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Scott Daniel Moore, MD, PhD

Professor of Psychiatry and Behavioral Sciences
Division: 
Addiction
Category: 
Office: 116A VA Med Ctr, 508 Fulton St, Durham, NC 27705
Campus Mail: DUMC Box 3309 Med Ctr, Durham, NC 27710

We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.

We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.

Education and Training

  • Ph.D., University of Virginia, 1986
  • M.D., University of Virginia, 1986

Publications

Li, Qiang, Rebecca C. Klein, and Scott D. Moore. “Multiple sources of internal calcium stores mediate ethanol-induced presynaptic inhibitory GABA release in the central nucleus of the amygdala in mice.” Psychopharmacology (Berl) 237, no. 11 (November 2020): 3303–14. https://doi.org/10.1007/s00213-020-05613-w.

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Morey, Rajendra A., Courtney C. Haswell, Daniel Stjepanović, Daniel Mid-Atlantic MIRECC Workgroup, Joseph E. Dunsmoor, and Kevin S. LaBar. “Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.” Neuropsychopharmacology 45, no. 8 (July 2020): 1380–89. https://doi.org/10.1038/s41386-020-0661-8.

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Morey, Rajendra A., Emily K. Clarke, Courtney C. Haswell, Rachel D. Phillips, Ashley N. Clausen, Mary S. Mufford, Zeynep Saygin, Zeynep VA Mid-Atlantic MIRECC Workgroup, H Ryan Wagner, and Kevin S. LaBar. “Amygdala Nuclei Volume and Shape in Military Veterans With Posttraumatic Stress Disorder.” Biol Psychiatry Cogn Neurosci Neuroimaging 5, no. 3 (March 2020): 281–90. https://doi.org/10.1016/j.bpsc.2019.11.016.

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Sun, Delin, Andrea L. Gold, Chelsea A. Swanson, Courtney C. Haswell, Vanessa M. Brown, Daniel Stjepanovic, Daniel VA Mid-Atlantic MIRECC Workgroup, Kevin S. LaBar, and Rajendra A. Morey. “Threat-induced anxiety during goal pursuit disrupts amygdala-prefrontal cortex connectivity in posttraumatic stress disorder.” Transl Psychiatry 10, no. 1 (February 10, 2020): 61. https://doi.org/10.1038/s41398-020-0739-4.

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Naylor, Jennifer C., H Ryan Wagner, Cynthia Johnston, Eric E. Elbogen, Mira Brancu, Christine E. Marx, Christine E. VA Mid-Atlantic MIRECC Work Group, Christine E. VA Mid-Atlantic MIRECC Women Veterans Work Group, and Jennifer L. Strauss. “Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans.” Womens Health Issues 29 Suppl 1 (June 25, 2019): S24–31. https://doi.org/10.1016/j.whi.2019.04.015.

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Landin, Justine D., Magdalena Palac, Jenna M. Carter, Yvette Dzumaga, Jessica L. Santerre-Anderson, Gina M. Fernandez, Lisa M. Savage, et al. “General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.” Neuropharmacology 150 (May 15, 2019): 153–63. https://doi.org/10.1016/j.neuropharm.2019.03.022.

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Shura, Robert D., Sarra Nazem, Holly M. Miskey, Trisha A. Hostetter, Jared A. Rowland, Lisa A. Brenner, Lisa A. Va Mid-Atlantic Mirecc Workgroup, and Katherine H. Taber. “Relationship between traumatic brain injury history and recent suicidal ideation in Iraq/Afghanistan-era veterans.” Psychol Serv 16, no. 2 (May 2019): 312–20. https://doi.org/10.1037/ser0000208.

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Wilson, Sarah M., Alexandra C. Thompson, Emily D. Currence, Shaun P. Thomas, Eric A. Dedert, Angela C. Kirby, Eric B. Elbogen, Scott D. Moore, Patrick S. Calhoun, and Jean C. Beckham. “Patient-Informed Treatment Development of Behavioral Smoking Cessation for People With Schizophrenia.” Behav Ther 50, no. 2 (March 2019): 395–409. https://doi.org/10.1016/j.beth.2018.07.004.

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Sheerin, Christina M., Ananda B. Amstadter, Erin D. Kurtz, Kaitlin E. Bountress, Kelcey J. Stratton, Scott D. McDonald, and Scott D. Mid-Atlantic Va Mirecc Workgroup. “The association of resilience on psychiatric, substance use, and physical health outcomes in combat trauma-exposed military service members and veterans.” Eur J Psychotraumatol 10, no. 1 (2019): 1625700. https://doi.org/10.1080/20008198.2019.1625700.

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Martindale, Sarah L., Erica L. Epstein, Katherine H. Taber, Katherine H. VA Mid-Atlantic MIRECC Workgroup, and Jared A. Rowland. “Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans.” Arch Phys Med Rehabil 99, no. 12 (December 2018): 2485–95. https://doi.org/10.1016/j.apmr.2018.04.029.

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