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Edward Daniel Levin, PhD

Professor in Psychiatry and Behavioral Sciences
Professor in the Environmental Sciences and Policy Division
Associate Professor of Pharmacology & Cancer Biology
Professor of Psychology and Neuroscience
Division: 
Addiction
Category: 
Office: 323 Foster St, Durham, NC 27701
Campus Mail: DUMC Box 104790, Durham, NC 27710

Dr. Levin is Chief of the Neurobehavioral Research Lab in the Psychiatry Department of Duke University Medical Center. His primary academic appointment is as Professor in the Department of Psychiatry and Behavioral Sciences. He also has secondary appointments in the Department Pharmacology and Cancer Biology, the Department of Psychological and Brain Sciences and the Nicholas School of the Environment at Duke. His primary research effort is to understand basic neural interactions underlying cognitive function and addiction and to apply this knowledge to better understand cognitive dysfunction and addiction disorders and to develop novel therapeutic treatments.

The three main research components of his laboratory are focused on the themes of the basic neurobiology of cognition and addiction, neurobehavioral toxicology and the development of novel therapeutic treatments for cognitive dysfunction and substance abuse. Currently, our principal research focus concerns nicotine. We have documented the basic effects of nicotine on learningm memory and attention as well as nicotine self-administration. We are continuing with more mechanistic studies in rat models using selective lesions, local infusions and neurotransmitter interaction studies. We have found that nicotine improves memory performance not only in normal rats, but also in rats with lesions of hippocampal and basal forebrain connections. We are concentrating on alpha7 and alpha4beta2 nicotinic receptor subtypes in the hippocampus, amygdala , thalamus and frontal cortex and how they interact with dopamine D1 and D2 and glutamate NMDA systems with regard to memory and addiction. I am also conducting studies on human cognitive behavior. We have current studies to assess nicotine effects on attention, memory and mental processing speed in schizophrenics, Alzheimer's Disease patients and people with Attention Deficit Hyperactivity Disorder. In the area of neurobehavioral toxicology, I have continuing projects to characterize the adverse effects of prenatal and adolescent nicotine exposure. Our primary project in neurobehavioral toxicology focuses on the cognitive deficits caused by the marine toxins including domoic acid, ciguatera toxin and pfiesteria. We have documented a persistent neurobehavioral effects caused by Pfiesteria and domoic acid exposure. We are determining the neurobehavioral nature and mechanisms of this deficit. The basic and applied aims of our research complement each other nicely. The findings concerning neural mechanisms underlying cognitive function help direct the behavioral toxicology and therapeutic development studies, while the applied studies provide important functional information concerning the importance of the basic mechanisms under investigation.

Education and Training

  • Ph.D., University of Wisconsin - Madison, 1984

Selected Grants

Publications

Pitt, Jordan A., Rafael Trevisan, Andrey Massarsky, Jordan S. Kozal, Edward D. Levin, and Richard T. Di Giulio. “Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene.” Sci Total Environ 643 (December 1, 2018): 324–34. https://doi.org/10.1016/j.scitotenv.2018.06.186.

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Cauley, Marty, Brandon J. Hall, Yael Abreu-Villaça, Shaqif Junaid, Hannah White, Abtin Kiany, Theodore A. Slotkin, and Edward D. Levin. “Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance.” Neurotoxicology 68 (September 2018): 81–87. https://doi.org/10.1016/j.neuro.2018.07.012.

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Oliveri, Anthony N., Erica Ortiz, and Edward D. Levin. “Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae.” Neurotoxicol Teratol 67 (May 2018): 25–30. https://doi.org/10.1016/j.ntt.2018.03.002.

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Glazer, Lilah, Corinne N. Wells, Meghan Drastal, Kathryn-Ann Odamah, Richard E. Galat, Mamta Behl, and Edward D. Levin. “Developmental exposure to low concentrations of two brominated flame retardants, BDE-47 and BDE-99, causes life-long behavioral alterations in zebrafish.” Neurotoxicology 66 (May 2018): 221–32. https://doi.org/10.1016/j.neuro.2017.09.007.

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Rezvani, Amir H., Yousef Tizabi, Susan Slade, Bruk Getachew, and Edward D. Levin. “Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.” Neurosci Lett 668 (March 6, 2018): 98–102. https://doi.org/10.1016/j.neulet.2018.01.022.

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Levin, Edward D., Corrine Wells, Susan Slade, and Amir H. Rezvani. “Mutually augmenting interactions of dextromethorphan and sazetidine-A for reducing nicotine self-administration in rats.” Pharmacol Biochem Behav 166 (March 2018): 42–47. https://doi.org/10.1016/j.pbb.2018.01.005.

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Massarsky, Andrey, Ayham Abdel, Lilah Glazer, Edward D. Levin, and Richard T. Di Giulio. “Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio).” Neurotoxicology 65 (March 2018): 111–24. https://doi.org/10.1016/j.neuro.2018.02.007.

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Pitt, Jordan A., Jordan S. Kozal, Nishad Jayasundara, Andrey Massarsky, Rafael Trevisan, Nick Geitner, Mark Wiesner, Edward D. Levin, and Richard T. Di Giulio. “Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio).” Aquat Toxicol 194 (January 2018): 185–94. https://doi.org/10.1016/j.aquatox.2017.11.017.

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Lacagnina, Michael J., Ashley M. Kopec, Stewart S. Cox, Richa Hanamsagar, Corinne Wells, Susan Slade, Peter M. Grace, Linda R. Watkins, Edward D. Levin, and Staci D. Bilbo. “Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.” Neuropsychopharmacology 42, no. 11 (October 2017): 2128–40. https://doi.org/10.1038/npp.2017.82.

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Rezvani, Amir H., Susan Slade, Corinne Wells, Venkata M. Yenugonda, Yong Liu, Milton L. Brown, Yingxian Xiao, Kenneth J. Kellar, and Edward D. Levin. “Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats.” Psychopharmacology (Berl) 234, no. 17 (September 2017): 2517–23. https://doi.org/10.1007/s00213-017-4641-6.

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