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Edward Daniel Levin, PhD

Professor in Psychiatry and Behavioral Sciences
Professor in the Environmental Sciences and Policy Division
Associate Professor of Pharmacology & Cancer Biology
Professor of Psychology and Neuroscience
Office: 323 Foster St, Durham, NC 27701
Campus Mail: DUMC Box 104790, Durham, NC 27710

Dr. Levin is Chief of the Neurobehavioral Research Lab in the Psychiatry Department of Duke University Medical Center. His primary academic appointment is as Professor in the Department of Psychiatry and Behavioral Sciences. He also has secondary appointments in the Department Pharmacology and Cancer Biology, the Department of Psychological and Brain Sciences and the Nicholas School of the Environment at Duke. His primary research effort is to understand basic neural interactions underlying cognitive function and addiction and to apply this knowledge to better understand cognitive dysfunction and addiction disorders and to develop novel therapeutic treatments.

The three main research components of his laboratory are focused on the themes of the basic neurobiology of cognition and addiction, neurobehavioral toxicology and the development of novel therapeutic treatments for cognitive dysfunction and substance abuse. Currently, our principal research focus concerns nicotine. We have documented the basic effects of nicotine on learningm memory and attention as well as nicotine self-administration. We are continuing with more mechanistic studies in rat models using selective lesions, local infusions and neurotransmitter interaction studies. We have found that nicotine improves memory performance not only in normal rats, but also in rats with lesions of hippocampal and basal forebrain connections. We are concentrating on alpha7 and alpha4beta2 nicotinic receptor subtypes in the hippocampus, amygdala , thalamus and frontal cortex and how they interact with dopamine D1 and D2 and glutamate NMDA systems with regard to memory and addiction. I am also conducting studies on human cognitive behavior. We have current studies to assess nicotine effects on attention, memory and mental processing speed in schizophrenics, Alzheimer's Disease patients and people with Attention Deficit Hyperactivity Disorder. In the area of neurobehavioral toxicology, I have continuing projects to characterize the adverse effects of prenatal and adolescent nicotine exposure. Our primary project in neurobehavioral toxicology focuses on the cognitive deficits caused by the marine toxins including domoic acid, ciguatera toxin and pfiesteria. We have documented a persistent neurobehavioral effects caused by Pfiesteria and domoic acid exposure. We are determining the neurobehavioral nature and mechanisms of this deficit. The basic and applied aims of our research complement each other nicely. The findings concerning neural mechanisms underlying cognitive function help direct the behavioral toxicology and therapeutic development studies, while the applied studies provide important functional information concerning the importance of the basic mechanisms under investigation.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 1984

Selected Grants


Rezvani, A. H., E. D. Levin, M. P. Arolfo, C. Wells, M. Graupe, and I. Diamond. “Inhibition of aldehyde dehydrogenase-2 (ALDH-2) suppresses nicotine self-administration in rats.” Journal of Drug and Alcohol Research 4 (January 1, 2015).

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Burke, Dennis A., Pooneh Heshmati, Ehsan Kholdebarin, and Edward D. Levin. “Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats.” Eur J Pharmacol 741 (October 15, 2014): 132–39.

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Rezvani, Amir H., and Edward D. Levin. “Assessment of pregnenolone effects on alcohol intake and preference in male alcohol preferring (P) rats.” In Eur J Pharmacol, 740:53–57, 2014.

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Cousins, Vanessa, Jed E. Rose, and Edward D. Levin. “IV nicotine self-administration in rats using a consummatory operant licking response: sensitivity to serotonergic, glutaminergic and histaminergic drugs.” Prog Neuropsychopharmacol Biol Psychiatry 54 (October 3, 2014): 200–205.

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Levin, Edward D., Ian Hao, Dennis A. Burke, Marty Cauley, Brandon J. Hall, and Amir H. Rezvani. “Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats.” J Psychopharmacol 28, no. 10 (October 2014): 915–22.

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Rezvani, Amir H., Marty C. Cauley, and Edward D. Levin. “Lorcaserin, a selective 5-HT(2C) receptor agonist, decreases alcohol intake in female alcohol preferring rats.” Pharmacol Biochem Behav 125 (October 2014): 8–14.

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Zhang, C., J. M. Bailey, A. N. Oliveri, J. Frazier, A. Delarosa, E. Crosby, S. Janardhan, S. Mackinnon, E. D. Levin, and G. J. Cole. “LONG-TERM BEHAVIORAL EFFECTS OF EMBRYONIC ETHANOL EXPOSURE IN ZEBRAFISH.” In Alcoholism Clinical and Experimental Research, 38:176A-176A. WILEY-BLACKWELL, 2014.


Hall, Brandon J., Corinne Wells, Cheyenne Allenby, Mung Yan Lin, Ian Hao, Lindsey Marshall, Jed E. Rose, and Edward D. Levin. “Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats.” Pharmacol Biochem Behav 120 (May 2014): 103–8.

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Slotkin, Theodore A., Jennifer Card, Ashley Stadler, Edward D. Levin, and Frederic J. Seidler. “Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene.” Neurotoxicol Teratol 43 (May 2014): 19–24.

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Cauley, M., D. Burke, B. J. Hall, F. J. Seidler, T. A. Slotkin, and E. D. Levin. “Sex-selective interaction of prenatal nicotine with neonatal chlorpyrifos on novel object recognition in rats.” In Neurotoxicology and Teratology, 43:88–89. Elsevier BV, 2014.

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