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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Li, Q., C. Contet, S. Treistman, and S. D. Moore. “INTERMITTENT ALCOHOL EXPOSURE ALTERS GABAERGIC FUNCTION IN THE CENTRAL NUCLEI OF AMYGADALA IN MICE LACKING BK CHANNEL BETA1 OR BETA4 SUBUNITS.” In Alcoholism Clinical and Experimental Research, 40:191A-191A. WILEY-BLACKWELL, 2016.

Scholars@Duke

Klein, Rebecca C., Shawn K. Acheson, Laura H. Qadri, Alina A. Dawson, Ramona M. Rodriguiz, William C. Wetsel, Scott D. Moore, Daniel T. Laskowitz, and Hana N. Dawson. “Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress.” J Neurosci Res 94, no. 6 (June 2016): 579–89. https://doi.org/10.1002/jnr.23702.

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Naylor, Jennifer C., Jason D. Kilts, Steven T. Szabo, Charlotte E. Dunn, Francis J. Keefe, Larry A. Tupler, Lawrence J. Shampine, et al. “Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.” Pain Med 17, no. 1 (January 2016): 25–32. https://doi.org/10.1111/pme.12860.

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Naylor, Jennifer C., Jason D. Kilts, Jennifer L. Strauss, Steven T. Szabo, Charlotte E. Dunn, H Ryan Wagner, Robert M. Hamer, et al. “An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.” J Rehabil Res Dev 53, no. 4 (2016): 499–510. https://doi.org/10.1682/JRRD.2014.11.0294.

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Calhoun, P. S., W. S. Sampson, H. B. Bosworth, M. E. Feldman, A. C. Kirby, M. A. Hertzberg, T. P. Wampler, F. Tate-Williams, S. D. Moore, and J. C. Beckham. “Drug use and validity of substance use self-reports in veterans seeking help for posttraumatic stress disorder.” In Educational and Psychological Research: A Cross-Section of Journal Articles for Analysis and Evaluation, 182–87, 2016. https://doi.org/10.4324/9781315266497-31.

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Risher, Mary-Louise, Hannah G. Sexton, W Christopher Risher, Wilkie A. Wilson, Rebekah L. Fleming, Roger D. Madison, Scott D. Moore, Cagla Eroglu, and H Scott Swartzwelder. “Adolescent Intermittent Alcohol Exposure: Dysregulation of Thrombospondins and Synapse Formation are Associated with Decreased Neuronal Density in the Adult Hippocampus.” Alcohol Clin Exp Res 39, no. 12 (December 2015): 2403–13. https://doi.org/10.1111/acer.12913.

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Schry, Amie R., Rachel Hibberd, H Ryan Wagner, Jessica A. Turchik, Nathan A. Kimbrel, Madrianne Wong, Eric E. Elbogen, Jennifer L. Strauss, Jennifer L. Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center Workgroup, and Mira Brancu. “Functional correlates of military sexual assault in male veterans.” Psychol Serv 12, no. 4 (November 2015): 384–93. https://doi.org/10.1037/ser0000053.

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Kang-Park, Maenghee, Brigitte L. Kieffer, Amanda J. Roberts, George R. Siggins, and Scott D. Moore. “Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala.” J Pharmacol Exp Ther 355, no. 2 (November 2015): 206–11. https://doi.org/10.1124/jpet.115.225870.

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Kimbrel, Nathan A., Melanie E. Garrett, Michelle F. Dennis, Yutao Liu, Ilyas Patanam, Va Mid-Atlantic Mirecc Workgroup, Allison E. Ashley-Koch, Michael A. Hauser, and Jean C. Beckham. “Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.” Psychiatry Res 229, no. 1–2 (September 30, 2015): 326–31. https://doi.org/10.1016/j.psychres.2015.07.002.

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Kelley, Michelle L., Mira Brancu, Allison T. Robbins, Gabrielle M. D’Lima, Jennifer L. Strauss, John F. Curry, John A. Fairbank, Jennifer Runnals, and Jennifer VA Mid-Atlantic MIRECC Women Veterans Workgroup, VA Mid-Atlantic MIRECC Workgroup. “Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.” Drug Alcohol Depend 152 (July 1, 2015): 201–8. https://doi.org/10.1016/j.drugalcdep.2015.03.038.

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