1260 Betty's Creek Rd., Sylva, NC 28779
1260 Betty's Creek Rd., Sylva, NC 28779
In collaboration with Dr. Scott Swartzwelder, research in our lab has focused on the neurodevelopmental effects of alcohol and other drugs of abuse. In particular, we have been interested in how and why adolescents are more sensitive to some effects of ethanol and THC (e.g., learning and memory) and less sensitive to other effects (e.g., sedation). Beginning in Fall 2011, my lab will begin a new line of research focused on potential pharmacotherapies for TBI and the basic underlying mechanisms of recovery of function following acquired brain injury. This work is funded by a Career Development Award from the Veterans Administration Biomedical Laboratory Research & Development service.
Adolescent Ethanol Exposure Enhances NMDA Receptor-Mediated Currents in Hippocampal Neurons: Reversal by Gabapentin.
Behavioral Inefficiency on a Risky Decision-Making Task in Adulthood after Adolescent Intermittent Ethanol Exposure in Rats.
A blood-based biomarker panel to risk-stratify mild traumatic brain injury.
Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.
Opposing effects of traumatic brain injury on excitatory synaptic function in the lateral amygdala in the absence and presence of preinjury stress.
Neurosteroids and traumatic brain injury translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veteransRead Full Text
Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood.
Adolescent Intermittent Alcohol Exposure: Deficits in Object Recognition Memory and Forebrain Cholinergic Markers.
Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus.
Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.
Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats.
Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult ratsRead Full Text
Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement miceRead Full Text
Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.
Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.
Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells.
ApolipoproteinE mimetic peptides improve outcome after focal ischemia.
Long-Term Modulation of A-Type K+ Conductances in Hippocampal CA1 Interneurons in Rats After Chronic Intermittent Ethanol Exposure During Adolescence or AdulthoodRead Full Text
Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding.
Effects of acute or chronic ethanol exposure during adolescence on behavioral inhibition and efficiency in a modified water maze task.
Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cellsRead Full Text
Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats.
IN THE RAT, CHRONIC INTERMITTENT ETHANOL EXPOSURE DURING ADOLESCENCE, BUT NOT LATER, ALTERS THE ETHANOL SENSITIVITY OF TONIC INHIBITION IN ADULTHOODRead Full Text
In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood.
Tobacco use among Iraq- and Afghanistan-era veterans: a qualitative study of barriers, facilitators, and treatment preferences.
GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus.
Characteristics and correlates of cigarette use among recent U.S. veteransRead Full Text
Public health clinical demonstration project for smoking cessation in american veterans who served since september 11, 2001.
The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals.
Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats.
Predictors of relapse during treatment and treatment completion among marijuana-dependent adolescents in an intensive outpatient substance abuse program.
Age-independent and dose-response effects of ethanol on spatial memory in rats.
Neurotoxicity of ethyl methacrylate in rats.
Developmental changes in seizure susceptibility during ethanol withdrawal.
Impairment of semantic and figural memory by acute ethanol: age-dependent effects.
Differential effects of ethanol on memory in adolescent and adult rats.
Infant and preschool mental and verbal abilities: How are infant scores related to preschool scores?Read Full Text
An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models