Faculty

Adrian Angold

Associate Professor Emeritus of Psychiatry and Behavioral Sciences

Psychiatry, Child & Family Mental Health & Developmental Neuroscience
School of Medicine

Box 3454 Med Ctr, Durham, NC 27710

Brightleaf Sq Ste 22B, 905 W Main St, Durham, NC 27701

(919) 687-4686 adrian.angold@duke.edu

Developmental epidemiology seeks to apply developmental and epidemiological principles to the study of psychopathology. Within this overall framework, my main research interests relate to the study of depression, anxiety, and disruptive behavior disorders and their effects on service use in children and adolescents. Current activities include studies of (1) relationships among pubertal hormonal changes, morphological changes, life strain, and psychopathology; (2) the development of measures of psychopathology and their links with psychiatric nosology (at the levels of symptoms, diagnoses, and disability); (3) parental burden and service use resulting from child and adolescent psychopathology; (4) comorbidity among psychiatric disorders; (5) factors affecting mental health service use; and (7) psychological predictors of risk for cardiovascular disorders in adolescence.


Education & Training

M.B.B.S. 1979

University College London (United Kingdom)

Grants

Vulnerability to Drug Abuse:Pathways to Recovery

National Institutes of Health

A developmental model of gene-environment interplay in SUDs

National Institutes of Health

Prefrontal Function in Adolescent Limited vs Life Course Persistent SUD

National Institutes of Health

Longitudinal Functional Imaging of Early Childhood Anxiety Disorders

National Institutes of Health

Sex, stress, emotional disorders: uniting preclinical and epidemiologic research

National Institutes of Health

Preschool Anxiety Disorders in Primary Care

National Institutes of Health

Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa

National Institutes of Health

Stress and Behavior in Health and Disease

National Institutes of Health

Training in Psychological Intervention Research

National Institutes of Health

Outcomes of Preschool Mental Health Problems

National Institutes of Health

Multi-Site Longitudinal Analysis of Psychiatric Risk of SUDs

National Institutes of Health

Validity Without a Gold Standard

National Institutes of Health

Growing Up Violent in Rural America

National Institutes of Health

Prepubertal Comorbidity: Gender and Developmental Heterotypy

National Institutes of Health

CADPRC in Developmental Epidemiology

National Institutes of Health

Assessing Preschool Comorbidity: A Test-Retest Study

National Institutes of Health

CADPRC in Developmental Epidemiology

Cadprc In Developmental Epidemiology

National Institutes of Health

Epidemiology of Pubertal Hormonal Changes and Depression

National Institutes of Health

Caring For Children In The Community

National Institutes of Health

Caring For Children In The Community

National Institutes of Health

Caring For Children In The Community

National Institutes of Health

Caring for Children in the Community

National Institutes of Health

Service Use For Adm Comorbidity In Rual Adolescents

National Institutes of Health

Adolescent Drug Abuse: Controlled Trial Of Family Therapy

National Institutes of Health

Service Use For Adm Comorbidity In Rural Adolescents

National Institutes of Health

Adolescent Adm: Service Use And Risks Of Comorbidity

National Institutes of Health

Adolescent Adm: Service Use And Risks Of Co-Morbidity

National Institutes of Health
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Publications

Early Pubertal Timing and Testosterone Associated With Higher Levels of Adolescent Depression in Girls.

PMID 30768421
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The Great Smoky Mountains Study: developmental epidemiology in the southeastern United States.

PMID 27010203
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Developmental Epidemiology

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Psychological and Psychosocial Impairment in Preschoolers With Selective Eating.

PMID 26240213
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Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

PMID 26081443
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Increase in untreated cases of psychiatric disorders during the transition to adulthood.

PMID 25554854
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Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.

PMID 25625285
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Are children and adolescents with food allergies at increased risk for psychopathology?

PMID 25454290
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Adult diagnostic and functional outcomes of DSM-5 disruptive mood dysregulation disorder.

PMID 24781389
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Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder.

PMID 24745954
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Perceived family impact of preschool anxiety disorders.

PMID 24655653
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Longitudinal patterns of anxiety from childhood to adulthood: the Great Smoky Mountains Study.

PMID 24342383
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C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.

PMID 24099969
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Preschool anxiety disorders in pediatric primary care: prevalence and comorbidity.

PMID 24290462
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Children with both asthma and depression are at risk for heightened inflammation.

PMID 23919906
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Sex-differentiated changes in C-reactive protein from ages 9 to 21: the contributions of BMI and physical/sexual maturation.

PMID 23711900
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Impact of bullying in childhood on adult health, wealth, crime, and social outcomes.

PMID 23959952
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Irritable mood as a symptom of depression in youth: prevalence, developmental, and clinical correlates in the Great Smoky Mountains Study.

PMID 23880493
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Diagnostic transitions from childhood to adolescence to early adulthood.

PMID 23451804
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Young Adult Obesity and Household Income: Effects of Unconditional Cash Transfers.

PMID 24707346
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Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.

PMID 23461817
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Adult psychiatric outcomes of bullying and being bullied by peers in childhood and adolescence.

PMID 23426798
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Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder.

PMID 23377638
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Indirect comorbidity in childhood and adolescence.

PMID 24204349
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Generalized anxiety and C-reactive protein levels: a prospective, longitudinal analysis.

PMID 22716910
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About 7% of 4-year-olds in Norway meet criteria for a psychiatric diagnosis

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Predicting persistent alcohol problems: a prospective analysis from the Great Smoky Mountain Study.

PMID 22153225
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Prevalence of psychiatric disorders in preschoolers.

PMID 22211517
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Psychiatric diagnostic interviews for children and adolescents: a comparative study.

PMID 22525957
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Cumulative depression episodes predict later C-reactive protein levels: a prospective analysis.

PMID 22047718
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Child-, adolescent- and young adult-onset depressions: differential risk factors in development?

PMID 21557889
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Trends in psychopathology across the adolescent years: what changes when children become adolescents, and when adolescents become adults?

PMID 21815892
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The NIMH Child Emotional Faces Picture Set (NIMH-ChEFS): a new set of children's facial emotion stimuli.

PMID 22547297
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Child μ-opioid receptor gene variant influences parent-child relations.

PMID 21326192
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Distinct neural signatures of threat learning in adolescents and adults.

PMID 21368210
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Cumulative prevalence of psychiatric disorders by young adulthood: a prospective cohort analysis from the Great Smoky Mountains Study.

PMID 21334565
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The developmental epidemiology of anxiety disorders: Phenomenology, prevalence, and comorbidity

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Developmental pathways in oppositional defiant disorder and conduct disorder.

PMID 21090876
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Psychiatric symptoms in bereaved versus nonbereaved youth and young adults: a longitudinal epidemiological study.

PMID 20970702
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Outcomes of early pubertal timing in young women: a prospective population-based study.

PMID 20478880
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Posttraumatic stress without trauma in children.

PMID 20551161
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Longitudinal dimensionality of adolescent psychopathology: testing the differentiation hypothesis.

PMID 20345843
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Specifying criminogenic strains: Stress dynamics and conduct disorder trajectories

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Association of family income supplements in adolescence with development of psychiatric and substance use disorders in adulthood among an American Indian population.

PMID 20483972
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Developmental transitions to psychopathology: are there prodromes of substance use disorders?

PMID 20132418
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Parents' Incomes and Children's Outcomes: A Quasi-Experiment.

PMID 20582231
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Transitions into underage and problem drinking: Summary of developmental processes and mechanisms: Ages 10-15

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Measurement and design for life course studies of individual differences and development

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Childhood and adolescent psychiatric disorders as predictors of young adult disorders.

PMID 19581568
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Moving from ethnography to epidemiology: lessons learned in Appalachia.

PMID 19353406
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Configurations of common childhood psychosocial risk factors.

PMID 19220623
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Nosology and measurement in child and adolescent psychiatry.

PMID 19175818
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Childhood psychopathology can be really bad for your health.

PMID 19096294
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Parent-reported attention-deficit/hyperactivity disorder symptomatology and sleep problems in a preschool-age pediatric clinic sample.

PMID 18664997
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Cultural and community determinants of subjective social status among Cherokee and White youth.

PMID 18701990
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Transitions into underage and problem drinking: developmental processes and mechanisms between 10 and 15 years of age.

PMID 18381494
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Specificity of putative psychosocial risk factors for psychiatric disorders in children and adolescents.

PMID 18181879
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What do childhood anxiety disorders predict?

PMID 18093022
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Childhood psychiatric disorders and young adult crime: a prospective, population-based study.

PMID 17974931
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Preschool psychopathology: lessons for the lifespan.

PMID 17914996
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Diagnostic specificity and nonspecificity in the dimensions of preschool psychopathology.

PMID 17915001
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Traumatic events and posttraumatic stress in childhood.

PMID 17485609
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Pubertal maturation and the development of alcohol use and abuse.

PMID 17275214
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Prediction from low birth weight to female adolescent depression: a test of competing hypotheses.

PMID 17339522
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Differences among children whose mothers have been in contact with the criminal justice system

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Is there an epidemic of child or adolescent depression?

PMID 17176381
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Bayesian semi-parametric ROC analysis.

PMID 16416403
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Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children.

PMID 17056393
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Puberty and depression.

PMID 16952768
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Proximal psychiatric risk factors for suicidality in youth: the Great Smoky Mountains Study.

PMID 16953004
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A comparison of pure and comorbid CD/ODD and depression.

PMID 16790005
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Test-Retest Reliability of the Preschool Age Psychiatric Assessment (PAPA).

PMID 16601400
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Common emotional and behavioral disorders in preschool children: presentation, nosology, and epidemiology.

PMID 16492262
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The epidemiology and diagnostic issues in preschool attention-deficit/ hyperactivity disorder: A review

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10-year research update review: the epidemiology of child and adolescent psychiatric disorders: II. Developmental epidemiology.

PMID 16327577
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Defining oppositional defiant disorder.

PMID 16313431
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Application of Bayesian inference using Gibbs sampling to item-response theory modeling of multi-symptom genetic data.

PMID 16273316
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The developmental epidemiology of anxiety disorders: phenomenology, prevalence, and comorbidity.

PMID 16171696
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10-year research update review: the epidemiology of child and adolescent psychiatric disorders: I. Methods and public health burden.

PMID 16175102
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Making sense of informant disagreement for overanxious disorder.

PMID 15533704
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Distant Trauma: A prospective study of the effects of september 11th on young adults in North Carolina

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Genetic and environmental influences on the relative timing of pubertal change.

PMID 15527663
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Effects of age at first substance use and psychiatric comorbidity on the development of substance use disorders.

PMID 15283950
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Informant disagreement for separation anxiety disorder.

PMID 15187805
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Testosterone, antisocial behavior, and social dominance in boys: pubertal development and biosocial interaction.

PMID 15023584
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Effect of poverty on emotional symptoms in children.

PMID 14747497
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Pathways to violence in the children of mothers who were depressed postpartum.

PMID 14584986
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Relationships between poverty and psychopathology: a natural experiment.

PMID 14559956
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Relations between Continuous Performance Test performance measures and ADHD behaviors.

PMID 14561061
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Continuous performance test performance in a normative epidemiological sample.

PMID 14561062
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Prevalence and development of psychiatric disorders in childhood and adolescence.

PMID 12912767
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Mental health assessments in juvenile justice: report on the consensus conference.

PMID 12819434
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School refusal and psychiatric disorders: a community study.

PMID 12819439
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Adolescent depression, cortisol and DHEA.

PMID 12785459
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Obesity and psychiatric disorder: developmental trajectories.

PMID 12671123
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Maternal smoking during pregnancy and risk to boys' conduct disturbance: an examination of the causal hypothesis.

PMID 12547468
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Puberty and depression

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Pathways into and through mental health services for children and adolescents.

PMID 12509668
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Natural categories or fundamental dimensions: on carving nature at the joints and the rearticulation of psychopathology.

PMID 14582931
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Depression scale scores in 8-17-year-olds: effects of age and gender.

PMID 12455926
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Psychiatric disorder, impairment, and service use in rural African American and white youth.

PMID 12365876
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The prevalence of potentially traumatic events in childhood and adolescence.

PMID 12013070
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The relationship between DSM-IV oppositional defiant disorder and conduct disorder: findings from the Great Smoky Mountains Study.

PMID 11944878
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Use of mental health services by youth in contact with social services

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Exposure to violence against a family member and internalizing symptoms in Colombian adolescents: the protective effects of family support.

PMID 11777124
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Epidemiology of psychiatric disability in childhood and adolescence.

PMID 11693585
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Poverty, race/ethnicity, and psychiatric disorder: a study of rural children.

PMID 11527787
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Do high-threat life events really provoke the onset of psychiatric disorder in children?

PMID 11383968
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Bayesian analyses of longitudinal binary data using Markov regression models of unknown order.

PMID 11241574
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Multimodal treatment of ADHD in the MTA: an alternative outcome analysis.

PMID 11211364
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Effectiveness of mental health services

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Effectiveness of mental health services.

PMID 11195557
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Implications of early versus late onset of attention-deficit/hyperactivity disorder symptoms.

PMID 11128328
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Stimulant treatment for children: a community perspective.

PMID 10939226
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Epstein-Barr virus antibodies in whole blood spots: a minimally invasive method for assessing an aspect of cell-mediated immunity.

PMID 10949102
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Effectiveness of nonresidential specialty mental health services for children and adolescents in the "real world".

PMID 10673824
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The Child and Adolescent Psychiatric Assessment (CAPA).

PMID 10638066
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Developmental psychopathology and public health: past, present, and future.

PMID 11202035
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Developmental Trajectories of Aggressive and Non-Aggressive Conduct Problems

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Development of psychiatric comorbidity with substance abuse in adolescents: effects of timing and sex.

PMID 10446679
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Pubertal changes in hormone levels and depression in girls.

PMID 10576297
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Somatic complaints and psychopathology in children and adolescents: stomach aches, musculoskeletal pains, and headaches.

PMID 10405503
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Use, persistence, and intensity: patterns of care for children's mental health across one year.

PMID 10094508
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Impaired but undiagnosed.

PMID 9951211
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Adolescent outcomes of childhood disorders: the consequences of severity and impairment.

PMID 9951210
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Assessing Functional Impairment and Social Adaptation for Child Mental Health Services Research: A Review of Measures

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Life events and post-traumatic stress: the development of a new measure for children and adolescents.

PMID 9854269
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Headaches and psychopathology in children and adolescents.

PMID 9735614
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Optimal Bayesian two-phase designs

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Perceived parental burden and service use for child and adolescent psychiatric disorders.

PMID 9584037
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Puberty and depression: the roles of age, pubertal status and pubertal timing.

PMID 9483683
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The relative diagnostic utility of child and parent reports of oppositional defiant behaviors

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The child and adolescent burden assessment (CABA): Measuring the family impact of emotional and behavioral problems

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Psychiatric disorders among American Indian and white youth in Appalachia: the Great Smoky Mountains Study.

PMID 9184514
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Development of substance use and psychiatric comorbidity in an epidemiologic study of white and American Indian young adolescents the Great Smoky Mountains Study.

PMID 9088778
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Impact of Children's Mental Health Problems on Families: Relationships with Service Use

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Insurance coverage and mental health services use by adolescents with serious emotional disturbance

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Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents: factor composition and structure across development

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Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents

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The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders.

PMID 8956679
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Precision, reliability and accuracy in the dating of symptom onsets in child and adolescent psychopathology.

PMID 8894946
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Toward establishing an empirical basis for the diagnosis of oppositional defiant disorder.

PMID 8824064
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The Child and Adolescent Services Assessment (CASA): Description and Psychometrics

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Disappearing Depression in a Population Sample of Boys

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A test-retest reliability study of child-reported psychiatric symptoms and diagnoses using the Child and Adolescent Psychiatric Assessment (CAPA-C).

PMID 7480452
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The Child and Adolescent Psychiatric Assessment (CAPA).

PMID 7480451
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Children's mental health service use across service sectors.

PMID 7498888
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Developmental epidemiology.

PMID 8521948
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Reliability of self-reported service use: Test-retest consistency of children's responses to the Child and Adolescent Services Assessment (CASA)

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Epidemiology and health care reform.

PMID 7832878
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Depressive comorbidity in children and adolescents: empirical, theoretical, and methodological issues.

PMID 8238631
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How can epidemiology improve mental health services for children and adolescents?

PMID 8282654
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Puberty onset of gender differences in rates of depression: a developmental, epidemiologic and neuroendocrine perspective.

PMID 8300975
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Seclusion on an adolescent unit.

PMID 8408379
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Toward a developmental epidemiology of the disruptive behavior disorders

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Effects of age and pubertal status on depression in a large clinical sample

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Mood variability in adolescents: a study of depressed, nondepressed and comorbid patients.

PMID 1791265
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The effects of age and sex on depression ratings in children and adolescents.

PMID 2005066
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Seclusion.

PMID 2686793
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Scales to assess child and adolescent depression: checklists, screens, and nets.

PMID 3058677
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Childhood and adolescent depression. II: Research in clinical populations.

PMID 3074855
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Childhood and adolescent depression. I. Epidemiological and aetiological aspects.

PMID 3048525
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Parent and child reports of depressive symptoms in children at low and high risk of depression.

PMID 3436996
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Depressed parents and their children. General health, social, and psychiatric problems.

PMID 3728409
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CHILDHOOD DEPRESSION

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