Faculty

Tih-Shih Lee

Associate Professor in Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, General Psychiatry
School of Medicine

4584 Hosp South, Durham, NC 27710

Box 3950 Med Ctr, Durham, NC 27710

(919) 684-5616 tish.lee@duke.edu


Education & Training

M.D. 1987

Yale University

Ph.D. 2006

Yale University

Publications

Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder.

PMID 30472167
Read Full Text

Neural indexes of attention extracted from EEG correlate with elderly reaction time in response to an attentional task

Read Full Text

Mild Cognitive Impairment Reversion and Progression: Rates and Predictors in Community-Living Older Persons in the Singapore Longitudinal Ageing Studies Cohort.

PMID 30022996
Read Full Text

Levels of serum brain-derived neurotropic factor in individuals at ultra-high risk for psychosis - Findings from the Longitudinal Youth at Risk Study (LYRIKS).

PMID 29584866
Read Full Text

Effectiveness of a Personalized Brain-Computer Interface System for Cognitive Training in Healthy Elderly: A Randomized Controlled Trial.

PMID 30248056
Read Full Text

Elucidation of shared and specific white matter findings underlying psychopathology clusters in schizophrenia

Read Full Text

Peripheral blood gene expression of acute phase proteins in people with first episode psychosis.

PMID 28627459
Read Full Text

Personalized features for attention detection in children with Attention Deficit Hyperactivity Disorder

Read Full Text

Physical Frailty, Cognitive Impairment, and the Risk of Neurocognitive Disorder in the Singapore Longitudinal Ageing Studies.

PMID 27013397
Read Full Text

Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition.

PMID 27769717
Read Full Text

GAD1 Gene Expression in Blood of Patients with First-Episode Psychosis.

PMID 28122016
Read Full Text

Depressive Symptoms Increase the Risk of Mild Neurocognitive Disorders among Elderly Chinese.

PMID 28112770
Read Full Text

Psychosocial Risk and Protective Factors and Incident Mild Cognitive Impairment and Dementia in Community Dwelling Elderly: Findings from the Singapore Longitudinal Ageing Study.

PMID 28269770
Read Full Text

Hearing Loss and Risk of Mild Cognitive Impairment and Dementia: Findings from the Singapore Longitudinal Ageing Study.

PMID 28420004
Read Full Text

Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment.

PMID 28453482
Read Full Text

Levels of Serum Brain-Derived Neurotrophic Factor in Schizophrenia.

PMID 27479612
Read Full Text

Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort.

PMID 26926205
Read Full Text

Therapeutic Misconception in Psychiatry Research: A Systematic Review

Read Full Text

Tea Consumption Reduces the Incidence of Neurocognitive Disorders: Findings from the Singapore Longitudinal Aging Study.

PMID 27925140
Read Full Text

A Risk Score for the Prediction of Neurocognitive Disorders among Community-Dwelling Chinese Older Adults.

PMID 27433801
Read Full Text

An ocular artefacts correction method for discriminative EEG analysis based on logistic regression

Read Full Text

Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.

PMID 26262937
Read Full Text

Unconditional and Conditional Standards Using Cognitive Function Curves for the Modified Mini-Mental State Exam: Cross-Sectional and Longitudinal Analyses in Older Chinese Adults in Singapore.

PMID 25260558
Read Full Text

Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy.

PMID 26220375
Read Full Text

Ministry of Health Clinical Practice Guidelines: Anxiety Disorders.

PMID 26106237
Read Full Text

A pilot randomized controlled trial using EEG-based brain-computer interface training for a Chinese-speaking group of healthy elderly.

PMID 25624754
Read Full Text

Montreal Cognitive Assessment for screening mild cognitive impairment: variations in test performance and scores by education in Singapore.

PMID 25572449
Read Full Text

Brain-computer interface and its applications in cognitive training

Read Full Text

TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period.

PMID 25201778
Read Full Text

Intrinsic Affective Network Is Impaired in Children with Attention-Deficit/Hyperactivity Disorder.

PMID 26406311
Read Full Text

Tea and Cognitive Health: A Focus on Community-Based Studies

Read Full Text

CACNA1C genomewide supported psychosis genetic variation affects cortical brain white matter integrity in Chinese patients with schizophrenia.

PMID 25470093
Read Full Text

Molecular imaging for depressive disorders.

PMID 24831591
Read Full Text

Schizophrenia: no health without physical health.

PMID 24919488
Read Full Text

A comparison of cardio-metabolic risk between the deficit and non-deficit subtypes of schizophrenia.

PMID 24451398
Read Full Text

A comparison of cardio-metabolic risk between the deficit and non-deficit subtypes of schizophrenia

Read Full Text

Long-term metformin usage and cognitive function among older adults with diabetes.

PMID 24577463
Read Full Text

The Longitudinal Youth at Risk Study (LYRIKS) - An Asian UHR perspective

Read Full Text

Reassessing the role of astrocytes in ammonia neurotoxicity.

PMID 24309654
Read Full Text

Regulation of astrocyte glutamine synthetase in epilepsy.

PMID 23791709
Read Full Text

The Longitudinal Youth at Risk Study (LYRIKS)--an Asian UHR perspective.

PMID 24139196
Read Full Text

A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.

PMID 24260218
Read Full Text

Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.

PMID 23234877
Read Full Text

Metabolic syndrome and amnestic mild cognitive impairment: Singapore Longitudinal Ageing Study-2 findings.

PMID 23246920
Read Full Text

Infection, the caudate, and movement disorder

PMID 23761573
Read Full Text

Regulation of astrocyte glutamine synthetase in epilepsy

Read Full Text

Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy

PMID 23384343
Read Full Text

Autism spectrum disorder in Chinese populations: A brief review

PMID 23857805
Read Full Text

Absence of A673T amyloid-β precursor protein variant in Alzheimer's disease and other neurological diseases

PMID 23652020
Read Full Text

Absence of A673T amyloid-β precursor protein variant in alzheimer's disease and other neurological diseases

Read Full Text

Erratum: Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy (Epilepsia (2013) 54 228-238)

Read Full Text

Association Between Tea Consumption and Depressive Symptoms in Older Chinese Adults

PMID 23231552
Read Full Text

Analysis of blood-based gene expression signature in first-episode psychosis.

PMID 22503327
Read Full Text

TEA DRINKING AND COGNITIVE FUNCTION IN OLDEST-OLD CHINESE

PMID 23131816
Read Full Text

Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus.

PMID 22535546
Read Full Text

Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls

PMID 22472643
Read Full Text

The effectiveness of antidepressant monotherapy in a naturalistic outpatient setting.

PMID 23469327
Read Full Text

A brain-computer interface based attention training program for treating attention deficit hyperactivity disorder.

PMID 23115630
Read Full Text

Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.

PMID 21856423
Read Full Text

Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.

PMID 22859933
Read Full Text

Tea drinking and cognitive function in oldest-old Chinese

Read Full Text

Roles of glutamine synthetase inhibition in epilepsy

PMID 22488332
Read Full Text

Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy

PMID 22659305
Read Full Text

Diffusion tensor imaging findings of white matter changes in first episode schizophrenia: A systematic review

Read Full Text

Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus.

PMID 21081165
Read Full Text

Integrated genetic and genomic approach in the Singapore translational and clinical research in psychosis study: An overview

PMID 21535421
Read Full Text

White matter abnormalities in major depression: Evidence from post-mortem, neuroimaging and genetic studies

PMID 20889213
Read Full Text

Acute and subacute neuropsychiatric presentations in H1N1 viral encephalitis

PMID 21677235
Read Full Text

Genetic and genomic aspects of Alzheimer's disease

Read Full Text

Making sense of kleptomania: Clinical considerations

Read Full Text

Psychogenomics and psychiatric practice, a new paradigm

Read Full Text

Effectiveness of a brain-computer interface based programme for the treatment of ADHD: A pilot study

PMID 20581801
Read Full Text

Alzheimer's disease-The inexorable epidemic

PMID 20697666
Read Full Text

Histopathology of human epilepsy

Read Full Text

Dissimilar neuropsychiatric presentations of two siblings with juvenile neuronal ceroid lipofuscinosis (Batten disease)

PMID 20160229
Read Full Text

Astrocytes and Epilepsy

PMID 20880506
Read Full Text

Huntington's disease and behavioral dyscontrol

PMID 21037138
Read Full Text

Electroconvulsive therapy for catatonia in neuropsychiatric systemic lupus erythematosus

PMID 20514698
Read Full Text

Transient and spontaneously-remitting complex hallucinations in a patient with melanoma and brain metastases

PMID 20484725
Read Full Text

Genomic expression in the epileptogenic hippocampus and psychiatric co-morbidities

Read Full Text

Genomic and molecular characterization of alzheimer disease

Read Full Text

Reply from author: Is it time to revise the definition of attention deficit hyperactivity disorder?

Read Full Text

The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study.

PMID 19747915
Read Full Text

Attention deficit hyperactivity disorder: Coping or curing?

PMID 19890587
Read Full Text

Enigmas in psychiatry

PMID 19521649
Read Full Text

Delirium in a patient with natural killer/T-cell lymphoma without overt central nervous system involvement

Read Full Text

Psychiatric manifestations in churg-strauss syndrome

PMID 19622703
Read Full Text

Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats.

PMID 18669513
Read Full Text

Pulmonary embolism in a patient taking clozapine.

PMID 18583682
Read Full Text

Catatonia and psychosis associated with sibutramine: a case report and pathophysiologic correlation.

PMID 18158006
Read Full Text

Hypnotherapy for sleep disorders

PMID 18797562
Read Full Text

Neuropsychiatry - An emerging field

PMID 18695776
Read Full Text

Multiple embolic phenomenon in the brain associated with parenteral buprenorphine abuse

PMID 18451197
Read Full Text

Delirium with psychotic features possibly associated with mesotherapy

PMID 18448787
Read Full Text

Cognitive and psychotic symptoms in idiopathic hypereosinophilic syndrome

Read Full Text

Glutamate and astrocytes - Key players in human mesial temporal lobe epilepsy?

PMID 18226171
Read Full Text

Catatonia and psychosis associated with sibutramine: A case report and pathophysiologic correlation

Read Full Text

Reflections on a mass homicide

PMID 17597973
Read Full Text

Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes.

PMID 17515952
Read Full Text

Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy

PMID 17115168
Read Full Text

A psychodynamic perspective on relational structures

PMID 16998420
Read Full Text

Abuse of prescription buprenorphine, regulatory controls and the role of the primary physician

PMID 16902726
Read Full Text

GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus

PMID 16456667
Read Full Text

Revisiting cycloid psychosis: A case of an acute, transient and recurring psychotic disorder

PMID 16442782
Read Full Text

Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus.

PMID 15657133
Read Full Text

New facets of the neuropathology and molecular profile of human temporal lobe epilepsy

PMID 16098816
Read Full Text

Psychodynamic perspectives of collaborative treatment

PMID 15803044
Read Full Text

Psychodynamic understanding and the therapeutic alliance in the psychiatric emergency room

PMID 15772414
Read Full Text

Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy.

PMID 15517312
Read Full Text

Atomoxetine and tics in ADHD [2]

PMID 15322408
Read Full Text

An Emergency Treatment Hub-and-Spoke Model for Psychiatric Emergency Services

PMID 14645795
Read Full Text
Show More