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William Herman Wilson, PhD

Professor Emeritus in Psychiatry and Behavioral Sciences
Division: 
Behavioral Medicine & Neurosciences
Category: 
Office: 242 Civitan Bldg, Durham, NC 27710
Campus Mail: DUMC Box 3930 Med Ctr, Durham, NC 27710

During the past year my research efforts continued in brain blood flow and metabolism. Areas of focus have been on the effects of marijuana and other substances of abuse on cerebral blood flow and metabolism and brain morphology. Several new grants to continue this research have been submitted. An ongoing project involves the effects of marijuana on cerebral blood flow measured with Positron Emission Tomography. This project will look at
neurocognative effects of marijuana. In this project subjects who have used marijuana in the past are studied while THC (marijuana) is infused. A third project has been funded on the effects of marijuana on postural syncope. The plans for the coming year include the continuation of these two with new grant submissions, and further expansion of this research using PET and other imaging technology. This includes an new grant submission to examine the
effects of merijuana on learning and memory. In addition to these basic research efforts I continue my interest in clinical psychopharmacology. In that effort I have been the PI on one clinical trial this past year on outpatient schizophrenia.
Finally, because of my research and statistical background, I continue to collaborate with a number of investigators in the Departments of Psychiatry and Radiology.

Education and Training

  • Ph.D., Vanderbilt University, 1973

Publications

Carroll, B. J., A. Iranmanesh, D. M. Keenan, F. Cassidy, W. H. Wilson, and J. D. Veldhuis. “Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback.” Acta Psychiatr Scand 125, no. 6 (June 2012): 478–91. https://doi.org/10.1111/j.1600-0447.2011.01821.x.

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Carroll, B. J., F. Cassidy, D. Naftolowitz, N. E. Tatham, W. H. Wilson, A. Iranmanesh, P. Y. Liu, and J. D. Veldhuis. “Pathophysiology of hypercortisolism in depression.” Acta Psychiatr Scand Suppl, no. 433 (2007): 90–103. https://doi.org/10.1111/j.1600-0447.2007.00967.x.

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Davidson, Jonathan R. T., Kathryn M. Connor, Michael A. Hertzberg, Richard H. Weisler, William H. Wilson, and Victoria M. Payne. “Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study.” J Clin Psychopharmacol 25, no. 2 (April 2005): 166–69. https://doi.org/10.1097/01.jcp.0000155817.21467.6c.

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Wilson, W. H. “A visual guide to expected blood levels of long-acting injectable risperidone in clinical practice.” Journal of Psychiatric Practice 10, no. 6 (2004): 393–401. https://doi.org/10.1097/00131746-200411000-00009.

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Wilson, W. H., and D. A. Bigelow. “Brain activation during affective visual cues in schizophrenia: A pilot study using fMRI [3].” Journal of Clinical Psychopharmacology 24, no. 4 (2004): 450–52.

Scholars@Duke

Mathew, Roy J., William H. Wilson, and Robin Davis. “Postural syncope after marijuana: a transcranial Doppler study of the hemodynamics.” Pharmacol Biochem Behav 75, no. 2 (May 2003): 309–18. https://doi.org/10.1016/s0091-3057(03)00086-8.

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Yang, Yen Kuang, Joseph P. McEvoy, William H. Wilson, Edward D. Levin, and Jed E. Rose. “Reliabilities and intercorrelations of reported and objective measures of smoking in patients with schizophrenia.” Schizophr Res 60, no. 1 (March 1, 2003): 9–12. https://doi.org/10.1016/s0920-9964(02)00208-6.

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Mathew, Roy J., William H. Wilson, Timothy G. Turkington, Thomas C. Hawk, R Edward Coleman, Timothy R. DeGrado, and James Provenzale. “Time course of tetrahydrocannabinol-induced changes in regional cerebral blood flow measured with positron emission tomography.” Psychiatry Res 116, no. 3 (December 30, 2002): 173–85. https://doi.org/10.1016/s0925-4927(02)00069-0.

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Yang, Yen Kuang, Leann Nelson, Lakshmi Kamaraju, William Wilson, and Joseph P. McEvoy. “Nicotine decreases bradykinesia-rigidity in haloperidol-treated patients with schizophrenia.” Neuropsychopharmacology 27, no. 4 (October 2002): 684–86. https://doi.org/10.1016/S0893-133X(02)00325-1.

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Keefe, Richard S. E., Miriam C. Arnold, Ute J. Bayen, Joseph P. McEvoy, and William H. Wilson. “Source-monitoring deficits for self-generated stimuli in schizophrenia: multinomial modeling of data from three sources.” Schizophr Res 57, no. 1 (September 1, 2002): 51–67. https://doi.org/10.1016/s0920-9964(01)00306-1.

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