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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Landin, J. D., Y. Dzumaga, M. D. Tyneway, J. M. Carter, S. D. Moore, H. S. Swartzwelder, R. L. Fleming, and D. F. Werner. “ISOFLURANE EXPOSURE ENHANCES ETHANOL-RELATED BEHAVIORAL RESPONSES IN ADOLESCENT RATS.” In Alcoholism Clinical and Experimental Research, 38:286A-286A. WILEY-BLACKWELL, 2014.

Scholars@Duke

Szabo, Steven T., Jason D. Kilts, Jennifer C. Naylor, Nagy A. Youssef, Jennifer L. Strauss, Rajendra A. Morey, Mira Brancu, et al. “Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.” Mil Med 179, no. 5 (May 2014): 486–91. https://doi.org/10.7205/MILMED-D-13-00337.

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Klein, Rebecca C., Shyla Saini, M-Louise Risher, Shawn K. Acheson, Rebekah L. Fleming, Hannah G. Sexton, H Scott Swartzwelder, and Scott D. Moore. “Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.” Plos One 9, no. 4 (2014): e94071. https://doi.org/10.1371/journal.pone.0094071.

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Li, Qiang, Rebekah L. Fleming, Shawn K. Acheson, Roger D. Madison, Scott D. Moore, Mary-Louise Risher, Wilkie A. Wilson, and H Scott Swartzwelder. “Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.” Alcohol Clin Exp Res 37, no. 12 (December 2013): 2074–85. https://doi.org/10.1111/acer.12204.

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Klein, R. C., S. M. Goetz, W. B. Liedtke, S. D. Moore, and A. V. Peterchev. “Static magnetic field modulates excitatory activity in layer II/III pyramidal neurons of the rat motor cortex.” In International Ieee/Embs Conference on Neural Engineering, Ner, 1190–93, 2013. https://doi.org/10.1109/NER.2013.6696152.

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Hertzberg, Jeffrey S., Vickie L. Carpenter, Angela C. Kirby, Patrick S. Calhoun, Scott D. Moore, Michelle F. Dennis, Paul A. Dennis, Eric A. Dedert, and Jean C. Beckham. “Mobile contingency management as an adjunctive smoking cessation treatment for smokers with posttraumatic stress disorder.” Nicotine Tob Res 15, no. 11 (November 2013): 1934–38. https://doi.org/10.1093/ntr/ntt060.

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Fleming, Rebekah L., Qiang Li, Mary-Louise Risher, Hannah G. Sexton, Scott D. Moore, Wilkie A. Wilson, Shawn K. Acheson, and H Scott Swartzwelder. “Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells.” Alcohol Clin Exp Res 37, no. 7 (July 2013): 1154–60. https://doi.org/10.1111/acer.12087.

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Swinkels, C. M., C. S. Ulmer, J. C. Beckham, N. Buse, P. S. Calhoun, J. A. Fairbank, C. E. Marx, et al. “The association of sleep duration, mental health, and health risk behaviors among U.S. Afghanistan/Iraq era veterans.” Sleep 36, no. 7 (July 1, 2013): 1019–25. https://doi.org/10.5665/sleep.2800.

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Kang-Park, Maenghee, Brigitte L. Kieffer, Amanda J. Roberts, George R. Siggins, and Scott D. Moore. “κ-Opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites.” J Pharmacol Exp Ther 346, no. 1 (July 2013): 130–37. https://doi.org/10.1124/jpet.112.202903.

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Li, Q., R. Madison, and S. D. Moore. “DOWNREGULATION OF NEURONAL BK CHANNELS AFTER CHRONIC INTERMITTENT ETHANOL EXPOSURE.” In Alcoholism Clinical and Experimental Research, 37:181A-181A. WILEY-BLACKWELL, 2013.

Scholars@Duke

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