Rebekah Jakel, MD, PhD


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Consulting Associate in the Department of Psychiatry and Behavioral Sciences
Department / Division:
Psychiatry / Translational Neuroscience
508 Fulton Street
Durham, NC 27705
Office Telephone:
(919) 684-8111
  • MD, University of Wisconsin at Madison, 2008
  • PhD, University of Wisconsin at Madison, 2006
  • residency, Psychiatry And Behavioral Sciences, Duke University School of Medicine
Representative Publications:
  • Muzyk, AJ; Jakel, RJ; Preud'homme, X. Serotonin syndrome after a massive overdose of controlled-release paroxetine. Psychosomatics. 2010;51:437-442.  Abstract
  • Johnson, JA; Johnson, DA; Kraft, AD; Calkins, MJ; Jakel, RJ; Vargas, MR; Chen, PC. The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Annals of the New York Academy of Sciences. 2008;1147:61-69.  Abstract
  • Jakel, RJ; Townsend, JA; Kraft, AD; Johnson, JA. Nrf2-mediated protection against 6-hydroxydopamine. Brain Research. 2007;1144:192-201.  Abstract
  • Calkins, MJ; Jakel, RJ; Johnson, DA; Chan, K; Kan, YW; Johnson, JA. Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription. Proceedings of the National Academy of Sciences of USA. 2005;102:244-249.  Abstract
  • Jakel, RJ; Kern, JT; Johnson, DA; Johnson, JA. Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. Toxicological Sciences (Elsevier). 2005;87:176-186.  Abstract
  • Lee, JM; Li, J; Johnson, DA; Stein, TD; Kraft, AD; Calkins, MJ; Jakel, RJ; Johnson, JA. Nrf2, a multi-organ protector?. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005;19:1061-1066.  Abstract
  • Jakel, RJ; Schneider, BL; Svendsen, CN. Using human neural stem cells to model neurological disease. Nature Reviews Genetics. 2004;5:136-144.  Abstract
  • McBride, JL; Behrstock, SP; Chen, EY; Jakel, RJ; Siegel, I; Svendsen, CN; Kordower, JH. Human neural stem cell transplants improve motor function in a rat model of Huntington's disease. The Journal of Comparative Neurology. 2004;475:211-219.  Abstract
  • Jakel, RJ; Maragos, WF. Neuronal cell death in Huntington's disease: a potential role for dopamine. Trends in Neurosciences. 2000;23:239-245.  Abstract
  • Maragos, WF; Jakel, R; Chesnut, D; Pocernich, CB; Butterfield, DA; St Clair, D; Cass, WA. Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase. Brain Research. 2000;878:218-222.  Abstract
  • Kruman, II; Nath, A; Maragos, WF; Chan, SL; Jones, M; Rangnekar, VM; Jakel, RJ; Mattson, MP. Evidence that Par-4 participates in the pathogenesis of HIV encephalitis. The American journal of pathology. 1999;155:39-46.  Abstract
  • Maragos, WF; Jakel, RJ; Chesnut, MD; Geddes, JW; Dwoskin, LP. Does dopamine contribute to striatal damage caused by impaired mitochondrial function?. Annals of the New York Academy of Sciences. 1999;893:345-349.  Abstract
  • Maragos, WF; Tillman, PA; Chesnut, MD; Jakel, RJ. Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. Brain Research. 1999;834:168-172.  Abstract
  • Maragos, WF; Jakel, RJ; Pang, Z; Geddes, JW. 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions. Experimental Neurology. 1998;154:637-644.  Abstract