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Li-Tzy Wu, MA, DSc

Professor in Psychiatry and Behavioral Sciences
Professor in Medicine
Division: 
Social and Community Psychiatry
Category: 
Office: Duke South Hospital, Rm 3521, Box 3903, Durham, NC 27710
Campus Mail: DUMC Duke University Medical Center, Psychiatry Box 3903, Durham, NC 27710

Education/Training: Pre- and post-doctoral training in mental health service research, psychiatric epidemiology (NIMH T32), and addiction epidemiology (NIDA T32) from Johns Hopkins University School of Public Health (Maryland); Fellow of the NIH Summer Institute on the Design and Conduct of Randomized Clinical Trials.

Director: Duke Community Based Substance Use Disorder Research Program.

Research interests: COVID-19, Opioid misuse, Opioid overdose, Opioid use disorder, Opioid addiction prevention and treatment, Pain and addiction, Chronic diseases and substance use disorders, diabetes, pharmacy-based care models and services, medication treatment for opioid use disorder (MOUD), Drug overdose, Polysubstance use and disorders, cannabis, alcohol, tobacco, hallucinogens, stimulants, e-cigarette, SBIRT (substance use Screening, Brief Intervention, Referral to Treatment), EHR-based research and intervention, data science, psychometric analysis (IRT), epidemiology of addictions and comorbidity, behavioral health care integration, health services research (mental health disorders, substance use disorders, chronic diseases), nosology, research design, HIV risk behavior. 

FUNDED Research projects (Principal Investigator: PI, Site PI, or Subaward PI): 
R03: Substance use/dependence (PI).
R21: Treatment use for alcohol use disorders (PI).
R21: Inhalant use & disorders (PI).
R01: MDMA/hallucinogen use/disorders (PI).
R01: Prescription pain reliever (opioids) misuse and use disorders (PI).
R01: Substance use disorders in adolescents (PI).
R21: CTN Substance use diagnoses & treatment (PI).
R33: CTN Substance use diagnoses & treatment (PI).
R01: Evolution of Psychopathology in the Population (ECA Duke site PI).
R01: Substance use disorders and treatment use among Asian Americans and Pacific Islanders (PI).
UG1: SBIRT in Primary Care (NIDA CTN-0057, PI).
UG1: TAPS Tool, Substance use screening tool validation in primary care (NIDA CTN-0059, PI).
UG1: CAMP, Computer-facilitated intervention for adolescent marijuana use prevention (NIDA CTN-0060, PI).
UG1: NIDA CTN Mid-Southern Node (Clinical Trials Network, PI).
UG1: EHR Data Element Study (NIDA CTN-0071, PI).
UG1: Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder (NIDA CTN-0075, PI).
PCORI: INSPIRE-Integrated Health Services to Reduce Opioid Use While Managing Chronic Pain (Duke Site PI).
R01: Evaluation of state-mandated acute and post-surgical pain-specific CDC opioid prescribing (Duke Site PI).
Pilot: Measuring Opioid Use Disorders in Secondary Electronic Health Records Data (Carolinas Collaborative Grant: Duke PI).
R21: Developing a prevention model of alcohol use disorder for Pacific Islander young adults (Subaward to Wu, Investigator).
UG1: Medication Treatment for Opioid-dependent Expecting Mothers: A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations (supplement for study site, NIDA CTN-0080)
UG1: Subthreshold Opioid Use Disorder Prevention Trial (NIH HEAL Initiative) (supplement, CTN-0101, Investigator)
NIDA: A Pilot Study to Permit Opioid Treatment Program Physicians to Prescribe Methadone through Community Pharmacies for their Stable Methadone Patients (NIDA/FRI: Study PI)
UG1: Integrating pharmacy-based prevention and treatment of opioid and other substance use disorders: A survey of pharmacists and stakeholder (NIH HEAL Initiative, CTN-0105, PI)
UG1: COMPUTE 2.0: Clinic-Randomized Trial of Clinical Decision Support for Opioid Use Disorders in Medical Settings (NIH HEAL Initiative, CTN-0095 Site PI)

Committee member of the NIDA Asian American and Pacific Islander Researchers and Scholars Workgroup (NIDA AAPI Workgroup).

Education and Training

  • D.Sc., Johns Hopkins University, 1997
  • M.A., State University of New York, New Paltz, 1992

Publications

Bobashev, Georgiy, Lauren Warren, and Li-Tzy Wu. “Predictive model of multiple emergency department visits among adults: analysis of the data from the National Survey of Drug Use and Health (NSDUH).” Bmc Health Serv Res 21, no. 1 (March 25, 2021): 280. https://doi.org/10.1186/s12913-021-06221-w.

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Karnik, Niranjan S., Cynthia I. Campbell, Megan E. Curtis, David A. Fiellin, Udi Ghitza, Kathryn Hefner, Yih-Ing Hser, et al. “Core outcomes set for research on the treatment of opioid use disorder (COS-OUD): the National Institute on Drug Abuse Clinical Trials Network protocol for an e-Delphi consensus study.” Trials 22, no. 1 (January 28, 2021): 102. https://doi.org/10.1186/s13063-021-05051-9.

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Wu, Li-Tzy, William S. John, Udi E. Ghitza, Aimee Wahle, Abigail G. Matthews, Mitra Lewis, Brett Hart, et al. “Buprenorphine physician-pharmacist collaboration in the management of patients with opioid use disorder: results from a multisite study of the National Drug Abuse Treatment Clinical Trials Network.” Addiction, January 11, 2021. https://doi.org/10.1111/add.15353.

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Wu, Li-Tzy. “Substance Use and Misuse in Older Adults: A Need for Research and Intervention.” The Gerontologist 60, no. 6 (August 14, 2020): 1184–85. https://doi.org/10.1093/geront/gnaa049.

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Zhu, He, and Li-Tzy Wu. “Multiple drug use disorder diagnoses among drug-involved hospitalizations in the United States: Results from the 2016 National Inpatient Sample.” Drug Alcohol Depend 213 (June 12, 2020): 108113. https://doi.org/10.1016/j.drugalcdep.2020.108113.

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Carmona, Jasmin, Jane Carlisle Maxwell, Ji-Yeun Park, and Li-Tzy Wu. “Prevalence and Health Characteristics of Prescription Opioid Use, Misuse, and Use Disorders Among U.S. Adolescents.” J Adolesc Health 66, no. 5 (May 2020): 536–44. https://doi.org/10.1016/j.jadohealth.2019.11.306.

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John, William S., and Li-Tzy Wu. “Chronic non-cancer pain among adults with substance use disorders: Prevalence, characteristics, and association with opioid overdose and healthcare utilization.” Drug Alcohol Depend 209 (April 1, 2020): 107902. https://doi.org/10.1016/j.drugalcdep.2020.107902.

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Nordeck, Courtney D., Jan Gryczynski, Kevin E. O’Grady, Kathryn Polak, Dace S. Svikis, Jennifer McNeely, Li-Tzy Wu, and Robert P. Schwartz. “Comparison of timeline follow-back self-report and oral fluid testing to detect substance use in adult primary care patients.” Drug Alcohol Depend 209 (April 1, 2020): 107939. https://doi.org/10.1016/j.drugalcdep.2020.107939.

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Wu, Li-Tzy, Elizabeth H. Payne, Kimberly Roseman, Ashley Case, Casey Nelson, and Robert Lindblad. “Using a health information technology survey to explore the availability of addiction treatment data in the electronic health records: A National Drug Abuse Treatment Clinical Trials Network study.” J Subst Abuse Treat 112S (March 2020): 56–62. https://doi.org/10.1016/j.jsat.2020.01.015.

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John, William S., Kiran Grover, Lawrence H. Greenblatt, Robert P. Schwartz, and Li-Tzy Wu. “E-Cigarette Use Among Adult Primary Care Patients: Results from a Multisite Study.” J Gen Intern Med 35, no. 1 (January 2020): 268–75. https://doi.org/10.1007/s11606-019-05488-4.

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