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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Beckham, Jean C., Mary E. Becker, Kim W. Hamlett-Berry, Pamela D. Drury, Han K. Kang, Matthew T. Wiley, Patrick S. Calhoun, Scott D. Moore, Mary Anne Bright, and Miles E. McFall. “Preliminary findings from a clinical demonstration project for veterans returning from Iraq or Afghanistan.” Mil Med 173, no. 5 (May 2008): 448–51. https://doi.org/10.7205/milmed.173.5.448.

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Chung, L., and S. D. Moore. “Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala.” Neuropeptides 41, no. 6 (December 2007): 453–63. https://doi.org/10.1016/j.npep.2007.08.001.

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Roberts, M. E., S. D. Moore, and J. C. Beckham. “Post-Traumatic Stress Disorder and Substance Use Disorders,” December 1, 2007, 315–31. https://doi.org/10.1016/B978-012370632-4/50019-X.

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Kang-Park, Maeng-Hee, Wilkie A. Wilson, Cynthia M. Kuhn, Scott D. Moore, and H Scott Swartzwelder. “Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats.” J Neurophysiol 98, no. 3 (September 2007): 1223–30. https://doi.org/10.1152/jn.00091.2007.

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Kang-Park, M. -. H., and S. D. Moore. “MU opioid receptor activation mediates effects of ethanol on membrane excitability in rat central amygdala.” In Alcoholism Clinical and Experimental Research, 31:145A-145A. BLACKWELL PUBLISHING, 2007.

Scholars@Duke

Becker, Mary E., Michael A. Hertzberg, Scott D. Moore, Michelle F. Dennis, Deo S. Bukenya, and Jean C. Beckham. “A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder.” J Clin Psychopharmacol 27, no. 2 (April 2007): 193–97. https://doi.org/10.1097/JCP.0b013e318032eaed.

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Wang, Chunsheng, Christine E. Marx, A Leslie Morrow, Wilkie A. Wilson, and Scott D. Moore. “Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors.” Neurosci Lett 415, no. 2 (March 26, 2007): 118–23. https://doi.org/10.1016/j.neulet.2007.01.004.

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Kang-Park, Maeng-Hee, Brigitte L. Kieffer, Amanda J. Roberts, George Robert Siggins, and Scott D. Moore. “Presynaptic delta opioid receptors regulate ethanol actions in central amygdala.” J Pharmacol Exp Ther 320, no. 2 (February 2007): 917–25. https://doi.org/10.1124/jpet.106.112722.

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Park, Maeng-Hee K., and Scott D. Moore. “Correlation of ethanol, CRF and mu-opioid peptide actions on gabaergic neurotransmission in rat central amygdala.” In Alcoholism Clinical and Experimental Research, 30:143A-143A. BLACKWELL PUBLISHING, 2006.

Scholars@Duke

Kang-Park, M. -. H., G. R. Siggins, B. L. Kieffer, and S. D. Moore. “Interaction of a delta opioid receptor antagonist and ethanol on evoked gabaa receptor-mediated inhibitory neurotransmission in the mouse central amygdala (cea).” In Alcoholism Clinical and Experimental Research, 30:128A-128A. BLACKWELL PUBLISHING, 2006.

Scholars@Duke

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