Addiction Research

Addiction Research

Faculty in the Addictions Division conduct internationally recorgnized research in a broad spectrum of mental health areas related to substance use and addictions. This work includes understanding how addictions change the fuctions of the brain, creating innovative therapies for treating those in our care, and discovering the co-morbidities between addictions and other metnal illnesses. 

Duke Center for Smoking Cessation is a multidisciplinary, multisite center working to elucidate the biological mechanisms underlying tobacco addiction and to promote the development of more effective smoking cessation treatments.
Faculty: Jed Rose, Alexi Mukhin, Thangaraju Murugesan, Yantao Zuo, Joe McClernon 

McClernon Lab/Triangle Smoking Studies investigates the neural and behavioral bases of tobacco use and other addictive behaviors, the comorbidity between addiction and mental illness, and the development of novel technologies to improve treatment outcomes. The public face of the lab—Triangle Smoking Studies—recruits smokers from the Triangle area to participate in research.
Faculty: Joe McClernon, Meridtih Addicott, Scott Kollins 

HIV and Addictions Research Program (HARP) seeks to understand and develop interventions, both locally and globally, to improve HIV-related health outcomes among persons who use cocaine, methamphetamine, and marijuana. Research focuses on the neuropsychiatric basis of health risk behaviors among vulnerable populations, integrating neuroimaging and behavioral assessment strategies, with projects in the United States and South Africa.
Faculty: Christina Meade 

Levin Lab conducts research concerning the neurobehavioral bases of cognitive, emotional and addictive function in animal models. Research is focused on understanding the functional interactions of cholinergic systems with other brain areas and systems.
Faculty: Edward Levin, Amir Rezvani 

Kollins Lab seeks to understand the behavioral, neuropharmacological, and genetic basis of smoking among individuals with Attention Deficit Hyperactivity Disorder (ADHD) using human laboratory psychopharmacology studies. The Kollins lab also explores the effects of secondhand smoke exposure on neurodevelopment and evaluates new pharmacological and non-pharmacological treatments for children and adults with ADHD.
Faculty: Scott Kollins, John Mitchell, Joe McClernon 

VA Alcohol Research Group uses preclinical neurophysiological and behavioral methods to understand the neural basis of substance abuse. The lab is particularly interested in adolescence as a neurologically and psychosocially significant phase for the initiation of and sensitivity to drug use.
Faculty: Scott Swartzwelder, Scott Moore, Qiang Li 

Kuhn Lab seeks to understand the interaction of hormonal and neural mechanisms that increase sensitivity to drug abuse and depression in adolescents and females. The lab takes a multidisciplinary approach which includes studying the behavioral response of rats to addictive drugs, the effects of gonadal steroids and other hormones on dopamine neuron function, and the activation of neural circuits by rewarding and aversive stimuli.
Faculty: Cynthia Kuhn