3521 Hosp South, Durham, NC 27710
Box 3003 Med Ctr, Durham, NC 27710
I am currently semi-retired. Most of my recent work has been focused on roles with the National Academy of Medicine (former Institute of Medicine). I have chaired three committees during the past four years, one on the mental health and substance use workforce, one on cognitive aging, and one on hearing loss in adults. I currently also chair the Board on the Health of Select Populations for the National Academies.
In the past I have been PI on a number of research projects, including the Epidemiologic Catchment Area Study, and the Clinical Research Center for Late Life Depression. More recently I have been involved with five research projects. The first, the Established Populations for Epidemiologic Study of the Elderly (EPESE), included a study demonstrating that sleep complaints are more frequent in white compared to blacks, even when relevant demographic variables are controlled. In a second study, day-time napping was a significant predictor of mortality. A third study in the Piedmont of North Carolina revealed no difference in utilization or satisfaction with health services when urban elders were compared with rural elders. In a fourth study, self-rated health was not as strong a predictor of mortality, as has been found in previous studies, especially when controlling for important covariates.
A second research endeavor has been with the National Comorbidity Study. I led investigators who demonstrated that the prevalence of major depression is higher than previously estimated in national samples of persons between the ages of eighteen and fifty-five in the community and discussed the methodological issues that may contribute to this differing estimate. The risk-factor profile of pure major depression was compared with comorbid major depression. I will continue in this research during 1994/95 to look at Seasonal Affective Disorders (SAD).
I have also worked with my colleague Litzy Wu ScD in the study of substance use disorders and have published a number of papers related to substance use in the elderly. I also work closely with my colleague Celia Hybels, PhD looking at trajectories of depressive symptoms in older adults over time.
I spent considerable time during 1994/97 working on four books. I co-edited the second edition of Geriatric Psychiatry, to be published in the late winter of 1994 or early spring of 1995. I am working on a single author book, Freud vs. God: The End of the Debate/How Psychiatry Lost Its Soul and Christianity Lost Its Mind and on a research methods textbook for clinical psychiatry research. I have produced a second edition of Emotional Problems in Later Life. Since then our Textbook of Geriatric Psychiatry has gone through three additional editions and I published (based on my work during a sabbatical at the Center for Advanced Studies of Behavioral Sciences at Stanford) The Age of Melancholy (for which I received the Oscar Pfister Award from the American Psychiatric Association).
World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions.
Measuring and Intervening to Instill Purpose in Life for Older Adults to Prevent Cognitive Decline.
Pharmacologic Intervention for the Treatment and Prevention of Delirium: Looking Beneath the Modeling.
Hearing loss and psychiatric disorders: a review.
The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.
Perspectives: Measuring the Impact of Articles Published in The American Journal of Geriatric Psychiatry, July 1, 2017, to June 30, 2018.
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies.
Sexual Harassment, Sexual Assault, and Physical Activity Among U.S. Military Service Members in the Millennium Cohort StudyRead Full Text
A Bridge to I Know Not WhereRead Full Text
Persistent Depressive Symptoms in a Population With High Levels of Occupational Stress: Trajectories Offer Insights Into Both Chronicity and Resilience.
Cardiac Disease in Elderly Holocaust Survivors Who Live in Israel: A Case for Risk and Resilience.
Spirituality in geriatric psychiatry.
Promoting Wellness in Older Adults with Mental Illnesses and Substance Use Disorders: Call to Action to All Stakeholders.
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.
Advancing our diagnostic tools and treatment options for delirium.
WHEN GERIATRIC PSYCHIATRISTS RETIRE: A CONVERSATION ABOUT CRITICAL TRANSITIONS IN A PROFESSIONAL CAREERRead Full Text
Hearing Loss: The Silent Risk for Psychiatric Disorders in Late Life.
Battles Worth Fighting.
Neuroendocrine Neoplasms of the Appendix: A Review of the Literature.
Depression Among Older Adults: A 20-Year Update on Five Common Myths and Misconceptions.
Bipolar Disorder and Dementia: Weighing the Evidence.
Cognitive Aging: What We Fear and What We Know.
Age-Friendly Communities Initiative: Public Health Approach to Promoting Successful Aging.
The Three Cs of a Scientific Autobiography: Curiosity, Circumstance, and Colleagues.
Hearing health care for adults: Priorities for improving access and affordabilityRead Full Text
Hearing Health Care: Review of a Report From the National Academies of Sciences, Engineering, and Medicine.
Do We Ever Escape the Consequences of Childhood Deprivation?
Cognitive Aging: What Every Geriatric Psychiatrist Should Know.
Can eHealth Technology Enhance the Patient-Provider Relationship in Rehabilitation?
Peer Review at the American Journal of Geriatric Psychiatry-An Appeal to the Better Angels of Our Nature.
Priorities for Improving Hearing Health Care for Adults: A Report From the National Academies of Sciences, Engineering, and Medicine.
Heterogeneity in the three-year course of major depression among older adults.
Empirical Studies About Attendance at Religious Services and Health.
Epidemiology of psychiatric illnessRead Full Text
Marking 20 years of aging and mental health.
Cognitive aging: Progress in understanding and opportunities for actionRead Full Text
Meet our editorial board memberRead Full Text
Cognitive aging: a report from the Institute of Medicine.
Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific Islanders.
An unsubstantiated conclusion.
Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific IslandersRead Full Text
The new DSM-5 diagnosis of mild neurocognitive disorder and its relation to research in mild cognitive impairment.
Depression and cognition in the elderly.
Nonmedical stimulant use among young Asian-Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals aged 12-34 years in the United States.
Classifying neurocognitive disorders: the DSM-5 approach.
Risk factors for suicide among older adults with cancer.
Substance abuse among older adults.
Diagnostic criteria for vascular cognitive disorders: a VASCOG statement.
Late life depression: a historical perspective upon a maturing field of inquiry.
Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults.
Dysphoria and anhedonia as risk factors for disability or death in older persons: implications for the assessment of geriatric depression.
Long-term cumulative depressive symptom burden and risk of cognitive decline and dementia among very old women.
Independent research by early investigators: an underutilized option.
Substance use disorders and psychiatric comorbidity in mid and later life: a review.
Glycated hemoglobin measurement and prediction of cardiovascular disease.
Recovery on higher ground: Spirituality in the treatment of substance abuseRead Full Text
Commentary on "Individual and societal wisdom: explaining the paradox of human aging and high well-being" by Dilip V. Jeste and Andrew J. Oswald: societal wisdom and longevity.
Illicit and nonmedical drug use among Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals.
Progress in delirium.
Why gerontologists should care about empirical research on religion and health: transdisciplinary perspectives.
Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people.
The prevalence and distribution of major depression in a national community sample: The national comorbidity surveyRead Full Text
MRI-defined vascular depressionRead Full Text
Latent subtypes of depression in a community sample of older adults: can depression clusters predict future depression trajectories?
The Institute of Medicine Report on the Mental Health and Substance Use Workforce for Older Adults: a reflection.
Tobacco use among Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals: 2002-2010.
Neurocognitive disorders in DSM-5.
Trajectory classes of body mass index in a representative elderly community sample.
Using electronic health records data to assess comorbidities of substance use and psychiatric diagnoses and treatment settings among adults.
Health consequences of familial longevity influence among the Chinese elderly.
Antipsychotics and dementia: where do we go from here?
Systematic review of the effectiveness of pharmacologic interventions to improve quality of life and well-being in people with dementia.
ForewordRead Full Text
The course of depression in the elderly: A longitudinal community-based study in australiaRead Full Text
Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults.
The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis.
LONG-TERM DEPRESSIVE SYMPTOM BURDEN AND RISK OF COGNITIVE DECLINE AND DEMENTIA AMONG VERY OLD WOMENRead Full Text
Life satisfaction and preterm birth among urban black women: findings from the Baltimore preterm birth study.
The mental health and substance use workforce for older adults: In whose hands?Read Full Text
Twenty-year depressive trajectories among older women.
The complex association between religious activities and functional limitations in older adults.
Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis.
Datapoints: Use of medications and counseling for depression by Asian and multiple-race adolescents aged 12-17 years.
Alcohol and drug use disorders among adults in emergency department settings in the United States.
Review: antidepressants are effective for the treatment of major depressive disorder in individuals aged 55 years or older.
Maternal prenatal depressive symptoms, nicotine addiction, and smoking-related knowledge, attitudes, beliefs, and behaviors.
Age differences in symptom expression in patients with major depression.
Trajectory classes of depressive symptoms in a community sample of older adults.
A dimensional approach to understanding severity estimates and risk correlates of marijuana abuse and dependence in adults.
The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons.
Systematic review of the effectiveness of non-pharmacological interventions to improve quality of life of people with dementia.
Time does not heal all wounds: trauma, stress, and resilience among older adults.
Evidence for the diagnostic criteria of delirium: an update.
Depression and anxiety associated with dementiaRead Full Text
Depression in Later Life: Aetiology, Epidemiology, Assessment, Diagnosis and TreatmentRead Full Text
Alcohol and drug dependence symptom items as brief screeners for substance use disorders: results from the Clinical Trials Network.
Comparison of outcomes and the use of multimodality therapy in young and elderly people undergoing surgical resection of pancreatic cancer.
A framework for quantifying net benefits of alternative prognostic models.
Systematic review of the effectiveness of pharmacologic interventions to improve quality of life and well-being in people with dementiaRead Full Text
Erratum: Heterogeneity in symptom profiles among older adults diagnosed with major depression (International Psychogeriatrics (2011) 23:5 (906-922) DOI: 10.1017/S1041610210002346)Read Full Text
Religion/spirituality and depression: what can we learn from empirical studies?
Patterns of tobacco use and tobacco-related psychiatric morbidity and substance use among middle-aged and older adults in the United States.
Treatment use and barriers among adolescents with prescription opioid use disorders.
Use of item response theory and latent class analysis to link poly-substance use disorders with addiction severity, HIV risk, and quality of life among opioid-dependent patients in the Clinical Trials Network.
Substance use disorders and comorbid Axis I and II psychiatric disorders among young psychiatric patients: findings from a large electronic health records database.
Racial/ethnic variations in substance-related disorders among adolescents in the United States.
When a chance to cut is not a chance to cure: a future for palliative surgery?
Heterogeneity in symptom profiles among older adults diagnosed with major depression.
The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sample.
A systematic review of treatments for refractory depression in older people.
Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
Epidemiology and Geriatric PsychiatryRead Full Text
Illicit and nonmedical drug use among older adults: a review.
Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers.
Psychotropic drug use in late life: a diverse look at an expanding field.
Abuse and dependence on prescription opioids in adults: a mixture categorical and dimensional approach to diagnostic classification.
How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
Classification of neurocognitive disorders in DSM-5: a work in progress.
Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: Collaborative analysis of 58 prospective studiesRead Full Text
Co-occurring amphetamine use and associated medical and psychiatric comorbidity among opioid-dependent adults: results from the Clinical Trials Network.
Depressive symptoms, substance use, and HIV-related high-risk behaviors among opioid-dependent individuals: results from the Clinical Trials Network.
Why John wasn't healed by prayer: perspectives across disciplines.
Nosology and Classification of Mood DisordersRead Full Text
Preface to Second EditionRead Full Text
Epidemiology of Alcohol Problems and Drinking PatternsRead Full Text
Gender and racial/ethnic differences in addiction severity, HIV risk, and quality of life among adults in opioid detoxification: results from the National Drug Abuse Treatment Clinical Trials Network.
Subtypes of nonmedical opioid users: results from the national epidemiologic survey on alcohol and related conditions.
Shortness of breath as a predictor of depressive symptoms in a community sample of older adults.
Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.
Expert consensus on characteristics of wisdom: a Delphi method study.
APOE epsilon4 allele carriers: Biological, psychological, and social variables associated with cognitive impairment.
Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects.
Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study.
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
Problems meeting basic needs moderate the association between the APOE epsilon4 allele and cognitive decline.
An item response theory analysis of DSM-IV criteria for hallucinogen abuse and dependence in adolescents.
Depressive symptoms in middle age and the development of later-life functional limitations: the long-term effect of depressive symptoms.
Protection from late life depression.
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studiesRead Full Text
Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studiesRead Full Text
The Rise and Fall of the Biopsychosocial Model Reconciling Art and Science in PsychiatryRead Full Text
Geriatric PsychiatryRead Full Text
The origins of late-life depressionRead Full Text
Genetic testing for Alzheimer's and long-term care insurance.
Trajectories of mobility and IADL function in older patients diagnosed with major depression.
A prospective study of depression following combat deployment in support of the wars in Iraq and Afghanistan.
The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sampleRead Full Text
Drs. Blazer and Wu replyRead Full Text
Religious attendance reduces cognitive decline among older women with high levels of depressive symptoms.
The variety of ecstasy/MDMA users: results from the National Epidemiologic Survey on alcohol and related conditions.
DEPRESSIVE SYMPTOM CLUSTERS AND THE RELATIONSHIP TO COGNITIVE FUNCTIONINGRead Full Text
The complex relationship between depressive symptoms and functional limitations in community-dwelling older adults: the impact of subthreshold depression.
The epidemiology of at-risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health.
Hallucinogen-related disorders in a national sample of adolescents: the influence of ecstasy/MDMA use.
Identifying a national death index match.
The construct and measurement equivalence of cocaine and opioid dependences: a National Drug Abuse Treatment Clinical Trials Network (CTN) study.
The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention.
Association of MDMA/ecstasy and other substance use with self-reported sexually transmitted diseases among college-aged adults: a national study.
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.
Recognition and Prevention of Major Mental and Substance Use DisordersRead Full Text
Clinical outcomes of molecularly confirmed clear cell sarcoma from a single institution and in comparison with data from the Surveillance, Epidemiology, and End Results registry.
Nonprescription use of pain relievers by middle-aged and elderly community-living adults: National Survey on Drug Use and Health.
DEPRESSION IS PROSPECTIVELY ASSOCIATED WITH COMBAT DEPLOYMENT IN SUPPORT OF THE WARS IN IRAQ AND AFGHANISTANRead Full Text
PROSPECTIVE INVESTIGATION OF MENTAL HEALTH CHALLENGES AND COPING BEHAVIORS IN DEPLOYERS SUPPORTING THE WARS IN IRAQ AND AFGHANISTANRead Full Text
Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents.
Profiles of depressive symptoms in older adults diagnosed with major depression: latent cluster analysis.
Religion, spirituality, and mental health: what we know and why this is a tough topic to research.
An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network study.
Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study.
Smoking cessation behavior in older adults by race and gender: the role of health problems and psychological distress.
Treating Late-Life Depression: Aiming for the OptimumRead Full Text
The epidemiology of substance use and disorders among middle aged and elderly community adults: national survey on drug use and health.
Depressive symptoms moderate the influence of the apolipoproteine epsilon4 allele on cognitive decline in a sample of community dwelling older adults.
Racial differences in the influence of the APOE epsilon 4 allele on cognitive decline in a sample of community-dwelling older adults.
Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases.
Social support in older individuals: the role of the BDNF Val66Met polymorphism.
PROFILES OF DEPRESSIVE SYMPTOMS IN COMMUNITY-DWELLING OLDER ADULTS: A LATENT CLUSTER ANALYSISRead Full Text
Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage.
How do you feel about...? Health outcomes in late life and self-perceptions of health and well-being.
Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network study.
Throwing down the gauntlet: can we do better than the MMSE?
Strategies for resection using portal vein embolization: hepatocellular carcinoma and hilar cholangiocarcinoma.
Acetylcholinesterase inhibition and Gulf War illnesses: conclusions are not supported by independent reviews of the same evidence.
The course of depressive symptoms in older adults with comorbid major depression and dysthymia.
ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia.
Profiles of Functional Impairment in Older Patients Treated for Major DepressionRead Full Text
Social Support in Older Individuals: The Role of the BDNF Va166Met PolymorphismRead Full Text
The influence of lifetime depression on self-reported memory and cognitive problems: results from the National Comorbidity Survey-Replication.
Depression in long-term care.
Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreas.
Epidemiology of psychiatric illnessRead Full Text
Religious and spiritual factors and the consequences of trauma: a review and model of the interrelationship.
Geographical segregation and IL-6: a marker of chronic inflammation in older adults.
Religion, Culture and Mental Health. By K. Loewenthal. (Pp. 169; $85.00; ISBN 13-978-0-521-85023-0 hb.) Cambridge University Press: New York. 2007.Read Full Text
Application of assessing care of vulnerable elders-3 quality indicators to patients with advanced dementia and poor prognosis.
Body mass index and depressive symptoms in older adults: the moderating roles of race, sex, and socioeconomic status.
Traumatic events and posttraumatic stress in cross-cultural mission assignments.
The relationship between spirituality and depressive symptoms: testing psychosocial mechanisms.
Maternal prenatal pregnancy-related anxiety and spontaneous preterm birth in Baltimore, Maryland.
Spirituality and depression: a case study.
Section introduction: spirituality, depression & suicide.
Selected annotated bibliography on depression and suicide.
Spirituality, depression and suicide: a cross-cultural perspective.
Inguinal node dissection for melanoma in the era of sentinel lymph node biopsy.
Surgical therapy of cutaneous melanoma.
Depressive symptoms and indicators of maternal health status during pregnancy.
Cerebrospinal fluid DHEA levels are elevated in Alzheimer's disease, related to neuropathological disease stage, and correlated with brain DHEA levelsRead Full Text
Religious beliefs, practices and mental health outcomes: what is the research question?
Health service use and outcome: comparison of low charge, integrated, comprehensive services with usual health care.
Perception of unmet basic needs as a predictor of depressive symptoms among community-dwelling older adults.
Millennium Cohort: the 2001-2003 baseline prevalence of mental disorders in the U.S. military.
Response letter to Dr. Cheng Read Full Text
Anxiety disordersRead Full Text
Effect of cancer screening and desirable health behaviors on functional status, self-rated health, health service use and mortality.
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases.
The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.
Genes, behavior, and the social environment: Moving beyond the nature/nurture debateRead Full Text
Spirituality and depressive symptoms in a racially diverse US sample of community-dwelling adults.
Perception of unmet basic needs as a predictor of physical functioning among community-dwelling older adults.
Spirituality, depression, and the elderly.
Leighton's theory of sentiments: explorations and speculations on barriers to interpersonal forgiveness.
Provider characteristics related to antidepressant use in older people.
Sociodemographic characteristics of the neighborhood and depressive symptoms in older adults: using multilevel modeling in geriatric psychiatry.
Racial disparities in elevated prenatal depressive symptoms among black and white women in eastern north Carolina.
Partial remission. A common outcome in older adults treated for major depression.
Metabolic syndrome predicts mobility decline in a community-based sample of older adults.
ForewordRead Full Text
Deficit in the GABAergic neuroactive steroid allopregnanolone in Alzheimer's dementia and relevance to neuropathological disease stage: Investigations in temporal cortexRead Full Text
A randomized, double-blind, placebo-controlled, flexible-dose, trial of augmentation with oros methylphenidate in treatment resistant depressionRead Full Text
Children of Alzheimer patients: an overview.
Depression and social support in late life: a clear but not obvious relationship.
Racial differences in cognitive decline in a sample of community-dwelling older adults: the mediating role of education and literacy.
Mobility limitations as a predictor of depressive symptoms over time in community dwelling older adultsRead Full Text
Origins of depression in later life.
Aging-related diagnostic variations: need for diagnostic criteria appropriate for elderly psychiatric patients.
Predictors of partial remission in older patients treated for major depression: the role of comorbid dysthymia.
The age of melancholy: "Major depression" and its social originsRead Full Text
The influence of depression on cognitive decline in community-dwelling elderly persons.
Racial differences in the frequency of depressive symptoms among community dwelling elders: the role of socioeconomic factors.
Neuroactive steroids and neurodegenerative disorders: Investigations in subjects with Alzheimer's and relevance to neuropathological disease stageRead Full Text
Predictors of antidepressant use among older adults: have they changed over time?
The association between successful treatment of depression and physical functioning in older people seeking primary care.
How Healthy Are We?: A National Study of Well-being at Midlife. Edited by O. G. Brim, C. D. Ryff and R. C. Kessler. (Pp. 687; $42.00; ISBN 0-226-07475-7.) University of Chicago Press: Chicago. 2003.Read Full Text
Perception of unmet basic needs as a predictor of mortality among community-dwelling older adults.
The influence of depression on cognitive decline in community-dwelling elderly personsRead Full Text
Predictors of antidepressant use by older adults in the community: Have the changed over time?Read Full Text
Childhood sexual and physical abuse and the 1-year prevalence of medical problems in the National Comorbidity Survey.
Neuroactive steroids in Alzheimer's disease: Investigations in prefrontal cortexRead Full Text
Self-reported delay in seeking care has poor validity for predicting adverse outcomes.
What symptoms of depression predict mortality in community-dwelling elders?
Commentary: longitudinal studies on aging and the development of geriatrics in North America.
Comment on Nasrallah et al: lower mortality in geriatric patients receiving risperidone and olanzapine versus haloperidol.
Is the APOE ε4 allele a risk to person-environment fit?Read Full Text
In memoriam - Ewald W. Busse, MD, ScD, 1918-2004Read Full Text
Antiangiogenic gene therapy of cancer: recent developments.
How the question is asked makes a difference in the assessment of depressive symptoms in older persons.
Epidemiology of late-life mental disorders.
Is there a role for sentinel lymph node biopsy in the management of sarcoma?
APOE epsilon4 as a predictor of subjective quality of life in a biracial older person community sample.
Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life.
Appropriateness of quality indicators for older patients with advanced dementia and poor prognosis.
Mortality and apolipoprotein E in African-American, and White elders: An attempted replicationRead Full Text
Mortality and apolipoprotein E in African-American, and White elders: an attempted replication.
Assessing depression in older persons: How you ask makes a difference.Read Full Text
Depression in late life: review and commentary.
Is the APOE epsilon4 genotype associated with higher hospital costs among elderly patients?
Self-efficacy and depression in late life: a primary prevention proposal.
Depression in diabetes and obesity: racial/ethnic/gender issues in older adults.
APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample.
Apolipoprotein E epsilon4 and risk of mortality in African American and white older community residents.
The millennium Cohort Study: a 21-year prospective cohort study of 140,000 military personnel.
Sex differences in the relationship between subthreshold depression and mortality in a community sample of older adults.
The prevalence of depressive symptoms.
Relationship of race/ethnicity and blood pressure to change in cognitive function.
Abstinence versus alcohol use among elderly rural Baptists: a test of reference group theory and health outcomes.
The association of depression and mortality in elderly persons.
APOE ε4 and low cholesterol as risks for depression in a biracial elderly community sampleRead Full Text
The impact of borderline personality disorder on post-traumatic stress in the community: a study of health status, health utilization, and functioning.
Emotion: The science of sentimentRead Full Text
The APOE-E4 allele and the risk of functional decline in a community sample of African American and white older adults.
Breaking the watch: The meanings of retirement in AmericaRead Full Text
The creative age: Awakening human potential in the second half of lifeRead Full Text
Social integration in the second half of lifeRead Full Text
The American Psychiatric Press Textbook of Psychopharmacology (Second Edition)Read Full Text
Handbook of the Sociology of Mental HealthRead Full Text
The relationship of APOE genotype to cognitive functioning in older African-American and Caucasian community residents.
The association of depression and mortality in elderly persons: a case for multiple, independent pathways.
Accuracy of self-reported stroke among elderly veterans.
Toward a threshold for subthreshold depression: an analysis of correlates of depression by severity of symptoms using data from an elderly community sample.
Antidepressant use by race.
Blood pressure and mortality risk in older people: comparison between African Americans and whites.
Duke's 3rd year: a 35-year retrospective.
Psychiatry and the oldest old.
A multivariate analysis of factors associated with depression: evaluating the role of health literacy as a potential contributor.
Impact of depressive symptoms on hospitalization risk in community-dwelling older persons.
Sedative, hypnotic, and antianxiety medication use in an aging cohort over ten years: a racial comparison.
Marked differences in antidepressant use by race in an elderly community sample: 1986-1996.
Does private religious activity prolong survival? A six-year follow-up study of 3,851 older adults.
Social and personal resources and the prevalence of phobic disorder in a community population.
Practice guideline for the treatment of patients with major depressive disorder (revision). American Psychiatric Association.
Controversies in community-based psychiatric epidemiology: let the data speak for themselves.
The effect of race and health-related factors on naming and memory. The MacArthur Studies of Successful Aging.
Religious activity, alcohol use, and depression in a sample of elderly baptistsRead Full Text
Vitamin D receptor polymorphisms and prostate cancer.
Issues for academic health centers to consider before implementing a balanced-scorecard effort.
New onset and remission of suicidal ideation among a depressed adult sample.
Correlates of suicidal ideation among an elderly depressed sample.
Insomnia and heart disease: a review of epidemiologic studies.
Functional impairment and utilization of services associated with posttraumatic stress in the community.
Perceived social support among depressed elderly, middle-aged, and young-adult samples: cross-sectional and longitudinal analyses.
Depression and the older man.
Does religious attendance prolong survival? A six-year follow-up study of 3,968 older adults.
Incidence and remission of insomnia among elderly adults: an epidemiologic study of 6,800 persons over three years.
Incidence and remission of insomnia among elderly adults in a biracial cohort.
EURODEP Consortium and late-life depression.
Dysthymia, somatisation disorder and generalised anxiety in the elderlyRead Full Text
Association of interleukin-6 and other biologic variables with depression in older people living in the community.
Disability and depressive symptoms in the elderly: the effects of instrumental support and its subjective appraisal.
Benzodiazepine use and cognitive function among community-dwelling elderly.
Symptoms of depression among community-dwelling elderly African-American and white older adults.
Aging, health, and the "electronic church".
The relationship between religious activities and cigarette smoking in older adults.
Prevalence of seasonal affective disorder.
Are sleep complaints an independent risk factor for myocardial infarction?
Striving for excellence. A neglected challenge to young physicians.
Managing depression in the elderlyRead Full Text
Alternative medicine: readers have their say.
Epidemiology of recurrent major and minor depression with a seasonal pattern. The National Comorbidity Survey.
Suicidal behaviors in depressed men with a family history of suicide: Effects of psychosocial factors and ageRead Full Text
Geriatric psychiatry matures: Advantages and problems as the psychiatry of old age grows olderRead Full Text
Late life affective disordersRead Full Text
Social correlates of the dimensions of depression in the elderly.
Age of first onset of bipolar disorder: demographic, family history, and psychosocial correlates.
The relationship between religious activities and blood pressure in older adults.
Six-month outcomes for MRI-related vascular depression.
Psychosocial and physical correlates of chronic depression.
Apolipoprotein E allele frequencies in a population-based sample of cognitively intact Caucasians and African Americans.Read Full Text
Double depression: A distinctive subtype of unipolar depression - DiscussionRead Full Text
Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey.
Generalized anxiety disorder and panic disorder in the elderly: a review.
Memory complaint as a predictor of cognitive decline: a comparison of African American and White elders.
MRI-defined vascular depression.
Depression in the elderly. Myths and misconceptions.
Inhibition of established pancreatic cancers following specific active immunotherapy with interleukin-2 gene-transduced tumor cells.
Social support and depression as risk factors for loss of physical function in late lifeRead Full Text
Medicine as a mission.
The US National Comorbidity Survey: overview and future directions.
Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system.
On the new clinical case conferences.
Attendance at religious services, interleukin-6, and other biological parameters of immune function in older adults.
Modeling the cross-sectional relationships between religion, physical health, social support, and depressive symptoms.
Severe episode of depression in late life: the long road to recovery.
Older adults in North Carolina. A demographic and health status profile.
Minor depression in late lifeRead Full Text
Minor depression in late lifeRead Full Text
Global self-ratings of health and mortality: hazard in the North Carolina Piedmont.
Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines.
Sociodemographic and clinical correlates of number of previous depressive episodes in the depressed elderly.
The danger of reducing reimbursement for psychiatric disorders in late life.
Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey.Read Full Text
The association of sexual assault and attempted suicide within the community.
Risk of napping: excessive daytime sleepiness and mortality in an older community population.
Effects of gender and ethnic group on blood pressure control in the elderly.
Comorbidity of DSM-III-R major depressive disorder in the general population: results from the US National Comorbidity Survey.
Do racial differences in hypertension persist in successful agers? Findings from the MacArthur Study of Successful Aging.
Is medication use by community-dwelling elderly people influenced by cognitive function?
Factors associated with paranoid symptoms in a community sample of older adults.
Lifetime perturbations of bipolar disorder.
Predictors of cognitive change in older persons: MacArthur studies of successful aging.
Interrelationships of peak expiratory flow rate with physical and cognitive function in the elderly: MacArthur Foundation studies of aging.
Health services access and use among older adults in North Carolina: urban vs rural residents.
Depressive symptomatology and hypertension-associated morbidity and mortality in older adults.
Sleep complaints in older adults: a racial comparison.
Black-white and urban-rural differences in stability of household composition among elderly persons.
Depressive symptoms in the elderly: association with total white blood cell count.
Sleep complaints among elderly persons: an epidemiologic study of three communities.
Behavioral and psychosocial predictors of physical performance: MacArthur studies of successful aging.
Religious coping and cognitive symptoms of depression in elderly medical patients.
Clinical and phenomenological comparisons of late-onset and early-onset depression.
Medication taking behaviors in the high- and low-functioning elderly: MacArthur field studies of successful aging.
Antidepressant use in the elderly: association with demographic characteristics, health-related factors, and health care utilization.
Does weight loss from middle age to old age explain the inverse weight mortality relation in old age?
Geriatric syndromes: An introductionRead Full Text
MODELING THE IMPACT OF CHRONIC ILLNESS, RELIGION, AND SOCIAL SUPPORT ON DEPRESSIVE SYMPTOMSRead Full Text
The boundary of social phobia. Exploring the threshold.
The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging.
Dysthymia in community and clinical samples of older adults.
The health burden of diabetes for the elderly in four communities.
Investigation of antiestrogenic properties of unleaded gasoline in female mice.
Depression in the elderly.
The prevalence and distribution of major depression in a national community sample: the National Comorbidity Survey.
Age and functional correlations of markers of coagulation and inflammation in the elderly: functional implications of elevated crosslinked fibrin degradation products (D-dimers).
Religious affiliation and psychiatric disorder among Protestant baby boomers.
Estimating increment-decrement life tables with multiple covariates from panel data: the case of active life expectancy.
Self-rated health and mortality in the high-functioning elderly--a closer look at healthy individuals: MacArthur field study of successful aging.
Predicting changes in physical performance in a high-functioning elderly cohort: MacArthur studies of successful aging.
Religious practices and alcoholism in a southern adult population.
A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission.
Plasma homovanillic acid and performance on motor and cognitive tasks in community-dwelling elderly: MacArthur studies of successful aging.
Adult onset of severe and pervasive antisocial behavior: A distinct syndrome?Read Full Text
Social ties and support and neuroendocrine function: The MacArthur studies of successful agingRead Full Text
Sex and depression in the National Comorbidity Survey. II: Cohort effects.
Depression and smoking cessation in older adults: a longitudinal study.
Profile of depressive symptoms in younger and older medical inpatients with major depression.
Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence.
High, usual and impaired functioning in community-dwelling older men and women: findings from the MacArthur Foundation Research Network on Successful Aging.
The epidemiology of social phobia: findings from the Duke Epidemiological Catchment Area Study.
Educational status and active life expectancy among older blacks and whites.
Measured versus estimated creatinine clearance in a high-functioning elderly sample: MacArthur Foundation Study of Successful Aging.
Intercommunity variations in the association between social ties and mortality in the elderly. A comparative analysis of three communities.
Does age make a difference in the effects of physical health and social support on the outcome of a major depressive episode?
Psychiatric disorders in adult children of alcoholics: data from the Epidemiologic Catchment Area project.
Reducing antipsychotic drug use in nursing homes. A controlled trial of provider education.
CES-D: cutpoint or change score?
Established populations for epidemiologic studies of the elderly: study design and methodology.
The relationship between religion and anxiety in a sample of community dwelling older adultsRead Full Text
Religion and anxiety disorder: An examination and comparison of associations in young, middle-aged, and elderly adultsRead Full Text
Black/white differences in hypertension in the elderly: an epidemiologic analysis in central North Carolina.
DIAGNOSIS AND EPIDEMIOLOGY OF DEPRESSIONRead Full Text
Abbreviating the Duke Social Support Index for use in chronically ill elderly individuals.
Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.
Should physicians screen for depression in elderly medical inpatients?: Results of a decision analysis.
Diagnosis and treatment of depression in late life: the NIH Consensus Development Conference Statement.
Religious coping and depression among elderly, hospitalized medically ill men.
Religious affiliation and major depression.
Screening for depression in hospitalized elderly medical patients: taking a closer look.
William W.K. Zung, MDiv, MS, MDRead Full Text
Family history of psychiatric disorder and low self-confidence: predictors of depressive symptoms at 12-month follow-up.
Epidemiology of geriatric affective disorders.
Drug-use patterns among black and nonblack community-dwelling elderly.
Sociocultural Factors in Sexual Assault: Comparison of Two Representative Samples of WomenRead Full Text
Mathematical models and clinical care of nursing home patients.
Age and impaired subjective support. Predictors of depressive symptoms at one-year follow-up.
The prevention of major depression in the elderly.
Issues in the treatment of major depression: Selection, efficacy, and safetyRead Full Text
Diagnosis and treatment of depression in late lifeRead Full Text
Major depression in hospitalized medically ill older men: Documentation, management, and outcomeRead Full Text
A brief depression scale for use in the medically ill.
Self-rated depressive symptoms in medical inpatients: age and racial differences.
Secretaries, depression and absenteeismRead Full Text
Occurrence of subcortical hyperintensities in elderly subjects with mania.
The association of age and depression among the elderly: an epidemiologic exploration.
Adult vulnerability for psychiatric disorders: interactive effects of negative childhood experiences and recent stress.
Major depressive disorder in hospitalized medically ill patients: an examination of young and elderly male veterans.
Post-traumatic stress disorder in the community: an epidemiological study.
Tricyclic antidepressant prescribing for nonpsychiatric disorders. An analysis based on data from the 1985 National Ambulatory Medical Care Survey.
Benzodiazepine anti-anxiety agents: prevalence and correlates of use in a southern community.
Training in Geriatric PsychiatryRead Full Text
Clinical features in depression in old age: A case for minor depressionRead Full Text
Suicide risk factors in the elderly: An epidemiological studyRead Full Text
PUTATIVE ENDOGENOUS INHIBITOR OF THE TRITIATED IMIPRAMINE BINDING-SITE IN DEPRESSED-PATIENTSRead Full Text
Epidemiologic data and planning mental health services. A tale of two surveys.
Subjective social support and depressive symptoms in major depression: separate phenomena or epiphenomena.
Social outcomes related to age of onset among psychiatric disorders.
Depression, disability days, and days lost from work in a prospective epidemiologic survey.
Elevated plasma concentrations of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the tritiated imipramine binding site, in depressed patients.
Sexual assault and psychiatric disorders among a community sample of women.
Demographic and health characteristics of elderly smokers: results from established populations for epidemiologic studies of the elderly.
Estimating the prevalence of borderline personality disorder in the communityRead Full Text
What should the Federal government do about Alzheimer's disease? Report of the Secretary's Advisory Panel on Alzheimer's disease.
Anticipating the future and change.
Antidepressant use in elderly medical inpatients: lessons from an attempted clinical trial.
Neuroanatomical changes and hypothalamo-pituitary-adrenal axis abnormalities.
Alternative models of the stress buffering hypothesis.
The prevalence of major depression in black and white adults in five United States communities.
Major depression in later life.
Antisocial and related disorders in a southern community. An application of grade of membership analysis.
The association between depressive symptoms and mortality among older participants in the Epidemiologic Catchment Area-Piedmont Health Survey.
Survival and health care utilization in elderly medical inpatients with major depression.
Depression in the elderly.
The effects of childhood parental death and divorce on six-month history of anxiety disorders.
Social support and the outcome of major depression.
Reduced inhibitory effect of imipramine on radiolabeled serotonin uptake into platelets in geriatric depression.
Dizziness in a community elderly population.
Identification of borderline personality disorder with the NIMH Diagnostic Interview Schedule.
Religious affiliations in mental health research samples as compared with national samples.
Depression in the elderly.
Antisocial and related disorders in a southern community: An application of grade of membership analysisRead Full Text
In response to 'psychiatric diagnosis as reified measurement'. An invited comment on Mirowsky and Ross (1989)Read Full Text
Anxiety as an outcome symptom of depression in elderly and middle‐aged adultsRead Full Text
Depression in late lifeRead Full Text
A statistical analysis of the classification of depression in a mixed community and clinical sample.
Somatization symptoms in the community: a rural/urban comparison.
Major depression and the NIMH Diagnostic Interview Schedule: validation in medically ill hospitalized patients.
The construct validity of the ischemic score of Hachinski for the detection of dementias.
Depression in late life: an update.
The epidemiology of depression in late life.
Social support as a predictor of the natural history of major depressionRead Full Text
Depressive symptoms and depressive diagnoses in a community population. Use of a new procedure for analysis of psychiatric classification.
Scoring nonresponse on the Mini-Mental State Examination.
Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression.
Depression in elderly hospitalized patients with medical illness.
Self-rated depression scales and screening for major depression in the older hospitalized patient with medical illness.
Relationship of health and demographic characteristics to Mini-Mental State examination score among community residents.
Dr. Blazer's ResponseRead Full Text
Trends in US suicide mortality rates 1968 to 1982: race and sex differences in age, period and cohort components.
Age differences in life event qualities: Multivariate controlled analysesRead Full Text
New concepts in the diagnosis and management of depression.
Leukoencephalopathy in patients diagnosed as major depressive.
Home health care: house calls revisited.
Affective disorders in five United States communities.
Detection and treatment of major depression in older medically ill hospitalized patients.
Age differences in life events: a multivariate controlled analysis.
Reducing antipsychotic drug prescribing for nursing home patients: a controlled trial of the effect of an educational visit.
Major depression with melancholia: a comparison of middle-aged and elderly adults.
Stressful life events and the onset of a generalized anxiety syndrome.
Alcohol abuse and dependence in the rural South.
The epidemiology of depression in an elderly community population.
Suicide in middle age and later life: sex and race specific life table and cohort analyses.
Hospital treatment of anorexia nervosa: A 25 year retrospective study form 1958 to 1982Read Full Text
Somatization disorder in the community. A study of diagnostic concordance among three diagnostic systems.
A study of somatization disorder in a community population utilizing grade of membership analysis.
Reducing Long-term Diazepam Prescribing in Office Practice: A Controlled Trial of Educational VisitsRead Full Text
Reducing long-term diazepam prescribing in office practice. A controlled trial of educational visits.
Somatization disorder in a community population.
Premenstrual symptoms in black and white community samples.
The economic burden of depression.
Community adjustment among the elderly: psychopharmacological patterns and diagnoses.
Psychosocial risk factors and urban/rural differences in the prevalence of major depression.
Comparison of lifetime psychiatric diagnoses in Premenstrual Syndrome Clinic and community samples.
Caring for the older adult: avoiding the lumping syndrome.
Somatization disorder in a US southern community: use of a new procedure for analysis of medical classification.
Suicide in late life. Review and commentary.
HELPING THE ELDERLY - THE COMPLEMENTARY ROLES OF INFORMAL NETWORKS AND FORMAL SYSTEMS - LITWAK,ERead Full Text
Systematic analysis of research on religious variables in four major psychiatric journals, 1978-1982.
Developing a screening index for community studies of somatization disorder.
The relationship between panic disorder and agoraphobia: an epidemiologic perspective.
Psychiatric disorders. A rural/urban comparison.
The epidemiology of psychiatric disorders in the elderly.
Problems in the Definition and Measurement of Prevalence and Incidence of Psychiatric DisordersRead Full Text
The Diagnostic Interview ScheduleRead Full Text
Historical Context, Major Objectives, and Study DesignRead Full Text
The NIMH Epidemiologic Catchment Area program. Historical context, major objectives, and study population characteristics.
Epidemiology of persecutory ideation in an elderly population in the community.
Family therapy and the dementia patient.
DEPRESSION IN THE ELDERLY - EPIDEMIOLOGIC, CLINICAL AND PHARMACOTHERAPEUTIC ISSUESRead Full Text
ARE DEPRESSIVE SYMPTOMS DIFFERENT IN THE DEPRESSED ELDERLYRead Full Text
The NIMH epidemiologic catchment area programRead Full Text
Community adjustment of older schizophrenics.
Impact of late-life depression on the social network.
MID LIFE AND LATER LIFERead Full Text
The risk of anticholinergic toxicity in the elderly: a study of prescribing practices in two populations.
The epidemiology of late life depression.
Social support and mortality in an elderly community population.
Diagnosing organic mental disorders in the elderly.
Using epidemiologic survey data to plan geriatric mental health services.
Hypersomnia in manic-depressive illness: a case of sleep apnea.
Chronic pain: a multiaxial approach to psychosocial assessment and intervention.
Life events, mental health functioning and the use of health care services by the elderly.
Older adults and their families in a community mental health center: strategies for intervention.
Epidemiology of dysphoria and depression in an elderly population.
The diagnosis of depression in the elderly.
Narcissism and the development of chronic pain.
Sex offenses: a short questionnaire assessing knowledge and attitudes.
Depression in late life.
Perception of poor health in the healthy older adult.
Atypical facial pain and trigeminal neuralgia: a comparison study.
Hospice in North Carolina: background and unanswered questions.
Techniques for communicating with your elderly patient.
Working with the elderly patient's family.
Adding life to years: late life sexuality and patient care.
Anorexia nervosa: a combined therapeutic approach.
Affective psychoses following renal transplant.
Religion and aging in a longitudinal panel.
Observations on pain and suffering.
Pentazocine psychosis: a case of persistent delusions.
RELIGION AND AGING - ANALYSIS OF A LONGITUDINAL PANELRead Full Text
Determinants of Poor Self-Rated Health in Late Life.
Health indices as predictors of cognition among older African Americans: MacArthur studies of successful aging.
Is Depression More Frequent in Late Life?: An Honest Look at the Evidence.