Andrew Sherwood, PhD

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Professor in Psychiatry and Behavioral Sciences
Professor in the Department of Psychology and Neuroscience
Department / Division:
Psychiatry / Behavioral Medicine
Address:
4569 Hosp South
Durham, NC 27710
Office Telephone:
(919) 684-8835
Training:
  • PhD, University of Hull (England), 1972
Research Interests:
My current research focus is on biological, behavioral and sociocultural factors involved in the etiology and management of hypertension, coronary artery disease, and congestive heart failure. The role of stress and the sympathetic nervous system in disease onset and progression is of central interest. Current research issues being studied include: (i) Ethnicity and gender as factors related to the pathogenesis of hypertension; (ii) Mechanisms by which menopause increases the risk of cardiovascular disease in women; (iii) Mechanisms by which stress may provoke episodes of myocardial ischemia in patients with coronary artery disease; (iv) Stress biomarkers that are associated with adverse clinical outcomes in cardiac patients; (v) The development of coping skills interventions to improve prognosis and quality of life in patients with congestive heart failure; (vi) Circadian blood pressure profiles for risk stratification in patients with hypertension; (vii) Biological and behavioral factors contributing to elevated nighttime blood pressure and blunted nighttime blood pressure dipping.

Comprehensive assessments of cardiovascular regulatory systems define the daily activity in the biobehavioral research laboratory. Assessments include: (i) hemodynamic (blood pressure, cardiac output, systemic vascular resistance) and neurohumoral responses (plasma epinephrine and norepinephrine) during psychological and physical stress testing; (ii) alpha and beta adrenergic receptor function, the baroreceptor reflex, and cardiac vagal control; (iii) endothelial function, and vascular structure and compliance; (iv) left ventricular structure and function by echocardiography; (v) 24-hour ambulatory blood pressure and cardiac output monitoring; (vi) Nonivasive assessments of arterial stiffness and central aortic pressure; (vii) Psychometric assessments of personality and lifestyle characteristics related to cardiovascular disease.

A secondary research interest is in the use and development of noninvasive techniques for evaluating the cardiovascular system. Developments include an ambulatory impedance cardiography system, permitting assessment of 24-hour hemodynamics during normal daily activities, and biomarkers of cardiovascular risk obtained using ultrasound imaging.

RESINT.DOC 1/5/99
Representative Publications:
  • Fan, LB; Blumenthal, JA; Hinderliter, AL; Sherwood, A. The effect of job strain on nighttime blood pressure dipping among men and women with high blood pressure. Scandinavian Journal of Work Environment and Health. 2013;39:112-119.  Abstract
  • Blumenthal, JA; Sherwood, A; Babyak, MA; Watkins, LL; Smith, PJ; Hoffman, BM; O'Hayer, CV; Mabe, S; Johnson, J; Doraiswamy, PM; Jiang, W; Schocken, DD; Hinderliter, AL. Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study. Journal of the American College of Cardiology. 2012;60:1053-1063.  Abstract
  • Routledge, FS; Hinderliter, AL; Blumenthal, JA; Sherwood, A. Sex differences in the endothelial function of untreated hypertension. Journal of Clinical Hypertension. 2012;14:228-235.  Abstract
  • Sherwood, A; Bower, JK; Routledge, FS; Blumenthal, JA; McFetridge-Durdle, JA; Newby, LK; Hinderliter, AL. Nighttime blood pressure dipping in postmenopausal women with coronary heart disease. American Journal of Hypertension. 2012;25:1077-1082.  Abstract
  • Sherwood, A; Wosiski-Kuhn, M; Nguyen, T; Holland, PC; Lakaye, B; Adamantidis, A; Johnson, AW. The role of melanin-concentrating hormone in conditioned reward learning. European Journal of Neuroscience. 2012;36:3126-3133.  Abstract
  • Prather, AA; Blumenthal, JA; Hinderliter, AL; Sherwood, A. Ethnic differences in the effects of the DASH diet on nocturnal blood pressure dipping in individuals with high blood pressure. American Journal of Hypertension. 2011;24:1338-1344.  Abstract
  • Sherwood, A; Blumenthal, JA; Hinderliter, AL; Koch, GG; Adams, KF; Dupree, CS; Bensimhon, DR; Johnson, KS; Trivedi, R; Bowers, M; Christenson, RH; O'Connor, CM. Worsening depressive symptoms are associated with adverse clinical outcomes in patients with heart failure. Journal of the American College of Cardiology. 2011;57:418-423.  Abstract
  • Sherwood, A; O'Connor, CM; Routledge, FS; Hinderliter, AL; Watkins, LL; Babyak, MA; Koch, GG; Adams, KF; Dupree, CS; Chang, PP; Hoffman, BM; Johnson, J; Bowers, M; Johnson, KS; Blumenthal, JA. Coping effectively with heart failure (COPE-HF): design and rationale of a telephone-based coping skills intervention. Journal of Cardiac Failure. 2011;17:201-207.  Abstract
  • Sherwood, A; Routledge, FS; Wohlgemuth, WK; Hinderliter, AL; Kuhn, CM; Blumenthal, JA. Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity. American Journal of Hypertension. 2011;24:982-988.  Abstract
  • Smith, PJ; Blumenthal, JA; Babyak, MA; Hinderliter, A; Sherwood, A. Association of vascular health and neurocognitive performance in overweight adults with high blood pressure. Journal of Clinical and Experimental Neuropsychology. 2011;33:559-566.  Abstract
  • Blumenthal, JA; Babyak, MA; Hinderliter, A; Watkins, LL; Craighead, L; Lin, PH; Caccia, C; Johnson, J; Waugh, R; Sherwood, A. Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study. Archives of Internal Medicine. 2010;170:126-135.  Abstract
  • Blumenthal, JA; Babyak, MA; Sherwood, A; Craighead, L; Lin, PH; Johnson, J; Watkins, LL; Wang, JT; Kuhn, C; Feinglos, M; Hinderliter, A. Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids. Hypertension. 2010;55:1199-1205.  Abstract
  • Dedert, EA; Calhoun, PS; Watkins, LL; Sherwood, A; Beckham, JC. Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence. Annals of Behavioral Medicine. 2010;39:61-78.  Abstract
  • Hoffman, BM; Sherwood, A; Smith, PJ; Babyak, MA; Doraiswamy, PM; Hinderliter, A; Blumenthal, JA. Cardiovascular disease risk, vascular health and erectile dysfunction among middle-aged, clinically depressed men. International Journal of Impotence Research. 2010;22:30-35.  Abstract
  • Sherwood, A; Park, SB; Hughes, JW; Blumenthal, JA; Hinderliter, A; Trivedi, R; McFetridge-Durdle, J. Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. Menopause: The Journal of the North American Menopause Society. 2010;17:403-409.  Abstract
  • Smith, PJ; Blumenthal, JA; Babyak, MA; Doraiswamy, PM; Hinderliter, A; Hoffman, BM; Waugh, R; Sherwood, A. Intima-media thickness and age of first depressive episode. Biological Psychology. 2009;80:361-364.  Abstract
  • Trivedi, RB; Blumenthal, JA; O'Connor, C; Adams, K; Hinderliter, A; Dupree, C; Johnson, K; Sherwood, A. Coping styles in heart failure patients with depressive symptoms. Journal of Psychosomatic Research. 2009;67:339-346.  Abstract
  • Sherwood, A; Blumenthal, JA; Trivedi, R; Johnson, KS; O'Connor, CM; Adams, KF; Dupree, CS; Waugh, RA; Bensimhon, DR; Gaulden, L; Christenson, RH; Koch, GG; Hinderliter, AL. Relationship of depression to death or hospitalization in patients with heart failure. Archives of Internal Medicine. 2007;167:367-373.  Abstract
  • Sherwood, A; Bower, JK; McFetridge-Durdle, J; Blumenthal, JA; Newby, LK; Hinderliter, AL. Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal women. Arteriosclerosis, Thrombosis and Vascular Biology. 2007;27:1782-1787.  Abstract
  • Sherwood, A; Hinderliter, AL; Watkins, LL; Waugh, RA; Blumenthal, JA. Impaired endothelial function in coronary heart disease patients with depressive symptomatology. Journal of the American College of Cardiology. 2005;46:656-659.  Abstract
  • Hinderliter, AL; Blumenthal, JA; Waugh, R; Chilukuri, M; Sherwood, A. Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation. American Journal of Hypertension. 2004;17:43-49.  Abstract
  • Hughes, JW; Watkins, L; Blumenthal, JA; Kuhn, C; Sherwood, A. Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged women. Journal of Psychosomatic Research. 2004;57:353-358.  Abstract
  • Sherwood, A; Hughes, JW; Kuhn, C; Hinderliter, AL. Hostility is related to blunted beta-adrenergic receptor responsiveness among middle-aged women. Psychosomatic Medicine. 2004;66:507-513.  Abstract
  • Sherwood, A; Hughes, JW; McFetridge, J. Ethnic differences in the hemodynamic mechanisms of ambulatory blood pressure regulation. American Journal of Hypertension. 2003;16:270-273.  Abstract
  • Steffen, PR; McNeilly, M; Anderson, N; Sherwood, A. Effects of perceived racism and anger inhibition on ambulatory blood pressure in African Americans. Psychosomatic Medicine. 2003;65:746-750.  Abstract
  • Hinderliter, AL; Sherwood, A; Blumenthal, JA; Light, KC; Girdler, SS; McFetridge, J; Johnson, K; Waugh, R. Changes in hemodynamics and left ventricular structure after menopause. American Journal of Cardiology. 2002;89:830-833.  Abstract
  • Sherwood, A; Gullette, EC; Hinderliter, AL; Georgiades, A; Babyak, M; Waugh, RA; Blumenthal, JA. Relationship of clinic, ambulatory, and laboratory stress blood pressure to left ventricular mass in overweight men and women with high blood pressure. Psychosomatic Medicine. 2002;64:247-257.  Abstract
  • Sherwood, A; Steffen, PR; Blumenthal, JA; Kuhn, C; Hinderliter, AL. Nighttime blood pressure dipping: the role of the sympathetic nervous system. American Journal of Hypertension. 2002;15:111-118.  Abstract
  • Sherwood, A; Thurston, R; Steffen, P; Blumenthal, JA; Waugh, RA; Hinderliter, AL. Blunted nighttime blood pressure dipping in postmenopausal women. American Journal of Hypertension. 2001;14:749-754.  Abstract
  • Steffen, PR; Hinderliter, AL; Blumenthal, JA; Sherwood, A. Religious coping, ethnicity, and ambulatory blood pressure. Psychosomatic Medicine. 2001;63:523-530.  Abstract
  • Blumenthal, JA; Sherwood, A; Gullette, EC; Babyak, M; Waugh, R; Georgiades, A; Craighead, LW; Tweedy, D; Feinglos, M; Appelbaum, M; Hayano, J; Hinderliter, A. Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning. Archives of Internal Medicine. 2000;160:1947-1958.  Abstract
  • Carels, RA; Blumenthal, JA; Sherwood, A. Emotional responsivity during daily life: relationship to psychosocial functioning and ambulatory blood pressure. International Journal of Psychophysiology. 2000;36:25-33.  Abstract
  • Carels, RA; Sherwood, A; Szczepanski, R; Blumenthal, JA. Ambulatory blood pressure and marital distress in employed women. Behavioral Medicine: relating behavior and health. 2000;26:80-85.  Abstract
  • McFetridge, JA; Sherwood, A. Hemodynamic and sympathetic nervous system responses to stress during the menstrual cycle. AACN Advanced Critical Care. 2000;11:158-167.  Abstract
  • Sherwood, A; Johnson, K; Blumenthal, JA; Hinderliter, AL. Endothelial function and hemodynamic responses during mental stress. Psychosomatic Medicine. 1999;61:365-370.  Abstract
  • Carels, RA; Sherwood, A; Blumenthal, JA. High anxiety and white coat hypertension. JAMA: Journal of the American Medical Association. 1998;279:197-198.  Abstract
  • Carels, RA; Sherwood, A; Blumenthal, JA. Psychosocial influences on blood pressure during daily life. International Journal of Psychophysiology. 1998;28:117-129.  Abstract
  • Carels, RA; Szczepanski, R; Blumenthal, JA; Sherwood, A. Blood pressure reactivity and marital distress in employed women. Psychosomatic Medicine. 1998;60:639-643.  Abstract
  • Sherwood, A; McFetridge, J; Hutcheson, JS. Ambulatory impedance cardiography: a feasibility study. Journal of Applied Physiology. 1998;85:2365-2369.  Abstract
  • Sherwood, A; Girdler, SS; Bragdon, EE; West, SG; Brownley, KA; Hinderliter, AL; Light, KC. Ten-year stability of cardiovascular responses to laboratory stressors. Psychophysiology: an international journal. 1997;34:185-191.  Abstract
  • Sherwood, A; Hinderliter, AL; Light, KC. Physiological determinants of hyperreactivity to stress in borderline hypertension. Hypertension. 1995;25:384-390.  Abstract
  • Sherwood, A; May, CW; Siegel, WC; Blumenthal, JA. Ethnic differences in hemodynamic responses to stress in hypertensive men and women. American Journal of Hypertension. 1995;8:552-557.  Abstract
  • Sherwood, A; Turner, JR. Hemodynamic responses during psychological stress: implications for studying disease processes. International Journal of Behavioral Medicine. 1995;2:193-218.  Abstract
  • Sherwood, A; Davis, MR; Dolan, CA; Light, KC. Cardiovascular reactivity assessment: effects of choice of difficulty on laboratory task responses. International Journal of Psychophysiology. 1992;12:87-94.  Abstract
  • Sherwood, A; Royal, SA; Hutcheson, JS; Turner, JR. Comparison of impedance cardiographic measurements using band and spot electrodes. Psychophysiology: an international journal. 1992;29:734-741.  Abstract
  • Sherwood, A; Carter, LS; Murphy, CA. Cardiac output by impedance cardiography: two alternative methodologies compared with thermodilution. Aviation, Space, and Environmental Medicine. 1991;62:116-122.  Abstract
  • Sherwood, A; Allen, MT; Fahrenberg, J; Kelsey, RM; Lovallo, WR; van Doornen, LJ. Methodological guidelines for impedance cardiography. Psychophysiology: an international journal. 1990;27:1-23.  Abstract
  • Sherwood, A; Dolan, CA; Light, KC. Hemodynamics of blood pressure responses during active and passive coping. Psychophysiology: an international journal. 1990;27:656-668.  Abstract
  • Sherwood, A; Allen, MT; Murrell, D; Obrist, PA. Motor preparation aspects of cardiovascular reactivity to psychological challenge. International Journal of Psychophysiology. 1988;6:263-272.  Abstract