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Dr Georgiades research has focused on evaluating bio-behavioral risk-factors, in particular the role mental stress, in the development of diabetes and cardiovascular disease. She have written and co-authored over 45 papers in the area of behavioral medicine and have vast experience from designing experimental studies and evaluating epidemiological cohort studies. In addition, she has been co-investigator on intervention studies examining the effects of cognitive behavioral therapy, stress management and exercise programs in diabetic, hypertensive and cardiac patients.
For the past 10 years, her focus been to examine the role of stress and stress hormones in glucose regulation. Results from her recent studies suggest that increased stress hormone activity, manifested as elevated circulating epinephrine after a glucose challenge, interact with central adiposity in the prediction of increased glucose levels in obese individuals.
Dr Georgiades is presently a collaborator on a Program Project Grant (PPG) lead by Dr Redford Williams. The aim of her work within the PPG is to study the relationship between behavioral factors and various measures of glucose metabolism and identify genes/loci that account for the clustering of metabolic abnormalities with cardiovascular, neuroendocrine, platelet function and inflammatory markers. The overall aim of the PPG is to increase understanding of the gene-environment interactions that contribute to pathogenic mechanisms whereby psychosocial and biobehavioral risk factors increase risk for cardiovascular disease.