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Andrew Sherwood, PhD

Professor in Psychiatry and Behavioral Sciences
Professor in the Department of Psychology and Neuroscience
Division: 
Behavioral Medicine & Neurosciences
Category: 
Office: 4569 Hosp South, Durham, NC 27710
Campus Mail: DUMC Box 3119 Med Ctr, Durham, NC 27710

My current research focus is on biological, behavioral and sociocultural factors involved in the etiology and management of hypertension, coronary artery disease, and congestive heart failure. The role of stress and the sympathetic nervous system in disease onset and progression is of central interest. Current research issues being studied include: (i) Ethnicity and gender as factors related to the pathogenesis of hypertension; (ii) Mechanisms by which menopause increases the risk of cardiovascular disease in women; (iii) Mechanisms by which stress may provoke episodes of myocardial ischemia in patients with coronary artery disease; (iv) Stress biomarkers that are associated with adverse clinical outcomes in cardiac patients; (v) The development of coping skills interventions to improve prognosis and quality of life in patients with congestive heart failure; (vi) Circadian blood pressure profiles for risk stratification in patients with hypertension; (vii) Biological and behavioral factors contributing to elevated nighttime blood pressure and blunted nighttime blood pressure dipping.

Comprehensive assessments of cardiovascular regulatory systems define the daily activity in the biobehavioral research laboratory. Assessments include: (i) hemodynamic (blood pressure, cardiac output, systemic vascular resistance) and neurohumoral responses (plasma epinephrine and norepinephrine) during psychological and physical stress testing; (ii) alpha and beta adrenergic receptor function, the baroreceptor reflex, and cardiac vagal control; (iii) endothelial function, and vascular structure and compliance; (iv) left ventricular structure and function by echocardiography; (v) 24-hour ambulatory blood pressure and cardiac output monitoring; (vi) Nonivasive assessments of arterial stiffness and central aortic pressure; (vii) Psychometric assessments of personality and lifestyle characteristics related to cardiovascular disease.

A secondary research interest is in the use and development of noninvasive techniques for evaluating the cardiovascular system. Developments include an ambulatory impedance cardiography system, permitting assessment of 24-hour hemodynamics during normal daily activities, and biomarkers of cardiovascular risk obtained using ultrasound imaging.

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Education and Training

  • Ph.D., University of Hull (United Kingdom), 1982

Selected Grants

Publications

Blumenthal, James A., Patrick J. Smith, Wei Jiang, Alan Hinderliter, Lana L. Watkins, Benson M. Hoffman, William E. Kraus, Lawrence Liao, Jonathan Davidson, and Andrew Sherwood. “Effect of Exercise, Escitalopram, or Placebo on Anxiety in Patients With Coronary Heart Disease: The Understanding the Benefits of Exercise and Escitalopram in Anxious Patients With Coronary Heart Disease (UNWIND) Randomized Clinical Trial.” Jama Psychiatry, August 18, 2021. https://doi.org/10.1001/jamapsychiatry.2021.2236.

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Malian, Hannah M., Patrick J. Smith, Benson Hoffman, Wei Jiang, Katharine Ammerman, William E. Kraus, Alan Hinderliter, Andrew Sherwood, and James A. Blumenthal. “Effects of Acute Exercise on Anxiety Ratings in Patients With Coronary Heart Disease and Elevated Anxiety.” Journal of Cardiopulmonary Rehabilitation and Prevention 41, no. 4 (July 2021): 277–81. https://doi.org/10.1097/hcr.0000000000000579.

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Hinderliter, Alan L., Patrick Smith, Andrew Sherwood, and James Blumenthal. “Lifestyle Interventions Reduce the Need for Guideline-Directed Antihypertensive Medication.” In Am J Hypertens, 2021. https://doi.org/10.1093/ajh/hpab090.

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Hill, LaBarron K., Jade Q. Wu, Alan L. Hinderliter, James A. Blumenthal, and Andrew Sherwood. “Actigraphy-Derived Sleep Efficiency Is Associated With Endothelial Function in Men and Women With Untreated Hypertension.” American Journal of Hypertension 34, no. 2 (March 2021): 207–11. https://doi.org/10.1093/ajh/hpaa167.

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LoSavio, Stefanie T., Jean C. Beckham, Stephanie Y. Wells, Patricia A. Resick, Andrew Sherwood, Cynthia J. Coffman, Angela C. Kirby, Tiffany A. Beaver, Michelle F. Dennis, and Lana L. Watkins. “The effect of reducing posttraumatic stress disorder symptoms on cardiovascular risk: Design and methodology of a randomized clinical trial.” Contemporary Clinical Trials 102 (March 2021): 106269. https://doi.org/10.1016/j.cct.2021.106269.

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Blumenthal, James A., Michael A. Babyak, Wade Edward Craighead, Jonathan Davidson, Alan Hinderliter, Benson Hoffman, Pudugramam Murali Doraiswamy, and Andrew Sherwood. “The role of comorbid anxiety in exercise and depression trials: Secondary analysis of the SMILE-II randomized clinical trial.” Depress Anxiety 38, no. 2 (February 2021): 124–33. https://doi.org/10.1002/da.23088.

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Willeit, Peter, Lena Tschiderer, Elias Allara, Kathrin Reuber, Lisa Seekircher, Lu Gao, Ximing Liao, et al. “Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100 667 Patients.” Circulation 142, no. 7 (August 18, 2020): 621–42. https://doi.org/10.1161/CIRCULATIONAHA.120.046361.

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Yano, Yuichiro, Anthony J. Viera, Alan L. Hinderliter, Lana L. Watkins, James A. Blumenthal, Kristy S. Johnson, LaBarron K. Hill, and Andrew Sherwood. “Vascular α1-Adrenergic Receptor Responsiveness in Masked Hypertension.” Am J Hypertens 33, no. 8 (August 4, 2020): 713–17. https://doi.org/10.1093/ajh/hpaa032.

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Smith, Patrick J., James Blumenthal, Stephanie Mabe, Alan Hinderliter, and Andrew Sherwood. “ASSOCIATION OF ARTERIAL FUNCTION WITH CEREBROVASCULAR RESERVE CAPACITY IN RESISTANT HYPERTENSIVES.” In Annals of Behavioral Medicine, 54:S7–S7, 2020.

Scholars@Duke

Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, P Murali Doraiswamy, et al. “Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.” J Am Geriatr Soc 68, no. 3 (March 2020): 559–68. https://doi.org/10.1111/jgs.16252.

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