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Li-Tzy Wu, MA, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Child & Family Mental Health & Community Psychiatry
Office: Duke South Hospital, Rm 3521, Box 3903, Durham, NC 27710
Campus Mail: DUMC Duke University Medical Center, Psychiatry Box 3903, Durham, NC 27710

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.

Research interests: COVID-19, Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior. 

FUNDED Research projects (Principal Investigator: PI, Site PI, or Subaward PI): 
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA, PI).
UG1: NIDA CTN Mid-Southern Node (Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Site PI).
CDC R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward PI, Investigator).
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (NIDA supplement, CTN-0101, Investigator).
NIDA: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI).
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, NIDA, PI).
UG1: NorthStar Node of the Clinical Trials Network (NIDA, Site PI).
R34: Intervention Development and Pilot Study to Reduce Untreated Native Hawaiian and Pacific Islander Opioid Use Disorders (Subaward PI, Investigator).

Committee member of the NIDA Asian American and Pacific Islander Researchers and Scholars Workgroup (NIDA AAPI Workgroup).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York, New Paltz, 1992


Subica, Andrew M., Erick G. Guerrero, Phong Hong, Nia Aitaoto, Howard B. Moss, Derek K. Iwamoto, and Li-Tzy Wu. “Alcohol Use Disorder Risk and Protective Factors and Associated Harms Among Pacific Islander Young Adults.” J Racial Ethn Health Disparities, August 10, 2021.

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Wu, Li-Tzy, William S. John, Eric D. Morse, Steve Adkins, Jennifer Pippin, Robert K. Brooner, and Robert P. Schwartz. “Opioid treatment program and community pharmacy collaboration for methadone maintenance treatment: results from a feasibility clinical trial.” Addiction, July 19, 2021.

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Wu, Li-Tzy, William S. John, Udi E. Ghitza, Aimee Wahle, Abigail G. Matthews, Mitra Lewis, Brett Hart, et al. “Buprenorphine physician-pharmacist collaboration in the management of patients with opioid use disorder: results from a multisite study of the National Drug Abuse Treatment Clinical Trials Network.” Addiction 116, no. 7 (July 2021): 1805–16.

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John, William S., He Zhu, Lawrence H. Greenblatt, and Li-Tzy Wu. “Recent and active problematic substance use among primary care patients: Results from the alcohol, smoking, and substance involvement screening test in a multisite study.” Subst Abus, April 2, 2021, 1–6.

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Bobashev, Georgiy, Lauren Warren, and Li-Tzy Wu. “Predictive model of multiple emergency department visits among adults: analysis of the data from the National Survey of Drug Use and Health (NSDUH).” Bmc Health Serv Res 21, no. 1 (March 25, 2021): 280.

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Von Gunten, Curtis D., and Li-Tzy Wu. “Comorbid Substance Use Disorder Profiles and Receipt of Substance Use Disorder Treatment Services: A National Study.” J Stud Alcohol Drugs 82, no. 2 (March 2021): 246–56.


Karnik, Niranjan S., Cynthia I. Campbell, Megan E. Curtis, David A. Fiellin, Udi Ghitza, Kathryn Hefner, Yih-Ing Hser, et al. “Core outcomes set for research on the treatment of opioid use disorder (COS-OUD): the National Institute on Drug Abuse Clinical Trials Network protocol for an e-Delphi consensus study.” Trials 22, no. 1 (January 28, 2021): 102.

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Wu, Li-Tzy. “Substance Use and Misuse in Older Adults: A Need for Research and Intervention.” The Gerontologist 60, no. 6 (August 14, 2020): 1184–85.

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Zhu, He, and Li-Tzy Wu. “Multiple drug use disorder diagnoses among drug-involved hospitalizations in the United States: Results from the 2016 National Inpatient Sample.” Drug Alcohol Depend 213 (June 12, 2020): 108113.

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Carmona, Jasmin, Jane Carlisle Maxwell, Ji-Yeun Park, and Li-Tzy Wu. “Prevalence and Health Characteristics of Prescription Opioid Use, Misuse, and Use Disorders Among U.S. Adolescents.” J Adolesc Health 66, no. 5 (May 2020): 536–44.

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