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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Wang, Hong-Gang, Xiao Ping He, Qiang Li, Roger D. Madison, Scott D. Moore, James O. McNamara, and Geoffrey S. Pitt. “The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability.” J Biol Chem 288, no. 19 (May 10, 2013): 13258–68. https://doi.org/10.1074/jbc.M112.434548.

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Li, Q., and S. D. Moore. “BLOCKADE OF PRESYNAPTIC BK CHANNELS OCCLUDES ETHANOL-INDUCED ENHANCEMENT OF GABAERGIC TRANSMISSION IN THE RAT CENTRAL NUCLEUS OF THE AMYGDALA.” In Alcoholism Clinical and Experimental Research, 36:189A-189A. WILEY-BLACKWELL, 2012.

Scholars@Duke

Fleming, R. L., S. K. Acheson, M. L. Risher, Q. Li, W. A. Wilson, S. D. Moore, and H. S. Swartzwelder. “IN THE RAT, CHRONIC INTERMITTENT ETHANOL EXPOSURE DURING ADOLESCENCE, BUT NOT LATER, ALTERS THE ETHANOL SENSITIVITY OF TONIC INHIBITION IN ADULTHOOD.” In Alcoholism Clinical and Experimental Research, 36:105A-105A. WILEY-BLACKWELL, 2012.

Scholars@Duke

Park, M., and S. D. Moore. “TARGET SPECIFIC EFFECTS OF NEUROPEPTIDE SYSTEMS IN THE CENTRAL AMYGDALA.” In Alcoholism Clinical and Experimental Research, 36:189A-189A. WILEY-BLACKWELL, 2012.

Scholars@Duke

Fleming, Rebekah L., Shawn K. Acheson, Scott D. Moore, Wilkie A. Wilson, and H Scott Swartzwelder. “In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood.” Alcohol Clin Exp Res 36, no. 2 (February 2012): 279–85. https://doi.org/10.1111/j.1530-0277.2011.01615.x.

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Fleming, Rebekah L., Shawn K. Acheson, Scott D. Moore, Wilkie A. Wilson, and H Scott Swartzwelder. “GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus.” Alcohol 45, no. 6 (September 2011): 577–83. https://doi.org/10.1016/j.alcohol.2011.03.003.

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Zaborowski, Daphne E., Eric A. Dedert, Kristy Straits-Troster, Sherman Lee, Sarah M. Wilson, Patrick S. Calhoun, Scott D. Moore, Shawn Acheson, Kim W. Hamlett-Berry, and Jean C. Beckham. “Public health clinical demonstration project for smoking cessation in american veterans who served since september 11, 2001.” J Addict Med 5, no. 1 (March 2011): 79–83. https://doi.org/10.1097/ADM.0b013e3181df97d5.

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Klein, R. C., B. E. Mace, S. D. Moore, and P. M. Sullivan. “Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.” Neuroscience 171, no. 4 (December 29, 2010): 1265–72. https://doi.org/10.1016/j.neuroscience.2010.10.027.

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Naylor, Jennifer C., Qiang Li, Maeng-hee Kang-Park, Wilkie A. Wilson, Cynthia Kuhn, and Scott D. Moore. “Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons.” Eur J Neurosci 32, no. 11 (December 2010): 1836–42. https://doi.org/10.1111/j.1460-9568.2010.07457.x.

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Elbogen, Eric B., H Ryan Wagner, Sara R. Fuller, Patrick S. Calhoun, Patricia M. Kinneer, Patricia M. Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, and Jean C. Beckham. “Correlates of anger and hostility in Iraq and Afghanistan war veterans.” Am J Psychiatry 167, no. 9 (September 2010): 1051–58. https://doi.org/10.1176/appi.ajp.2010.09050739.

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