Li-Tzy Wu, DSc, MA

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Professor in Psychiatry and Behavioral Sciences
Department / Division:
Psychiatry / Social & Community Psychiatry
Address:
Duke South Hospital, Rm 3521
Box 3903
Durham, NC 27710
Office Telephone:
(919) 889-9369
Training:
  • DSc, Johns Hopkins University, 1997
  • MA, State University of New York at New Paltz, 1992
Research Interests:
Epidemiology of addictions and comorbidity, utilization of mental health and substance abuse treatments and outcomes, health service research, diagnostic validity & assessments, nosology, psychometric analysis, HIV risk behavior, new research methodologies.

Recipient of the Harold and Sylvia Halpert Endowment Award (mental health service research), Johns Hopkins University

Recipient of the Morton Kramer Fund Award (biostatistics & mental health research), Johns Hopkins University

NIMH and NIDA post-doctoral fellow in psychiatric and addiction research

Fellow of the NIH Summer Institute for Randomized Clinical Trials

Editor-In-Chief of Substance Abuse and Rehabilitation (Subst Abuse Rehabil)

Publication reviewer of the National Drug Abuse Treatment Clinical Trials Network (NIDA CTN)

Funded research projects: treatment use for drug use disorders, treatment use for alcohol use disorders, inhalant use & disorders, MDMA/hallucinogens, prescription opioids, substance use disorders in adolescents, substance use diagnoses & treatment (NIDA CTN), substance use disorders and treatment use among Asian Americans and Pacific Islanders, SBIRT, substance use screening tool and assessment, substance use & older adults

Committee member of the NIDA Asian American and Pacific Islander Researchers and Scholars Workgroup (NIDA AAPI Workgroup)

Lifetime member of the Alpha Chapter of the Delta Omega Honorary Public Health Society, Johns Hopkins University

Commission on Graduates of Foreign Nursing School certificate, USA
Registered Nurse License, RN, USA
Representative Publications:
  • Chapman, SL; Wu, LT. Food, class, and health: the role of the perceived body in the social reproduction of health. Health Communication. 2013;28:341-350.  Abstract
  • Wu, LT; Swartz, MS; Pan, JJ; Burchett, B; Mannelli, P; Yang, C; Blazer, DG. Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults. General Hospital Psychiatry. 2013;35:74-82.  Abstract
  • Blazer, DG; Wu, LT. Patterns of tobacco use and tobacco-related psychiatric morbidity and substance use among middle-aged and older adults in the United States. Aging and Mental Health. 2012;16:296-304.  Abstract
  • Carroll Chapman, SL; Wu, LT. Substance abuse among individuals with intellectual disabilities. Research in Developmental Disabilities. 2012;33:1147-1156.  Abstract
  • Crome, I; Li, TK; Rao, R; Wu, LT. Alcohol limits in older people. Addiction. 2012;107:1541-1543.  Abstract
  • Lee, HY; Li, JH; Wu, LT; Wu, JS; Yen, CF; Tang, HP. Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. Substance Abuse Treatment, Prevention, and Policy. 2012;7:11.  Abstract
  • Ling, W; Mooney, L; Wu, LT. Advances in opioid antagonist treatment for opioid addiction. Psychiatric Clinics of North America. 2012;35:297-308.  Abstract
  • Mannelli, P; Peindl, K; Wu, LT; Patkar, AA; Gorelick, DA. The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal. American Journal of Drug and Alcohol Abuse. 2012;38:200-205.  Abstract
  • Mannelli, P; Peindl, KS; Lee, T; Bhatia, KS; Wu, LT. Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives. Current Drug Abuse Reviews. 2012;5:52-63.  Abstract
  • Perron, BE; Ahmedani, BK; Vaughn, MG; Glass, JE; Abdon, A; Wu, LT. Use of Salvia divinorum in a nationally representative sample. American Journal of Drug and Alcohol Abuse. 2012;38:108-113.  Abstract
  • Pilowsky, DJ; Wu, LT. Screening for alcohol and drug use disorders among adults in primary care: a review. Substance Abuse and Rehabilitation. 2012;3:25-34.  Abstract
  • Vaughn, MG; Fu, Q; Perron, BE; Wu, LT. Risk profiles among adolescent nonmedical opioid users in the United States. Addictive Behaviors. 2012;37:974-977.  Abstract
  • Vaughn, MG; Perron, BE; Abdon, A; Olate, R; Groom, R; Wu, LT. Correlates of handgun carrying among adolescents in the United States. Journal of Interpersonal Violence: concerned with the study and treatment of victims and perpetrators of physical and sexual violence. 2012;27:2003-2021.  Abstract
  • Wu, LT; Blazer, DG. Datapoints: Use of medications and counseling for depression by Asian and multiple-race adolescents aged 12-17 years. Psychiatric Services. 2012;63:850.  Abstract
  • Wu, LT; Blazer, DG; Woody, GE; Burchett, B; Yang, C; Pan, JJ; Ling, W. Alcohol and drug dependence symptom items as brief screeners for substance use disorders: results from the Clinical Trials Network. Journal of Psychiatric Research. 2012;46:360-369.  Abstract
  • Wu, LT; Swartz, MS; Wu, Z; Mannelli, P; Yang, C; Blazer, DG. Alcohol and drug use disorders among adults in emergency department settings in the United States. Annals of Emergency Medicine. 2012;60:172-80.e5.  Abstract
  • Wu, LT; Woody, GE; Yang, C; Pan, JJ; Reeve, BB; Blazer, DG. A dimensional approach to understanding severity estimates and risk correlates of marijuana abuse and dependence in adults. International Journal of Methods in Psychiatric Research. 2012;21:117-133.  Abstract
  • Blazer, DG; Wu, LT. The epidemiology of alcohol use disorders and subthreshold dependence in a middle-aged and elderly community sample. American Journal of Geriatric Psychiatry. 2011;19:685-694.  Abstract
  • Burlew, AK; Weekes, JC; Montgomery, L; Feaster, DJ; Robbins, MS; Rosa, CL; Ruglass, LM; Venner, KL; Wu, LT. Conducting research with racial/ethnic minorities: methodological lessons from the NIDA Clinical Trials Network. American Journal of Drug and Alcohol Abuse. 2011;37:324-332.  Abstract
  • Fishman, MJ; Wu, LT; Woody, GE. Buprenorphine for prescription opioid addiction in a patient with depression and alcohol dependence. American Journal of Psychiatry. 2011;168:675-679.  Abstract
  • Mannelli, P; Peindl, K; Patkar, AA; Wu, LT; Tharwani, HM; Gorelick, DA. Problem drinking and low-dose naltrexone-assisted opioid detoxification. Journal of Studies on Alcohol and Drugs. 2011;72:507-513.  Abstract
  • Mannelli, P; Peindl, KS; Wu, LT. Pharmacological enhancement of naltrexone treatment for opioid dependence: a review. Substance Abuse and Rehabilitation. 2011;2011:113-123.  Abstract
  • Perron, BE; Glass, JE; Ahmedani, BK; Vaughn, MG; Roberts, DE; Wu, LT. The prevalence and clinical significance of inhalant withdrawal symptoms among a national sample. Substance Abuse and Rehabilitation. 2011;2011:69-76.  Abstract
  • Pilowsky, DJ; Wu, LT; Burchett, B; Blazer, DG; Ling, W. Depressive symptoms, substance use, and HIV-related high-risk behaviors among opioid-dependent individuals: results from the Clinical Trials Network. Substance Use and Misuse. 2011;46:1716-1725.  Abstract
  • Pilowsky, DJ; Wu, LT; Burchett, B; Blazer, DG; Woody, GE; Ling, W. Co-occurring amphetamine use and associated medical and psychiatric comorbidity among opioid-dependent adults: results from the Clinical Trials Network. Substance Abuse and Rehabilitation. 2011;2:133-144.  Abstract
  • Wu, LT; Blazer, DG. Illicit and nonmedical drug use among older adults: a review. Journal of Aging and Health. 2011;23:481-504.  Abstract
  • Wu, LT; Blazer, DG; Li, TK; Woody, GE. Treatment use and barriers among adolescents with prescription opioid use disorders. Addictive Behaviors. 2011;36:1233-1239.  Abstract
  • Wu, LT; Gersing, K; Burchett, B; Woody, GE; Blazer, DG. Substance use disorders and comorbid Axis I and II psychiatric disorders among young psychiatric patients: findings from a large electronic health records database. Journal of Psychiatric Research. 2011;45:1453-1462.  Abstract
  • Wu, LT; Ling, W; Burchett, B; Blazer, DG; Yang, C; Pan, JJ; Reeve, BB; Woody, GE. Use of item response theory and latent class analysis to link poly-substance use disorders with addiction severity, HIV risk, and quality of life among opioid-dependent patients in the Clinical Trials Network. Drug and Alcohol Dependence. 2011;118:186-193.  Abstract
  • Wu, LT; Woody, GE; Yang, C; Blazer, DG. How do prescription opioid users differ from users of heroin or other drugs in psychopathology: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of Addiction Medicine. 2011;5:28-35.  Abstract
  • Wu, LT; Woody, GE; Yang, C; Li, JH; Blazer, DG. Recent national trends in Salvia divinorum use and substance-use disorders among recent and former Salvia divinorum users compared with nonusers. Substance Abuse and Rehabilitation. 2011;2011:53-68.  Abstract
  • Wu, LT; Woody, GE; Yang, C; Mannelli, P; Blazer, DG. Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Substance Abuse and Rehabilitation. 2011;2011:77-88.  Abstract
  • Wu, LT; Woody, GE; Yang, C; Pan, JJ; Blazer, DG. Abuse and dependence on prescription opioids in adults: a mixture categorical and dimensional approach to diagnostic classification. Psychological Medicine. 2011;41:653-664.  Abstract
  • Wu, LT; Woody, GE; Yang, C; Pan, JJ; Blazer, DG. Racial/ethnic variations in substance-related disorders among adolescents in the United States. Archives of General Psychiatry. 2011;68:1176-1185.  Abstract
  • Mannelli, P; Peindl, K; Patkar, AA; Wu, LT; Pae, CU; Gorelick, DA. Reduced cannabis use after low-dose naltrexone addition to opioid detoxification. Journal of Clinical Psychopharmacology. 2010;30:476-478.  Abstract
  • Wu, LT. Substance abuse and rehabilitation: responding to the global burden of diseases attributable to substance abuse. Substance Abuse and Rehabilitation. 2010;2010:5-11.  Abstract
  • Wu, LT; Ling, W; Burchett, B; Blazer, DG; Shostak, J; Woody, GE. Gender and racial/ethnic differences in addiction severity, HIV risk, and quality of life among adults in opioid detoxification: results from the National Drug Abuse Treatment Clinical Trials Network. Substance Abuse and Rehabilitation. 2010;2010:13-22.  Abstract
  • Wu, LT; Pan, JJ; Blazer, DG; Tai, B; Stitzer, ML; Woody, GE. Using a latent variable approach to inform gender and racial/ethnic differences in cocaine dependence: a National Drug Abuse Treatment Clinical Trials Network study. Journal of Substance Abuse Treatment. 2010;38 Suppl 1:S70-S79.  Abstract
  • Wu, LT; Pan, JJ; Yang, C; Reeve, BB; Blazer, DG. An item response theory analysis of DSM-IV criteria for hallucinogen abuse and dependence in adolescents. Addictive Behaviors. 2010;35:273-277.  Abstract
  • Wu, LT; Woody, GE; Yang, C; Blazer, DG. Subtypes of nonmedical opioid users: results from the national epidemiologic survey on alcohol and related conditions. Drug and Alcohol Dependence. 2010;112:69-80.  Abstract
  • Blazer, DG; Wu, LT. Nonprescription use of pain relievers by middle-aged and elderly community-living adults: National Survey on Drug Use and Health. Journal of the American Geriatrics Society. 2009;57:1252-1257.  Abstract
  • Blazer, DG; Wu, LT. The epidemiology of at-risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health. American Journal of Psychiatry. 2009;166:1162-1169.  Abstract
  • Blazer, DG; Wu, LT. The epidemiology of substance use and disorders among middle aged and elderly community adults: national survey on drug use and health. American Journal of Geriatric Psychiatry. 2009;17:237-245.  Abstract
  • Han, C; Kwak, KP; Marks, DM; Pae, CU; Wu, LT; Bhatia, KS; Masand, PS; Patkar, AA. The impact of the CONSORT statement on reporting of randomized clinical trials in psychiatry. Contemporary Clinical Trials. 2009;30:116-122.  Abstract
  • Mannelli, P; Patkar, AA; Peindl, K; Gorelick, DA; Wu, LT; Gottheil, E. Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial. Addiction Biology. 2009;14:204-213.  Abstract
  • Mannelli, P; Patkar, AA; Peindl, K; Gottheil, E; Wu, LT; Gorelick, DA. Early outcomes following low dose naltrexone enhancement of opioid detoxification. American Journal on Addictions. 2009;18:109-116.  Abstract
  • Wechsberg, WM; Wu, LT; Zule, WA; Parry, CD; Browne, FA; Luseno, WK; Kline, T; Gentry, A. Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South Africa. Substance Abuse Treatment, Prevention, and Policy. 2009;4:11.  Abstract
  • Wu, LT; Blazer, DG; Patkar, AA; Stitzer, ML; Wakim, PG; Brooner, RK. Heterogeneity of stimulant dependence: a national drug abuse treatment clinical trials network study. American Journal on Addictions. 2009;18:206-218.  Abstract
  • Wu, LT; Pan, JJ; Blazer, DG; Tai, B; Brooner, RK; Stitzer, ML; Patkar, AA; Blaine, JD. The construct and measurement equivalence of cocaine and opioid dependences: a National Drug Abuse Treatment Clinical Trials Network (CTN) study. Drug and Alcohol Dependence. 2009;103:114-123.  Abstract
  • Wu, LT; Pan, JJ; Blazer, DG; Tai, B; Stitzer, ML; Brooner, RK; Woody, GE; Patkar, AA; Blaine, JD. An item response theory modeling of alcohol and marijuana dependences: a National Drug Abuse Treatment Clinical Trials Network study. Journal of Studies on Alcohol and Drugs. 2009;70:414-425.  Abstract
  • Wu, LT; Parrott, AC; Ringwalt, CL; Patkar, AA; Mannelli, P; Blazer, DG. The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention. Addictive Behaviors. 2009;34:654-661.  Abstract
  • Wu, LT; Parrott, AC; Ringwalt, CL; Yang, C; Blazer, DG. The variety of ecstasy/MDMA users: results from the National Epidemiologic Survey on alcohol and related conditions. American Journal on Addictions. 2009;18:452-461.  Abstract
  • Wu, LT; Ringwalt, CL; Patkar, AA; Hubbard, RL; Blazer, DG. Association of MDMA/ecstasy and other substance use with self-reported sexually transmitted diseases among college-aged adults: a national study. Public Health. 2009;123:557-564.  Abstract
  • Wu, LT; Ringwalt, CL; Weiss, RD; Blazer, DG. Hallucinogen-related disorders in a national sample of adolescents: the influence of ecstasy/MDMA use. Drug and Alcohol Dependence. 2009;104:156-166.  Abstract
  • Wu, LT; Ringwalt, CL; Yang, C; Reeve, BB; Pan, JJ; Blazer, DG. Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. 2009;48:563-572.  Abstract
  • Howard, MO; Balster, RL; Cottler, LB; Wu, LT; Vaughn, MG. Inhalant use among incarcerated adolescents in the United States: prevalence, characteristics, and correlates of use. Drug and Alcohol Dependence. 2008;93:197-209.  Abstract
  • Patkar, AA; Mannelli, P; Peindl, K; Hill, KP; Wu, LT; Lee, T; Kuhn, C. Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence. Journal of Psychiatric Research. 2008;42:1213-1219.  Abstract
  • Wu, LT; Blazer, DG; Stitzer, ML; Patkar, AA; Blaine, JD. Infrequent illicit methadone use among stimulant-using patients in methadone maintenance treatment programs: a national drug abuse treatment clinical trials network study. American Journal on Addictions. 2008;17:304-311.  Abstract
  • Wu, LT; Howard, MO; Pilowsky, DJ. Substance use disorders among inhalant users: results from the National Epidemiologic Survey on alcohol and related conditions. Addictive Behaviors. 2008;33:968-973.  Abstract
  • Wu, LT; Pilowsky, DJ; Patkar, AA. Non-prescribed use of pain relievers among adolescents in the United States. Drug and Alcohol Dependence. 2008;94:1-11.  Abstract
  • Wu, LT; Ringwalt, CL; Mannelli, P; Patkar, AA. Hallucinogen use disorders among adult users of MDMA and other hallucinogens. American Journal on Addictions. 2008;17:354-363.  Abstract
  • Wu, LT; Ringwalt, CL; Mannelli, P; Patkar, AA. Prescription pain reliever abuse and dependence among adolescents: a nationally representative study. Journal of the American Academy of Child and Adolescent Psychiatry. 2008;47:1020-1029.  Abstract
  • Mannelli, P; Patkar, AA; Peindl, K; Murray, HW; Wu, LT; Hubbard, R. Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence. Journal of Clinical Psychopharmacology. 2007;27:468-474.  Abstract
  • Peindl, KS; Mannelli, P; Wu, LT; Patkar, AA. Trends in nonheroin opioid abuse admissions: 1992-2004. Journal of Opioid Management: a medical journal of proper and adequate use. 2007;3:215-223.  Abstract
  • Wu, LT; Howard, MO. Is inhalant use a risk factor for heroin and injection drug use among adolescents in the United States?. Addictive Behaviors. 2007;32:265-281.  Abstract
  • Wu, LT; Howard, MO. Psychiatric disorders in inhalant users: results from The National Epidemiologic Survey on Alcohol and Related Conditions. Drug and Alcohol Dependence. 2007;88:146-155.  Abstract
  • Wu, LT; Pilowsky, DJ; Schlenger, WE; Galvin, DM. Misuse of methamphetamine and prescription stimulants among youths and young adults in the community. Drug and Alcohol Dependence. 2007;89:195-205.  Abstract
  • Wu, LT; Pilowsky, DJ; Schlenger, WE; Hasin, D. Alcohol use disorders and the use of treatment services among college-age young adults. Psychiatric Services. 2007;58:192-200.  Abstract
  • Pilowsky, DJ; Wu, LT. Psychiatric symptoms and substance use disorders in a nationally representative sample of American adolescents involved with foster care. Journal of Adolescent Health. 2006;38:351-358.  Abstract
  • Wu, LT; Ringwalt, CL. Inhalant use and disorders among adults in the United States. Drug and Alcohol Dependence. 2006;85:1-11.  Abstract
  • Wu, LT; Ringwalt, CL. Use of alcohol treatment and mental health services among adolescents with alcohol use disorders. Psychiatric Services. 2006;57:84-92.  Abstract
  • Wu, LT; Schlenger, WE; Galvin, DM. Concurrent use of methamphetamine, MDMA, LSD, ketamine, GHB, and flunitrazepam among American youths. Drug and Alcohol Dependence. 2006;84:102-113.  Abstract
  • O'Brien, MS; Wu, LT; Anthony, JC. Cocaine use and the occurrence of panic attacks in the community: a case-crossover approach. Substance Use and Misuse. 2005;40:285-297.  Abstract
  • Wu, LT; Pilowsky, DJ; Schlenger, WE. High prevalence of substance use disorders among adolescents who use marijuana and inhalants. Drug and Alcohol Dependence. 2005;78:23-32.  Abstract
  • Wu, LT; Ringwalt, C. Use of substance abuse services by young uninsured american adults. Psychiatric Services. 2005;56:946-953.  Abstract
  • Wu, LT; Schlenger, WE; Ringwalt, CL. Use of nitrite inhalants ("poppers") among American youth. Journal of Adolescent Health. 2005;37:52-60.  Abstract
  • Wu, LT; Pilowsky, DJ; Schlenger, WE. Inhalant abuse and dependence among adolescents in the United States. Journal of the American Academy of Child and Adolescent Psychiatry. 2004;43:1206-1214.  Abstract
  • Wu, LT; Pilowsky, DJ; Wechsberg, WM; Schlenger, WE. Injection drug use among stimulant users in a national sample. American Journal of Drug and Alcohol Abuse. 2004;30:61-83.  Abstract
  • Wu, LT; Ringwalt, CL. Alcohol dependence and use of treatment services among women in the community. American Journal of Psychiatry. 2004;161:1790-1797.  Abstract
  • Wu, LT; Schlenger, WE. Private health insurance coverage for substance abuse and mental health services, 1995 to 1998. Psychiatric Services. 2004;55:180-182.  Abstract
  • Wu, LT; Kouzis, AC; Schlenger, WE. Substance use, dependence, and service utilization among the US uninsured nonelderly population. American Journal of Public Health. 2003;93:2079-2085.  Abstract
  • Wu, LT; Ringwalt, CL; Williams, CE. Use of substance abuse treatment services by persons with mental health and substance use problems. Psychiatric Services. 2003;54:363-369.  Abstract
  • Wu, LT; Schlenger, WE. Psychostimulant dependence in a community sample. Substance Use and Misuse. 2003;38:221-248.  Abstract
  • Wu, LT; Schlenger, WE; Galvin, DM. The relationship between employment and substance use among students aged 12 to 17. Journal of Adolescent Health. 2003;32:5-15.  Abstract
  • Wu, LT; Anthony, JC. The estimated rate of depressed mood in US adults: recent evidence for a peak in later life. Journal of Affective Disorders. 2000;60:159-171.  Abstract
  • Wu, LT; Anthony, JC. The use of the case-crossover design in studying illicit drug use. Substance Use and Misuse. 2000;35:1035-1050.  Abstract
  • Pilowsky, DJ; Wu, LT; Anthony, JC. Panic attacks and suicide attempts in mid-adolescence. American Journal of Psychiatry. 1999;156:1545-1549.  Abstract
  • Wu, LT; Anthony, JC. Tobacco smoking and depressed mood in late childhood and early adolescence. American Journal of Public Health. 1999;89:1837-1840.  Abstract
  • Wu, LT; Anthony, JC. Tobacco smoking and other suspected antecedents of nonmedical psychostimulant use in the United States, 1995. Substance Use and Misuse. 1999;34:1243-1259.  Abstract
  • Wu, LT; Kouzis, AC; Leaf, PJ. Influence of comorbid alcohol and psychiatric disorders on utilization of mental health services in the National Comorbidity Survey. American Journal of Psychiatry. 1999;156:1230-1236.  Abstract