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Angel Vladimirov Peterchev, MS, PhD

Associate Professor in Psychiatry and Behavioral Sciences
Associate Professor in the Department of Electrical and Computer Engineering
Associate Professor of Biomedical Engineering
Associate Professor in Neurosurgery
Division: 
Behavioral Medicine & Neurosciences
Category: 
Office: Dept. Psychiatry & Behavioral, Box 3620 DUMC, Durham, NC 27710

I direct the Brain Stimulation Engineering Lab (BSEL) which focuses on the development and modeling of devices and application paradigms for transcranial brain stimulation. Transcranial brain stimulation involves non-invasive delivery of fields (e.g., electric and magnetic) to the brain that modulate neural activity. Transcranial brain stimulation is increasingly used as a tool for brain research and a therapeutic intervention in neurology and psychiatry. My lab works closely with neuroscientists and clinicians to translate novel brain stimulation technology and optimize existing techniques. For example, we have developed a device for transcranial magnetic stimulation (TMS) that allows extensive control over the magnetic pulse parameters. We are currently deploying this device to optimize the magnetic stimulus in neuromodulatory TMS paradigms. We are also developing efficient algorithms for response estimation and individualization of brain stimulation. Another line of work is finite element computational modeling of the fields induced in the brain by electric and magnetic stimulation. My lab is involved in the integration of transcranial brain stimulation with imaging modalities such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), as well as the evaluation of the safety of device–device interactions, for example between transcranial stimulators and implants like deep-brain stimulation (DBS) systems.

In parallel, I pursue projects related to power electronics, with applications in electrical energy conversion and storage. Recent projects include modular multilevel converters for solar energy conversion and storage, grid storage applications, as well as electric vehicles.

Education and Training

  • Ph.D., University of California - Berkeley, 2005
  • M.S., University of California - Berkeley, 2002
  • B.A., Harvard University , 1999

Selected Grants

Publications

Koponen, Lari M., Stefan M. Goetz, and Angel V. Peterchev. “Double-Containment Coil With Enhanced Winding Mounting for Transcranial Magnetic Stimulation With Reduced Acoustic Noise.” Ieee Trans Biomed Eng 68, no. 7 (July 2021): 2233–40. https://doi.org/10.1109/TBME.2020.3048321.

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Wang, Boshuo, Zhongxi Li, Charles Sebesta, Daniel Torres Hinojosa, Qingbo Zhang, Jacob Robinson, Gang Bao, Angel Peterchev, and Stefan Goetz. “High Bandwidth Power Electronics and Magnetic Nanoparticles for Multichannel Magnetogenetic Neurostimulation,” June 24, 2021. https://doi.org/10.1101/2021.06.23.447876.

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Huang, Wei A., Iain M. Stitt, Ehsan Negahbani, D. J. Passey, Sangtae Ahn, Marshall Davey, Moritz Dannhauer, et al. “Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform.” Nature Communications 12, no. 1 (May 25, 2021): 3151. https://doi.org/10.1038/s41467-021-23021-2.

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Dannhauer, Moritz, Ziping Huang, Lysianne Beynel, Eleanor Wood, Noreen Bukhari-Parlakturk, and Angel Peterchev. ““TAP: Targeting and analysis pipeline for optimization and verification of TMS coil placement”,” May 10, 2021. https://doi.org/10.1101/2021.05.09.443339.

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Price, Rebecca B., Claire M. Gillan, Colleen Hanlon, Fabio Ferrarelli, Tae Kim, Helmet T. Karim, Marlee Renard, et al. “Effect of Experimental Manipulation of the Orbitofrontal Cortex on Short-Term Markers of Compulsive Behavior: A Theta Burst Stimulation Study.” The American Journal of Psychiatry 178, no. 5 (May 2021): 459–68. https://doi.org/10.1176/appi.ajp.2020.20060821.

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Lizana F., R., S. Rivera, Z. Li, A. Dekka, L. Rosenthal, H. Bahamonde I., A. V. Peterchev, and S. M. Goetz. “Modular Multilevel Series/Parallel Converter for Bipolar DC Distribution and Transmission.” Ieee Journal of Emerging and Selected Topics in Power Electronics 9, no. 2 (April 1, 2021): 1765–79. https://doi.org/10.1109/JESTPE.2020.2998738.

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Gomez, Luis J., Moritz Dannhauer, and Angel V. Peterchev. “Fast computational optimization of TMS coil placement for individualized electric field targeting.” Neuroimage 228 (March 2021): 117696. https://doi.org/10.1016/j.neuroimage.2020.117696.

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Li, Z., J. K. Motwani, Z. Zeng, S. M. Lukic, A. V. Peterchev, and S. M. Goetz. “A Reduced Series/Parallel Module for Cascade Multilevel Static Compensators Supporting Sensorless Balancing.” Ieee Transactions on Industrial Electronics 68, no. 1 (January 1, 2021): 15–24. https://doi.org/10.1109/TIE.2020.2965470.

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Turner, Dennis A., Simone Degan, Francesca Galeffi, Stephen Schmidt, and Angel V. Peterchev. “Rapid, Dose-Dependent Enhancement of Cerebral Blood Flow by transcranial AC Stimulation in Mouse.” Brain Stimul 14, no. 1 (January 2021): 80–87. https://doi.org/10.1016/j.brs.2020.11.012.

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Rossi, Simone, Andrea Antal, Sven Bestmann, Marom Bikson, Carmen Brewer, Jürgen Brockmöller, Linda L. Carpenter, et al. “Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.” Clin Neurophysiol 132, no. 1 (January 2021): 269–306. https://doi.org/10.1016/j.clinph.2020.10.003.

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