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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Adult Psychiatry & Psychology
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Graziano, Robert C., Frances M. Aunon, Stefanie T. LoSavio, Eric B. Elbogen, Jean C. Beckham, Jean C. VA Mid-Atlantic MIRECC Workgroup, and Kirsten H. Dillon. “A network analysis of risk factors for suicide in Iraq/Afghanistan-era veterans.” J Psychiatr Res 138 (June 2021): 264–71. https://doi.org/10.1016/j.jpsychires.2021.03.065.

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Dillon, Kirsten H., Elizabeth E. Van Voorhees, Eric B. Elbogen, Jean C. Beckham, Jean C. VA Mid-Atlantic MIRECC Workgroup, and Patrick S. Calhoun. “Cannabis use disorder, anger, and violence in Iraq/Afghanistan-era veterans.” J Psychiatr Res 138 (June 2021): 375–79. https://doi.org/10.1016/j.jpsychires.2021.04.018.

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Nieuwsma, Jason A., Mira Brancu, Jennifer Wortmann, Melissa A. Smigelsky, Heather A. King, Heather A. VISN 6 MIRECC Workgroup, and Keith G. Meador. “Screening for moral injury and comparatively evaluating moral injury measures in relation to mental illness symptomatology and diagnosis.” Clin Psychol Psychother 28, no. 1 (January 2021): 239–50. https://doi.org/10.1002/cpp.2503.

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Bjork, J. M., P. B. Perrin, M. Redae, L. A. Tupler, M. Brancu, J. C. Beckham, P. S. Calhoun, et al. “Warzone experiences and subsequent clinician suicide risk assessment in veterans.” Suicide and Life Threatening Behavior, January 1, 2021. https://doi.org/10.1111/sltb.12789.

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Smith, Alicia K., Andrew Ratanatharathorn, Adam X. Maihofer, Robert K. Naviaux, Allison E. Aiello, Ananda B. Amstadter, Allison E. Ashley-Koch, et al. “Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR.” Nat Commun 11, no. 1 (November 24, 2020): 5965. https://doi.org/10.1038/s41467-020-19615-x.

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Li, Qiang, Rebecca C. Klein, and Scott D. Moore. “Multiple sources of internal calcium stores mediate ethanol-induced presynaptic inhibitory GABA release in the central nucleus of the amygdala in mice.” Psychopharmacology (Berl) 237, no. 11 (November 2020): 3303–14. https://doi.org/10.1007/s00213-020-05613-w.

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Morey, Rajendra A., Courtney C. Haswell, Daniel Stjepanović, Daniel Mid-Atlantic MIRECC Workgroup, Joseph E. Dunsmoor, and Kevin S. LaBar. “Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.” Neuropsychopharmacology 45, no. 8 (July 2020): 1380–89. https://doi.org/10.1038/s41386-020-0661-8.

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Morey, Rajendra A., Emily K. Clarke, Courtney C. Haswell, Rachel D. Phillips, Ashley N. Clausen, Mary S. Mufford, Zeynep Saygin, Zeynep VA Mid-Atlantic MIRECC Workgroup, H Ryan Wagner, and Kevin S. LaBar. “Amygdala Nuclei Volume and Shape in Military Veterans With Posttraumatic Stress Disorder.” Biol Psychiatry Cogn Neurosci Neuroimaging 5, no. 3 (March 2020): 281–90. https://doi.org/10.1016/j.bpsc.2019.11.016.

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Sun, Delin, Andrea L. Gold, Chelsea A. Swanson, Courtney C. Haswell, Vanessa M. Brown, Daniel Stjepanovic, Daniel VA Mid-Atlantic MIRECC Workgroup, Kevin S. LaBar, and Rajendra A. Morey. “Threat-induced anxiety during goal pursuit disrupts amygdala-prefrontal cortex connectivity in posttraumatic stress disorder.” Transl Psychiatry 10, no. 1 (February 10, 2020): 61. https://doi.org/10.1038/s41398-020-0739-4.

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Naylor, Jennifer C., H Ryan Wagner, Cynthia Johnston, Eric E. Elbogen, Mira Brancu, Christine E. Marx, Christine E. VA Mid-Atlantic MIRECC Work Group, Christine E. VA Mid-Atlantic MIRECC Women Veterans Work Group, and Jennifer L. Strauss. “Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans.” Womens Health Issues 29 Suppl 1 (June 25, 2019): S24–31. https://doi.org/10.1016/j.whi.2019.04.015.

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