Cache County Study on Memory Health and Aging (CCMS)


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The Cache County Study on Memory Health and Aging (CCMS), begun in 1995, is a population-based longitudinal investigation of AD in relation to genetic and environmental antecedents [1]. Funded from 1994-2008, the CCMS collected risk factor information and screened the population (baseline n=5,092) for dementia and AD in essentially 4 triennial “waves” (1995 through 1997, 1998 through 2000, 2002 through 2004, and 2005 through 2007). To accomplish the study aims, methodology was developed that included some novel features, such as (1) a method of sequential screening and clinical assessment for dementia in the subject’s residence rather than requiring subjects to travel to a medical site; (2) physician examination and laboratory workup of all suspicious cases of dementia, including early neurocognitive disorders and prodromal dementia; and the (3) careful construction of a “designated control panel” for purposes of case-control comparisons. The construction of the “designated control” panel in the study has proven especially advantageous for the detection of incident cases of dementia and mild neurocognitive disorders of aging.

Primary references:

Breitner JC, Wyse BW, Anthony JC, Welsh-Bohmer KA, Steffens DC, Norton MC, et al. APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study. Neurology. 1999 Jul 22;53(2):321-31.

Miech RA, Breitner JCS, Zandi PP, Khachaturian AS, Anthony JC, Mayer L. Incidence of AD may decline in the early 90s for men, later for women: The Cache County study. Neurology. 2002 January 22, 2002;58(2):209-18.

Welsh-Bohmer KA, Ostbye T, Sanders L, Pieper CF, Hayden KM, Tschanz JT, et al. Neuropsychological performance in advanced age: influences of demographic factors and Apolipoprotein E: findings from the Cache County Memory Study. Clin Neuropsychol. 2009 Jan;23(1):77-99.