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John Calvin Barefoot, PhD

Professor Emeritus of Psychiatry and Behavioral Sciences
Division: 
Behavioral Medicine
Category: 
Office: 2212 Elder Street, Box 2969, Durham, NC 27710
Campus Mail: DUMC Box 2969 Med Ctr, Durham, NC 27710

Psychosocial factors such as hostility, depression, social isolation, and social status have been shown to play an important role in health, especially cardiovascular health. My research is devoted to the documentation of these effects and the biological mechanisms involved. Epidemiologic methods have been used to examine the roles of psychosocial factors in the development of cardiovascular disease and other health outcomes. The importance of psychosocial factors for the prognosis of pateints with existing coronary artery disease has been examined in a sample of 1500 patients who were assessed between 1974 and 1980 and who have been followed since then. Laboratory studies have evaluated the cardiovascular responses to the induction of emotion in volunteers with different personality profiles. Special attention has been given to the process of psychological assessment, including the refinement of existing questionnaire measures and the development of observational methods for the assessment of hostility from behavior.

Much of the work has investigated the adverse health consequences of high levels of hostility and differences in the nature of hostility across age groups. Recently, the health impact of chronic depressive affect has been an area of particular interest as well. This is being studied in a 30-year longitudinal study of older people in Denmark and in the sample of Duke cardiac patients that we have been following for 20 years. A natural extension is the investigation of the joint impact of both high hostility and high depression in individuals invarious age and socioeconomic groups.

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 1968

Publications

Fanaroff, Alexander C., Kristi Prather, Amanda Brucker, Daniel Wojdyla, Linda Davidson-Ray, Daniel B. Mark, Redford B. Williams, et al. “Relationship Between Optimism and Outcomes in Patients With Chronic Angina Pectoris.” Am J Cardiol 123, no. 9 (May 1, 2019): 1399–1405. https://doi.org/10.1016/j.amjcard.2019.01.036.

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Boyle, Stephen H., Beverly H. Brummett, Cynthia M. Kuhn, John C. Barefoot, Ilene C. Siegler, Redford B. Williams, and Anastasia Georgiades. “The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.” Psychosom Med 81, no. 1 (January 2019): 34–40. https://doi.org/10.1097/PSY.0000000000000637.

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Barefoot, John C., Morten Grønbaek, Gorm Jensen, Peter Schnohr, and Eva Prescott. “Social network diversity and risks of ischemic heart disease and total mortality: findings from the Copenhagen City Heart Study.” Am J Epidemiol 161, no. 10 (May 15, 2005): 960–67. https://doi.org/10.1093/aje/kwi128.

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Barefoot, John C., Matthew M. Burg, Robert M. Carney, Carol E. Cornell, Susan M. Czajkowski, Kenneth E. Freedland, James D. Hosking, Parinda Khatri, Carol Rogers Pitula, and David Sheps. “Aspects of social support associated with depression at hospitalization and follow-up assessment among cardiac patients.” J Cardiopulm Rehabil 23, no. 6 (November 2003): 404–12. https://doi.org/10.1097/00008483-200311000-00002.

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Barefoot, John C., Morten Grønbaek, John R. Feaganes, R Sue McPherson, Redford B. Williams, and Ilene C. Siegler. “Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study.” Am J Clin Nutr 76, no. 2 (August 2002): 466–72. https://doi.org/10.1093/ajcn/76.2.466.

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Barefoot, J. C., E. L. Mortensen, M. J. Helms, K. Avlund, and M. Schroll. “A longitudinal study of gender differences in depressive symptoms from age 50 to 80.” Psychol Aging 16, no. 2 (June 2001): 342–45. https://doi.org/10.1037//0882-7974.16.2.342.

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Barefoot, J. C., B. H. Brummett, M. J. Helms, D. B. Mark, I. C. Siegler, and R. B. Williams. “Depressive symptoms and survival of patients with coronary artery disease.” Psychosom Med 62, no. 6 (November 2000): 790–95. https://doi.org/10.1097/00006842-200011000-00008.

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Barefoot, J. C., B. H. Brummett, N. E. Clapp-Channing, I. C. Siegler, P. P. Vitaliano, R. B. Williams, and D. B. Mark. “Moderators of the effect of social support on depressive symptoms in cardiac patients.” Am J Cardiol 86, no. 4 (August 15, 2000): 438–42. https://doi.org/10.1016/s0002-9149(00)00961-9.

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Barefoot, J. C., and M. Schroll. “Symptoms of depression, acute myocardial infarction, and total mortality in a community sample.” Circulation 93, no. 11 (June 1, 1996): 1976–80. https://doi.org/10.1161/01.cir.93.11.1976.

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