Faculty

Cynthia Kuhn

Professor of Pharmacology and Cancer Biology

Pharmacology & Cancer Biology
School of Medicine

Professor in Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Medical Psychology
School of Medicine

Faculty Network Member of the Duke Institute for Brain Sciences

Duke Institute for Brain Sciences
Institutes and Provost's Academic Units

Affiliate of the Center for Child and Family Policy

Center for Child and Family Policy
Sanford School of Public Policy
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308 Research Drive, Durham, NC 27710

Duke Box 3813, Durham, NC 27710

(919) 684-8828 ckuhn@duke.edu

This laboratory uses a multidisciplinary approach using both animal and model systems to study the biology of addiction and stress/depression. We are specifically interested in how adolescence and the hormonal changes of puberty and aging influence vulnerability to these conditions. Specific projects underway include: (1) the biology of sex differences in addictive drug action, (2) role of maturing dopamine systems in the onset of drug taking during adolescence, (3) the neurobiology of adolescent insensitivity to threat and its role in drug use.
Studies of sex differences focus on understanding estrogen and testosterone actions in the brain that are relevant to addiction, depression and stress-related behaviors. We are particularly interested in molecular targets of estrogen action including key proteins that regulate dopamine neurons and the stress peptide CRF. Current projects include the role of glucocorticoid and reproductive hormones in alcohol and opioid dependence in adolescence.  Adolescent studies are exploring the impact of maturing dopamine systems as well as cortical inhibition of these systems on novelty-seeking/risk taking as predictors of substance abuse vulnerability as well as responses to addictive drugs.
In addition to these animal studies, we collaborate actively with clinicians in psychiatry who are studying addiction and stress-related illness in humans, and participate in development of drug-abuse education and general neuroscience education materials for students, parents and other members of the lay public.


Education & Training

Ph.D. 1976

Duke University

Grants

Duke University Program in Environmental Health

National Institutes of Health

Duke CTSA (KL2)

National Institutes of Health

Duke CTSA (TL1)

National Institutes of Health

Building Interdisciplinary Research Careers in Women's Health

National Institutes of Health

Building Interdisciplinary Research Careers in Women's Health

National Institutes of Health

Organization and Function of Cellular Structure

National Institutes of Health

Organization and Function of Cellular Structure

National Institutes of Health

Pharmacological Sciences Training Program

National Institutes of Health

Simultaneous and Bidirectional Chemogenetic Control of Mesolimbic and Nigrostriatal Circuits

National Institutes of Health

Pharmacology Industry Internships for Ph.D. Students

American Society for Pharmacology and Experimental Therapeutics

Duke University Program in Environmental Health

National Institute of Environmental Health Sciences

IPA - David Walker

Fibroblast Growth Factor Homologous Factor Modulation and Effect on Cardiac Ion Channel Trafficking

National Institutes of Health

Alcohol, Puberty, and Adolescent Brain Development

National Institutes of Health

Depression & CHD: Cellular-Molecular Mechanisms

National Institutes of Health

A Neuroscience-Based Health Curriculum to Promote Academic Success

Department of Education

Gender Differences in Stimulant Action

National Institutes of Health

Responses of Myocardial Ischemia to Sertraline Treatment

National Institutes of Health

Nasal adjuvant to enhance anti-cocaine vaccines

National Institutes of Health

Serotonergic Contribution to Adolescent Risk Taking

National Institutes of Health

Role of HPA Axis in Adolescent Vulnerability to Drug Addiction

National Institutes of Health

Stress and Behavior in Health and Disease

National Institutes of Health

Developmental THC Sensitivity in Male and Female Rats

National Institutes of Health

Ethanol and GABA Function: Developmental Sensitivity

National Institutes of Health

Dopamine Function During Adolescence

National Institutes of Health

PTSD & Childhood Sexual Abuse: Psychobiology

National Institutes of Health

Maternal MDMA (Ectasy) Exposure & Fetal Physiology

National Institutes of Health

IPA - David Walker

Veterans Administration Medical Center

Adolescent Vulnerability to Neuroplastic Changes Induced by High Dose Cocaine.

National Institutes of Health

PTSD & Childhood Sexual Abuse: Psychobiology

National Institutes of Health

Duke PREP: Minority Recruitment into Biomedical Sciences

National Institutes of Health

Child Neglect: Psychobiological Consequences

National Institutes of Health

GHB Tolerance and Dependence

National Institutes of Health

Stress, Serotonin Genes, & Health Disparities

Graduate Training in Pharmalogical Sciences

National Institutes of Health

Behavioral Neuroscience

National Science Foundation

Estrogen Inhibits Noradrenergic Function through ER Beta

National Institutes of Health

Early Experience, Serotonin and Adult Function

National Institutes of Health

Hostility & Chd--Sns Lipid & Cell Molecular Mechanisms

National Institutes of Health

Graduate Training Program in Pharmacological Sciences

National Institutes of Health

Hostility & Chd: Sns, Lipid, & Cell-Molecular Mechanisms

National Institutes of Health

Graduate Training In Pharmacological Sciences

National Institutes of Health

Drugs: Integrating High School Biology And Chemistry

National Institutes of Health

Opiate Effects On Maturation Of Endocrine Regulation

National Institutes of Health

Graduate Training In Pharmacological Research

National Institutes of Health

Gender Differences In Stimulant Sensitization

National Institutes of Health

Gender Differences In Stiumlant Sensitization

National Institutes of Health

Opiate Effects On Maturation Of Endocrine Regluation

National Institutes of Health

Claude D. Pepper Older Americans Independence Center

National Institutes of Health

Biobehavioral Factors In Coronary Heart Disease

National Institutes of Health

Biobehaviorial Factors In Coronary Heart Disease

National Institutes of Health

Preclinical Sciences Center For Cocaine Treatment

National Institutes of Health

Genetics Of A Murine Model Of Type 2 Diabetes

National Institutes of Health

Integration Of Stress Response In Ontogeny--Role Of Crf

National Institutes of Health

Integration Of Stress Response In Ontogeny: Role Of Crf

National Institutes of Health

Opioid Effects On Maturation Of Endocrine Regulation

National Institutes of Health

Nutrition And Adrenergic Receptor Mechanisms In Ontog

National Institutes of Health

Nutrition And Adrenergic Receptor Mechanisms In Ontog

National Institutes of Health
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Publications

Withdrawal from Brief Repeated Alcohol Treatment in Adolescent and Adult Male and Female Rats.

PMID 30566247
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The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.

PMID 30188382
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Perinatal western-type diet and associated gestational weight gain alter postpartum maternal mood.

PMID 29075574
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Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.

PMID 28249185
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Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients.

PMID 28067532
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Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia.

PMID 28107887
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Emergence of sex differences in the development of substance use and abuse during adolescence.

PMID 26049025
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The Role of Serotonin (5-HT) in Behavioral Control: Findings from Animal Research and Clinical Implications.

PMID 25991656
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Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.

PMID 25819856
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Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.

PMID 24806470
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Association of depressive and anxiety symptoms with 24-hour urinary catecholamines in individuals with untreated high blood pressure.

PMID 25647750
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Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study

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Simplified dietary acute tryptophan depletion: effects of a novel amino acid mixture on the neurochemistry of C57BL/6J mice.

PMID 26278978
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A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.

PMID 25457638
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Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease: insights from the REMIT study.

PMID 25323254
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Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.

PMID 25029353
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Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats.

PMID 24158502
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Acute tryptophan depletion - converging evidence for decreasing central nervous serotonin synthesis in rodents and humans.

PMID 24237607
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Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures.

PMID 24061481
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Use of the light/dark test for anxiety in adult and adolescent male rats.

PMID 23721963
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Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease.

PMID 24163385
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Enduring effects of adolescent drug exposure.

PMID 24034365
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Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats.

PMID 23774134
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Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha.

PMID 23608737
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Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial.

PMID 23695483
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Prevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease.

PMID 23410543
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Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine.

PMID 23103347
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Sex differences in novelty- and psychostimulant-induced behaviors of C57BL/6 mice.

PMID 22975726
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Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.

PMID 23223800
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Acute tryptophan depletion - converging evidence for decreasing central nervous serotonin synthesis in rodents and humans

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A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.

PMID 24386118
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Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy.

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Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy.

PMID 22342988
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Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial.

PMID 22172432
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Cortisol responses to emotional stress in men: association with a functional polymorphism in the 5HTR2C gene.

PMID 21967853
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Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice.

PMID 22629305
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Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine.

PMID 21927632
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Alcohol and women: What is the role of biologic factors?

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Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity.

PMID 21633397
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Role of individual and developmental differences in voluntary cocaine intake in rats.

PMID 21347641
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Low- and high-testosterone individuals exhibit decreased aversion to economic risk.

PMID 21393575
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The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals.

PMID 21055447
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Intravascular food reward.

PMID 21980372
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Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking.

PMID 20860614
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Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons.

PMID 20955472
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Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats.

PMID 20668056
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Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.

PMID 20605908
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Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.

PMID 20595415
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Plasma epinephrine predicts fasting glucose in centrally obese African-American women.

PMID 20300086
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Stressful politics: voters' cortisol responses to the outcome of the 2008 United States Presidential election.

PMID 19962831
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The emergence of gonadal hormone influences on dopaminergic function during puberty.

PMID 19900453
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Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.

PMID 20212264
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Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c.

PMID 19800635
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Androgen decreases dopamine neurone survival in rat midbrain.

PMID 20136692
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Oestrogen receptors enhance dopamine neurone survival in rat midbrain.

PMID 20136693
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Comorbid depression and anxiety effects on pregnancy and neonatal outcome.

PMID 19945170
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Series Preface

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Personality and inflammation: the protective effect of openness to experience.

PMID 20178176
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The effect of acute tryptophan depletion on emotional distraction and subsequent memory.

PMID 19628700
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Serotonin shapes risky decision making in monkeys.

PMID 19553236
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Dominance, politics, and physiology: voters' testosterone changes on the night of the 2008 United States presidential election.

PMID 19844583
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Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models.

PMID 19547960
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Hostility and minimal model of glucose kinetics in African American women.

PMID 19561162
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Positive affect is associated with cardiovascular reactivity, norepinephrine level, and morning rise in salivary cortisol.

PMID 19470128
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Hostility and fasting glucose in African American women.

PMID 19553288
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Maturation of coordinated immediate early gene expression by cocaine during adolescence.

PMID 19245875
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Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults.

PMID 18790706
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Depressed pregnant black women have a greater incidence of prematurity and low birthweight outcomes.

PMID 19004502
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Prenatal depression restricts fetal growth.

PMID 18723301
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Prenatal dopamine and neonatal behavior and biochemistry.

PMID 18774177
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Insulin and insulin-like growth factor-1 increased in preterm neonates following massage therapy.

PMID 18714203
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HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR).

PMID 18639608
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Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.

PMID 18321529
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5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.

PMID 18661222
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Cocaine increases stimulated dopamine release more in periadolescent than adult rats.

PMID 18508233
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Lavender bath oil reduces stress and crying and enhances sleep in very young infants.

PMID 18053656
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Early ethanol consumption predicts relapse-like behavior in adolescent male rats.

PMID 18336637
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Associations among central nervous system serotonergic function and neuroticism are moderated by gender.

PMID 18417268
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Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats.

PMID 18275993
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Prenatal serotonin and neonatal outcome: brief report.

PMID 18279966
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Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress.

PMID 18158371
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Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR).

PMID 17955359
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Chronic prenatal depression and neonatal outcome.

PMID 18041608
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Prenatal dysthymia versus major depression effects on maternal cortisol and fetal growth.

PMID 17587221
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Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex.

PMID 17904295
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Sleep quality varies as a function of 5-HTTLPR genotype and stress.

PMID 17766685
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Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats.

PMID 17634345
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Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats.

PMID 17762524
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A single high dose of cocaine induces differential sensitization to specific behaviors across adolescence.

PMID 17426961
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Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality.

PMID 17585061
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Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats.

PMID 17211649
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Sleep disturbances in depressed pregnant women and their newborns.

PMID 17292785
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Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats.

PMID 17019566
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Maternal psychological distress, prenatal cortisol, and fetal weight.

PMID 17012528
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Effects of stress and sex on acquisition and consolidation of human fear conditioning.

PMID 16847304
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Sex differences in neurochemical effects of dopaminergic drugs in rat striatum.

PMID 16237396
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Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chloride.

PMID 16815539
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Stability of mood states and biochemistry across pregnancy.

PMID 17138281
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Prenatal cortisol, prematurity and low birthweight.

PMID 17138282
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Differential effects of delta9-THC on learning in adolescent and adult rats.

PMID 16631921
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Erratum: Enhanced behavioral response to related-dose cocaine in adolescent rats (Psychopharmacology (2005) 183 (218-225) DOI: doi.org/10.1007/s00213-005- 0159-4)

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Enhanced behavioral response to repeated-dose cocaine in adolescent rats.

PMID 16175404
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Cortisol decreases and serotonin and dopamine increase following massage therapy.

PMID 16162447
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Sex, stress, and fear: individual differences in conditioned learning.

PMID 16180625
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Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy.

PMID 15809216
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Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged women.

PMID 15518669
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Prenatal maternal biochemistry predicts neonatal biochemistry.

PMID 15527200
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Hostility is related to blunted beta-adrenergic receptor responsiveness among middle-aged women.

PMID 15272095
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Breast cancer patients have improved immune and neuroendocrine functions following massage therapy.

PMID 15256294
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Massage therapy effects on depressed pregnant women.

PMID 15715034
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EEG responses to mock facial expressions by infants of depressed mothers

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Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress.

PMID 15102131
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Prenatal predictors of maternal and newborn EEG

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Prepartum, postpartum, and chronic depression effects on newborns.

PMID 15139586
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Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells.

PMID 12810537
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Serotonin-related gene polymorphisms and central nervous system serotonin function.

PMID 12629534
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Depressed mothers who are "good interaction" partners versus those who are withdrawn or intrusive

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Effect of maternal smoking on fetal catecholamine concentrations at birth.

PMID 12508090
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Pregnancy anxiety and comorbid depression and anger: effects on the fetus and neonate.

PMID 12768648
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The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men.

PMID 12480498
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Vaginal lavage attenuates cocaine-stimulated activity and establishes place preference in rats.

PMID 12213518
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Relative right versus left frontal EEG in neonates.

PMID 12209656
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Prenatal depression effects on the foetus and neonate in different ethnic and socio-economic status groups

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Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study.

PMID 12122086
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Caffeine affects cardiovascular and neuroendocrine activation at work and home.

PMID 12140349
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UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors

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Higher levels of CSF homovanillic acid in recently abstinent cocaine-dependent patients.

PMID 12042199
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Prenatal anger effects on the fetus and neonate.

PMID 12521495
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UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.

PMID 11788430
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Nighttime blood pressure dipping: the role of the sympathetic nervous system.

PMID 11863245
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Parkinson's disease symptoms are differentially affected by massage therapy vs. progressive muscle relaxation: A pilot study

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Anabolic steroids.

PMID 12017555
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Facial expressions and EEG in infants of intrusive and withdrawn mothers with depressive symptoms.

PMID 11816047
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Right frontal EEG and pregnancy/neonatal outcomes.

PMID 11980045
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Anorexia nervosa symptoms are reduced by massage therapy

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Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy.

PMID 11377925
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Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.

PMID 11369941
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Sex, steroids, and stimulant sensitivity.

PMID 11458537
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Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo-pituitary-adrenal axis by cocaine.

PMID 11259556
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Central nervous system serotonin function and cardiovascular responses to stress.

PMID 11292279
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Depressed withdrawn and intrusive mothers’ effects on their fetuses and neonates

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Physiological stress response of the neuroendocrine system during outdoor adventure tasks

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Opiate withdrawal in the neonatal rat: relationship to duration of treatment and naloxone dose.

PMID 10923752
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Stress management intervention for primary prevention of hypertension: detailed results from Phase I of Trials of Hypertension Prevention (TOHP-I).

PMID 10658688
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Dopamine release and uptake are greater in female than male rat striatum as measured by fast cyclic voltammetry.

PMID 10682713
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Targeting adolescent mothers with depressive symptoms for early intervention.

PMID 11019779
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Effects of sex and gonadectomy on cocaine metabolism in the rat.

PMID 10454509
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Pregnant women benefit from massage therapy.

PMID 10212885
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Prenatal depression effects on neonates

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Aromatherapy positively affects mood, EEG patterns of alertness and math computations.

PMID 10069621
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Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Perioperative Desensitization Group.

PMID 9743395
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Responses to maternal separation: mechanisms and mediators.

PMID 9785122
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Burn injuries benefit from massage therapy.

PMID 9622469
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Children with asthma have improved pulmonary functions after massage therapy.

PMID 9602199
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Elder retired volunteers benefit from giving massage therapy to infants

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Neuroendocrine, cardiovascular, and emotional responses of hostile men: the role of interpersonal challenge.

PMID 9492244
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Bulimic adolescents benefit from massage therapy.

PMID 9831872
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Polydrug-using adolescent mothers and their infants receiving early intervention.

PMID 9583666
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Massage therapy effects on depression and somatic symptoms in chronic fatigue syndrome

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Juvenile rheumatoid arthritis: benefits from massage therapy.

PMID 9383925
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The relationship between hostility and beta-adrenergic receptor physiology in health young males.

PMID 9316180
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Stress in employed women: impact of marital status and children at home on neurohormone output and home strain.

PMID 9251153
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Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats.

PMID 9190871
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Immediate early gene expression to examine neuronal activity following acute and chronic stressors in rat pups: examination of neurophysiological alterations underlying behavioral consequences of prenatal cocaine exposure.

PMID 9177564
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Gender difference in cocaine-induced HPA axis activation.

PMID 9165495
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Infants of intrusive and withdrawn mothers

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Effects of sexual abuse are lessened by massage therapy

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Ontogeny of the behavioral response to dopamine agonists after chronic cocaine.

PMID 9040117
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Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans.

PMID 16250732
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Relation of mood ratings and neurohormonal responses during daily life in employed women.

PMID 16250739
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The influence of dietary cholesterol on cardiac and hepatic Beta-adrenergic receptors in egyptian sand rats.

PMID 16250738
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Development of dopamine neurotransmission and uptake inhibition in the caudate nucleus as measured by fast-cyclic voltammetry.

PMID 8923671
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Differential effects of ethanol in adolescent and adult rats.

PMID 8947309
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Age-related differences in the chronic and acute response to cocaine in the rat.

PMID 8911774
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Massage therapy reduces anxiety and enhances EEG pattern of alertness and math computations.

PMID 8884390
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mu-Opioid agonists stimulate growth hormone secretion in immature rats.

PMID 8793890
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Cocaine-exposed preterm neonates show behavioral and hormonal differences.

PMID 8657526
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Role of noradrenergic hyperactivity in neonatal opiate abstinence.

PMID 8793309
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Role of leptin in fat regulation.

PMID 8614460
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Inhibition of GH in maternal separation may be mediated through altered serotonergic activity at 5-HT2A and 5-HT2C receptors.

PMID 8774064
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Fibromyalgia benefits from massage therapy and transcutaneous electrical stimulation.

PMID 19078022
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Massage therapy for infants of depressed mothers

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Ontogenetic studies of tolerance development: effects of chronic morphine on the hypothalamic-pituitary-adrenal axis.

PMID 8711068
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Cocaine sensitization in periadolescent and adult rats.

PMID 7562570
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Effects of prenatal cocaine exposure on haloperidol-induced increases in prolactin release and dopamine turnover in weanling, periadolescent, and adult offspring.

PMID 7565497
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Increased sensitivity to mu opiate antinociception in the neonatal rat despite weaker receptor-guanyl nucleotide binding protein coupling.

PMID 7791108
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The ontogeny of mu opiate tolerance and dependence in the rat: antinociceptive and biochemical studies.

PMID 7791109
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Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.

PMID 7652047
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Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.

PMID 7752914
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Glipizide stimulates sympathetic outflow in diabetes-prone mice.

PMID 7869847
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Glycemic response to stress is altered in euglycemic Pima Indians.

PMID 7866478
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Glycogen synthase: a putative locus for diet-induced hyperglycemia.

PMID 8040269
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Hyperinsulinemia in the pregnant C57BL/6J mouse.

PMID 7927197
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Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus.

PMID 8231834
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GBR12909 stimulates hypothalamo-pituitary-adrenal activity by inhibition of uptake at hypothalamic dopamine neurons.

PMID 8186972
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Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus

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Necessity of 5-HT in opiate-induced prolactin secretion

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Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus.

PMID 8430889
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Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor.

PMID 8265736
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Dopamine efflux during withdrawal from continuous or intermittent cocaine.

PMID 7870949
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Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.

PMID 1332851
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Effect of ether stress on growth hormone during development in the neonatal rat.

PMID 1488092
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Selective activation of mesoamygdaloid dopamine neurons by conditioned stress: attenuation by diazepam.

PMID 1422845
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Intermittent and continuous cocaine administration: residual behavioral states during withdrawal.

PMID 1409810
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The effects of liver denervation on the regulation of hepatic biliary secretion.

PMID 1352920
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D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats.

PMID 1328919
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Accentuated vagal antagonism of beta-adrenergic effects on ventricular repolarization. Evidence of weaker antagonism in hostile type A men.

PMID 1317272
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Chronic administration of U50,488H fails to produce hypothalamo-pituitary-adrenal axis tolerance in neonatal rats.

PMID 1553027
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Massage reduces anxiety in child and adolescent psychiatric patients.

PMID 1537763
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Corticosterone hypersecretion in preweanling rats exposed neonatally to trimethyltin.

PMID 1436758
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Menstrual cycle effects on caffeine elimination in the human female.

PMID 1483492
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D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats

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Relaxation therapy reduces anxiety in child and adolescent psychiatric patients.

PMID 1585802
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Biobehavioral basis of coronary-prone behavior in middle-age men. Part II: Serum cholesterol, the Type A behavior pattern, and hostility as interactive modulators of physiological reactivity.

PMID 1758939
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Biobehavioral basis of coronary-prone behavior in middle-aged men. Part I: Evidence for chronic SNS activation in Type As.

PMID 1661901
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Tactile-kinesthetic stimulation effects on sympathetic and adrenocortical function in preterm infants.

PMID 1880659
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Ontogeny of mu- and kappa-opiate receptor control of the hypothalamo-pituitary-adrenal axis in rats.

PMID 1649751
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Chronic cocaine administration sensitizes behavioral but not neuroendocrine responses.

PMID 1647834
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Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation.

PMID 1671094
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Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice.

PMID 2015977
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Stress reactivity and exercise training in premenopausal and postmenopausal women.

PMID 1765033
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Corticotropin releasing factor stimulates growth hormone secretion in neonatal rats.

PMID 1943449
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Endocrine function as a target of perinatal drug effects: methodologic issues.

PMID 1754015
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Effects of specific mu and kappa opiate tolerance and abstinence on hypothalamo-pituitary-adrenal axis secretion in the rat.

PMID 2175800
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Evaluation of selective liver denervation methods.

PMID 2240220
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Endocrine responses to mother-infant separation in developing rats.

PMID 2253817
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Caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption.

PMID 2195579
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Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake.

PMID 2157002
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Aerobic exercise reduces levels of cardiovascular and sympathoadrenal responses to mental stress in subjects without prior evidence of myocardial ischemia.

PMID 2294687
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Massage stimulates growth in preterm infants: A replication

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Evaluation of selective liver denervation methods

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Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice.

PMID 2576006
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Naltrexone potentiates glycemic responses during stress and epinephrine challenge in genetically obese mice.

PMID 2549557
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Anterior and posterior, but not cheek, intraoral cannulation procedures elevate serum corticosterone levels in neonatal rat pups.

PMID 2721821
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Abnormalities in the response of plasma arginine vasopressin during hypertonic saline infusion in patients with eating disorders.

PMID 2541809
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Differential sensitivity to dexamethasone suppression in an animal model of the DST.

PMID 2720021
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Opiate antagonist treatment reinstates estrous cycles in middle-aged persistent-estrous rats.

PMID 2752072
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Differential glycemic effects of morphine in diabetic and normal mice.

PMID 2645504
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Hormonal effects of early rearing conditions in the infant rhesus monkey

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Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.

PMID 2747414
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Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men.

PMID 3251510
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Infants of depressed mothers show "depressed" behavior even with nondepressed adults.

PMID 3208568
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Opioid inhibition of luteinizing hormone release declines with age and acyclicity in female rats.

PMID 3197639
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Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.

PMID 3070619
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Diet-induced type II diabetes in C57BL/6J mice.

PMID 3044882
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Exercise training in healthy type A middle-aged men: effects on behavioral and cardiovascular responses.

PMID 3413273
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Relative ontogeny of opioid and catecholaminergic regulation of thyrotropin secretion in the rat.

PMID 3133201
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Physiological responses to catecholamine infusions in type A and type B men.

PMID 2854049
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Early ontogeny of kappa-opioid receptor regulation of prolactin secretion in the rat.

PMID 2894234
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Alpha 1-adrenergic effects and liver regeneration.

PMID 2824312
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Perinatal effects of drugs of abuse.

PMID 3494635
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Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.

PMID 3554269
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Role of serotonin in opiate-induced prolactin secretion and antinociception in the developing rat.

PMID 2435887
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Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion.

PMID 3031276
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α1-Adrenergic effects and liver regeneration

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Endocrine consequences of perinatal methadone exposure.

PMID 3123991
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Positive effects of tactile versus kinesthetic or vestibular stimulation on neuroendocrine and ODC activity in maternally-deprived rat pups.

PMID 3491272
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Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth.

PMID 2941633
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Tactile/kinesthetic stimulation effects on preterm neonates.

PMID 3754633
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Catecholaminergic regulation of opiate-stimulated growth hormone secretion in the developing rat.

PMID 3007734
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Alprazolam reduces stress hyperglycemia in ob/ob mice.

PMID 2871583
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Effects of tactile/kinesthetic stimulation on the clinical course and sleep/wake behavior of preterm neonates

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Pharmacologic evaluation of dopaminergic receptor blockade by metoclopramide.

PMID 3829008
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Ontogeny of food deprivation effects on ornithine decarboxylase: ornithine decarboxylase induction by alpha and beta agonists.

PMID 2865350
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Effect of chronic methadone administration on neuroendocrine function in young adult rats.

PMID 4040169
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Hepatic cyclic AMP generation and ornithine decarboxylase induction by glucagon and beta adrenergic agonists.

PMID 2860551
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Intrahepatic glucose: a requirement for neonatal ODC induction by specific hormones.

PMID 6380309
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Behavioral manipulation of the diabetic phenotype in ob/ob mice.

PMID 6376217
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Tactile and nutritional aspects of maternal care: specific regulators of neuroendocrine function and cellular development.

PMID 6364149
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Intrahepatic glucose: A requirement for neonatal ODC induction by specific hormones

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Effect of chronic methadone administration on neuroendocrine function in developing rats.

PMID 6518945
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Endocrine effects of methadone in rats; acute effects in adults.

PMID 6653672
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Ontogeny of rat hepatic adrenoceptors.

PMID 6312016
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Hypertension and cardiovascular hypertrophy during chronic catecholamine infusion in rats.

PMID 6223191
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Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain.

PMID 6864517
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Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol.

PMID 6299612
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Ontogeny of stress effects on ornithine decarboxylase activity in rats.

PMID 6682977
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Ontogeny of endocrine responses to methadone in rats.

PMID 6835017
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Selective loss of ornithine decarboxylase response to adrenergic agonists and glucagon during food deprivation of neonatal rats.

PMID 6132000
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Neuroendocrine response to cold in Raynaud's syndrome.

PMID 6600810
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Lack of potency of metoclopramide's metabolites in various dopaminergic models.

PMID 6682229
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Modulating role of lithium on dopamine turnover, prolactin release, and behavioral supersensitivity following haloperidol and reserpine.

PMID 6415746
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Lack of potency of metoclopramide's metabolites in various dopaminergic models

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Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.

PMID 7162362
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Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks.

PMID 7123248
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Toxic effect of chlorisondamine in neonatal rat liver.

PMID 7104045
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Maturation of growth hormone stimulation of kidney ornithine decarboxylase in the rat.

PMID 7070214
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Differentiation of β1 and β2 mediated responses to exercise using atenolol and propranolol

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Heterogeneity in the response pattern of organ systems to stress: Mediators and mechanisms

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Tetrabenazine blocks dopaminergic receptors in rat brain

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Maturation of central nervous system control of growth hormone secretion in rats.

PMID 6970810
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Maturation of renal ornithine decarboxylase (ODC) responses to growth hormone (GH), serotonin (5-HT), angiotensin (AII), vasopressin (VP) and isoproterenol (ISO) in rats

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Phenylephrine insensitivity in liver after food deprivation in rat pups

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Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats.

PMID 6785814
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Differential effects of placental lactogen, growth hormone and prolactin on rat liver ornithine decarboxylase activity in the perinatal period.

PMID 7207018
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Synaptic development in brains of rats exposed perinatally to ethanol.

PMID 7439320
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Experimental dystonia induced by quaternary-chlorpromazine.

PMID 7191072
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Attenuation of the effect of punishment by thyrotropin-releasing hormone: comparisons with chlordiazepoxide.

PMID 6243358
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Attenuation of the effects of punishment by ethanol: comparisons with chlordiazepoxide.

PMID 6777811
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Loss of tissue sensitivity to growth hormone during maternal deprivation in rats.

PMID 231720
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The effect of tactile stimulation on serum growth hormone and tissue ornithine decarboxylase activity during maternal deprivation in rat pups.

PMID 548216
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Atypical antidopaminergic properties of CI-686: a potential antipsychotic agent.

PMID 44373
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Metabolism of amphetamine after acute and chronic administration to the rat.

PMID 712637
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Behavioral and prolactin responses to 5-hydroxytryptophan in rats treated during development with 5,7-dihydroxytryptamine.

PMID 308387
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Selective depression of serum growth hormone during maternal deprivation in rat pups.

PMID 684424
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Metabolism of amphetamine by rat brain tissue.

PMID 339925
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Intracisternal treatment with 5,7-dihydroxytryptamine enhances 5-HTP-induced release of prolactin

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An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.

PMID 132524
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An inhibitory role for brain serotonin containing systems in the locomotor effects of d amphetamine

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Metabolism of D amphetamine by rat brain in vivo and in vitro

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