2757586
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D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.

PMID 2573903
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Controlling puff volume without disrupting smoking topography

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Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys.

PMID 2502707
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Mecamylamine increases nicotine preference and attenuates nicotine discrimination.

PMID 2798542
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Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze.

PMID 2930437
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Morphological and behavioral effects of perinatal exposure to aspartame (Nutrasweet®) on rat pups

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Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.

PMID 2927401
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Chronic neuroleptic effects on spatial reversal learning in monkeys.

PMID 2567030
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Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs.

PMID 2687921
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Long-term effects of chronic postnatal lead exposure on delayed spatial alternation in monkeys.

PMID 3244342
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Neurobiochemical changes in tardive dyskinesia.

PMID 2463901
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Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats.

PMID 2906537
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Behavioral effects of developmental lead exposure in rhesus monkeys.

PMID 3378682
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Cholinergic-dopaminergic interactions in radial-arm maze performance.

PMID 3365189
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Characteristics of oral movements in rats during and after chronic haloperidol and fluphenazine administration.

PMID 3128820
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Delayed spatial alternation deficits resulting from perinatal PCB exposure in monkeys.

PMID 3149182
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Psychopharmacological effects in the radial-arm maze.

PMID 2902540
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Behavioral effects of acute hexamethonium in rats chronically intoxicated with nicotine.

PMID 2906149
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Chronic neuroleptics alter the effects of the D1 agonist SK&F 38393 and the D2 agonist LY171555 on oral movements in rats.

PMID 2906749
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Neurobehavioral effects of chronic halothane exposure during developmental and juvenile periods in the rat.

PMID 3678434
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Neuroleptic-induced oral movements in rats: methodological issues.

PMID 2887997
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Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats.

PMID 2823791
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Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788.

PMID 3111641
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Opposite effects of a D1 and a D2 agonist on oral movements in rats.

PMID 3493912
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Chronic haloperidol effects on oral movements and radial-arm maze performance in rats.

PMID 3562481
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Psychopharmacological investigations of a lead-induced long-term cognitive deficit in monkeys.

PMID 3104955
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The effects of D1 and D2 receptor antagonists on pain sensitivity and morphine analgesia in the rat.

PMID 3306694
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Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats.

PMID 3575490
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Tremorous mouth movements in rats administered chronic neuroleptics.

PMID 2885880
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Effects of the dopamine D-2 receptor agonist, LY 171555, on radial arm maze performance in rats.

PMID 2947250
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Behavioral effects of chronic exposure to low concentrations of halothane during development in rats.

PMID 3706802
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Long-term lead effects on the Hamilton Search Task and delayed alternation in monkeys.

PMID 3736749
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Scopolamine effects on Hamilton search task performance in monkeys.

PMID 3086904
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Behavioral evaluation of perinatal PCB exposure in rhesus monkeys: fixed-interval performance and reinforcement-omission.

PMID 3086763
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A visual exploration apparatus for infant monkeys

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A model for tardive dyskinesia: The effects of chronic fluphenazine decanoate on guinea pigs

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Analgesia produced by the benzodiazepine antagonist R015-1788

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Effects of halothane on the development of rat brain: a golgi study of dendritic growth.

PMID 4029332
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