B247 Levine Sci Res Ctr, Ctr Cognit Neurosci Box 90999, Durham, NC 27708-0999
Duke Box 90999, Durham, NC 27708-0999
My research focuses on understanding how emotional events modulate cognitive processes in the human brain. We aim to identify brain regions that encode the emotional properties of sensory stimuli, and to show how these regions interact with neural systems supporting social cognition, executive control, and learning and memory. To achieve this goal, we use a variety of cognitive neuroscience techniques in human subject populations. These include psychophysiological monitoring, functional magnetic resonance imaging (fMRI), virtual reality, and behavioral studies in healthy adults as well as psychiatric patients. This integrative approach capitalizes on recent advances in the field and may lead to new insights into cognitive-emotional interactions in the brain.
The central role of disgust in disorders of food avoidance.
Regulating emotion through distancing: A taxonomy, neurocognitive model, and supporting meta-analysis.
Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder.
Neural mechanisms underlying subsequent memory for personal beliefs:An fMRI study.
Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder.
Neural responses to emotional involuntary memories in posttraumatic stress disorder: Differences in timing and activity.
The Clinical Significance of Posterior Insular Volume in Adolescent Anorexia Nervosa.
Advances in neuroscience.
Adolescent development of insula-dependent interoceptive regulation.
Distinct medial temporal networks encode surprise during motivation by reward versus punishment.
Fear generalization gradients in visuospatial attention.
Decoding Spontaneous Emotional States in the Human Brain.
Decoding the Nature of Emotion in the Brain.
Variability in emotional responsiveness and coping style during active avoidance as a window onto psychological vulnerability to stress.
Emotional modulation of interval timing and time perception.
Somatosensory Representations Link the Perception of Emotional Expressions and Sensory Experience.
Discriminative Fear Learners are Resilient to Temporal Distortions during Threat Anticipation.
Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.
Multivariate neural biomarkers of emotional states are categorically distinct.
Medial prefrontal pathways for the contextual regulation of extinguished fear in humans.
Spatial proximity amplifies valence in emotional memory and defensive approach-avoidance.
EmotionRead Full Text
Developmental trajectories of cortical-subcortical interactions underlying the evaluation of trust in adolescence.
Therapeutic affect reduction, emotion regulation, and emotional memory reconsolidation: A neuroscientific quandary.
Aversive learning modulates cortical representations of object categories.
Extinction in multiple virtual reality contexts diminishes fear reinstatement in humans.
Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression.
Learning and Memory: Basic MechanismsRead Full Text
Prior perceptual processing enhances the effect of emotional arousal on the neural correlates of memory retrieval.
Encoding negative events under stress: high subjective arousal is related to accurate emotional memory despite misinformation exposure.
Hear it playing low and slow: how pitch level differentially influences time perception.
Fear Learning Circuitry in PTSD is Biased Toward Generalization of Conditioned ResponseRead Full Text
Advancing emotion theory with multivariate pattern classification.
Development and validation of an unsupervised scoring system (Autonomate) for skin conductance response analysis.
Acute effects of trauma-focused research procedures on participant safety and distressRead Full Text
Effects of induced moods on economic choicesRead Full Text
Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depressionRead Full Text
Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder.
Neural similarity between encoding and retrieval is related to memory via hippocampal interactions.
Multivariate pattern classification reveals autonomic and experiential representations of discrete emotions.
Effects of discrimination training on fear generalization gradients and perceptual classification in humans.
Dissociable Prefrontal Brain Systems for Attention and EmotionRead Full Text
Perception of affect in biological motion cues in anorexia nervosa.
Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.
Threat of punishment motivates memory encoding via amygdala, not midbrain, interactions with the medial temporal lobe.
Emotional Influences on Visuospatial AttentionRead Full Text
Neural mechanisms mediating contingent capture of attention by affective stimuli.
Resting State Connectivity Between Amygdalar Subregions and the Prefrontal Cortex is Disrupted in PTSDRead Full Text
Neurocognitive mechanisms of gaze-expression interactions in face processing and social attention.
Imaging emotional influences on learning and memoryRead Full Text
Neural systems for guilt from actions affecting self versus others.
Brain activity associated with omission of an aversive event reveals the effects of fear learning and generalization.
Role of conceptual knowledge in learning and retention of conditioned fear.
Fear-relevant outcomes modulate the neural correlates of probabilistic classification learning.
Cortical reactivation predicts memory success for individual items via hippocampal interactionsRead Full Text
Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks.
Anticipatory anxiety hinders detection of a second target in dual-target search.
Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder.
Cracking the almond (Commentary on Prévost et al.).
Hemodynamic signals of mixed messages during a social exchange.
Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD.
Level of processing modulates the neural correlates of emotional memory formation.
Neurobehavioral mechanisms of human fear generalization.
Low- and high-testosterone individuals exhibit decreased aversion to economic risk.
Cognitive and neural contributors to emotion regulation in aging.
Reprint of: fMRI studies of successful emotional memory encoding: a quantitative meta-analysis.
Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data.
Generalization and specialization of conditioned learningRead Full Text
Is all motivation good for learning? Dissociable influences of approach and avoidance motivation in declarative memory.
Revealing context-specific conditioned fear memories with full immersion virtual reality.
Conceptual similarity promotes generalization of higher order fear learning.
Neural signaling of mixed messages during a social exchangeRead Full Text
Neurocognitive mechanisms of fear conditioning and vulnerability to anxiety.
Unpredictability and uncertainty in anxiety: a new direction for emotional timing research.
fMRI studies of successful emotional memory encoding: A quantitative meta-analysis.
Human fear conditioning conducted in full immersion 3-dimensional virtual reality.
Stressful politics: voters' cortisol responses to the outcome of the 2008 United States Presidential election.
Modulation of reflexive orienting to gaze direction by facial expressionsRead Full Text
COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.
Mental hoop diaries: emotional memories of a college basketball game in rival fans.
Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding.
Component Neural Systems for the Creation of Emotional Memories during Free Viewing of a Complex, Real-World Event.
Rebuttal to Hasan and Pedraza in comments and controversies: "Improving the reliability of manual and automated methods for hippocampal and amygdala volume measurements".
Dominance, politics, and physiology: voters' testosterone changes on the night of the 2008 United States presidential election.
Delayed extinction attenuates conditioned fear renewal and spontaneous recovery in humans.
Generalization of conditioned fear along a dimension of increasing fear intensity.
The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder.
A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes.
Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology.
Event-related potentials reveal temporal staging of dynamic facial expression and gaze shift effects on attentional orienting.
Fear relevancy, strategy use, and probabilistic learning of cue-outcome associations.
Prefrontal mechanisms for executive control over emotional distraction are altered in major depression.
The short and long of it: neural correlates of temporal-order memory for autobiographical events.
Age-dependent reduction of amygdala volume in bipolar disorder.
The Memory Enhancing Effect of Emotion: Functional Neuroimaging EvidenceRead Full Text
Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans.
The spatiotemporal dynamics of autobiographical memory: neural correlates of recall, emotional intensity, and reliving.
Happy and fearful emotion in cues and targets modulate event-related potential indices of gaze-directed attentional orienting.
Anorexia nervosa and autism spectrum disorders: guided investigation of social cognitive endophenotypes.
Development of emotional facial recognition in late childhood and adolescence.
Perception of dynamic changes in facial affect and identity in autism.
Dissociable effects of conscious emotion regulation strategies on explicit and implicit memory.
Garner interference reveals dependencies between emotional expression and gaze in face perception.
Neural systems for executive and emotional processing are modulated by level of posttraumatic stress disorder symptoms in Iraq war veteransRead Full Text
Reinstatement of conditioned fear and the hippocampus: an attentional-associative model.
Quantifying deficits in the perception of fear and anger in morphed facial expressions after bilateral amygdala damage.
Beyond Fear Emotional Memory Mechanisms in the Human Brain.
Mood alters amygdala activation to sad distractors during an attentional task.
Dissociation of event-related potentials indexing arousal and semantic cohesion during emotional word encoding.
Effects of stress and sex on acquisition and consolidation of human fear conditioning.
Fear and anxiety pathwaysRead Full Text
Cognitive neuroscience of emotional memory.
Sequential ordering of morphed faces and facial expressions following temporal lobe damage.
Integrating psychophysiology and fMRI to study attention and learningRead Full Text
Startle modulation during conscious emotion regulation is arousal-dependent.
Sex, stress, and fear: individual differences in conditioned learning.
Reinstatement of conditioned fear in humans is context dependent and impaired in amnesia.
Amygdala activation to sad pictures during high-field (4 tesla) functional magnetic resonance imaging.
Remembering one year later: role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories.
Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval.
Emotional arousal enhances word repetition priming
Emotional enhancement of perceptual priming is preserved in aging and early-stage Alzheimer's disease.
Sex, stress, and fear: Individual differences in conditioned learningRead Full Text
The Garner paradigm reveals asymmetric dependencies between facial emotional expression and gaze processingRead Full Text
Perception of dynamic changes in facial expressions of emotion in autismRead Full Text
Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm.
Emotional intensity predicts autobiographical memory experience.
Impact of healthy aging on awareness and fear conditioning.
Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study.
Emotion-attention network interactions during a visual oddball task.
Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events.
Dynamic perception of facial affect and identity in the human brain.
Emotional memory functions of the human amygdala.
Neural correlates of person recognition.
Increased event-related theta activity during emotional scene encodingRead Full Text
Electromyography as a recording system for eyeblink conditioning with functional magnetic resonance imaging.
Dissociable prefrontal brain systems for attention and emotion.
Functional changes in temporal lobe activity during transient global amnesia.
Impact of signal-to-noise on functional MRI of the human amygdala.
Hunger selectively modulates corticolimbic activation to food stimuli in humans.
Impact of signal-to-noise on functional MRI.
Real-time monitoring of eye movements using infrared video-oculography during functional magnetic resonance imaging of the frontal eye fields.
Emotional curiosity: modulation of visuospatial attention by arousal is preserved in aging and early-stage Alzheimer's disease.
Neuroanatomic overlap of working memory and spatial attention networks: a functional MRI comparison within subjects.
A large-scale distributed network for covert spatial attention: further anatomical delineation based on stringent behavioural and cognitive controls.
The large-scale neural network for spatial attention displays multifunctional overlap but differential asymmetry.
Specifying the contributions of the human amygdala to emotional memory: A case studyRead Full Text
Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study.
Arousal-mediated memory consolidation: Role of the Medial Temporal Lobe in HumansRead Full Text
Conditioning, awareness, and the hippocampus.
Memory for emotional words following unilateral temporal lobectomy.
"Willed action": a functional MRI study of the human prefrontal cortex during a sensorimotor task.
Partial disruption of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans.
Impaired fear conditioning following unilateral temporal lobectomy in humans.