John S. March, MD, MPH


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Professor of Psychiatry and Behavioral Sciences
Professor in the Department of Psychology & Neuroscience
Division of Neurosciences Medicine, Duke Clinical Research Institute
Department / Division:
Psychiatry / Child & Fam Mental Health & Dev Neuro
DUMC 3850
Durham, NC 27710
Appointment Telephone:
Office Telephone:
  • MD, MPH, University of California–Los Angeles David Geffen School of Medicine, 1978
  • Family Practice, University of California–Los Angeles, 1978-1981
  • Psychiatry, University of Wisconsin Health, 1986-1988
  • Child Psychiatry, University of Wisconsin Health, 1988-1990
Clinical Interests:
Clinical trials in adult and pediatric neurology, psychiatry, and pain; pediatric psychopharmacology, intervention, biomarkers/biosignatures
Research Interests:
Dr. March is Professor of Psychiatry and Psychology and Director of the Division of Neurosciences Medicine at the Duke Clinical Research Institute. Dr. March develops, conducts and facilitates research projects in adult and child neurology and psychiatry that range from biomarker/biosignature development and validation, imaging genomics, Phase I-IV industry and Federal clinical trials, to outcomes research.
Representative Publications:
  • March, JS; Fegert, JM. Drug development in pediatric psychiatry: current status, future trends. Child and Adolescent Psychiatry and Mental Health. 2012;6:7.  Abstract
  • Franklin, ME; Sapyta, J; Freeman, JB; Khanna, M; Compton, S; Almirall, D; Moore, P; Choate-Summers, M; Garcia, A; Edson, AL; Foa, EB; March, JS. Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial. JAMA : the journal of the American Medical Association. 2011;306:1224-1232.  Abstract
  • Kratochvil, CJ; Vaughan, BS; Stoner, JA; Daughton, JM; Lubberstedt, BD; Murray, DW; Chrisman, AK; Faircloth, MA; Itchon-Ramos, NB; Kollins, SH; Maayan, LA; Greenhill, LL; Kotler, LA; Fried, J; March, JS. A double-blind, placebo-controlled study of atomoxetine in young children with ADHD. Pediatrics. 2011;127:e862-e868.  Abstract
  • Leckman, JF; March, JS. Editorial: Developmental neuroscience comes of age. The Journal of Child Psychology and Psychiatry and Allied Disciplines. 2011;52:333-338.  Abstract
  • March, JS. Looking to the future of research in pediatric anxiety disorders. Depression and Anxiety. 2011;28:88-98.  Abstract
  • March, JS. The preschool ADHD Treatment Study (PATS) as the culmination of twenty years of clinical trials in pediatric psychopharmacology. Journal of the American Academy of Child and Adolescent Psychiatry. 2011;50:427-430.  Abstract
  • March, JS. Attention bias modification training and the new interventions research. Biological Psychiatry. 2010;68:978-979.  Abstract
  • March, JS. Commentary on 'Forum: use of antidepressants in children and adolescents'. Current Opinion in Psychiatry. 2010;23:63-65.  Abstract
  • Brent, DA; Greenhill, LL; Compton, S; Emslie, G; Wells, K; Walkup, JT; Vitiello, B; Bukstein, O; Stanley, B; Posner, K; Kennard, BD; Cwik, MF; Wagner, A; Coffey, B; March, JS; Riddle, M; Goldstein, T; Curry, J; Barnett, S; Capasso, L; Zelazny, J; Hughes, J; Shen, S; Gugga, SS; Turner, JB. The Treatment of Adolescent Suicide Attempters study (TASA): predictors of suicidal events in an open treatment trial. Journal of the American Academy of Child and Adolescent Psychiatry. 2009;48:987-996.  Abstract
  • March, JS. The future of psychotherapy for mentally ill children and adolescents. The Journal of Child Psychology and Psychiatry and Allied Disciplines. 2009;50:170-179.  Abstract
  • March, JS; Vitiello, B. Benefits exceed risks of newer antidepressant medications in youth--maybe. Clinical Pharmacology & Therapeutics (Nature). 2009;86:355-357.  Abstract
  • March, JS; Vitiello, B. Clinical messages from the Treatment for Adolescents With Depression Study (TADS). American Journal of Psychiatry. 2009;166:1118-1123.  Abstract
  • Shapiro, M; Silva, SG; Compton, S; Chrisman, A; DeVeaugh-Geiss, J; Breland-Noble, A; Kondo, D; Kirchner, J; March, JS. The child and adolescent psychiatry trials network (CAPTN): infrastructure development and lessons learned. Child and Adolescent Psychiatry and Mental Health. 2009;3:12.  Abstract
  • Vitiello, B; Silva, SG; Rohde, P; Kratochvil, CJ; Kennard, BD; Reinecke, MA; Mayes, TL; Posner, K; May, DE; March, JS. Suicidal events in the Treatment for Adolescents With Depression Study (TADS). Journal of Clinical Psychiatry. 2009;70:741-747.  Abstract
  • Krystal, JH; Carter, CS; Geschwind, D; Manji, HK; March, JS; Nestler, EJ; Zubieta, JK; Charney, DS; Goldman, D; Gur, RE; Lieberman, JA; Roy-Byrne, P; Rubinow, DR; Anderson, SA; Barondes, S; Berman, KF; Blair, J; Braff, DL; Brown, ES; Calabrese, JR; Carlezon, WA; Cook, EH; Davidson, RJ; Davis, M; Desimone, R; Drevets, WC; Duman, RS; Essock, SM; Faraone, SV; Freedman, R; Friston, KJ; Gelernter, J; Geller, B; Gill, M; Gould, E; Grace, AA; Grillon, C; Gueorguieva, R; Hariri, AR; Innis, RB; Jones, EG; Kleinman, JE; Koob, GF; Krystal, AD; Leibenluft, E; Levinson, DF; Levitt, PR; Lewis, DA; Liberzon, I; Lipska, BK; Marder, SR; Markou, A; Mason, GF; McDougle, CJ; McEwen, BS; McMahon, FJ; Meaney, MJ; Meltzer, HY; Merikangas, KR; Meyer-Lindenberg, A; Mirnics, K; Monteggia, LM; Neumeister, A; O'Brien. . . It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 2008;63:725-727.  Abstract
  • Rohde, P; Silva, SG; Tonev, ST; Kennard, BD; Vitiello, B; Kratochvil, CJ; Reinecke, MA; Curry, JF; Simons, AD; March, JS. Achievement and maintenance of sustained response during the Treatment for Adolescents With Depression Study continuation and maintenance therapy. Archives of General Psychiatry. 2008;65:447-455.  Abstract
  • Walkup, JT; Albano, AM; Piacentini, J; Birmaher, B; Compton, SN; Sherrill, JT; Ginsburg, GS; Rynn, MA; McCracken, J; Waslick, B; Iyengar, S; March, JS; Kendall, PC. Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. The New England journal of medicine. 2008;359:2753-2766.  Abstract
  • Compton, SN; Kratochvil, CJ; March, JS. Pharmacotherapy for anxiety disorders in children and adolescents: an evidence-based medicine review. Pediatric annals. 2007;36:586-598.  Abstract
  • Kollins, SH; March, JS. Advances in the pharmacotherapy of attention-deficit/hyperactivity disorder. Biological Psychiatry. 2007;62:951-953.  Abstract
  • March, JS; Entusah, AR; Rynn, M; Albano, AM; Tourian, KA. A Randomized controlled trial of venlafaxine ER versus placebo in pediatric social anxiety disorder. Biological Psychiatry. 2007;62:1149-1154.  Abstract
  • March, JS; Franklin, ME; Leonard, H; Garcia, A; Moore, P; Freeman, J; Foa, E. Tics moderate treatment outcome with sertraline but not cognitive-behavior therapy in pediatric obsessive-compulsive disorder. Biological Psychiatry. 2007;61:344-347.  Abstract
  • March, JS; Silva, S; Petrycki, S; Curry, J; Wells, K; Fairbank, J; Burns, B; Domino, M; McNulty, S; Vitiello, B; Severe, J. The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes. Archives of General Psychiatry. 2007;64:1132-1143.  Abstract
  • March, JS; Szatmari, P; Bukstein, O; Chrisman, A; Kondo, D; Hamilton, JD; Kremer, CM; Kratochvil, CJ. AACAP 2005 Research Forum: speeding the adoption of evidence-based practice in pediatric psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry. 2007;46:1098-1110.  Abstract
  • March, JS; Klee, BJ; Kremer, CM. Treatment benefit and the risk of suicidality in multicenter, randomized, controlled trials of sertraline in children and adolescents. Journal of Child and Adolescent Psychopharmacology. 2006;16:91-102.  Abstract
  • March, JS; Chrisman, A; Breland-Noble, A; Clouse, K; D'Alli, R; Egger, H; Gammon, P; Gazzola, M; Lin, A; Mauro, C; Rana, A; Ravi, H; Srirama, M; Su, H; Thrall, G; van de Velde, P; Duke Pediatric Psychiatry EBM Seminar Team. Using and teaching evidence-based medicine: the Duke University child and adolescent psychiatry model. Child and Adolescent Psychiatric Clinics of North America. 2005;14:273-ix.  Abstract
  • March, JS; Silva, SG; Compton, S; Shapiro, M; Califf, R; Krishnan, R. The case for practical clinical trials in psychiatry. American Journal of Psychiatry. 2005;162:836-846.  Abstract
  • March, JS; Silva, SG; Compton, S; Anthony, G; DeVeaugh-Geiss, J; Califf, R; Krishnan, R. The Child and Adolescent Psychiatry Trials Network (CAPTN). Journal of the American Academy of Child and Adolescent Psychiatry. 2004;43:515-518.  Abstract
  • Greenhill, LL; Vitiello, B; Abikoff, H; Levine, J; March, JS; Riddle, MA; Capasso, L; Cooper, TB; Davies, M; Fisher, P; Findling, RL; Fried, J; Labellarte, MJ; McCracken, JT; McMahon, D; Robinson, J; Skrobala, A; Scahill, L; Varipatis, E; Walkup, JT; Zito, JM. Developing methodologies for monitoring long-term safety of psychotropic medications in children: report on the NIMH conference, September 25, 2000. Journal of the American Academy of Child and Adolescent Psychiatry. 2003;42:651-655.  Abstract
  • Greenhill, LL; Vitiello, B; Riddle, MA; Fisher, P; Shockey, E; March, JS; Levine, J; Fried, J; Abikoff, H; Zito, JM; McCracken, JT; Findling, RL; Robinson, J; Cooper, TB; Davies, M; Varipatis, E; Labellarte, MJ; Scahill, L; Walkup, JT; Capasso, L; Rosengarten, J. Review of safety assessment methods used in pediatric psychopharmacology. Journal of the American Academy of Child and Adolescent Psychiatry. 2003;42:627-633.  Abstract
  • March, JS. Acute stress disorder in youth: a multivariate prediction model. Biological Psychiatry. 2003;53:809-816.  Abstract
  • Costello, EJ; Pine, DS; Hammen, C; March, JS; Plotsky, PM; Weissman, MM; Biederman, J; Goldsmith, HH; Kaufman, J; Lewinsohn, PM; Hellander, M; Hoagwood, K; Koretz, DS; Nelson, CA; Leckman, JF. Development and natural history of mood disorders. Biological Psychiatry. 2002;52:529-542.  Abstract
  • March, JS; Biederman, J; Wolkow, R; Safferman, A; Mardekian, J; Cook, EH; Cutler, NR; Dominguez, R; Ferguson, J; Muller, B; Riesenberg, R; Rosenthal, M; Sallee, FR; Wagner, KD; Steiner, H. Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial. JAMA : the journal of the American Medical Association. 1998;280:1752-1756.  Abstract