This laboratory uses a multidisciplinary approach using both animal and model systems to study the biology of addiction and stress/depression. We are specifically interested in how adolescence and the hormonal changes of puberty and aging influence vulnerability to these conditions. Specific projects underway include: (1) the biology of sex differences in addictive drug action, (2) role of maturing dopamine systems in the onset of drug taking during adolescence, (3) the neurobiology of adolescent insensitivity to threat and its role in drug use.
Studies of sex differences focus on understanding estrogen and testosterone actions in the brain that are relevant to addiction, depression and stress-related behaviors. We are particularly interested in molecular targets of estrogen action including key proteins that regulate dopamine neurons and the stress peptide CRF. Current projects include the role of glucocorticoid and reproductive hormones in alcohol and opioid dependence in adolescence. Adolescent studies are exploring the impact of maturing dopamine systems as well as cortical inhibition of these systems on novelty-seeking/risk taking as predictors of substance abuse vulnerability as well as responses to addictive drugs.
In addition to these animal studies, we collaborate actively with clinicians in psychiatry who are studying addiction and stress-related illness in humans, and participate in development of drug-abuse education and general neuroscience education materials for students, parents and other members of the lay public.
Withdrawal from Brief Repeated Alcohol Treatment in Adolescent and Adult Male and Female Rats.
The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.
Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.
Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients.
Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia.
Emergence of sex differences in the development of substance use and abuse during adolescence.
The Role of Serotonin (5-HT) in Behavioral Control: Findings from Animal Research and Clinical Implications.
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.
Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.
Association of depressive and anxiety symptoms with 24-hour urinary catecholamines in individuals with untreated high blood pressure.
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) studyRead Full Text
Simplified dietary acute tryptophan depletion: effects of a novel amino acid mixture on the neurochemistry of C57BL/6J mice.
A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.
Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease: insights from the REMIT study.
Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.
Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats.
Acute tryptophan depletion - converging evidence for decreasing central nervous serotonin synthesis in rodents and humans.
Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures.
Use of the light/dark test for anxiety in adult and adolescent male rats.
Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease.
Enduring effects of adolescent drug exposure.
Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats.
Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha.
Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial.
Prevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease.
Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine.
Sex differences in novelty- and psychostimulant-induced behaviors of C57BL/6 mice.
Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.
Acute tryptophan depletion - converging evidence for decreasing central nervous serotonin synthesis in rodents and humansRead Full Text
A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.
Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy.Read Full Text
Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy.
Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial.
Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.
Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice.
Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine.
Alcohol and women: What is the role of biologic factors?Read Full Text
Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity.
Role of individual and developmental differences in voluntary cocaine intake in rats.
Low- and high-testosterone individuals exhibit decreased aversion to economic risk.
The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals.
Intravascular food reward.
Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking.
Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons.
Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats.
Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.
Plasma epinephrine predicts fasting glucose in centrally obese African-American women.
Stressful politics: voters' cortisol responses to the outcome of the 2008 United States Presidential election.
The emergence of gonadal hormone influences on dopaminergic function during puberty.
Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.
Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c.
Androgen decreases dopamine neurone survival in rat midbrain.
Oestrogen receptors enhance dopamine neurone survival in rat midbrain.
Comorbid depression and anxiety effects on pregnancy and neonatal outcome.
Series PrefaceRead Full Text
Personality and inflammation: the protective effect of openness to experience.
The effect of acute tryptophan depletion on emotional distraction and subsequent memory.
Serotonin shapes risky decision making in monkeys.
Dominance, politics, and physiology: voters' testosterone changes on the night of the 2008 United States presidential election.
Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models.
Hostility and minimal model of glucose kinetics in African American women.
Positive affect is associated with cardiovascular reactivity, norepinephrine level, and morning rise in salivary cortisol.
Hostility and fasting glucose in African American women.
Maturation of coordinated immediate early gene expression by cocaine during adolescence.
Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults.
Depressed pregnant black women have a greater incidence of prematurity and low birthweight outcomes.
Prenatal depression restricts fetal growth.
Prenatal dopamine and neonatal behavior and biochemistry.
Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy.
HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR).
Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.
5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.
Cocaine increases stimulated dopamine release more in periadolescent than adult rats.
Lavender bath oil reduces stress and crying and enhances sleep in very young infants.
Early ethanol consumption predicts relapse-like behavior in adolescent male rats.
Associations among central nervous system serotonergic function and neuroticism are moderated by gender.
Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats.
Prenatal serotonin and neonatal outcome: brief report.
Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress.
Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR).
Chronic prenatal depression and neonatal outcome.
Prenatal dysthymia versus major depression effects on maternal cortisol and fetal growth.
Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex.
Sleep quality varies as a function of 5-HTTLPR genotype and stress.
Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats.
Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats.
A single high dose of cocaine induces differential sensitization to specific behaviors across adolescence.
Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.
Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats.
Sleep disturbances in depressed pregnant women and their newborns.
Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats.
Maternal psychological distress, prenatal cortisol, and fetal weight.
Effects of stress and sex on acquisition and consolidation of human fear conditioning.
Sex differences in neurochemical effects of dopaminergic drugs in rat striatum.
Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chloride.
Stability of mood states and biochemistry across pregnancy.
Prenatal cortisol, prematurity and low birthweight.
Differential effects of delta9-THC on learning in adolescent and adult rats.
Erratum: Enhanced behavioral response to related-dose cocaine in adolescent rats (Psychopharmacology (2005) 183 (218-225) DOI: doi.org/10.1007/s00213-005- 0159-4)Read Full Text
Enhanced behavioral response to repeated-dose cocaine in adolescent rats.
Cortisol decreases and serotonin and dopamine increase following massage therapy.
Sex, stress, and fear: individual differences in conditioned learning.
Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy.
Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged women.
Prenatal maternal biochemistry predicts neonatal biochemistry.
Hostility is related to blunted beta-adrenergic receptor responsiveness among middle-aged women.
Breast cancer patients have improved immune and neuroendocrine functions following massage therapy.
Massage therapy effects on depressed pregnant women.
EEG responses to mock facial expressions by infants of depressed mothersRead Full Text
Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress.
Prenatal predictors of maternal and newborn EEGRead Full Text
Prepartum, postpartum, and chronic depression effects on newborns.
Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells.
Serotonin-related gene polymorphisms and central nervous system serotonin function.
Depressed mothers who are "good interaction" partners versus those who are withdrawn or intrusiveRead Full Text
Effect of maternal smoking on fetal catecholamine concentrations at birth.
Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate.
The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men.
Vaginal lavage attenuates cocaine-stimulated activity and establishes place preference in rats.
Relative right versus left frontal EEG in neonates.
Prenatal depression effects on the foetus and neonate in different ethnic and socio-economic status groupsRead Full Text
Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study.
Caffeine affects cardiovascular and neuroendocrine activation at work and home.
UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y
Higher levels of CSF homovanillic acid in recently abstinent cocaine-dependent patients.
Prenatal anger effects on the fetus and neonate.
UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.
Nighttime blood pressure dipping: the role of the sympathetic nervous system.
Parkinson's disease symptoms are differentially affected by massage therapy vs. progressive muscle relaxation: A pilot studyRead Full Text
Facial expressions and EEG in infants of intrusive and withdrawn mothers with depressive symptoms.
Right frontal EEG and pregnancy/neonatal outcomes.
Anorexia nervosa symptoms are reduced by massage therapyRead Full Text
Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy.
Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.
Sex, steroids, and stimulant sensitivity.
Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo-pituitary-adrenal axis by cocaine.
Central nervous system serotonin function and cardiovascular responses to stress.
Depressed withdrawn and intrusive mothers’ effects on their fetuses and neonatesRead Full Text
Physiological stress response of the neuroendocrine system during outdoor adventure tasksRead Full Text
Opiate withdrawal in the neonatal rat: relationship to duration of treatment and naloxone dose.
Stress management intervention for primary prevention of hypertension: detailed results from Phase I of Trials of Hypertension Prevention (TOHP-I).
Dopamine release and uptake are greater in female than male rat striatum as measured by fast cyclic voltammetry.
Targeting adolescent mothers with depressive symptoms for early intervention.
Effects of sex and gonadectomy on cocaine metabolism in the rat.
Pregnant women benefit from massage therapy.
Prenatal depression effects on neonatesRead Full Text
Aromatherapy positively affects mood, EEG patterns of alertness and math computations.
Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group.
Responses to maternal separation: mechanisms and mediators.
Burn injuries benefit from massage therapy.
Children with asthma have improved pulmonary functions after massage therapy.
Elder retired volunteers benefit from giving massage therapy to infantsRead Full Text
Neuroendocrine, cardiovascular, and emotional responses of hostile men: the role of interpersonal challenge.
Bulimic adolescents benefit from massage therapy.
Polydrug-using adolescent mothers and their infants receiving early intervention.
Massage therapy effects on depression and somatic symptoms in chronic fatigue syndromeRead Full Text
Juvenile rheumatoid arthritis: benefits from massage therapy.
The relationship between hostility and beta-adrenergic receptor physiology in health young males.
Stress in employed women: impact of marital status and children at home on neurohormone output and home strain.
Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats.
Immediate early gene expression to examine neuronal activity following acute and chronic stressors in rat pups: examination of neurophysiological alterations underlying behavioral consequences of prenatal cocaine exposure.
Gender difference in cocaine-induced HPA axis activation.
Infants of intrusive and withdrawn mothersRead Full Text
Effects of sexual abuse are lessened by massage therapyRead Full Text
Ontogeny of the behavioral response to dopamine agonists after chronic cocaine.
Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans.
Relation of mood ratings and neurohormonal responses during daily life in employed women.
The influence of dietary cholesterol on cardiac and hepatic Beta-adrenergic receptors in egyptian sand rats.
Development of dopamine neurotransmission and uptake inhibition in the caudate nucleus as measured by fast-cyclic voltammetry.
Differential effects of ethanol in adolescent and adult rats.
Age-related differences in the chronic and acute response to cocaine in the rat.
Massage therapy reduces anxiety and enhances EEG pattern of alertness and math computations.
mu-Opioid agonists stimulate growth hormone secretion in immature rats.
Cocaine-exposed preterm neonates show behavioral and hormonal differences.
Role of noradrenergic hyperactivity in neonatal opiate abstinence.
Role of leptin in fat regulation.
Inhibition of GH in maternal separation may be mediated through altered serotonergic activity at 5-HT2A and 5-HT2C receptors.
Fibromyalgia benefits from massage therapy and transcutaneous electrical stimulation.
Massage therapy for infants of depressed mothersRead Full Text
Ontogenetic studies of tolerance development: effects of chronic morphine on the hypothalamic-pituitary-adrenal axis.
Cocaine sensitization in periadolescent and adult rats.
Effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring.
Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling.
The ontogeny of mu opiate tolerance and dependence in the rat: antinociceptive and biochemical studies.
Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.
Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.
Glipizide stimulates sympathetic outflow in diabetes-prone mice.
Glycemic response to stress is altered in euglycemic Pima Indians.
Glycogen synthase: a putative locus for diet-induced hyperglycemia.
Hyperinsulinemia in the pregnant C57BL/6J mouse.
Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.
GBR12909 stimulates hypothalamo-pituitary-adrenal activity by inhibition of uptake at hypothalamic dopamine neurons.
Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitusRead Full Text
Necessity of 5-HT in opiate-induced prolactin secretionRead Full Text
Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus.
Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor.
Dopamine efflux during withdrawal from continuous or intermittent cocaine.
Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.
Effect of ether stress on growth hormone during development in the neonatal rat.
Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: attenuation by diazepam.
Intermittent and continuous cocaine administration: residual behavioral states during withdrawal.
The effects of liver denervation on the regulation of hepatic biliary secretion.
D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats.
Accentuated vagal antagonism of beta-adrenergic effects on ventricular repolarization. Evidence of weaker antagonism in hostile type A men.
Chronic administration of U50,488H fails to produce hypothalamo-pituitary-adrenal axis tolerance in neonatal rats.
Massage reduces anxiety in child and adolescent psychiatric patients.
Corticosterone hypersecretion in preweanling rats exposed neonatally to trimethyltin.
Menstrual cycle effects on caffeine elimination in the human female.
D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in ratsRead Full Text
Relaxation therapy reduces anxiety in child and adolescent psychiatric patients.
Biobehavioral basis of coronary-prone behavior in middle-age men. Part II: Serum cholesterol, the Type A behavior pattern, and hostility as interactive modulators of physiological reactivity.
Biobehavioral basis of coronary-prone behavior in middle-aged men. Part I: Evidence for chronic SNS activation in Type As.
Tactile-kinesthetic stimulation effects on sympathetic and adrenocortical function in preterm infants.
Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats.
Chronic cocaine administration sensitizes behavioral but not neuroendocrine responses.
Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation.
Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice.
Stress reactivity and exercise training in premenopausal and postmenopausal women.
Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.
Endocrine function as a target of perinatal drug effects: methodologic issues.
Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat.
Evaluation of selective liver denervation methods.
Endocrine responses to mother-infant separation in developing rats.
Caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption.
Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake.
Aerobic exercise reduces levels of cardiovascular and sympathoadrenal responses to mental stress in subjects without prior evidence of myocardial ischemia.
Massage stimulates growth in preterm infants: A replicationRead Full Text
Evaluation of selective liver denervation methodsRead Full Text
Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice.
Naltrexone potentiates glycemic responses during stress and epinephrine challenge in genetically obese mice.
Anterior and posterior, but not cheek, intraoral cannulation procedures elevate serum corticosterone levels in neonatal rat pups.
Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders.
Differential sensitivity to dexamethasone suppression in an animal model of the DST.
Opiate antagonist treatment reinstates estrous cycles in middle-aged persistent-estrous rats.
Differential glycemic effects of morphine in diabetic and normal mice.
Hormonal effects of early rearing conditions in the infant rhesus monkeyRead Full Text
Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.
Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men.
Infants of depressed mothers show "depressed" behavior even with nondepressed adults.
Opioid inhibition of luteinizing hormone release declines with age and acyclicity in female rats.
Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.
Diet-induced type II diabetes in C57BL/6J mice.
Exercise training in healthy type A middle-aged men: effects on behavioral and cardiovascular responses.
Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.
Physiological responses to catecholamine infusions in type A and type B men.
Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.
Alpha 1-adrenergic effects and liver regeneration.
Perinatal effects of drugs of abuse.
Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.
Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat.
Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion.
α1-Adrenergic effects and liver regenerationRead Full Text
Endocrine consequences of perinatal methadone exposure.
Positive effects of tactile versus kinesthetic or vestibular stimulation on neuroendocrine and ODC activity in maternally-deprived rat pups.
Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth.
Tactile/kinesthetic stimulation effects on preterm neonates.
Catecholaminergic regulation of opiate-stimulated growth hormone secretion in the developing rat.
Alprazolam reduces stress hyperglycemia in ob/ob mice.
Effects of tactile/kinesthetic stimulation on the clinical course and sleep/wake behavior of preterm neonatesRead Full Text
Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.
Ontogeny of food deprivation effects on ornithine decarboxylase: ornithine decarboxylase induction by alpha and beta agonists.
Effect of chronic methadone administration on neuroendocrine function in young adult rats.
Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists.
Intrahepatic glucose: a requirement for neonatal ODC induction by specific hormones.
Behavioral manipulation of the diabetic phenotype in ob/ob mice.
Tactile and nutritional aspects of maternal care: specific regulators of neuroendocrine function and cellular development.
Intrahepatic glucose: A requirement for neonatal ODC induction by specific hormonesRead Full Text
Effect of chronic methadone administration on neuroendocrine function in developing rats.
Endocrine effects of methadone in rats; acute effects in adults.
Ontogeny of rat hepatic adrenoceptors.
Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats.
Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain.
Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.
Ontogeny of stress effects on ornithine decarboxylase activity in rats.
Ontogeny of endocrine responses to methadone in rats.
Selective loss of ornithine decarboxylase response to adrenergic agonists and glucagon during food deprivation of neonatal rats.
Neuroendocrine response to cold in Raynaud's syndrome.
Lack of potency of metoclopramide's metabolites in various dopaminergic models.
Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine.
Lack of potency of metoclopramide's metabolites in various dopaminergic modelsRead Full Text
Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.
Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks.
Toxic effect of chlorisondamine in neonatal rat liver.
Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat.
Differentiation of β
Heterogeneity in the response pattern of organ systems to stress: Mediators and mechanismsRead Full Text
Tetrabenazine blocks dopaminergic receptors in rat brainRead Full Text
Maturation of central nervous system control of growth hormone secretion in rats.
Maturation of renal ornithine decarboxylase (ODC) responses to growth hormone (GH), serotonin (5-HT), angiotensin (AII), vasopressin (VP) and isoproterenol (ISO) in ratsRead Full Text
Phenylephrine insensitivity in liver after food deprivation in rat pupsRead Full Text
Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats.
Differential effects of placental lactogen, growth hormone and prolactin on rat liver ornithine decarboxylase activity in the perinatal period.
Synaptic development in brains of rats exposed perinatally to ethanol.
Experimental dystonia induced by quaternary-chlorpromazine.
Attenuation of the effect of punishment by thyrotropin-releasing hormone: comparisons with chlordiazepoxide.
Attenuation of the effects of punishment by ethanol: comparisons with chlordiazepoxide.
Loss of tissue sensitivity to growth hormone during maternal deprivation in rats.
The effect of tactile stimulation on serum growth hormone and tissue ornithine decarboxylase activity during maternal deprivation in rat pups.
Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.
Metabolism of amphetamine after acute and chronic administration to the rat.
Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.
Selective depression of serum growth hormone during maternal deprivation in rat pups.
Metabolism of amphetamine by rat brain tissue.
Intracisternal treatment with 5,7-dihydroxytryptamine enhances 5-HTP-induced release of prolactinRead Full Text
An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.
An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamineRead Full Text
Metabolism of D amphetamine by rat brain in vivo and in vitroRead Full Text