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P. Murali Doraiswamy, MBBS

Professor of Psychiatry and Behavioral Sciences
Professor in Medicine
Division: 
Behavioral Medicine & Neurosciences
Category: 
Office: 3550 Hosp South, Durham, NC 27710
Campus Mail: DUMC DUMC - 3018, Durham, NC 27710

Murali Doraiswamy MBBS FRCP is Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine where he is a highly cited physician scientist at the Duke Institute for Brain Sciences.  He is also a Senior Fellow at the Duke Center for the Study of Aging and an Affiliate Faculty at the Duke Center for Precision Medicine and Applied Genomics as well as the Duke Microbiome Center.  He directs a clinical trials unit that has been involved in the development of many modern diagnostic tests, apps, algorithms, and therapeutics in wide use today.  Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups including the NIH, FDA, and WHO as well as numerous life science companies. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and co-chaired the innovation advisory council for one of the world’s largest social impact funds dedicated to promoting innovative solutions to reverse age related disorders.  He has lectured at leading global forums to advance the forefront of aging and neuroscience research.  Moreover as an investigator on numerous landmark trials and co-author on more than 400 publications, he has received several awards in recognition of his scientific work.  Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain. He is the co-author of a popular book The Alzheiemr's Action Plan. Prof. Doraiswamy also serves on the board of several global charities.  

  

Education and Training

  • M.B.B.S., University of Madras (India), 1987

Selected Grants

Publications

Motter, Jeffrey N., Seonjoo Lee, Joel R. Sneed, P Murali Doraiswamy, Gregory H. Pelton, Jeffrey R. Petrella, and D. P. Devanand. “Cortical thickness predicts remission of depression with antidepressants in patients with late-life depression and cognitive impairment.” J Affect Disord 295 (December 1, 2021): 438–45. https://doi.org/10.1016/j.jad.2021.08.062.

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Wang, QuanQiu, Pamela B. Davis, Xin Qi, Shu G. Chen, Mark E. Gurney, George Perry, P Murali Doraiswamy, and Rong Xu. “Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization.” Alzheimer’S Research & Therapy 13, no. 1 (October 20, 2021): 177. https://doi.org/10.1186/s13195-021-00917-1.

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Grzesiak, Emilia, Brinnae Bent, Micah T. McClain, Christopher W. Woods, Ephraim L. Tsalik, Bradly P. Nicholson, Timothy Veldman, et al. “Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset.” Jama Netw Open 4, no. 9 (September 1, 2021): e2128534. https://doi.org/10.1001/jamanetworkopen.2021.28534.

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Occhipinti, Jo-An, Adam Skinner, P Murali Doraiswamy, Cameron Fox, Helen Herrman, Shekhar Saxena, Elisha London, Yun Ju Christine Song, and Ian B. Hickie. “Mental health: build predictive models to steer policy.” Nature 597, no. 7878 (September 2021): 633–36. https://doi.org/10.1038/d41586-021-02581-9.

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Califf, Robert M., Celeste Wong, P Murali Doraiswamy, David S. Hong, David P. Miller, Jessica L. Mega, and Jessica L. Baseline Study Group. “Importance of Social Determinants in Screening for Depression.” Journal of General Internal Medicine, August 17, 2021. https://doi.org/10.1007/s11606-021-06957-5.

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James, Olga G., Alexandra R. Linares, Caroline Hellegers, P Murali Doraiswamy, and Terence Z. Wong. “Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.” Clin Nucl Med 46, no. 7 (July 1, 2021): 605–8. https://doi.org/10.1097/RLU.0000000000003493.

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Hu, William T., Tugba Ozturk, Alexander Kollhoff, Whitney Wharton, J. Christina Howell, and J. Alzheimer’s Disease Neuroimaging Initiative. “Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.” Nat Commun 12, no. 1 (June 28, 2021): 4001. https://doi.org/10.1038/s41467-021-24220-7.

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Doraiswamy, P Murali, Mohan M. Chilukuri, Dan Ariely, and Alexandra R. Linares. “Physician Perceptions of Catching COVID-19: Insights from a Global Survey.” J Gen Intern Med 36, no. 6 (June 2021): 1832–34. https://doi.org/10.1007/s11606-021-06724-6.

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Baumel, Barry S., P Murali Doraiswamy, Marwan Sabbagh, and Richard Wurtman. “Potential Neuroregenerative and Neuroprotective Effects of Uridine/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review.” Neurol Ther 10, no. 1 (June 2021): 43–60. https://doi.org/10.1007/s40120-020-00227-y.

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Lu, Ming, Michael J. Pontecorvo, Michael D. Devous, Anupa K. Arora, Nicholas Galante, Anne McGeehan, Catherine Devadanam, et al. “Aggregated Tau Measured by Visual Interpretation of Flortaucipir Positron Emission Tomography and the Associated Risk of Clinical Progression of Mild Cognitive Impairment and Alzheimer Disease: Results From 2 Phase III Clinical Trials.” Jama Neurol 78, no. 4 (April 1, 2021): 445–53. https://doi.org/10.1001/jamaneurol.2020.5505.

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