Associate Professor of Psychiatry and Behavioral Sciences
Department / Division:
/ Biological Psychiatry
Durham, NC 27710
- MD, PhD, University of Virginia School of Medicine, 1986
- Psychiatry, Duke University Medical Center, 1989-1992
Psychopharmacology, electroconvulsive therapy, neurobehavioral disorders
We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.
We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.