Faculty

Kevin LaBar

Professor of Psychology and Neuroscience

Psychology and Neuroscience
Trinity College of Arts & Sciences

Associate Director of the Center for Cognitive Neuroscience

Center for Cognitive Neuroscience
Institutes and Provost's Academic Units

Professor in Psychiatry and Behavorial Sciences

Psychiatry & Behavioral Sciences, Translational Neuroscience
School of Medicine

Member of the Center for Cognitive Neuroscience

Center for Cognitive Neuroscience
Institutes and Provost's Academic Units

Associate of the Duke Initiative for Science & Society

Duke Science & Society
Institutes and Provost's Academic Units

Affiliate of the Center for Brain Imaging and Analysis

Duke-UNC Center for Brain Imaging and Analysis
School of Medicine
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B247 Levine Sci Res Ctr, Ctr Cognit Neurosci Box 90999, Durham, NC 27708-0999

Duke Box 90999, Durham, NC 27708-0999

(919) 681-0664 klabar@duke.edu

My research focuses on understanding how emotional events modulate cognitive processes in the human brain. We aim to identify brain regions that encode the emotional properties of sensory stimuli, and to show how these regions interact with neural systems supporting social cognition, executive control, and learning and memory. To achieve this goal, we use a variety of cognitive neuroscience techniques in human subject populations. These include psychophysiological monitoring, functional magnetic resonance imaging (fMRI), virtual reality,  and behavioral studies in healthy adults as well as psychiatric patients. This integrative approach capitalizes on recent advances in the field and may lead to new insights into cognitive-emotional interactions in the brain.            


Education & Training

B.A. 1990

Lafayette College

Ph.D. 1996

New York University

Grants

Neurobehavioral Mechanisms of Emotion Regulation in Depression across the Adult Lifespan

National Institutes of Health

Neuromodulation Enhanced Cognitive Restructuring for Emotion Dysregulation: A Proof of Concept Study

Brain and Behavior Research Foundation

Contextual Influences on Fear Memories

National Science Foundation

Evaluating a Novel Method of Generalizing Emotion Regulation

National Institutes of Health

A Compute Cluster for Brain Imaging and Analysis

National Institutes of Health

Motivated Memory as Therapeutic Target

National Institutes of Health

MRI: Acquisition of a High-Resolution Stereoscopic Interactive Visualization System for Research and Education in Scienc

National Science Foundation

Multivariate Representations of Emotion

National Institutes of Health

Social Threat and Aging: Neural Mechanisms of Emotion Regulation

National Institutes of Health

Brain Imaging Studies of Negative Reinforcement in Humans

National Institutes of Health

Emotion Regulation in Late-Life Depression: Effectiveness and Neural Mechanisms

National Institutes of Health

The Neural Correlates of Stress Reactivity, Learning and Memory in Depressed Patients

National Alliance for Research on Schizophrenia & Depression

IPA - Kevin Labar

Durham Veterans Affairs Medical Center

IPA - Kevin LaBar

Veterans Administration Medical Center

Brain Mechanisms Supporting the Generalization of Learned Fear

National Institutes of Health

Emotional modulation of procedural learning

National Science Foundation

Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa

National Institutes of Health

FMRI Assessment of Attention and Memory in PTSD

National Institutes of Health

Neuroimaging of emotional association formation and subsequent effect on memory

National Institutes of Health

Neural Correlates of Autobiographical Memory

National Institute of Mental Health

Neural Compensation and Economic Decision Making in Aging

National Institutes of Health

Neurodevelopmental Processes of Social Cognition in Anorexia Nervosa and Autism

National Institutes of Health

A Linux Cluster Computational Facility for Neuroimaging Research

National Institutes of Health

Neuroimaging of Trauma Memory and Cognitive Reappraisal in PTSD

National Institutes of Health

Neural Mechanisms of Fear Renewal in Humans

National Institutes of Health

CAREER: Cognitive Neuroscience of Emotional Memory

National Science Foundation

Neural Substrates of Implicit Emotional Learning

National Institutes of Health

Neural Basis of Interactions Between Attention & Emotion

National Institutes of Health

Neural Basis of Interactions between Attention & Emotion

National Institutes of Health

Spatiotemporal Dynamics of Emotional Memory Networks

National Institutes of Health
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Publications

Smaller hippocampal CA1 subfield volume in posttraumatic stress disorder.

PMID 30256497
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Neural mechanisms underlying subsequent memory for personal beliefs:An fMRI study.

PMID 29427182
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Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder.

PMID 29651256
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Neural responses to emotional involuntary memories in posttraumatic stress disorder: Differences in timing and activity.

PMID 30013923
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The Clinical Significance of Posterior Insular Volume in Adolescent Anorexia Nervosa.

PMID 28691997
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Advances in neuroscience.

PMID 29152575
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Adolescent development of insula-dependent interoceptive regulation.

PMID 27320796
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Distinct medial temporal networks encode surprise during motivation by reward versus punishment.

PMID 26854903
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Fear generalization gradients in visuospatial attention.

PMID 27213724
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Decoding Spontaneous Emotional States in the Human Brain.

PMID 27627738
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Decoding the Nature of Emotion in the Brain.

PMID 27133227
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Variability in emotional responsiveness and coping style during active avoidance as a window onto psychological vulnerability to stress.

PMID 26922874
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Emotional modulation of interval timing and time perception.

PMID 26972824
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Somatosensory Representations Link the Perception of Emotional Expressions and Sensory Experience.

PMID 27280154
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Discriminative Fear Learners are Resilient to Temporal Distortions during Threat Anticipation.

PMID 27347480
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Fear learning circuitry is biased toward generalization of fear associations in posttraumatic stress disorder.

PMID 26670285
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Multivariate neural biomarkers of emotional states are categorically distinct.

PMID 25813790
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Medial prefrontal pathways for the contextual regulation of extinguished fear in humans.

PMID 26220745
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Spatial proximity amplifies valence in emotional memory and defensive approach-avoidance.

PMID 25541499
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Emotion

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Developmental trajectories of cortical-subcortical interactions underlying the evaluation of trust in adolescence.

PMID 24682131
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Therapeutic affect reduction, emotion regulation, and emotional memory reconsolidation: A neuroscientific quandary.

PMID 26050673
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Aversive learning modulates cortical representations of object categories.

PMID 23709642
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Extinction in multiple virtual reality contexts diminishes fear reinstatement in humans.

PMID 24583374
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Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression.

PMID 24021222
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Learning and Memory: Basic Mechanisms

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Prior perceptual processing enhances the effect of emotional arousal on the neural correlates of memory retrieval.

PMID 24380867
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Encoding negative events under stress: high subjective arousal is related to accurate emotional memory despite misinformation exposure.

PMID 24055594
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Hear it playing low and slow: how pitch level differentially influences time perception.

PMID 24746941
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Fear Learning Circuitry in PTSD is Biased Toward Generalization of Conditioned Response

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Advancing emotion theory with multivariate pattern classification.

PMID 27453724
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Development and validation of an unsupervised scoring system (Autonomate) for skin conductance response analysis.

PMID 24184342
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Acute effects of trauma-focused research procedures on participant safety and distress

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Effects of induced moods on economic choices

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Relative effectiveness of reappraisal and distraction in regulating emotion in late-life depression

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Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder.

PMID 23929546
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Neural similarity between encoding and retrieval is related to memory via hippocampal interactions.

PMID 22967731
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Multivariate pattern classification reveals autonomic and experiential representations of discrete emotions.

PMID 23527508
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Effects of discrimination training on fear generalization gradients and perceptual classification in humans.

PMID 23421709
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Dissociable Prefrontal Brain Systems for Attention and Emotion

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Perception of affect in biological motion cues in anorexia nervosa.

PMID 23109257
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Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group.

PMID 23117638
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Threat of punishment motivates memory encoding via amygdala, not midbrain, interactions with the medial temporal lobe.

PMID 22745496
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Emotional Influences on Visuospatial Attention

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Neural mechanisms mediating contingent capture of attention by affective stimuli.

PMID 22360642
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Resting State Connectivity Between Amygdalar Subregions and the Prefrontal Cortex is Disrupted in PTSD

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Neurocognitive mechanisms of gaze-expression interactions in face processing and social attention.

PMID 22285906
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Imaging emotional influences on learning and memory

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Neural systems for guilt from actions affecting self versus others.

PMID 22230947
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Brain activity associated with omission of an aversive event reveals the effects of fear learning and generalization.

PMID 22387662
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Role of conceptual knowledge in learning and retention of conditioned fear.

PMID 22118937
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Fear-relevant outcomes modulate the neural correlates of probabilistic classification learning.

PMID 21827859
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Cortical reactivation predicts memory success for individual items via hippocampal interactions

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Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks.

PMID 20865733
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Anticipatory anxiety hinders detection of a second target in dual-target search.

PMID 21670427
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Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder.

PMID 22448769
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Cracking the almond (Commentary on Prévost et al.).

PMID 21722206
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Hemodynamic signals of mixed messages during a social exchange.

PMID 21602650
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Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD.

PMID 21047644
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Level of processing modulates the neural correlates of emotional memory formation.

PMID 20350176
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Neurobehavioral mechanisms of human fear generalization.

PMID 21256233
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Low- and high-testosterone individuals exhibit decreased aversion to economic risk.

PMID 21393575
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Cognitive and neural contributors to emotion regulation in aging.

PMID 20385663
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Reprint of: fMRI studies of successful emotional memory encoding: a quantitative meta-analysis.

PMID 21414466
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Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data.

PMID 21030008
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Generalization and specialization of conditioned learning

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Is all motivation good for learning? Dissociable influences of approach and avoidance motivation in declarative memory.

PMID 22021253
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Revealing context-specific conditioned fear memories with full immersion virtual reality.

PMID 22069384
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Conceptual similarity promotes generalization of higher order fear learning.

PMID 21330378
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Neural signaling of mixed messages during a social exchange

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Neurocognitive mechanisms of fear conditioning and vulnerability to anxiety.

PMID 21519378
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Unpredictability and uncertainty in anxiety: a new direction for emotional timing research.

PMID 21954380
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fMRI studies of successful emotional memory encoding: A quantitative meta-analysis.

PMID 20688087
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Human fear conditioning conducted in full immersion 3-dimensional virtual reality.

PMID 20736913
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Stressful politics: voters' cortisol responses to the outcome of the 2008 United States Presidential election.

PMID 19962831
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Modulation of reflexive orienting to gaze direction by facial expressions

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COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.

PMID 19641018
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Mental hoop diaries: emotional memories of a college basketball game in rival fans.

PMID 20147540
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Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding.

PMID 21212840
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Component Neural Systems for the Creation of Emotional Memories during Free Viewing of a Complex, Real-World Event.

PMID 20508750
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Rebuttal to Hasan and Pedraza in comments and controversies: "Improving the reliability of manual and automated methods for hippocampal and amygdala volume measurements".

PMID 19616634
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Dominance, politics, and physiology: voters' testosterone changes on the night of the 2008 United States presidential election.

PMID 19844583
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Delayed extinction attenuates conditioned fear renewal and spontaneous recovery in humans.

PMID 19634943
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Generalization of conditioned fear along a dimension of increasing fear intensity.

PMID 19553384
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The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder.

PMID 19091328
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A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes.

PMID 19162198
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Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology.

PMID 19237269
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Event-related potentials reveal temporal staging of dynamic facial expression and gaze shift effects on attentional orienting.

PMID 19274577
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Fear relevancy, strategy use, and probabilistic learning of cue-outcome associations.

PMID 18832564
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Prefrontal mechanisms for executive control over emotional distraction are altered in major depression.

PMID 18455373
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The short and long of it: neural correlates of temporal-order memory for autobiographical events.

PMID 18284345
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Age-dependent reduction of amygdala volume in bipolar disorder.

PMID 18407469
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The Memory Enhancing Effect of Emotion: Functional Neuroimaging Evidence

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Neural systems for executive and emotional processing are modulated by symptoms of posttraumatic stress disorder in Iraq War veterans.

PMID 18093809
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The spatiotemporal dynamics of autobiographical memory: neural correlates of recall, emotional intensity, and reliving.

PMID 17548799
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Happy and fearful emotion in cues and targets modulate event-related potential indices of gaze-directed attentional orienting.

PMID 18626515
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Anorexia nervosa and autism spectrum disorders: guided investigation of social cognitive endophenotypes.

PMID 17967091
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Development of emotional facial recognition in late childhood and adolescence.

PMID 17683341
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Perception of dynamic changes in facial affect and identity in autism.

PMID 18174910
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Dissociable effects of conscious emotion regulation strategies on explicit and implicit memory.

PMID 17516813
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Garner interference reveals dependencies between emotional expression and gaze in face perception.

PMID 17516809
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Neural systems for executive and emotional processing are modulated by level of posttraumatic stress disorder symptoms in Iraq war veterans

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Reinstatement of conditioned fear and the hippocampus: an attentional-associative model.

PMID 17178163
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Quantifying deficits in the perception of fear and anger in morphed facial expressions after bilateral amygdala damage.

PMID 16806315
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Beyond Fear Emotional Memory Mechanisms in the Human Brain.

PMID 18604284
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Mood alters amygdala activation to sad distractors during an attentional task.

PMID 16713587
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Dissociation of event-related potentials indexing arousal and semantic cohesion during emotional word encoding.

PMID 16678953
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Effects of stress and sex on acquisition and consolidation of human fear conditioning.

PMID 16847304
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Cognitive neuroscience of emotional memory.

PMID 16371950
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Sequential ordering of morphed faces and facial expressions following temporal lobe damage.

PMID 16464481
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Integrating psychophysiology and fMRI to study attention and learning

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Startle modulation during conscious emotion regulation is arousal-dependent.

PMID 16187839
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Sex, stress, and fear: individual differences in conditioned learning.

PMID 16180625
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Reinstatement of conditioned fear in humans is context dependent and impaired in amnesia.

PMID 15998188
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Amygdala activation to sad pictures during high-field (4 tesla) functional magnetic resonance imaging.

PMID 15755216
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Remembering one year later: role of the amygdala and the medial temporal lobe memory system in retrieving emotional memories.

PMID 15703295
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Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval.

PMID 15721179
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Emotional arousal enhances word repetition priming

PMID 26321783
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Emotional enhancement of perceptual priming is preserved in aging and early-stage Alzheimer's disease.

PMID 16154458
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Sex, stress, and fear: Individual differences in conditioned learning

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The Garner paradigm reveals asymmetric dependencies between facial emotional expression and gaze processing

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Perception of dynamic changes in facial expressions of emotion in autism

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Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm.

PMID 15622612
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Emotional intensity predicts autobiographical memory experience.

PMID 15813494
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Impact of healthy aging on awareness and fear conditioning.

PMID 15506873
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Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study.

PMID 15325353
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Emotion-attention network interactions during a visual oddball task.

PMID 15130591
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Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events.

PMID 15182723
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Dynamic perception of facial affect and identity in the human brain.

PMID 12967919
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Emotional memory functions of the human amygdala.

PMID 12914677
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Neural correlates of person recognition.

PMID 12888543
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Increased event-related theta activity during emotional scene encoding

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Electromyography as a recording system for eyeblink conditioning with functional magnetic resonance imaging.

PMID 12377171
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Dissociable prefrontal brain systems for attention and emotion.

PMID 12177452
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Functional changes in temporal lobe activity during transient global amnesia.

PMID 11865146
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Impact of signal-to-noise on functional MRI of the human amygdala.

PMID 11733691
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Hunger selectively modulates corticolimbic activation to food stimuli in humans.

PMID 11345973
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Impact of signal-to-noise on functional MRI.

PMID 11108630
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Real-time monitoring of eye movements using infrared video-oculography during functional magnetic resonance imaging of the frontal eye fields.

PMID 10686117
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Emotional curiosity: modulation of visuospatial attention by arousal is preserved in aging and early-stage Alzheimer's disease.

PMID 11099731
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Neuroanatomic overlap of working memory and spatial attention networks: a functional MRI comparison within subjects.

PMID 10600415
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A large-scale distributed network for covert spatial attention: further anatomical delineation based on stringent behavioural and cognitive controls.

PMID 10356062
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The large-scale neural network for spatial attention displays multifunctional overlap but differential asymmetry.

PMID 10075897
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Arousal-Mediated Memory Consolidation: Role of the Medial Temporal Lobe in Humans

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Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study.

PMID 9620698
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Conditioning, awareness, and the hippocampus.

PMID 9882019
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Specifying the contributions of the human amygdala to emotional memory: A case study

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Memory for emotional words following unilateral temporal lobectomy.

PMID 9339304
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"Willed action": a functional MRI study of the human prefrontal cortex during a sensorimotor task.

PMID 9192679
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Partial disruption of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans.

PMID 8919001
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Impaired fear conditioning following unilateral temporal lobectomy in humans.

PMID 7472442
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