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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Park, M., and S. D. Moore. “THE INTERACTION BETWEEN ETHANOL AND KAPPA OPIOID SYSTEM IN THE MICE CENTRAL AMYGDALE.” In Alcoholism Clinical and Experimental Research, 34:127A-127A. WILEY-BLACKWELL PUBLISHING, INC, 2010.

Scholars@Duke

Green, Kimberly T., Patrick S. Calhoun, Michelle F. Dennis, Michelle F. Mid-Atlantic Mental Illness Research, Education and Clinical Center Workgroup, and Jean C. Beckham. “Exploration of the resilience construct in posttraumatic stress disorder severity and functional correlates in military combat veterans who have served since September 11, 2001.” J Clin Psychiatry 71, no. 7 (July 2010): 823–30. https://doi.org/10.4088/JCP.09m05780blu.

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Kang-Park, M., and S. D. Moore. “KAPPA OPIOID RECEPTOR REGULATION OF ETHANOL EFFECTS ON INHIBITORY SYNAPTIC TRANSMISSION IN CENTRAL AMYGDALA NUCLEUS: SEX DIFFERENCES.” In Alcoholism Clinical and Experimental Research, 34:16A-16A. WILEY-BLACKWELL PUBLISHING, INC, 2010.

Scholars@Duke

Flood, Amanda M., Stephen H. Boyle, Patrick S. Calhoun, Michelle F. Dennis, John C. Barefoot, Scott D. Moore, and Jean C. Beckham. “Prospective study of externalizing and internalizing subtypes of posttraumatic stress disorder and their relationship to mortality among Vietnam veterans.” Compr Psychiatry 51, no. 3 (May 2010): 236–42. https://doi.org/10.1016/j.comppsych.2009.08.002.

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Dedert, Eric A., Sarah M. Wilson, Patrick S. Calhoun, Scott D. Moore, Kim W. Hamlett-Berry, and Jean C. Beckham. “Public health clinical demonstration project for smoking cessation in veterans with posttraumatic stress disorder.” Addict Behav 35, no. 1 (January 2010): 19–22. https://doi.org/10.1016/j.addbeh.2009.08.007.

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Chung, L., and S. D. Moore. “Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala.” Neuroscience 164, no. 4 (December 29, 2009): 1389–97. https://doi.org/10.1016/j.neuroscience.2009.09.061.

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Chung, Leeyup, Scott D. Moore, and Charles L. Cox. “Cholecystokinin action on layer 6b neurons in somatosensory cortex.” Brain Res 1282 (July 28, 2009): 10–19. https://doi.org/10.1016/j.brainres.2009.05.061.

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Chung, Leeyup, and Scott D. Moore. “Cholecystokinin excites interneurons in rat basolateral amygdala.” J Neurophysiol 102, no. 1 (July 2009): 272–84. https://doi.org/10.1152/jn.90769.2008.

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Kang-Park, Maeng-hee, and Scott D. Moore. “POTENTIATION OF CRF SENSITIVITY IN ETHANOL WITHDRAWN RATS: GENDER DIFFERENCES.” In Alcoholism Clinical and Experimental Research, 33:143A-143A. WILEY-BLACKWELL PUBLISHING, INC, 2009.

Scholars@Duke

Kang-Park, Maeng-Hee, Brigitte L. Kieffer, Amanda J. Roberts, Marisa Roberto, Samuel G. Madamba, George Robert Siggins, and Scott D. Moore. “Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: lack of ethanol interactions.” J Pharmacol Exp Ther 328, no. 1 (January 2009): 284–93. https://doi.org/10.1124/jpet.108.140749.

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