Henry Ryan Wagner II, PhD

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Associate Professor of Psychiatry and Behavioral Sciences
Department / Division:
Psychiatry / Translational Neuroscience
Address:
Brightleaf Sq Ste 22B
905 W Main St
Durham, NC 27701
Office Telephone:
(919) 687-4676
Training:
  • PhD, University of New Mexico, 0
Research Interests:
Program for Assertive Community Treatment (PACT): As an extension of studies into the effect of Assertive Community Treatment Programs on client outcomes, family burdens, service mix, and costs, we are extending our work to a meta-analysis of outcomes using data from five just-completed PACT studies at geographically diverse sites throughout the U.S. As existing research has suggested that a major point of impact of PACTs is on institutionalization, we will initially focus our analyses on psychiatric hospital admissions and hospital days. Interest is in (1) determining if PACTs effectively reduce admissions and days relative to state-of-the-art community mental health programs and (2) if so, are reductions associated with patient characteristics including age, race, sex, and diagnosis.

Outpatient Commitment Programs (OPC): Data collection and management continue on a study of the effects of outpatient commitment on client outcomes, compliance, and family burden among the severely and persistently mentally ill (SPMI). Substantial recruitment has already occurred allowing the possibility of panel analyses of the baseline profile of the sample. Questions of interest include sex and race differences in quality-of-life indices, social interactions, social networks, and diagnosis. We are also exploring the possibility of combining these data with a similar study sampel recruited for a study of PACT programs in Charleston, S.C. The two studies share considerable common information; combined analyses would expand the base of inference and provide a marked increase in power necessary for assessment of often highly variable psychosocial outcomes.

Somatic Manifestations of Depression: We are continuing to investigate the association between CES-D scores and mortality. Using a geriatric sample, we have demonstrated a positive association between CES-D scores and mortality over a five year interval. Current efforts are directed at refining the association between CES-D scores and the appearance of various disease states over the same interval. We continue to hypothesize a relationship between depression and impaired immune function as operationalized in the disproportionate incidence of infectious diseases and neoplastic events.
Representative Publications:
  • Morey, RA; Selgrade, ES; Wagner, HR; Huettel, SA; Wang, L; McCarthy, G. Scan-rescan reliability of subcortical brain volumes derived from automated segmentation. Human Brain Mapping. 2010;31:1751-1762.  Abstract
  • Morey, RA; Petty, CM; Xu, Y; Hayes, JP; Wagner, HR; Lewis, DV; LaBar, KS; Styner, M; McCarthy, G. A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes. Neuroimage. 2009;45:855-866.  Abstract
  • Morey, RA; Petty, CM; Xu, Y; Hayes, JP; Wagner, HR; Lewis, DV; Labar, KS; Styner, M; McCarthy, G. Rebuttal to Hasan and Pedraza in comments and controversies: "Improving the reliability of manual and automated methods for hippocampal and amygdala volume measurements". Neuroimage. 2009;48:499-500.  Abstract
  • Ulmer, CS; Calhoun, PS; Edinger, JD; Wagner, HR; Beckham, JC. Sleep disturbance and baroreceptor sensitivity in women with posttraumatic stress disorder. Journal of Traumatic Stress. 2009;22:643-647.  Abstract
  • Swanson, JW; Swartz, MS; Elbogen, EB; VAN Dorn, RA; Wagner, HR; Moser, LA; Wilder, C; Gilbert, AR. Psychiatric advance directives and reduction of coercive crisis interventions. Journal of Mental Health. 2008;17:255-267.  Abstract
  • Swanson, JW; Swartz, MS; Van Dorn, RA; Volavka, J; Monahan, J; Stroup, TS; McEvoy, JP; Wagner, HR; Elbogen, EB; Lieberman, JA; CATIE investigators. Comparison of antipsychotic medication effects on reducing violence in people with schizophrenia. British Journal of Psychiatry. 2008;193:37-43.  Abstract
  • Swartz, MS; Wagner, HR; Swanson, JW; Stroup, TS; McEvoy, JP; Reimherr, F; Miller, DD; McGee, M; Khan, A; Canive, JM; Davis, SM; Hsiao, JK; Lieberman, JA; CATIE Investigators. The effectiveness of antipsychotic medications in patients who use or avoid illicit substances: results from the CATIE study. Schizophrenia Research. 2008;100:39-52.  Abstract
  • Elbogen, EB; Ferron, JC; Swartz, MS; Wilder, CM; Swanson, JW; Wagner, HR. Characteristics of representative payeeship involving families of beneficiaries with psychiatric disabilities. Psychiatric Services. 2007;58:1433-1440.  Abstract
  • Elbogen, EB; Swanson, JW; Appelbaum, PS; Swartz, MS; Ferron, J; Van Dorn, RA; Wagner, HR. Competence to complete psychiatric advance directives: effects of facilitated decision making. Law and Human Behavior. 2007;31:275-289.  Abstract
  • Gadde, KM; Yonish, GM; Foust, MS; Wagner, HR. Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. Journal of Clinical Psychiatry. 2007;68:1226-1229.  Abstract
  • Lee, JS; Potter, GG; Wagner, HR; Welsh-Bohmer, KA; Steffens, DC. Persistent mild cognitive impairment in geriatric depression. International Psychogeriatrics. 2007;19:125-135.  Abstract
  • Sheidow, AJ; Schoenwald, SK; Wagner, HR; Allred, CA; Burns, BJ. Predictors of workforce turnover in a transported treatment program. Administration and Policy in Mental Health and Mental Health Services Research. 2007;34:45-56.  Abstract
  • Doraiswamy, PM; Varia, I; Hellegers, C; Wagner, HR; Clary, GL; Beyer, JL; Newby, LK; O'Connor, JF; Beebe, KL; O'Connor, C; Krishnan, KR. A randomized controlled trial of paroxetine for noncardiac chest pain. Psychopharmacology Bulletin. 2006;39:15-24.  Abstract
  • Gadde, KM; Yonish, GM; Wagner, HR; Foust, MS; Allison, DB. Atomoxetine for weight reduction in obese women: a preliminary randomised controlled trial. International Journal of Obesity. 2006;30:1138-1142.  Abstract
  • Sair, HI; Welsh-Bohmer, KA; Wagner, HR; Steffens, DC. Ascending digits task as a measure of executive function in geriatric depression. Journal of Neuropsychiatry and Clinical Neurosciences. 2006;18:117-120.  Abstract
  • Swanson, JW; Swartz, MS; Elbogen, EB; Van Dorn, RA; Ferron, J; Wagner, HR; McCauley, BJ; Kim, M. Facilitated psychiatric advance directives: a randomized trial of an intervention to foster advance treatment planning among persons with severe mental illness. American Journal of Psychiatry. 2006;163:1943-1951.  Abstract
  • Swanson, JW; Swartz, MS; Van Dorn, RA; Elbogen, EB; Wagner, HR; Rosenheck, RA; Stroup, TS; McEvoy, JP; Lieberman, JA. A national study of violent behavior in persons with schizophrenia. Archives of General Psychiatry. 2006;63:490-499.  Abstract
  • Swartz, MS; Wagner, HR; Swanson, JW; Stroup, TS; McEvoy, JP; Canive, JM; Miller, DD; Reimherr, F; McGee, M; Khan, A; Van Dorn, R; Rosenheck, RA; Lieberman, JA. Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study. Journal of Nervous and Mental Disease. 2006;194:164-172.  Abstract
  • Swartz, MS; Wagner, HR; Swanson, JW; Stroup, TS; McEvoy, JP; McGee, M; Miller, DD; Reimherr, F; Khan, A; CaƱive, JM; Lieberman, JA. Substance use and psychosocial functioning in schizophrenia among new enrollees in the NIMH CATIE study. Psychiatric Services. 2006;57:1110-1116.  Abstract
  • Breland-Noble, AM; Elbogen, EB; Farmer, EM; Dubs, MS; Wagner, HR; Burns, BJ. Use of psychotropic medications by youths in therapeutic foster care and group homes. Psychiatric Services. 2004;55:706-708.  Abstract
  • Burns, BJ; Phillips, SD; Wagner, HR; Barth, RP; Kolko, DJ; Campbell, Y; Landsverk, J. Mental health need and access to mental health services by youths involved with child welfare: a national survey. Journal of the American Academy of Child and Adolescent Psychiatry. 2004;43:960-970.  Abstract
  • Groff, A; Burns, B; Swanson, J; Swartz, M; Wagner, HR; Tompson, M. Caregiving for persons with mental illness: the impact of outpatient commitment on caregiving strain. Journal of Nervous and Mental Disease. 2004;192:554-562.  Abstract
  • Phillips, SD; Burns, BJ; Wagner, HR; Barth, RP. Parental arrest and children involved with child welfare services agencies. American Journal of Orthopsychiatry: interdisciplinary approaches to mental health and social justice. 2004;74:174-186.  Abstract
  • Potter, GG; Kittinger, JD; Wagner, HR; Steffens, DC; Krishnan, KR. Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology. 2004;29:2266-2271.  Abstract
  • Swartz, MS; Wagner, HR; Swanson, JW; Elbogen, EB. Consumers' perceptions of the fairness and effectiveness of mandated community treatment and related pressures. Psychiatric Services. 2004;55:780-785.  Abstract
  • Compton, SN; Swanson, JW; Wagner, HR; Swartz, MS; Burns, BJ; Elbogen, EB. Involuntary outpatient commitment and homelessness in persons with severe mental illness. Administration and Policy in Mental Health and Mental Health Services Research. 2003;5:27-38.  Abstract
  • Elbogen, EB; Swanson, JW; Swartz, MS; Wagner, HR. Characteristics of third-party money management for persons with psychiatric disabilities. Psychiatric Services. 2003;54:1136-1141.  Abstract
  • Gadde, KM; Franciscy, DM; Wagner, HR; Krishnan, KR. Zonisamide for weight loss in obese adults: a randomized controlled trial. JAMA: Journal of the American Medical Association. 2003;289:1820-1825.  Abstract
  • Swanson, JW; Swartz, MS; Elbogen, EB; Wagner, HR; Burns, BJ. Effects of involuntary outpatient commitment on subjective quality of life in persons with severe mental illness. Behavioral Sciences and the Law. 2003;21:473-491.  Abstract
  • Swartz, MS; Swanson, JW; Wagner, HR; Hannon, MJ; Burns, BJ; Shumway, M. Assessment of four stakeholder groups' preferences concerning outpatient commitment for persons with schizophrenia. American Journal of Psychiatry. 2003;160:1139-1146.  Abstract
  • Wagner, HR; Swartz, MS; swanson, JW; Burns, BJ. Does involuntary outpatient commitment lead to more intensive treatment?. Psychology Public Policy and Law. 2003;9:145-158.  Abstract
  • Hiday, VA; Swartz, MS; Swanson, JW; Borum, R; Wagner, HR. Impact of outpatient commitment on victimization of people with severe mental illness. American Journal of Psychiatry. 2002;159:1403-1411.  Abstract
  • Steffens, DC; Payne, ME; Greenberg, DL; Byrum, CE; Welsh-Bohmer, KA; Wagner, HR; MacFall, JR. Hippocampal volume and incident dementia in geriatric depression. American Journal of Geriatric Psychiatry. 2002;10:62-71.  Abstract
  • Swanson, JW; Swartz, MS; Essock, SM; Osher, FC; Wagner, HR; Goodman, LA; Rosenberg, SD; Meador, KG. The social-environmental context of violent behavior in persons treated for severe mental illness. American Journal of Public Health. 2002;92:1523-1531.  Abstract
  • Swartz, MS; Wagner, HR; Swanson, JW; Hiday, VA; Burns, BJ. The perceived coerciveness of involuntary outpatient commitment: findings from an experimental study. Journal of the American Academy of Psychiatry and the Law. 2002;30:207-217.  Abstract
  • Taylor, WD; Wagner, HR; Steffens, DC. Greater depression severity associated with less improvement in depression-associated cognitive deficits in older subjects. American Journal of Geriatric Psychiatry. 2002;10:632-635.  Abstract
  • Gadde, KM; Parker, CB; Maner, LG; Wagner, HR; Logue, EJ; Drezner, MK; Krishnan, KR. Bupropion for weight loss: an investigation of efficacy and tolerability in overweight and obese women. Obesity. 2001;9:544-551.  Abstract
  • Hiday, VA; Swanson, JW; Swartz, MS; Borum, R; Wagner, HR. Victimization: a link between mental illness and violence?. International Journal of Law and Psychiatry. 2001;24:559-572.  Abstract
  • Krishnan, KR; Levy, RM; Wagner, HR; Chen, G; Gersing, K; Doraiswamy, PM. Informant-rated cognitive symptoms in normal aging, mild cognitive impairment, and dementia. Initial development of an informant-rated screen (Brief Cognitive Scale) for mild cognitive impairment and dementia. Psychopharmacology Bulletin. 2001;35:79-88.  Abstract
  • Steffens, DC; Conway, CR; Dombeck, CB; Wagner, HR; Tupler, LA; Weiner, RD. Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression. The Journal of Electroconvulsive Therapy. 2001;17:45-49.  Abstract
  • Steffens, DC; Wagner, HR; Levy, RM; Horn, KA; Krishnan, KR. Performance feedback deficit in geriatric depression. Biological Psychiatry. 2001;50:358-363.  Abstract
  • Swartz, MS; Swanson, JW; Hiday, VA; Wagner, HR; Burns, BJ; Borum, R. A randomized controlled trial of outpatient commitment in North Carolina. Psychiatric Services. 2001;52:325-329.  Abstract
  • Swartz, MS; Swanson, JW; Wagner, HR; Burns, BJ; Hiday, VA. Effects of involuntary outpatient commitment and depot antipsychotics on treatment adherence in persons with severe mental illness. Journal of Nervous and Mental Disease. 2001;189:583-592.  Abstract
  • Taylor, WD; Payne, ME; Krishnan, KR; Wagner, HR; Provenzale, JM; Steffens, DC; MacFall, JR. Evidence of white matter tract disruption in MRI hyperintensities. Biological Psychiatry. 2001;50:179-183.  Abstract
  • Swanson, JW; Swartz, MS; Borum, R; Hiday, VA; Wagner, HR; Burns, BJ. Involuntary out-patient commitment and reduction of violent behaviour in persons with severe mental illness. British Journal of Psychiatry. 2000;176:324-331.  Abstract
  • Varia, I; Logue, E; O'connor, C; Newby, K; Wagner, HR; Davenport, C; Rathey, K; Krishnan, KR. Randomized trial of sertraline in patients with unexplained chest pain of noncardiac origin. American Heart Journal. 2000;140:367-372.  Abstract
  • Wagner, HR; Burns, BJ; Broadhead, WE; Yarnall, KS; Sigmon, A; Gaynes, BN. Minor depression in family practice: functional morbidity, co-morbidity, service utilization and outcomes. Psychological Medicine. 2000;30:1377-1390.  Abstract
  • Gaynes, BN; Magruder, KM; Burns, BJ; Wagner, HR; Yarnall, KS; Broadhead, WE. Does a coexisting anxiety disorder predict persistence of depressive illness in primary care patients with major depression?. General Hospital Psychiatry. 1999;21:158-167.  Abstract
  • Hiday, VA; Swartz, MS; Swanson, JW; Borum, R; Wagner, HR. Criminal victimization of persons with severe mental illness. Psychiatric Services. 1999;50:62-68.  Abstract
  • Salkever, D; Domino, ME; Burns, BJ; Santos, AB; Deci, PA; Dias, J; Wagner, HR; Faldowski, RA; Paolone, J. Assertive community treatment for people with severe mental illness: the effect on hospital use and costs. Health Services Research. 1999;34:577-601.  Abstract
  • Swartz, MS; Swanson, JW; Wagner, HR; Burns, BJ; Hiday, VA; Borum, R. Can involuntary outpatient commitment reduce hospital recidivism?: Findings from a randomized trial with severely mentally ill individuals. American Journal of Psychiatry. 1999;156:1968-1975.  Abstract
  • Hiday, VA; Swartz, MS; Swanson, JW; Borum, R; Wagner, HR. Male-female differences in the setting and construction of violence among people with severe mental illness. Social Psychiatry and Psychiatric Epidemiology. 1998;33 Suppl 1:S68-S74.  Abstract
  • Swartz, MS; Swanson, JW; Hiday, VA; Borum, R; Wagner, HR; Burns, BJ. Violence and severe mental illness: the effects of substance abuse and nonadherence to medication. American Journal of Psychiatry. 1998;155:226-231.  Abstract
  • Swartz, MS; Wagner, HR; Swanson, JW; Burns, BJ; George, LK; Padgett, DK. Administrative update: utilization of services. I. Comparing use of public and private mental health services: the enduring barriers of race and age. Community Mental Health Journal. 1998;34:133-144.  Abstract
  • Hiday, VA; Swartz, MS; Swanson, J; Wagner, HR. Patient perceptions of coercion in mental hospital admission. International Journal of Law and Psychiatry. 1997;20:227-241.  Abstract
  • Swanson, JW; Swartz, MS; George, LK; Burns, BJ; Hiday, VA; Borum, R; Wagner, HR. Interpreting the effectiveness of involuntary outpatient commitment: a conceptual model. Journal of the American Academy of Psychiatry and the Law. 1997;25:5-16.  Abstract
  • Swartz, MS; Burns, BJ; George, LK; Swanson, J; Hiday, VA; Borum, R; Wagner, HR. The ethical challenges of a randomized controlled trial of involuntary outpatient commitment. Journal of Mental Health Administration. 1997;24:35-43.  Abstract
  • Swartz, MS; Burns, BJ; Hiday, VA; George, LK; Swanson, J; Wagner, HR. New directions in research on involuntary outpatient commitment. Psychiatric Services. 1995;46:381-385.  Abstract
  • Landerman, LR; Burns, BJ; Swartz, MS; Wagner, HR; George, LK. The relationship between insurance coverage and psychiatric disorder in predicting use of mental health services. American Journal of Psychiatry. 1994;151:1785-1790.  Abstract
  • Burns, BJ; Wagner, HR; Taube, JE; Magaziner, J; Permutt, T; Landerman, LR. Mental health service use by the elderly in nursing homes. American Journal of Public Health. 1993;83:331-337.  Abstract
  • Traub, M; Reches, A; Wagner, HR; Fahn, S. Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade. Neuroscience Letters. 1986;70:245-249.  Abstract
  • Wagner, HR; Reches, A; Yablonskaya, E; Fahn, S. Clonazepam-induced up-regulation of serotonin1 and serotonin2 binding sites in rat frontal cortex. Advances in Neurology. 1986;43:645-651.  Abstract
  • Reches, A; Wagner, HR; Jackson-Lewis, V; Fahn, S. Presynaptic inhibition of dopamine synthesis in rat striatum: effects of chronic dopamine depletion and receptor blockade. Brain Research. 1985;347:346-349.  Abstract
  • Traub, M; Wagner, HR; Hassan, M; Jackson-Lewis, V; Fahn, S. The effects of chronic bromocriptine treatment on behaviour and dopamine receptor binding in the rat striatum. European Journal of Pharmacology. 1985;118:147-154.  Abstract
  • Wagner, HR; Reches, A; Fahn, S. Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of rat. Neuropharmacology. 1985;24:953-956.  Abstract
  • Jiang, DH; Reches, A; Wagner, HR; Fahn, S. Biochemical and behavioral evaluation of pergolide as a dopamine agonist in the rat brain. Neuropharmacology. 1984;23:295-301.  Abstract
  • Reches, A; Wagner, HR; Barkai, AI; Jackson, V; Yablonskaya-Alter, E; Fahn, S. Electroconvulsive treatment and haloperidol: effects on pre- and postsynaptic dopamine receptors in rat brain. Psychopharmacology. 1984;83:155-158.  Abstract
  • Reches, A; Wagner, HR; Jackson-Lewis, V; Yablonskaya-Alter, E; Fahn, S. Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology. 1984;34:1208-1212.  Abstract
  • Reches, A; Burke, RE; Jiang, D; Wagner, HR; Fahn, S. Neurotensin interacts with dopaminergic neurons in rat brain. Peptides. 1983;4:43-48.  Abstract
  • Burke, RE; Fahn, S; Wagner, HR; Smeal, M. Chlorpromazine methiodide-induced barrel rotation: an antimuscarinic effect. Brain Research. 1982;250:133-142.  Abstract
  • Reches, A; Wagner, HR; Jackson, V; Fahn, S. Chronic lithium administration has no effect on haloperidol-induced supersensitivity of pre- and postsynaptic dopamine receptors in rat brain. Brain Research. 1982;246:172-177.  Abstract
  • Reches, A; Wagner, HR; Jiang, D; Jackson, V; Fahn, S. The effect of chronic L-dopa administration on supersensitive pre- and postsynaptic dopaminergic receptors in rat brain. Life Sciences. 1982;31:37-44.  Abstract
  • Wagner, HR. Cardiac disease in congenital infections. Clinics in Perinatology. 1981;8:481-497.  Abstract
  • Wagner, HR; Davies, JN. Decreased beta-adrenergic responses in the female rat brain are eliminated by ovariectomy: correlation of [3H]dihydroalprenolol binding and catecholamine stimulated cyclic AMP levels. Brain Research. 1980;201:235-239.  Abstract
  • Wagner, HR; Crutcher, KA; Davis, JN. Chronic estrogen treatment decreases beta-adrenergic responses in rat cerebral cortex. Brain Research. 1979;171:147-151.  Abstract
  • Wagner, HR; Davis, JN. beta-Adrenergic receptor regulation by agonists and membrane depolarization in rat brain slices. Proceedings of the National Academy of Sciences of USA. 1979;76:2057-2061.  Abstract
  • Palmer, GC; Wagner, HR; Palmer, SJ; Manian, AA. Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol. Archives internationales de pharmacodynamie et de therapie. 1978;233:314-325.  Abstract
  • Wagner, HR; Palmer, GC; Hall, TL; Putnam, RW. Decreased spontaneous motor activity parallels reserpine-induced supersensitivity of catecholamine-responsive rat cerebral cortex adenylate cyclase. Behavioral Biology. 1978;23:225-229.  Abstract
  • Palmer, GC; Wagner, HR; Palmer, SJ; Manian, AA. Dopamine-sensitive adenylate cyclase: antagonism by impiramine and its analogues. Research Communications in Chemical Pathology and Pharmacology. 1977;16:573-576.  Abstract
  • Palmer, GC; Wagner, HR; Palmer, SJ; Manian, AA. Histamine-stimulated adenylate cyclase: blockade by imipramine and its analogues. Communications in psychopharmacology. 1977;1:61-69.  Abstract
  • Wagner, HR; Hall, TL; Cote, IL. The applicability of inescapable shock as a source of animal depression. Journal of General Psychology: experimental, physiological, and comparative psychology. 1977;96:313-318.  Abstract
  • Palmer, GC; Wagner, HR; Putnam, RW. Neuronal localization of the enhanced adenylate cyclase responsiveness to catecholamines in the rat cerebral cortex following reserpine injections. Neuropharmacology. 1976;15:695-702.  Abstract
  • Feeney, DM; Pittman, JC; Wagner, HR. Lateral inhibition and attention: comments on the neuropsychological theory of Walley and Weiden. Psychological Review. 1974;81:536-539.  Abstract
  • Halazun, JF; Wagner, HR; Gaeta, JF; Sinks, LF. Proceedings: Daunorubicin cardiac toxicity in children with acute lymphocytic leukemia. Cancer. 1974;33:545-554.  Abstract
  • Lambert, EC; Menon, VA; Wagner, HR; Vlad, P. Sudden unexpected death from cardiovascular disease in children. A cooperative international study. American Journal of Cardiology. 1974;34:89-96.  Abstract
  • Feeney, DM; Wagner, HR; McNamara, MC; Weiss, G. Effects of tetrahydrocannabinol on hippocampal evoked afterdischarges in cats. Experimental Neurology. 1973;41:357-365.  Abstract