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Edward Daniel Levin, PhD

Professor in Psychiatry and Behavioral Sciences
Professor in the Environmental Sciences and Policy Division
Associate Professor of Pharmacology & Cancer Biology
Professor of Psychology and Neuroscience
Division: 
Addiction
Category: 
Office: 323 Foster St, Durham, NC 27701
Campus Mail: DUMC Box 104790, Durham, NC 27710

Dr. Levin is Chief of the Neurobehavioral Research Lab in the Psychiatry Department of Duke University Medical Center. His primary academic appointment is as Professor in the Department of Psychiatry and Behavioral Sciences. He also has secondary appointments in the Department Pharmacology and Cancer Biology, the Department of Psychological and Brain Sciences and the Nicholas School of the Environment at Duke. His primary research effort is to understand basic neural interactions underlying cognitive function and addiction and to apply this knowledge to better understand cognitive dysfunction and addiction disorders and to develop novel therapeutic treatments.

The three main research components of his laboratory are focused on the themes of the basic neurobiology of cognition and addiction, neurobehavioral toxicology and the development of novel therapeutic treatments for cognitive dysfunction and substance abuse. Currently, our principal research focus concerns nicotine. We have documented the basic effects of nicotine on learningm memory and attention as well as nicotine self-administration. We are continuing with more mechanistic studies in rat models using selective lesions, local infusions and neurotransmitter interaction studies. We have found that nicotine improves memory performance not only in normal rats, but also in rats with lesions of hippocampal and basal forebrain connections. We are concentrating on alpha7 and alpha4beta2 nicotinic receptor subtypes in the hippocampus, amygdala , thalamus and frontal cortex and how they interact with dopamine D1 and D2 and glutamate NMDA systems with regard to memory and addiction. I am also conducting studies on human cognitive behavior. We have current studies to assess nicotine effects on attention, memory and mental processing speed in schizophrenics, Alzheimer's Disease patients and people with Attention Deficit Hyperactivity Disorder. In the area of neurobehavioral toxicology, I have continuing projects to characterize the adverse effects of prenatal and adolescent nicotine exposure. Our primary project in neurobehavioral toxicology focuses on the cognitive deficits caused by the marine toxins including domoic acid, ciguatera toxin and pfiesteria. We have documented a persistent neurobehavioral effects caused by Pfiesteria and domoic acid exposure. We are determining the neurobehavioral nature and mechanisms of this deficit. The basic and applied aims of our research complement each other nicely. The findings concerning neural mechanisms underlying cognitive function help direct the behavioral toxicology and therapeutic development studies, while the applied studies provide important functional information concerning the importance of the basic mechanisms under investigation.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 1984

Selected Grants

Publications

Bailey, Jordan M., Anthony N. Oliveri, and Edward D. Levin. “Pharmacological analyses of learning and memory in zebrafish (Danio rerio).” Pharmacol Biochem Behav 139 Pt B (December 2015): 103–11. https://doi.org/10.1016/j.pbb.2015.03.006.

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Oliveri, A. N., J. M. Bailey, and E. D. Levin. “Developmental exposure to organophosphate flame retardants causes behavioral effects in larval and adult zebrafish.” Neurotoxicol Teratol 52, no. Pt B (November 2015): 220–27. https://doi.org/10.1016/j.ntt.2015.08.008.

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Levin, Edward D. “Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery.” Neurotoxicol Teratol 52, no. Pt A (November 2015): 88–92. https://doi.org/10.1016/j.ntt.2015.05.007.

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Bailey, J. M., and E. D. Levin. “Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures.” Neurotoxicol Teratol 52, no. Pt B (November 2015): 210–19. https://doi.org/10.1016/j.ntt.2015.07.001.

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Macaulay, Laura J., Jordan M. Bailey, Edward D. Levin, and Heather M. Stapleton. “Persisting effects of a PBDE metabolite, 6-OH-BDE-47, on larval and juvenile zebrafish swimming behavior.” Neurotoxicol Teratol 52, no. Pt B (November 2015): 119–26. https://doi.org/10.1016/j.ntt.2015.05.002.

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Levin, Edward D., Corinne Wells, Joshua E. Johnson, Amir H. Rezvani, Frank P. Bymaster, and Jed E. Rose. “Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats.” Eur J Pharmacol 764 (October 5, 2015): 30–37. https://doi.org/10.1016/j.ejphar.2015.06.041.

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Levin, Edward D., Amir H. Rezvani, Yingxian Xiao, Venkata M. Yenugonda, Milton L. Brown, and Kenneth J. Kellar. “Nicotinic treatments not only for tobacco, but also other addictions.” In Biochemical Pharmacology, 97:635–635. Elsevier BV, 2015. https://doi.org/10.1016/j.bcp.2015.08.040.

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Slotkin, Theodore A., Samantha Skavicus, Jennifer Card, Ashley Stadler, Edward D. Levin, and Frederic J. Seidler. “Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine.” Toxicol Sci 147, no. 1 (September 2015): 178–89. https://doi.org/10.1093/toxsci/kfv123.

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Massarsky, Andrey, Nishad Jayasundara, Jordan M. Bailey, Anthony N. Oliveri, Edward D. Levin, G. L. Prasad, and Richard T. Di Giulio. “Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine.” Neurotoxicol Teratol 51 (September 2015): 77–88. https://doi.org/10.1016/j.ntt.2015.09.006.

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Larrauri, José A., Dennis A. Burke, Brandon J. Hall, and Edward D. Levin. “Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats.” Psychopharmacology (Berl) 232, no. 16 (August 2015): 3009–17. https://doi.org/10.1007/s00213-015-3940-z.

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