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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Carpenter, Vickie L., Jeffrey S. Hertzberg, Angela C. Kirby, Patrick S. Calhoun, Scott D. Moore, Michelle F. Dennis, Paul A. Dennis, Eric A. Dedert, Lauren P. Hair, and Jean C. Beckham. “Multicomponent smoking cessation treatment including mobile contingency management in homeless veterans.” J Clin Psychiatry 76, no. 7 (July 2015): 959–64. https://doi.org/10.4088/JCP.14m09053.

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Risher, Mary-Louise, Rebekah L. Fleming, W Christopher Risher, K. M. Miller, Rebecca C. Klein, Tiffany Wills, Shawn K. Acheson, et al. “Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.” Alcohol Clin Exp Res 39, no. 6 (June 2015): 989–97. https://doi.org/10.1111/acer.12725.

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Li, Q., C. Contet, S. Treistman, and S. D. Moore. “BK CHANNEL B1 AND B4 SUBUNITS IN NEURONAL FUNCTION OF CENTRAL NUCLEI OF AMYGDALA IN MICE EXPOSED TOCHRONIC ETHANOL.” In Alcoholism Clinical and Experimental Research, 39:187A-187A. WILEY-BLACKWELL, 2015.

Scholars@Duke

Kimbrel, Nathan A., Patrick S. Calhoun, Eric B. Elbogen, Mira Brancu, Mira VA Mid-Atlantic MIRECC Registry Workgroup, and Jean C. Beckham. “The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality.” Psychiatry Res 220, no. 1–2 (December 15, 2014): 397–403. https://doi.org/10.1016/j.psychres.2014.07.064.

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Gentes, Emily L., Paul A. Dennis, Nathan A. Kimbrel, Michelle B. Rissling, Jean C. Beckham, Jean C. VA Mid-Atlantic MIRECC Workgroup, and Patrick S. Calhoun. “DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis.” J Psychiatr Res 59 (December 2014): 60–67. https://doi.org/10.1016/j.jpsychires.2014.08.014.

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Li, Qiang, Roger Madison, and Scott D. Moore. “Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.” J Neurosci 34, no. 41 (October 8, 2014): 13714–24. https://doi.org/10.1523/JNEUROSCI.5284-13.2014.

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Guffanti, G., A. E. Ashley-Koch, A. L. Roberts, M. E. Garrett, N. Solovieff, A. Ratanatharathorn, I. De Vivo, et al. “No association between RORA polymorphisms and PTSD in two independent samples.” Mol Psychiatry 19, no. 10 (October 2014): 1056–57. https://doi.org/10.1038/mp.2014.19.

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Klein, Rebecca C., Shawn K. Acheson, Brian E. Mace, Patrick M. Sullivan, and Scott D. Moore. “Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.” Neurobiol Aging 35, no. 9 (September 2014): 2046–52. https://doi.org/10.1016/j.neurobiolaging.2014.02.019.

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Brancu, Mira, Nivonne L. Thompson, Jean C. Beckham, Kimberly T. Green, Patrick S. Calhoun, Eric B. Elbogen, Allison T. Robbins, John A. Fairbank, John A. VA Mid-Atlantic MIRECC Registry Workgroup, and H Ryan Wagner. “The impact of social support on psychological distress for U.S. Afghanistan/Iraq era veterans with PTSD and other psychiatric diagnoses.” Psychiatry Res 217, no. 1–2 (June 30, 2014): 86–92. https://doi.org/10.1016/j.psychres.2014.02.025.

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Li, Q., C. Contet, S. Treistman, and S. D. Moore. “CELLULAR AND SYNAPTIC PHYSIOLOGY OF CENTRAL AMYGDALA NEURONS FROM MICE LACKING BK CHANNEL BETA-1 SUBUNITS: IMPLICATIONS FOR ALCOHOLISM.” In Alcoholism Clinical and Experimental Research, 38:90A-90A. WILEY-BLACKWELL, 2014.

Scholars@Duke

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