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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Moore, S. D., S. G. Madamba, and G. R. Siggins. “Ethanol diminishes a voltage-dependent K+ current, the M-current, in CA1 hippocampal pyramidal neurons in vitro.” Brain Res 516, no. 2 (May 21, 1990): 222–28. https://doi.org/10.1016/0006-8993(90)90922-x.

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Joëls, M., S. G. Madamba, S. D. Moore, J. H. Morrison, and G. R. Siggins. “Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin.” Regul Pept 28, no. 2 (April 24, 1990): 215–21. https://doi.org/10.1016/0167-0115(90)90019-s.

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Moore, S. D., S. G. Madamba, W. Zieglgänsberger, and G. R. Siggins. “Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.” Neurosci Lett 91, no. 1 (August 15, 1988): 71–76. https://doi.org/10.1016/0304-3940(88)90251-0.

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Moore, S. D., S. G. Madamba, M. Joëls, and G. R. Siggins. “Somatostatin augments the M-current in hippocampal neurons.” Science 239, no. 4837 (January 15, 1988): 278–80. https://doi.org/10.1126/science.2892268.

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Moore, S. D., and P. G. Guyenet. “Effect of blood pressure on A2 noradrenergic neurons.” Brain Res 338, no. 1 (July 8, 1985): 169–72. https://doi.org/10.1016/0006-8993(85)90262-8.

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Moore, S. D., and P. G. Guyenet. “Alpha-receptor mediated inhibition of A2 noradrenergic neurons.” Brain Res 276, no. 1 (October 3, 1983): 188–91. https://doi.org/10.1016/0006-8993(83)90563-2.

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Levy, W. B., S. E. Brassel, and S. D. Moore. “Partial quantification of the associative synaptic learning rule of the dentate gyrus.” Neuroscience 8, no. 4 (April 1983): 799–808. https://doi.org/10.1016/0306-4522(83)90011-8.

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Moore, S. D., and P. G. Guyenet. “An electrophysiological study of the forebrain projection of nucleus commissuralis: preliminary identification of presumed A2 catecholaminergic neurons.” Brain Res 263, no. 2 (March 21, 1983): 211–22. https://doi.org/10.1016/0006-8993(83)90314-1.

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Dedert, Eric A., Patricia A. Resick, Paul A. Dennis, Sarah M. Wilson, Scott D. Moore, and Jean C. Beckham. “Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment.” J Addict Med 13, no. 4 (n.d.): 322–30. https://doi.org/10.1097/ADM.0000000000000502.

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