Faculty

Rachel Adcock

Associate Professor of Psychiatry and Behavioral Sciences

Psychiatry & Behavioral Sciences, Translational Neuroscience
School of Medicine

Director of the Center for Cognitive Neuroscience

Center for Cognitive Neuroscience
Institutes and Provost's Academic Units

Associate Professor of Neurobiology

Neurobiology
School of Medicine

Associate Professor of Psychology and Neuroscience

Psychology and Neuroscience
Trinity College of Arts & Sciences

Member of the Center for Cognitive Neuroscience

Center for Cognitive Neuroscience
Institutes and Provost's Academic Units

Faculty Network Member of the Duke Institute for Brain Sciences

Duke Institute for Brain Sciences
Institutes and Provost's Academic Units

Affiliate of the Center for Brain Imaging and Analysis

Duke-UNC Center for Brain Imaging and Analysis
School of Medicine
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Box 90999, Durham, NC 27708-0999

Center For Cognitive Neuroscie, Durham, NC 27708

(919) 681-7486

Dr. Adcock received her undergraduate degree in psychology from Emory University and her MD and PhD in Neurobiology from Yale University.  She completed her psychiatry residency training at Langley Porter Psychiatric Institute at UC-San Francisco and did neurosciences research as a postdoctoral fellow at UC-SF, the San Francisco VA Medical Center, and Stanford before joining the Duke faculty in 2007. Her work has been funded by NIDA, NIMH, NSF and Alfred P. Sloan and Klingenstein Fellowships in the Neurosciences, and the Brain & Behavior Research Foundation, and honored by NARSAD awards, the 2012 National Academy of Sciences Seymour Benzer Lectureship, and the 2015 ABAI BF Skinner Lectureship. The overall goals of her research program are to understand how brain systems for motivation support learning and to use mechanistic understanding of how behavior changes biology to meet the challenge of developing new therapies appropriate for early interventions for mental illness.


Education & Training

M.D. 1999

Yale University School of Medicine

Ph.D. 1999

Yale University

Grants

Duke CTSA (KL2)

National Institutes of Health

Duke CTSA (TL1)

National Institutes of Health

Targeting reward dysfunction as a mechanism to improve smoking cessation

National Institutes of Health

Modeling the Neurobehavioral Basis of Extrinsic and Volitional Motivation in ADHD

National Institutes of Health

Instructed Activation of the Human Dopaminergic Midbrain Using Real-Time fMRI in Nicotine-Dependent Individuals

Brain and Behavior Research Foundation

Smoking/Nicotine Dependence in Attention Deficit Hyperactivity Disorder (ADHD)

National Institutes of Health

Environment Cue-Reactivity: Brain, Behavior and Clinical Outcomes in Tobacco Use

National Institutes of Health

Characterizing Neural Mechanisms of Cognitive Control

National Institutes of Health

Basic predoctoral training in neuroscience

National Institutes of Health

Increasing Motivation in ADHD Via Self-activation of VTA

National Institutes of Health

Connectivity of the Dopaminergic Midbrain During Learned Regulation of Intrinsic Motivation

Canadian Institutes of Health Research

BRAIN EAGER: Bayesian Models of Translational Neural Networks: Motivation and Reward

National Science Foundation

Acute and chronic nicotine modulation of reinforcement learning

National Institutes of Health

A Compute Cluster for Brain Imaging and Analysis

National Institutes of Health

Motivated Memory as Therapeutic Target

National Institutes of Health

Instructed Activation of the Human Dopaminergic Midbrain using Real-Time fMRI

National Institutes of Health

Training in Fundamental &Translational Neuroscience

National Institutes of Health

Brain Imaging Studies of Negative Reinforcement in Humans

National Institutes of Health

From Phenotype to Mechanism: Mapping the Pathways underlying Risky Choice

National Institutes of Health
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Publications

Single session real-time fMRI neurofeedback has a lasting impact on cognitive behavioral therapy strategies.

PMID 29922575
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Individual differences in regulatory focus predict neural response to reward.

PMID 27074863
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Hippocampus and Prefrontal Cortex Predict Distinct Timescales of Activation in the Human Ventral Tegmental Area.

PMID 26826101
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Selectivity in post-encoding connectivity with high-level visual cortex is associated with reward-motivated memory.

PMID 27920146
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Distinct medial temporal networks encode surprise during motivation by reward versus punishment.

PMID 26854903
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Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study.

PMID 27396386
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Cognitive Neurostimulation: Learning to Volitionally Sustain Ventral Tegmental Area Activation.

PMID 26948894
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Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence.

PMID 26179147
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Reward Anticipation Dynamics during Cognitive Control and Episodic Encoding: Implications for Dopamine.

PMID 27847474
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Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study.

PMID 25745033
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Resting state networks distinguish human ventral tegmental area from substantia nigra.

PMID 24979343
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Enriched encoding: reward motivation organizes cortical networks for hippocampal detection of unexpected events.

PMID 23529005
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ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: Implications for smoking and nicotine dependence

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ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence.

PMID 24560930
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Altered striatal functional connectivity in subjects with an at-risk mental state for psychosis.

PMID 23861539
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Mechanisms of motivation-cognition interaction: challenges and opportunities.

PMID 24920442
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Context matters: the structure of task goals affects accuracy in multiple-target visual search.

PMID 23957930
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Context matters: The structure of task goals affects accuracy in multiple-target visual search

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Mechanisms of motivation-cognition interaction: Challenges and opportunities

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Preserved working memory and altered brain activation in persons at risk for psychosis.

PMID 24077560
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Size matters: how age and reaching experiences shape infants' preferences for different sized objects.

PMID 23454420
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Hippocampal networks habituate as novelty accumulates.

PMID 23512939
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DOPAMINERGIC MODULATION OF REWARD-MOTIVATED MEMORY

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THE ACTIVE AVOIDANCE OF THREAT ENHANCES NEURAL SENSITIVITY TO EXPECTANCY VIOLATION.

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MOVE FASTER TO LEARN BETTER: EXPLORATION SPEED IMPACTS LEARNING ABOUT OBJECTS AND THEIR LOCATIONS

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Threat of punishment motivates memory encoding via amygdala, not midbrain, interactions with the medial temporal lobe.

PMID 22745496
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Midbrain Modulation of Hippocampus Dependent Learning in Singaporeans at Ultra High Risk for the Development of Schizophrenia

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Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior.

PMID 21753011
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Amygdala Reactivity in Singaporeans at Ultra High Risk for the Development of Schizophrenia

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Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia.

PMID 20663254
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Reprint of: fMRI studies of successful emotional memory encoding: a quantitative meta-analysis.

PMID 21414466
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Is all motivation good for learning? Dissociable influences of approach and avoidance motivation in declarative memory.

PMID 22021253
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fMRI studies of successful emotional memory encoding: A quantitative meta-analysis.

PMID 20688087
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Dopamine and adaptive memory.

PMID 20829095
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Generalized Enhancement of Episodic Memory by Prior Reward Experience

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Functional significance of striatal responses during episodic decisions: recovery or goal attainment?

PMID 20357127
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Timing is everything: Neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjects

PMID 19879305
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When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia.

PMID 19745022
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Activation in the VTA and nucleus accumbens increases in anticipation of both gains and losses.

PMID 19753142
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Reward-motivated learning: mesolimbic activation precedes memory formation.

PMID 16675403
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Remembrance of rewards past

PMID 15694318
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Functional neuroanatomy of executive processes involved in dual-task performance.

PMID 10725387
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Respiratory sinus arrhythmia and cardiovascular responses to stress.

PMID 1410177
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Caffeine effects on cardiovascular and neuroendocrine responses to acute psychosocial stress and their relationship to level of habitual caffeine consumption.

PMID 2195579
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