Shirish Shenolikar, PhD, BS


email this

Professor Emeritus of Psychiatry and Behavioral Sciences
Adjunct Professor in the Department of Pharmacology and Cancer Biology
Department / Division:
Psychiatry / Translational Neuroscience
Dept Phar & Cancer Biol
Durham, NC 27710
Office Telephone:
(656) 516-2588
  • PhD, University of Leeds (UK), 1975
  • BS, University College of London, 1971
Research Interests:
Protein phosphorylation controls a wide range of physiological processes in mammalian tissues. Phosphorylation state of cellular proteins is controlled by the opposing actions of protein kinases and phosphatases that are regulated by hormones, neurotransmitters, growth factors and other environmental cues. Our research attempts to understand the communication between protein kinases and phosphatases that dictates cellular protein phosphorylation and the cell's response to hormones. Over the last decade, our work has provided critical information about the role of protein phosphatase-1 (PP1) in controlling synaptic function, cell stress, gene expression and growth. We have generated a large repertoire of reagents to decipher PP1's role in signaling pathways in mammalian cells and tissues. Emerging evidence suggests that in many cells, PP1 activity is fine tuned by the protein, inhibitor-1 (I-1). A major focus of our research is to elucidate the role of I-1 in kinase-phosphatase cross-talk and impact of the altered I-1 gene expression seen in several human diseases. Our studies showed that recognition of cellular substrates by PP1 is also directed by its association with a variety of targeting subunits that are themselves also subject to physiological control. Thus, the overall focus of our research is to define the physiological mechanisms that regulate PP1 functions relevant to human health and disease.
Representative Publications:
  • Brush, MH; Guardiola, A; Connor, JH; Yao, TP; Shenolikar, S. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. The Journal of biological chemistry. 2004;279:7685-7691.  Abstract
  • Cunningham, R; Steplock, D; Wang, F; Huang, H; E, X; Shenolikar, S; Weinman, EJ. Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. The Journal of biological chemistry. 2004;279:37815-37821.  Abstract
  • Yeh, E; Cunningham, M; Arnold, H; Chasse, D; Monteith, T; Ivaldi, G; Hahn, WC; Stukenberg, PT; Shenolikar, S; Uchida, T; Counter, CM; Nevins, JR; Means, AR; Sears, R. A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nature Cell Biology. 2004;6:308-318.  Abstract
  • Brush, MH; Weiser, DC; Shenolikar, S. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Molecular and Cellular Biology. 2003;23:1292-1303.  Abstract
  • Kang-Park, MH; Sarda, MA; Jones, KH; Moore, SD; Shenolikar, S; Clark, S; Wilson, WA. Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation. Journal of neurophysiology. 2003;89:684-690.  Abstract
  • Leach, C; Shenolikar, S; Brautigan, DL. Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. The Journal of biological chemistry. 2003;278:26015-26020.  Abstract
  • Margolis, SS; Walsh, S; Weiser, DC; Yoshida, M; Shenolikar, S; Kornbluth, S. PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. EMBO Journal. 2003;22:5734-5745.  Abstract
  • Wade, JB; Liu, J; Coleman, RA; Cunningham, R; Steplock, DA; Lee-Kwon, W; Pallone, TL; Shenolikar, S; Weinman, EJ. Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. American journal of physiology. Cell physiology. 2003;285:C1494-C1503.  Abstract
  • Weinman, EJ; Boddeti, A; Cunningham, R; Akom, M; Wang, F; Wang, Y; Liu, J; Steplock, D; Shenolikar, S; Wade, JB. NHERF-1 is required for renal adaptation to a low-phosphate diet. American Journal of Physiology: Renal Physiology. 2003;285:F1225-F1232.  Abstract
  • Weinman, EJ; Steplock, D; Shenolikar, S. NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. FEBS Letters. 2003;536:141-144.  Abstract
  • Weinman, EJ; Wang, Y; Wang, F; Greer, C; Steplock, D; Shenolikar, S. A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. Biochemistry. 2003;42:12662-12668.  Abstract
  • Oliver, CJ; Terry-Lorenzo, RT; Elliott, E; Bloomer, WA; Li, S; Brautigan, DL; Colbran, RJ; Shenolikar, S. Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. Molecular and Cellular Biology. 2002;22:4690-4701.  Abstract
  • Shenolikar, S; Voltz, JW; Minkoff, CM; Wade, JB; Weinman, EJ. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proceedings of the National Academy of Sciences of USA. 2002;99:11470-11475.  Abstract
  • Terry-Lorenzo, RT; Carmody, LC; Voltz, JW; Connor, JH; Li, S; Smith, FD; Milgram, SL; Colbran, RJ; Shenolikar, S. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. The Journal of biological chemistry. 2002;277:27716-27724.  Abstract
  • Terry-Lorenzo, RT; Elliot, E; Weiser, DC; Prickett, TD; Brautigan, DL; Shenolikar, S. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. The Journal of biological chemistry. 2002;277:46535-46543.  Abstract
  • Chiang, CW; Harris, G; Ellig, C; Masters, SC; Subramanian, R; Shenolikar, S; Wadzinski, BE; Yang, E. Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Blood. 2001;97:1289-1297.  Abstract
  • Connor, JH; Weiser, DC; Li, S; Hallenbeck, JM; Shenolikar, S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Molecular and Cellular Biology. 2001;21:6841-6850.  Abstract
  • Morishita, W; Connor, JH; Xia, H; Quinlan, EM; Shenolikar, S; Malenka, RC. Regulation of synaptic strength by protein phosphatase 1. Neuron. 2001;32:1133-1148.  Abstract
  • Schillace, RV; Voltz, JW; Sim, AT; Shenolikar, S; Scott, JD. Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation. The Journal of biological chemistry. 2001;276:12128-12134.  Abstract
  • Shenolikar, S; Minkoff, CM; Steplock, DA; Evangelista, C; Liu, M; Weinman, EJ. N-terminal PDZ domain is required for NHERF dimerization. FEBS Letters. 2001;489:233-236.  Abstract
  • Shenolikar, S; Weinman, EJ. NHERF: targeting and trafficking membrane proteins. American Journal of Physiology: Renal Physiology. 2001;280:F389-F395.  Abstract
  • Voltz, JW; Weinman, EJ; Shenolikar, S. Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene: Including Oncogene Reviews. 2001;20:6309-6314.  Abstract
  • Wade, JB; Welling, PA; Donowitz, M; Shenolikar, S; Weinman, EJ. Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. American journal of physiology. Cell physiology. 2001;280:C192-C198.  Abstract
  • Watanabe, T; Huang, HB; Horiuchi, A; da Cruze Silva, EF; Hsieh-Wilson, L; Allen, PB; Shenolikar, S; Greengard, P; Nairn, AC. Protein phosphatase 1 regulation by inhibitors and targeting subunits. Proceedings of the National Academy of Sciences of USA. 2001;98:3080-3085.  Abstract
  • Weinman, EJ; Evangelista, CM; Steplock, D; Liu, MZ; Shenolikar, S; Bernardo, A. Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. The Journal of biological chemistry. 2001;276:42339-42346.  Abstract
  • Weinman, EJ; Steplock, D; Shenolikar, S. Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex. Kidney international. 2001;60:450-454.  Abstract
  • Weinman, EJ; Steplock, D; Wade, JB; Shenolikar, S. Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. American Journal of Physiology: Renal Physiology. 2001;281:F374-F380.  Abstract
  • Brown, GP; Blitzer, RD; Connor, JH; Wong, T; Shenolikar, S; Iyengar, R; Landau, EM. Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000;20:7880-7887.  Abstract
  • Connor, JH; Frederick, D; Huang, HB; Yang, J; Helps, NR; Cohen, PT; Nairn, AC; DePaoli-Roach, A; Tatchell, K; Shenolikar, S. Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. The Journal of biological chemistry. 2000;275:18670-18675.  Abstract
  • Katayose, Y; Li, M; Al-Murrani, SW; Shenolikar, S; Damuni, Z. Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1. The Journal of biological chemistry. 2000;275:9209-9214.  Abstract
  • Liu, J; Wu, J; Oliver, C; Shenolikar, S; Brautigan, DL. Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit. The Biochemical journal. 2000;346 Pt 1:77-82.  Abstract
  • Shen, K; Teruel, MN; Connor, JH; Shenolikar, S; Meyer, T. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nature Neuroscience. 2000;3:881-886.  Abstract
  • Shenolikar, S; Brautigan, DL. Meeting report: targeting protein phosphatases-medicines for the new millenium. Sciences STKE [electronic resource] : signal transduction knowledge environment. 2000;2000:pe1.  Abstract
  • Terry-Lorenzo, RT; Inoue, M; Connor, JH; Haystead, TA; Armbruster, BN; Gupta, RP; Oliver, CJ; Shenolikar, S. Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. The Journal of biological chemistry. 2000;275:2439-2446.  Abstract
  • Weinman, EJ; Minkoff, C; Shenolikar, S. Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. American Journal of Physiology: Renal Physiology. 2000;279:F393-F399.  Abstract
  • Weinman, EJ; Steplock, D; Donowitz, M; Shenolikar, S. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry. 2000;39:6123-6129.  Abstract
  • Beullens, M; Van Eynde, A; Vulsteke, V; Connor, J; Shenolikar, S; Stalmans, W; Bollen, M. Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. The Journal of biological chemistry. 1999;274:14053-14061.  Abstract
  • Connor, JH; Kleeman, T; Barik, S; Honkanen, RE; Shenolikar, S. Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. The Journal of biological chemistry. 1999;274:22366-22372.  Abstract
  • Hansen, L; Fjordvang, H; Rasmussen, SK; Vestergaard, H; Echwald, SM; Hansen, T; Alessi, D; Shenolikar, S; Saltiel, AR; Barbetti, F; Pedersen, O. Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients. Diabetes. 1999;48:403-407.  Abstract
  • Minkoff, C; Shenolikar, S; Weinman, EJ. Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. Current Opinion in Nephrology and Hypertension. 1999;8:603-608.  Abstract
  • Weinman, EJ; Steplock, D; Lamprecht, G; Yun, CH; Shenolikar, S. Regulation of the Na/H exchanger regulatory factor in OK cells. Mineral and electrolyte metabolism. 1999;25:135-142.  Abstract
  • Weinman, EJ; Steplock, D; Zhang, X; Akhter, S; Shenolikar, S. Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 1999;1447:71-76.  Abstract
  • Zizak, M; Lamprecht, G; Steplock, D; Tariq, N; Shenolikar, S; Donowitz, M; Yun, CH; Weinman, EJ. cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. The Journal of biological chemistry. 1999;274:24753-24758.  Abstract
  • Blitzer, RD; Connor, JH; Brown, GP; Wong, T; Shenolikar, S; Iyengar, R; Landau, EM. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science. 1998;280:1940-1942.  Abstract
  • Connor, JH; Quan, H; Oliver, C; Shenolikar, S. Inhibitor-1, a regulator of protein phosphatase 1 function. Methods in molecular biology (Clifton, N.J.). 1998;93:41-58.  Abstract
  • Connor, JH; Quan, HN; Ramaswamy, NT; Zhang, L; Barik, S; Zheng, J; Cannon, JF; Lee, EY; Shenolikar, S. Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. The Journal of biological chemistry. 1998;273:27716-27724.  Abstract
  • Hall, RA; Premont, RT; Chow, CW; Blitzer, JT; Pitcher, JA; Claing, A; Stoffel, RH; Barak, LS; Shenolikar, S; Weinman, EJ; Grinstein, S; Lefkowitz, RJ. The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature. 1998;392:626-630.  Abstract
  • Oliver, CJ; Shenolikar, S. Physiologic importance of protein phosphatase inhibitors. Frontiers in bioscience : a journal and virtual library. 1998;3:D961-D972.  Abstract
  • Weinman, EJ; Steplock, D; Tate, K; Hall, RA; Spurney, RF; Shenolikar, S. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). Journal of Clinical Investigation. 1998;101:2199-2206.  Abstract
  • Wu, J; Liu, J; Thompson, I; Oliver, CJ; Shenolikar, S; Brautigan, DL. A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits. FEBS Letters. 1998;439:185-191.  Abstract
  • Endo, S; Connor, JH; Forney, B; Zhang, L; Ingebritsen, TS; Lee, EY; Shenolikar, S. Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. Biochemistry. 1997;36:6986-6992.  Abstract
  • Weinman, EJ; Shenolikar, S. The Na-H exchanger regulatory factor. Experimental nephrology. 1997;5:449-452.  Abstract
  • Endo, S; Zhou, X; Connor, J; Wang, B; Shenolikar, S. Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. Biochemistry. 1996;35:5220-5228.  Abstract
  • Endo, S; Critz, SD; Byrne, JH; Shenolikar, S. Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica. Journal of Neurochemistry. 1995;64:1833-1840.  Abstract
  • Shenolikar, S. Protein phosphatase regulation by endogenous inhibitors. Seminars in Cancer Biology. 1995;6:219-227.  Abstract
  • Weinman, EJ; Steplock, D; Wang, Y; Shenolikar, S. Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. Journal of Clinical Investigation. 1995;95:2143-2149.  Abstract
  • Alberts, AS; Montminy, M; Shenolikar, S; Feramisco, JR. Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. Molecular and Cellular Biology. 1994;14:4398-4407.  Abstract
  • Mulkey, RM; Endo, S; Shenolikar, S; Malenka, RC. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature. 1994;369:486-488.  Abstract
  • Shenolikar, S. Protein serine/threonine phosphatases--new avenues for cell regulation. Annual Review of Cell Biology. 1994;10:55-86.  Abstract
  • Alberts, AS; Thorburn, AM; Shenolikar, S; Mumby, MC; Feramisco, JR. Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proceedings of the National Academy of Sciences of USA. 1993;90:388-392.  Abstract
  • Clark, RB; Friedman, J; Kunkel, MW; January, BG; Shenolikar, S. Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells. The Journal of biological chemistry. 1993;268:3245-3250.  Abstract
  • Lutz, MP; Pinon, DI; Gates, LK; Shenolikar, S; Miller, LJ. Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells. The Journal of biological chemistry. 1993;268:12136-12142.  Abstract
  • Weinman, EJ; Shenolikar, S. Regulation of the renal brush border membrane Na(+)-H+ exchanger. Annual Review of Physiology. 1993;55:289-304.  Abstract
  • Weinman, EJ; Steplock, D; Corry, D; Shenolikar, S. Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes. Journal of Clinical Investigation. 1993;91:2097-2102.  Abstract
  • Weinman, EJ; Steplock, D; Shenolikar, S. CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. Journal of Clinical Investigation. 1993;92:1781-1786.  Abstract
  • Weinman, EJ; Steplock, DA; Shenolikar, S. Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane. Mineral and electrolyte metabolism. 1993;19:47-50.  Abstract
  • Endo, S; Shenolikar, S; Eskin, A; Zwartjes, RE; Byrne, JH. Characterization of neuronal protein phosphatases in Aplysia californica. Journal of Neurochemistry. 1992;58:975-982.  Abstract
  • Hagiwara, M; Alberts, A; Brindle, P; Meinkoth, J; Feramisco, J; Deng, T; Karin, M; Shenolikar, S; Montminy, M. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell. 1992;70:105-113.  Abstract
  • Nairn, AC; Shenolikar, S. The role of protein phosphatases in synaptic transmission, plasticity and neuronal development. Current Opinion in Neurobiology. 1992;2:296-301.  Abstract
  • Weinman, E; Hanley, R; Morell, G; Yuan, N; Steplock, D; Bui, G; Shenolikar, S. Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II. Mineral and electrolyte metabolism. 1992;18:35-39.  Abstract
  • La, BQ; Carosi, SL; Valentich, J; Shenolikar, S; Sansom, SC. Regulation of epithelial chloride channels by protein phosphatase. The American journal of physiology. 1991;260:C1217-C1223.  Abstract
  • Shenolikar, S; Nairn, AC. Protein phosphatases: recent progress. Advances in Second Messenger and Phosphoprotein Research. 1991;23:1-121.  Abstract
  • Dayani, N; McNaught, RW; Shenolikar, S; Smith, RG. Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor. Biochemistry. 1990;29:2691-2698.  Abstract
  • Elbrecht, A; DiRenzo, J; Smith, RG; Shenolikar, S. Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues. The Journal of biological chemistry. 1990;265:13415-13418.  Abstract
  • Hanley, RM; Shenolikar, S; Pollack, J; Steplock, D; Weinman, EJ. Identification of calcium-calmodulin multifunctional protein kinase II in rabbit kidney. Kidney international. 1990;38:63-66.  Abstract
  • Ichinose, M; Endo, S; Critz, SD; Shenolikar, S; Byrne, JH. Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica. Brain Research. 1990;533:137-140.  Abstract
  • Morell, G; Steplock, D; Shenolikar, S; Weinman, EJ. Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM. The American journal of physiology. 1990;259:F867-F871.  Abstract
  • Smith, RG; Nag, A; Dayani, N; McNaught, RW; Shenolikar, S. Estrogen receptor interconversion, factors regulating conformation and functions. Progress in Clinical and Biological Research. 1990;322:83-95.  Abstract
  • Weinman, EJ; Steplock, D; Bui, G; Yuan, N; Shenolikar, S. Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase. The American journal of physiology. 1990;258:F1254-F1258.  Abstract
  • Kunkel, MW; Friedman, J; Shenolikar, S; Clark, RB. Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1989;3:2067-2074.  Abstract
  • Weinman, EJ; Dubinsky, W; Shenolikar, S. Regulation of the renal Na+-H+ exchanger by protein phosphorylation. Kidney international. 1989;36:519-525.  Abstract
  • Weinman, EJ; Dubinsky, WP; Dinh, Q; Steplock, D; Shenolikar, S. Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase. The Journal of Membrane Biology. 1989;109:233-241.  Abstract
  • Weinman, EJ; Dubinsky, WP; Shenolikar, S. Regulation of the renal Na+-H+ exchanger. Hospital practice (Office ed.). 1989;24:157-passim.  Abstract
  • Hanley, RM; Means, AR; Kemp, BE; Shenolikar, S. Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain. Biochemical and Biophysical Research Communications. 1988;152:122-128.  Abstract
  • Lickteig, R; Shenolikar, S; Denner, L; Kelly, PT. Regulation of Ca2+/calmodulin-dependent protein kinase II by Ca2+/calmodulin-independent autophosphorylation. The Journal of biological chemistry. 1988;263:19232-19239.  Abstract
  • Maddox, AM; Steiner, AL; Shenolikar, S. Species specificity of antibodies to regulatory subunits of cyclic AMP-dependent protein kinases. Journal of Receptors and Signal Transduction. 1988;12:83-94.  Abstract
  • Shenolikar, S. Protein phosphorylation: hormones, drugs, and bioregulation. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1988;2:2753-2764.  Abstract
  • Shenolikar, S; Fischer, K; Chang, L; Weinman, EJ. Type II cAMP-dependent protein kinase is associated with the rabbit kidney brush border membranes. Journal of Receptors and Signal Transduction. 1988;12:95-104.  Abstract
  • Shenolikar, S; Langston, J; Schworer, CM; Kelly, PT. Substrate specificity of Ca2+/CaM-dependent multifunctional protein kinases: comparison of isoenzymes from brain, liver and skeletal muscle. Biochemical and Biophysical Research Communications. 1988;151:1332-1338.  Abstract
  • Weinman, EJ; Dubinsky, WP; Fisher, K; Steplock, D; Dinh, Q; Chang, L; Shenolikar, S. Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases. The Journal of Membrane Biology. 1988;103:237-244.  Abstract
  • Weinman, EJ; Dubinsky, WP; Shenolikar, S. Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger. The Journal of Membrane Biology. 1988;101:11-18.  Abstract
  • Weinman, EJ; Shenolikar, S; Cragoe, EJ; Dubinsky, WP. Solubilization and reconstitution of renal brush border Na+-H+ exchanger. The Journal of Membrane Biology. 1988;101:1-9.  Abstract
  • Hanley, RM; Dedman, JR; Shenolikar, S. Identification of high-affinity calmodulin-binding proteins in rat liver. The American journal of physiology. 1987;252:C277-C284.  Abstract
  • Hanley, RM; Strada, SJ; Steiner, AL; Thompson, WJ; Shenolikar, S. Increase in liver protein phosphatase-1 in spontaneously diabetic Chinese hamsters. Molecular and Cellular Endocrinology. 1987;50:115-122.  Abstract
  • Kelly, PT; Shenolikar, S. Role of autophosphorylation in regulating calmodulin-dependent protein kinases. Methods in Enzymology. 1987;139:690-714.  Abstract
  • Lavis, VR; Lee, DP; Shenolikar, S. Evidence that forskolin binds to the glucose transporter of human erythrocytes. The Journal of biological chemistry. 1987;262:14571-14575.  Abstract
  • Weinman, EJ; Shenolikar, S; Kahn, AM. cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. The American journal of physiology. 1987;252:F19-F25.  Abstract
  • Cornwell, T; Mehta, P; Shenolikar, S. Polyamine stimulation of protein phosphatase-2A from rat liver using a non-protein phosphoester substrate. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 1986;11:373-382.  Abstract
  • Hanley, RM; Dedman, JR; Steiner, AL; Shenolikar, S. Characterization of a major hepatic calmodulin acceptor protein (CAP-60). Transactions of the Association of American Physicians. 1986;99:78-85.  Abstract
  • Karbon, EW; Shenolikar, S; Enna, SJ. Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices. Journal of Neurochemistry. 1986;47:1566-1575.  Abstract
  • Shenolikar, S. Control of cell function by reversible protein phosphorylation. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 1986;11:531-541.  Abstract
  • Shenolikar, S; Karbon, EW; Enna, SJ. Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices. Biochemical and Biophysical Research Communications. 1986;139:251-258.  Abstract
  • Shenolikar, S; Lickteig, R; Hardie, DG; Soderling, TR; Hanley, RM; Kelly, PT. Calmodulin-dependent multifunctional protein kinase. Evidence for isoenzyme forms in mammalian tissues. European journal of biochemistry / FEBS. 1986;161:739-747.  Abstract
  • Weinman, EJ; Shenolikar, S. Protein kinase C activates the renal apical membrane Na+/H+ exchanger. The Journal of Membrane Biology. 1986;93:133-139.  Abstract
  • Shenolikar, S; Thompson, WJ; Strada, SJ. Characterization of a Ca2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain. Biochemistry. 1985;24:672-678.  Abstract
  • Alemany, S; Tung, HY; Shenolikar, S; Pilkis, SJ; Cohen, P. The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function. European journal of biochemistry / FEBS. 1984;145:51-56.  Abstract
  • Shenolikar, S; Ingebritsen, TS. Protein (serine and threonine) phosphate phosphatases. Methods in Enzymology. 1984;107:102-129.  Abstract
  • Shenolikar, S; Steiner, AL. Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones. Advances in cyclic nucleotide and protein phosphorylation research. 1984;17:405-415.  Abstract
  • Tung, HY; Resink, TJ; Hemmings, BA; Shenolikar, S; Cohen, P. The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products. European journal of biochemistry / FEBS. 1984;138:635-641.  Abstract
  • Picton, C; Shenolikar, S; Grand, R; Cohen, P. Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle. Methods in Enzymology. 1983;102:219-227.  Abstract
  • Shenolikar, S; Stevenson, KJ. Purification and partial characterization of a thiol proteinase from the thermophilic fungus Humicola lanuginosa. The Biochemical journal. 1982;205:147-152.  Abstract
  • Grand, RJ; Shenolikar, S; Cohen, P. The amino acid sequence of the delta subunit (calmodulin) of rabbit skeletal muscle phosphorylase kinase. European journal of biochemistry / FEBS. 1981;113:359-367.  Abstract
  • Cohen, P; Klee, CB; Picton, C; Shenolikar, S. Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin. Annals of the New York Academy of Sciences. 1980;356:151-161.  Abstract
  • Shenolikar, S; Cohen, PT; Cohen, P; Nairn, AC; Perry, SV. The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle. European journal of biochemistry / FEBS. 1979;100:329-337.  Abstract
  • Shenolikar, S; Cohen, P. The substrate specificity of cyclic AMP-dependent protein kinase: amino acid sequences at the phosphorylation sites of herring protamine (clupeine). FEBS Letters. 1978;86:92-98.  Abstract
  • Shenolikar, S; Foulkes, JG; Cohen, P. Isolation of an active fragment of protein phosphatase inhibitor-I from rabbit skeletal muscle. Biochemical Society transactions. 1978;6:935-937.  Abstract
  • Chattaway, FW; Shenolikar, S; O'Reilly, J; Barlow, AJ. Changes in the cell surface of the dimorphic forms of Candida albicans by treatment with hydrolytic enzymes. Journal of General Microbiology. 1976;96:335-347.  Abstract
  • Chattaway, FW; Shenolikar, S; Barlow, AJ. The release of acid phosphatase and polysaccharide- and protein-containing components from the surface of the dimorphic forms of Candida albicans by treatment with dithiothreitol. Journal of General Microbiology. 1974;83:423-425.  Abstract